UniProtKB - A0A0D9SGH8 (A0A0D9SGH8_HUMAN)
Protein
Submitted name:
Transcription factor 7-like 2
Gene
TCF7L2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 332 – 400 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
GO - Biological processi
- Wnt signaling pathway Source: InterPro
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor 7-like 2Imported |
Gene namesi | Name:TCF7L2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11641 TCF7L2 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-UniRule
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000148737 Expressed in 228 organ(s), highest expression level in lateral nuclear group of thalamus |
ExpressionAtlasi | A0A0D9SGH8 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 332 – 400 | HMG boxInterPro annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 96 | DisorderedSequence analysisAdd BLAST | 96 | |
Regioni | 300 – 332 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 400 – 426 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 460 – 512 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 534 – 584 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 16 – 46 | PolyampholyteSequence analysisAdd BLAST | 31 | |
Compositional biasi | 47 – 63 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 64 – 91 | PolyampholyteSequence analysisAdd BLAST | 28 | |
Compositional biasi | 300 – 314 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 315 – 332 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 485 – 502 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 549 – 584 | PolarSequence analysisAdd BLAST | 36 |
Phylogenomic databases
GeneTreei | ENSGT00940000155535 |
OrthoDBi | 807716at2759 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR027397 Catenin_binding_dom_sf IPR013558 CTNNB1-bd_N IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR024940 TCF/LEF |
PANTHERi | PTHR10373 PTHR10373, 1 hit |
Pfami | View protein in Pfam PF08347 CTNNB1_binding, 1 hit PF00505 HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398 HMG, 1 hit |
SUPFAMi | SSF47095 SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118 HMG_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
A0A0D9SGH8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPQLNGGGGD DLGANDELIS FKDEGEQEEK SSENSSAERD LADVKSSLVN
60 70 80 90 100
ESETNQNSSS DSEAERRPPP RSESFRDKSR ESLEEAAKRQ DGGLFKGPPY
110 120 130 140 150
PGYPFIMIPD LTSPYLPNGS LSPTARTYLQ MKWPLLDVQA GSLQSRQALK
160 170 180 190 200
DARSPSPAHI VSNKVPVVQH PHHVHPLTPL ITYSNEHFTP GNPPPHLPAD
210 220 230 240 250
VDPKTGIPRP PHPPDISPYY PLSPGTVGQI PHPLGWLVPQ QGQPVYPITT
260 270 280 290 300
GGFRHPYPTA LTVNASMSSF LSSRFPPHMV PPHHTLHTTG IPHPAIVTPT
310 320 330 340 350
VKQESSQSDV GSLHSSKHQD SKKEEEKKKP HIKKPLNAFM LYMKEMRAKV
360 370 380 390 400
VAECTLKESA AINQILGRRW HALSREEQAK YYELARKERQ LHMQLYPGWS
410 420 430 440 450
ARDNYGKKKK RKRDKQPGET NDANTPKKCR ALFGLDRQTL WCKPCRRKKK
460 470 480 490 500
CVRYIQGEGS CLSPPSSDGS LLDSPPPSPN LLGSPPRDAK SQTEQTQPLS
510 520 530 540 550
LSLKPDPLAH LSMMPPPPAL LLAEATHKAS ALCPNGALDL PPAALQPAAP
560 570 580
SSSIAQPSTS SLHSHSSLAG TQPQPLSLVT KSLE
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NQB0 | TF7L2_HUMAN | Transcription factor 7-like 2 | TCF7L2 TCF4 | 619 | Annotation score: | ||
Q5VVR7 | Q5VVR7_HUMAN | TCF7L2 isoform pFC8A_TCF7L2_H7_ex1-... | TCF7L2 | 455 | Annotation score: | ||
C6ZRK5 | C6ZRK5_HUMAN | TCF7L2 isoform pFC8A_TCF7L2_ex1-11-... | TCF7L2 hCG_40998 | 579 | Annotation score: | ||
A0A0A0MTL7 | A0A0A0MTL7_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 408 | Annotation score: | ||
C6ZRJ7 | C6ZRJ7_HUMAN | TCF7L2 isoform pFC8A_TCF7L2_A3,ex1-... | TCF7L2 | 476 | Annotation score: | ||
E2GH26 | E2GH26_HUMAN | T-cell factor-4 variant L | TCF7L2 | 607 | Annotation score: | ||
Q5JRY5 | Q5JRY5_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 206 | Annotation score: | ||
Q5JRY3 | Q5JRY3_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 157 | Annotation score: | ||
C6ZRJ6 | C6ZRJ6_HUMAN | TCF7L2 isoform pFC8A_TCF7L2_D5_ex3,... | TCF7L2 | 534 | Annotation score: | ||
Q5VVR5 | Q5VVR5_HUMAN | Transcription factor 7-like 2 | TCF7L2 | 222 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL135792 Genomic DNA No translation available. AL158212 Genomic DNA No translation available. AL445486 Genomic DNA No translation available. AL451084 Genomic DNA No translation available. |
RefSeqi | XP_005270146.1, XM_005270089.1 |
Genome annotation databases
Ensembli | ENST00000629706; ENSP00000487507; ENSG00000148737 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL135792 Genomic DNA No translation available. AL158212 Genomic DNA No translation available. AL445486 Genomic DNA No translation available. AL451084 Genomic DNA No translation available. |
RefSeqi | XP_005270146.1, XM_005270089.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
jPOSTi | A0A0D9SGH8 |
PeptideAtlasi | A0A0D9SGH8 |
PRIDEi | A0A0D9SGH8 |
Genome annotation databases
Ensembli | ENST00000629706; ENSP00000487507; ENSG00000148737 |
Organism-specific databases
CTDi | 6934 |
HGNCi | HGNC:11641 TCF7L2 |
OpenTargetsi | ENSG00000148737 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155535 |
OrthoDBi | 807716at2759 |
Miscellaneous databases
ChiTaRSi | TCF7L2 human |
GenomeRNAii | 6934 |
Gene expression databases
Bgeei | ENSG00000148737 Expressed in 228 organ(s), highest expression level in lateral nuclear group of thalamus |
ExpressionAtlasi | A0A0D9SGH8 baseline and differential |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR027397 Catenin_binding_dom_sf IPR013558 CTNNB1-bd_N IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR024940 TCF/LEF |
PANTHERi | PTHR10373 PTHR10373, 1 hit |
Pfami | View protein in Pfam PF08347 CTNNB1_binding, 1 hit PF00505 HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398 HMG, 1 hit |
SUPFAMi | SSF47095 SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118 HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0D9SGH8_HUMAN | |
Accessioni | A0A0D9SGH8Primary (citable) accession number: A0A0D9SGH8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 27, 2015 |
Last sequence update: | May 27, 2015 | |
Last modified: | September 18, 2019 | |
This is version 34 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |