UniProtKB - A0A0D9SEV4 (A0A0D9SEV4_HUMAN)
Protein
Submitted name:
Tyrosine-protein kinase Fer
Gene
FER
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- epidermal growth factor receptor binding Source: InterPro
- protein tyrosine kinase activity Source: InterPro
GO - Biological processi
- actin cytoskeleton reorganization Source: InterPro
- cell population proliferation Source: InterPro
- positive regulation of cell migration Source: InterPro
- positive regulation of NF-kappaB transcription factor activity Source: InterPro
- regulation of epidermal growth factor receptor signaling pathway Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Tyrosine-protein kinase FerImported |
Gene namesi | Name:FERImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151422.12 |
HGNCi | HGNC:3655, FER |
Expressioni
Gene expression databases
Bgeei | ENSG00000151422, Expressed in corpus callosum and 228 other tissues |
ExpressionAtlasi | A0A0D9SEV4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 163 | F-BARInterPro annotationAdd BLAST | 163 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 126 – 163 | Sequence analysisAdd BLAST | 38 |
Keywords - Domaini
Coiled coilPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154997 |
Family and domain databases
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028539, Fer |
PANTHERi | PTHR24418:SF227, PTHR24418:SF227, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A0D9SEV4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC
60 70 80 90 100
NQVDKESTVQ MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL
110 120 130 140 150
TMMIKDKQQV KKSYIGVHQQ IEAEMIKVTK TELEKLKCSY RQLIKEMNSA
160
KEKYKEALAK DKK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP16591 | FER_HUMAN | Tyrosine-protein kinase Fer | FER TYK3 | 822 | Annotation score: | ||
W0S4B9 | W0S4B9_HUMAN | Tyrosine-protein kinase | FER Pe1Fe10 | 411 | Annotation score: | ||
D6RAF9 | D6RAF9_HUMAN | Tyrosine-protein kinase Fer | FER | 84 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008871 Genomic DNA No translation available. AC008955 Genomic DNA No translation available. AC010228 Genomic DNA No translation available. AC011421 Genomic DNA No translation available. AC034207 Genomic DNA No translation available. AC109481 Genomic DNA No translation available. KF457961 Genomic DNA No translation available. KF457967 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000628534; ENSP00000486048; ENSG00000151422 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008871 Genomic DNA No translation available. AC008955 Genomic DNA No translation available. AC010228 Genomic DNA No translation available. AC011421 Genomic DNA No translation available. AC034207 Genomic DNA No translation available. AC109481 Genomic DNA No translation available. KF457961 Genomic DNA No translation available. KF457967 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A0A0D9SEV4 |
Protocols and materials databases
Antibodypediai | 2083, 566 antibodies |
Genome annotation databases
Ensembli | ENST00000628534; ENSP00000486048; ENSG00000151422 |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151422.12 |
HGNCi | HGNC:3655, FER |
OpenTargetsi | ENSG00000151422 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154997 |
Miscellaneous databases
ChiTaRSi | FER, human |
Gene expression databases
Bgeei | ENSG00000151422, Expressed in corpus callosum and 228 other tissues |
ExpressionAtlasi | A0A0D9SEV4, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR028539, Fer |
PANTHERi | PTHR24418:SF227, PTHR24418:SF227, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0D9SEV4_HUMAN | |
Accessioni | A0A0D9SEV4Primary (citable) accession number: A0A0D9SEV4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 27, 2015 |
Last sequence update: | May 27, 2015 | |
Last modified: | August 12, 2020 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |