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Protein
Submitted name:

Potassium voltage-gated channel subfamily KQT member 2

Gene

KCNQ2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily KQT member 2Imported
Gene namesi
Name:KCNQ2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000075043.17
HGNCiHGNC:6296 KCNQ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei124 – 147HelicalSequence analysisAdd BLAST24
Transmembranei168 – 187HelicalSequence analysisAdd BLAST20
Transmembranei234 – 252HelicalSequence analysisAdd BLAST19
Transmembranei293 – 318HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000075043

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0D9SEV1

Expressioni

Gene expression databases

BgeeiENSG00000075043
ExpressionAtlasiA0A0D9SEV1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0D9SEV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 318Ion_transInterPro annotationAdd BLAST223
Domaini426 – 566KCNQ_channelInterPro annotationAdd BLAST141
Domaini583 – 646KCNQ_channelInterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074513

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR003947 K_chnl_volt-dep_KCNQ2
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF6 PTHR11537:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 2 hits
PRINTSiPR00169 KCHANNEL
PR01461 KCNQ2CHANNEL
PR01459 KCNQCHANNEL

Sequencei

Sequence statusi: Complete.

A0A0D9SEV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKSRNGGV YPGPSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR
60 70 80 90 100
GSILSKPRAG GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF
110 120 130 140 150
LLVFSCLVLS VFSTIKEYEK SSEGALYILE IVTIVVFGVE YFVRIWAAGC
160 170 180 190 200
CCRYRGWRGR LKFARKPFCV IDIMVLIASI AVLAAGSQGN VFATSALRSL
210 220 230 240 250
RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF LCLILASFLV
260 270 280 290 300
YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI
310 320 330 340 350
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN
360 370 380 390 400
LSRTDLHSTW QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLAFRKDPP
410 420 430 440 450
PEPSPSPRGV AAKGKGSPQA QTVRRSPSAD QSLEDSPSKV PKSWSFGDRS
460 470 480 490 500
RARQAFRIKG AASRQNSEEA SLPGEDIVDD KSCPCEFVTE DLTPGLKVSI
510 520 530 540 550
RAVCVMRFLV SKRKFKESLR PYDVMDVIEQ YSAGHLDMLS RIKSLQSRID
560 570 580 590 600
MIVGPPPPST PRHKKYPTKG PTAPPRESPQ YSPRVDQIVG RGPAITDKDR
610 620 630 640 650
TKGPAEAELP EDPSMMGRLG KVEKQVLSME KKLDFLVNIY MQRMGIPPTE
660 670 680 690 700
TEAYFGAKEP EPAPPYHSPE DSREHVDRHG CIVKIVRSSS STGQKNFSAP
710 720 730 740 750
PAAPPVQCPP STSWQPQSHP RQGHGTSPVG DHGSLGRAPE TRAGQEGSHG

GVSH
Length:754
Mass (Da):83,419
Last modified:May 27, 2015 - v1
Checksum:i41CB34F37E6428FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121827 Genomic DNA No translation available.
AL121829 Genomic DNA No translation available.
AL353658 Genomic DNA No translation available.
KF456987 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000625514; ENSP00000486040; ENSG00000075043

Similar proteinsi

Entry informationi

Entry nameiA0A0D9SEV1_HUMAN
AccessioniPrimary (citable) accession number: A0A0D9SEV1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: March 28, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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