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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase kinase 4

Gene

MAP4K4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase kinase 4Imported
Gene namesi
Name:MAP4K4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000071054.16
HGNCiHGNC:6866 MAP4K4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000071054

PTM / Processingi

Proteomic databases

EPDiA0A0D9SG62
PeptideAtlasiA0A0D9SG62

Expressioni

Gene expression databases

BgeeiENSG00000071054 Expressed in 229 organ(s), highest expression level in brain
ExpressionAtlasiA0A0D9SG62 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0D9SG62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 321Protein kinaseInterPro annotationAdd BLAST297
Domaini731 – 1018CNHInterPro annotationAdd BLAST288

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili162 – 182Sequence analysisAdd BLAST21
Coiled coili212 – 232Sequence analysisAdd BLAST21
Coiled coili237 – 345Sequence analysisAdd BLAST109
Coiled coili360 – 380Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00930000150859

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

A0A0D9SG62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANDSPAKSL VDIDLSSLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL
60 70 80 90 100
AAIKVMDVTE DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ
110 120 130 140 150
LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG LAHLHIHHVI
160 170 180 190 200
HRDIKGQNVL LTENAEVKLD ETEYEYSGSE EEEEEVPEQE GEPSSIVNVP
210 220 230 240 250
GESTLRRDFL RLQQENKERS EALRRQQLLQ EQQLREQEEY KRQLLAERQK
260 270 280 290 300
RIEQQKEQRR RLEEQQRRER EARRQQEREQ RRREQEEKRR LEELERRRKE
310 320 330 340 350
EEERRRAEEE KRRVEREQEY IRRQLEEEQR HLEVLQQQLL QEQAMLLECR
360 370 380 390 400
WREMEEHRQA ERLQRQLQQE QAYLLSLQHD HRRPHPQHSQ QPPPPQQERS
410 420 430 440 450
KPSFHAPEPK AHYEPADRAR EVPVRTTSRS PVLSRRDSPL QGSGQQNSQA
460 470 480 490 500
GQRNSTSSIE PRLLWERVEK LVPRPGSGSS SGSSNSGSQP GSHPGSQSGS
510 520 530 540 550
GERFRVRSSS KSEGSPSQRL ENAVKKPEDK KEVFRPLKPA VRIVQDQTAL
560 570 580 590 600
AKELRAVEDV RPPHKVTDYS SSSEESGTTD EEDDDVEQEG ADESTSGPED
610 620 630 640 650
TRAASSLNLS NGETESVKTM IVHDDVESEP AMTPSKEGTL IVRQTQSASS
660 670 680 690 700
TLQKHKSSSS FTPFIDPRLL QISPSSGTTV TSVVGFSCDG MRPEAIRQDP
710 720 730 740 750
TRKGSVVNVN PTNTRPQSDT PEIRKYKKRF NSEILCAALW GVNLLVGTES
760 770 780 790 800
GLMLLDRSGQ GKVYPLINRR RFQQMDVLEG LNVLVTISGK KDKLRVYYLS
810 820 830 840 850
WLRNKILHND PEVEKKQGWT TVGDLEGCVH YKVVKYERIK FLVIALKSSV
860 870 880 890 900
EVYAWAPKPY HKFMAFKSFG ELVHKPLLVD LTVEEGQRLK VIYGSCAGFH
910 920 930 940 950
AVDVDSGSVY DIYLPTHIQC SIKPHAIIIL PNTDGMELLV CYEDEGVYVN
960 970 980 990 1000
TYGRITKDVV LQWGEMPTSV AYIRSNQTMG WGEKAIEIRS VETGHLDGVF
1010 1020 1030 1040
MHKRAQRLKF LCERNDKVFF ASVRSGGSSQ VYFMTLGRTS LLSW
Length:1,044
Mass (Da):119,698
Last modified:May 27, 2015 - v1
Checksum:iDAF2539FD619AE08
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95819M4K4_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4 HGK, KIAA0687, NIK
1,239Annotation score:
E7EN19E7EN19_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4
1,272Annotation score:
A0A0D9SEY1A0A0D9SEY1_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4 hCG_1640439
1,320Annotation score:
C9J840C9J840_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4
987Annotation score:
E7EX83E7EX83_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4
1,038Annotation score:
H7C360H7C360_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4
1,170Annotation score:
E7ENQ1E7ENQ1_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4
1,154Annotation score:
G5E948G5E948_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4
1,235Annotation score:
G3XAA2G3XAA2_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4 hCG_1640439
1,165Annotation score:
E7ETN6E7ETN6_HUMAN
Mitogen-activated protein kinase ki...
MAP4K4
102Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005035 Genomic DNA No translation available.
AC007005 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000627726; ENSP00000487176; ENSG00000071054

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005035 Genomic DNA No translation available.
AC007005 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A0D9SG62
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiA0A0D9SG62
PeptideAtlasiA0A0D9SG62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000627726; ENSP00000487176; ENSG00000071054

Organism-specific databases

EuPathDBiHostDB:ENSG00000071054.16
HGNCiHGNC:6866 MAP4K4
OpenTargetsiENSG00000071054
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00930000150859

Miscellaneous databases

ChiTaRSiMAP4K4 human

Gene expression databases

BgeeiENSG00000071054 Expressed in 229 organ(s), highest expression level in brain
ExpressionAtlasiA0A0D9SG62 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001180 CNH_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00036 CNH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50219 CNH, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0D9SG62_HUMAN
AccessioniPrimary (citable) accession number: A0A0D9SG62
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: November 7, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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