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UniProtKB - A0A0D9SFY2 (A0A0D9SFY2_HUMAN)
Protein
Submitted name:
Secretin receptor
Gene
SCTR
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- cell surface receptor signaling pathway Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Submitted name: Secretin receptor |
Gene namesi | Name:SCTR |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10608, SCTR |
VEuPathDBi | HostDB:ENSG00000080293 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 169 – 189 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000080293, Expressed in body of pancreas and 113 other tissues |
ExpressionAtlasi | A0A0D9SFY2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 152 | G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST | 84 | |
Domaini | 167 – 243 | G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST | 77 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160618 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR002144, GPCR_2_secretin_rcpt |
PANTHERi | PTHR45620:SF13, PTHR45620:SF13, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00490, SECRETINR |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
A0A0D9SFY2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVIPALWEA EVRGSLEPKS SRPAWATWVF SPCSIMLEFP ETMGFSKNQT
60 70 80 90 100
GALPRLCDVL QVLWEEQDQC LQELSREQTG DLGTEQPVPG CEGMWDNISC
110 120 130 140 150
WPSSVPGRMV EVECPRFLRM LTSRNGSLFR NCTQDGWSET FPRPNLACGV
160 170 180 190 200
NVNDSSNEKR HSYLLKLKVM YTVGYSSSLV MLLVALGILC AFRRLHCTRN
210 220 230 240
YIHMHLFVSF ILRALSNFIK DAVLFSSDDV TYCDAHRAGC KLV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP47872 | SCTR_HUMAN | Secretin receptor | SCTR | 440 | Annotation score: | ||
A0A0D9SFV7 | A0A0D9SFV7_HUMAN | Secretin receptor | SCTR | 150 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 243 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013275 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000627145.1; ENSP00000486987.1; ENSG00000080293.10 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013275 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0D9SFY2 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 18314, 280 antibodies from 34 providers |
Genome annotation databases
Ensembli | ENST00000627145.1; ENSP00000486987.1; ENSG00000080293.10 |
Organism-specific databases
HGNCi | HGNC:10608, SCTR |
OpenTargetsi | ENSG00000080293 |
VEuPathDBi | HostDB:ENSG00000080293 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160618 |
Miscellaneous databases
ChiTaRSi | SCTR, human |
Gene expression databases
Bgeei | ENSG00000080293, Expressed in body of pancreas and 113 other tissues |
ExpressionAtlasi | A0A0D9SFY2, baseline and differential |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR036445, GPCR_2_extracell_dom_sf IPR001879, GPCR_2_extracellular_dom IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR002144, GPCR_2_secretin_rcpt |
PANTHERi | PTHR45620:SF13, PTHR45620:SF13, 1 hit |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF02793, HRM, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN PR00490, SECRETINR |
SMARTi | View protein in SMART SM00008, HormR, 1 hit |
SUPFAMi | SSF111418, SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649, G_PROTEIN_RECEP_F2_1, 1 hit PS50227, G_PROTEIN_RECEP_F2_3, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0D9SFY2_HUMAN | |
Accessioni | A0A0D9SFY2Primary (citable) accession number: A0A0D9SFY2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 27, 2015 |
Last sequence update: | May 27, 2015 | |
Last modified: | May 25, 2022 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |