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Protein
Submitted name:

Four and a half LIM domains protein 1

Gene

FHL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Four and a half LIM domains protein 1Imported
Gene namesi
Name:FHL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000022267.16
HGNCiHGNC:3702 FHL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000022267

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0D9SFZ9

Expressioni

Gene expression databases

BgeeiENSG00000022267 Expressed in 243 organ(s), highest expression level in biceps brachii
ExpressionAtlasiA0A0D9SFZ9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0D9SFZ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 98LIM zinc-bindingInterPro annotationAdd BLAST61
Domaini99 – 160LIM zinc-bindingInterPro annotationAdd BLAST62

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118910

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

A0A0D9SFZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEKFDCHYC RDPLQGKKYV QKDGHHCCLK CFDKFCANTC VECRKPIGAD
60 70 80 90 100
SKEVHYKNRF WHDTCFRCAK CLHPLANETF VAKDNKILCN KCTTREDSPK
110 120 130 140 150
CKGCFKAIVA GDQNVEYKGT VWHKDCFTCS NCKQVIGTGS FFPKGEDFYC
160 170
VTCHETKFAK HCVKCNKAIT SGGIT
Length:175
Mass (Da):19,897
Last modified:May 27, 2015 - v1
Checksum:i603799253A512DBD
GO

Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13642FHL1_HUMAN
Four and a half LIM domains protein...
FHL1 SLIM1
323Annotation score:
Q5JXI2Q5JXI2_HUMAN
Four and a half LIM domains protein...
FHL1
210Annotation score:
Q5JXH7Q5JXH7_HUMAN
Four and a half LIM domains protein...
FHL1
205Annotation score:
Q5JXI8Q5JXI8_HUMAN
Four and a half LIM domains protein...
FHL1
257Annotation score:
Q5JXH8Q5JXH8_HUMAN
Four and a half LIM domains protein...
FHL1
204Annotation score:
Q5JXI0Q5JXI0_HUMAN
Four and a half LIM domains protein...
FHL1
141Annotation score:
Q5JXH9Q5JXH9_HUMAN
Four and a half LIM domains protein...
FHL1
155Annotation score:
Q5JXI3Q5JXI3_HUMAN
Four and a half LIM domains protein...
FHL1
207Annotation score:
A0A0D9SG53A0A0D9SG53_HUMAN
Four and a half LIM domains protein...
FHL1
130Annotation score:
A0A0D9SFI6A0A0D9SFI6_HUMAN
Four and a half LIM domains protein...
FHL1
147Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei175Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078638 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000628032; ENSP00000487030; ENSG00000022267

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078638 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A0D9SFZ9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0D9SFZ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000628032; ENSP00000487030; ENSG00000022267

Organism-specific databases

EuPathDBiHostDB:ENSG00000022267.16
HGNCiHGNC:3702 FHL1
OpenTargetsiENSG00000022267
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118910

Miscellaneous databases

ChiTaRSiFHL1 human

Gene expression databases

BgeeiENSG00000022267 Expressed in 243 organ(s), highest expression level in biceps brachii
ExpressionAtlasiA0A0D9SFZ9 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 2 hits
SMARTiView protein in SMART
SM00132 LIM, 2 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0D9SFZ9_HUMAN
AccessioniPrimary (citable) accession number: A0A0D9SFZ9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: September 12, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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