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Protein

Noggin

Gene

NOG

Organism
Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation
Biological processChondrogenesisUniRule annotation, DifferentiationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NogginUniRule annotation
Gene namesi
Name:NOGImported
OrganismiChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)Imported
Taxonomic identifieri60711 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeChlorocebus
Proteomesi
  • UP000029965 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500234680128 – 232NogginSequence analysisAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineUniRule annotation1
Disulfide bondi155 ↔ 192UniRule annotation
Disulfide bondi178 ↔ 228UniRule annotation
Disulfide bondi184 ↔ 230UniRule annotation
Disulfide bondi207 ↔ 215UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A0D9S9B8
SMRiA0A0D9S9B8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the noggin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000006009
KOiK04658
OMAiRCTWIPI

Family and domain databases

Gene3Di2.10.90.10, 2 hits
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR008717 Noggin
PANTHERiPTHR10494 PTHR10494, 1 hit
PIRSFiPIRSF008129 Noggin, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0D9S9B8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERCPSLGVT LYALVVVLGL RATPAGGQHY LHIRPAPSDN LPLVDLIEHP
60 70 80 90 100
DPIFDPKEKD LNETLLRSLL GGHYDPGFMA TSPPEDRPGG GGGAAGGAED
110 120 130 140 150
LAELDQLLRQ RPSGAMPSEI KGLEFSEGLA QGKKQRLSKK LRRKLQMWLW
160 170 180 190 200
SQTFCPVLYA WNDLGSRFWP RYVKVGSCFS KRSCSVPEGM VCKPSKSVHL
210 220 230
TVLRWRCQRR GGQRCGWIPI QYPIISECKC SC
Length:232
Mass (Da):25,774
Last modified:May 27, 2015 - v1
Checksum:iFCA0D8E1E2098580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AQIB01117355 Genomic DNA No translation available.
RefSeqiXP_008009584.1, XM_008011393.1

Genome annotation databases

EnsembliENSCSAT00000017987; ENSCSAP00000017457; ENSCSAG00000000548
GeneIDi103242882
KEGGicsab:103242882

Similar proteinsi

Entry informationi

Entry nameiA0A0D9S9B8_CHLSB
AccessioniPrimary (citable) accession number: A0A0D9S9B8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: March 28, 2018
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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