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Entry version 54 (02 Jun 2021)
Sequence version 1 (27 May 2015)
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Protein

Copper homeostasis protein CutC

Gene

cutC

Organism
Escherichia coli
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the control of copper homeostasis.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCopperUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Copper homeostasis protein CutCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cutCUniRule annotationImported
ORF Names:APU18_08740Imported, B6V57_09920Imported, C4K41_00540Imported, CT146_08135Imported, D1912_23210Imported, D3C88_19790Imported, DNR41_00860Imported, DU333_03720Imported, E8P32_10295Imported, EA239_03745Imported, EA250_04055Imported, EPS94_00965Imported, FQU83_12635Imported, HHG54_002689Imported, HHJ44_00850Imported, HJ411_001608Imported, HJM41_001315Imported, HJO02_001769Imported, HJS12_001708Imported, HJS53_002452Imported, HmCmsJML146_00968Imported, MS8345_01986Imported, NCTC9001_02620Imported, NCTC9434_04443Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coliImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri562 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000233584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000315141 Componenti: Chromosome
  • UP000283846 Componenti: Unassembled WGS sequence
  • UP000053450 Componenti: Unassembled WGS sequence
  • UP000284508 Componenti: Unassembled WGS sequence
  • UP000478303 Componenti: Unassembled WGS sequence
  • UP000324147 Componenti: Chromosome
  • UP000304638 Componenti: Unassembled WGS sequence
  • UP000249503 Componenti: Unassembled WGS sequence
  • UP000531585 Componenti: Unassembled WGS sequence
  • UP000558557 Componenti: Unassembled WGS sequence
  • UP000254730 Componenti: Unassembled WGS sequence
  • UP000530279 Componenti: Unassembled WGS sequence
  • UP000501919 Componenti: Chromosome
  • UP000531923 Componenti: Unassembled WGS sequence
  • UP000535533 Componenti: Unassembled WGS sequence
  • UP000272659 Componenti: Unassembled WGS sequence
  • UP000238807 Componenti: Unassembled WGS sequence
  • UP000372890 Componenti: Unassembled WGS sequence
  • UP000586631 Componenti: Unassembled WGS sequence
  • UP000229602 Componenti: Unassembled WGS sequence
  • UP000408798 Componenti: Unassembled WGS sequence
  • UP000290055 Componenti: Unassembled WGS sequence
  • UP000305235 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 200CutCInterPro annotationAdd BLAST198

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CutC family.UniRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.380, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00795, CutC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005627, Cu_homeostasis_CutC
IPR023648, Cu_homeostasis_CutC_dom
IPR036822, CutC_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12598, PTHR12598, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03932, CutC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110395, SSF110395, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0D8W4R9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLEICCYS MECALTAQQN GADRVELCAA PKEGGLTPSL GVLKSVRQRV
60 70 80 90 100
TIPVHPIIRP RGGDFCYSDG EFAAILEDVR TVRELGFPGL VTGVLEVDGN
110 120 130 140 150
VDMPRMEKIM AAAGPLAVTF HRAFDMCANP LNTLNNLTEL GITRVLTSGQ
160 170 180 190 200
KSDALQGLSK IMELIAHRDA PIIMAGAGVR AENLHHFLDA GVLEVHSSAG
210 220 230 240
AWQASPMRYR NQGLSMSSDA HADEYLRYVV DGAAVAEMKG IIERHQAK
Length:248
Mass (Da):26,741
Last modified:May 27, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC62059127ABE69A3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP025401 Genomic DNA Translation: AUG93595.1
CP020545 Genomic DNA Translation: AWG06801.1
BFRA01000043 Genomic DNA Translation: GCZ99869.1
DABAIH010000017 Genomic DNA Translation: HAH1050303.1
DABEBS010000003 Genomic DNA Translation: HAI3355907.1
DABEHY010000004 Genomic DNA Translation: HAI4142317.1
DABERY010000006 Genomic DNA Translation: HAI5399120.1
DABESK010000006 Genomic DNA Translation: HAI5447971.1
DABFNC010000004 Genomic DNA Translation: HAI8044337.1
REBD01000002 Genomic DNA Translation: KAA1840412.1
RDVP01000002 Genomic DNA Translation: KAA2147831.1
LNIP01000008 Genomic DNA Translation: KSZ21392.1
PENJ01000003 Genomic DNA Translation: PIM24419.1
PSNQ01000001 Genomic DNA Translation: PPE32675.1
CP042246 Genomic DNA Translation: QDX36523.1
CP053231 Genomic DNA Translation: QJS71725.1
QLAC01000001 Genomic DNA Translation: RAH25574.1
QXHA01001360 Genomic DNA Translation: RIB40208.1
QWNV01002079 Genomic DNA Translation: RIC83915.1
RRUU01000002 Genomic DNA Translation: RRK96899.1
SCIX01000001 Genomic DNA Translation: RXB50372.1
UGFV01000001 Genomic DNA Translation: STN19592.1
SSTR01000011 Genomic DNA Translation: THG85443.1
CAADIS010000004 Genomic DNA Translation: VFS18182.1

NCBI Reference Sequences

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RefSeqi
WP_001185753.1, NZ_WVVR01000012.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AUG93595; AUG93595; MS8345_01986
KSZ21392; KSZ21392; APU18_08740
PIM24419; PIM24419; CT146_08135
PPE32675; PPE32675; C4K41_00540
RAH25574; RAH25574; DNR41_00860
RID05072; RID05072; D1900_08745
STN19592; STN19592; NCTC9434_04443

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|562.7203.peg.4334

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025401 Genomic DNA Translation: AUG93595.1
CP020545 Genomic DNA Translation: AWG06801.1
BFRA01000043 Genomic DNA Translation: GCZ99869.1
DABAIH010000017 Genomic DNA Translation: HAH1050303.1
DABEBS010000003 Genomic DNA Translation: HAI3355907.1
DABEHY010000004 Genomic DNA Translation: HAI4142317.1
DABERY010000006 Genomic DNA Translation: HAI5399120.1
DABESK010000006 Genomic DNA Translation: HAI5447971.1
DABFNC010000004 Genomic DNA Translation: HAI8044337.1
REBD01000002 Genomic DNA Translation: KAA1840412.1
RDVP01000002 Genomic DNA Translation: KAA2147831.1
LNIP01000008 Genomic DNA Translation: KSZ21392.1
PENJ01000003 Genomic DNA Translation: PIM24419.1
PSNQ01000001 Genomic DNA Translation: PPE32675.1
CP042246 Genomic DNA Translation: QDX36523.1
CP053231 Genomic DNA Translation: QJS71725.1
QLAC01000001 Genomic DNA Translation: RAH25574.1
QXHA01001360 Genomic DNA Translation: RIB40208.1
QWNV01002079 Genomic DNA Translation: RIC83915.1
RRUU01000002 Genomic DNA Translation: RRK96899.1
SCIX01000001 Genomic DNA Translation: RXB50372.1
UGFV01000001 Genomic DNA Translation: STN19592.1
SSTR01000011 Genomic DNA Translation: THG85443.1
CAADIS010000004 Genomic DNA Translation: VFS18182.1
RefSeqiWP_001185753.1, NZ_WVVR01000012.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAUG93595; AUG93595; MS8345_01986
KSZ21392; KSZ21392; APU18_08740
PIM24419; PIM24419; CT146_08135
PPE32675; PPE32675; C4K41_00540
RAH25574; RAH25574; DNR41_00860
RID05072; RID05072; D1900_08745
STN19592; STN19592; NCTC9434_04443
PATRICifig|562.7203.peg.4334

Family and domain databases

Gene3Di3.20.20.380, 1 hit
HAMAPiMF_00795, CutC, 1 hit
InterProiView protein in InterPro
IPR005627, Cu_homeostasis_CutC
IPR023648, Cu_homeostasis_CutC_dom
IPR036822, CutC_dom_sf
PANTHERiPTHR12598, PTHR12598, 1 hit
PfamiView protein in Pfam
PF03932, CutC, 1 hit
SUPFAMiSSF110395, SSF110395, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0D8W4R9_ECOLX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0D8W4R9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: June 2, 2021
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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