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Protein

Glycoprotein hormones alpha chain

Gene

CGA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormones alpha chainUniRule annotation
Gene namesi
Name:CGAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135346.8
HGNCiHGNC:1885 CGA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135346

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_500539203825 – 62Glycoprotein hormones alpha chainUniRule annotationAdd BLAST38

Keywords - PTMi

Disulfide bondSAAS annotation, GlycoproteinUniRule annotation

Proteomic databases

PeptideAtlasiA0A0D9SFJ6

Expressioni

Gene expression databases

BgeeiENSG00000135346 Expressed in 91 organ(s), highest expression level in placenta
ExpressionAtlasiA0A0D9SFJ6 baseline and differential

Interactioni

Subunit structurei

Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0D9SFJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit alpha family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000012242

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A0D9SFJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL
60
QCMGCCFSRA YP
Length:62
Mass (Da):7,034
Last modified:May 27, 2015 - v1
Checksum:i851075E8EDDA64A0
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P01215GLHA_HUMAN
Glycoprotein hormones alpha chain
CGA
116Annotation score:
A0A087WYZ4A0A087WYZ4_HUMAN
Glycoprotein hormones alpha chain
CGA
147Annotation score:
A0A0D9SGA7A0A0D9SGA7_HUMAN
Glycoprotein hormones alpha chain
CGA hCG_33165
101Annotation score:
A0A0R4J2F0A0A0R4J2F0_HUMAN
Glycoprotein hormones alpha chain
CGA
116Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei62Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138827 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000625577; ENSP00000486666; ENSG00000135346

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138827 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA0A0D9SFJ6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0D9SFJ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000625577; ENSP00000486666; ENSG00000135346

Organism-specific databases

EuPathDBiHostDB:ENSG00000135346.8
HGNCiHGNC:1885 CGA
OpenTargetsiENSG00000135346
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000012242

Miscellaneous databases

ChiTaRSiCGA human

Gene expression databases

BgeeiENSG00000135346 Expressed in 91 organ(s), highest expression level in placenta
ExpressionAtlasiA0A0D9SFJ6 baseline and differential

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000476 Glyco_hormone
PANTHERiPTHR11509 PTHR11509, 1 hit
PfamiView protein in Pfam
PF00236 Hormone_6, 1 hit
PRINTSiPR00274 GLYCOHORMONE
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS50277 GLYCO_HORMONE_ALPHA_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0D9SFJ6_HUMAN
AccessioniPrimary (citable) accession number: A0A0D9SFJ6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: September 12, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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