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Entry version 51 (13 Nov 2019)
Sequence version 1 (27 May 2015)
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Protein

Type II pantothenate kinase

Gene

coaW

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type II pantothenate kinase (coaA), Type II pantothenate kinase (coaW), Type II pantothenate kinase (coaW), Type II pantothenate kinase (coaW), Pantothenate kinase (coaA), Type II pantothenate kinase (coaW), Type II pantothenate kinase (coaW), Type II pantothenate kinase (coaW), Type II pantothenate kinase (coaW), Pantothenate kinase (coaA), Type II pantothenate kinase (coaW)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (EP54_08455), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC_2), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (BSZ10_05900), Coenzyme A biosynthesis bifunctional protein CoaBC (EQ90_08205)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (EP54_08455), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC_2), Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC), Coenzyme A biosynthesis bifunctional protein CoaBC (BSZ10_05900), Coenzyme A biosynthesis bifunctional protein CoaBC (EQ90_08205)
  4. Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD_2), Phosphopantetheine adenylyltransferase (coaD), Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE_1), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE), Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei70Proton acceptorUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei99ATPUniRule annotation1
Binding sitei137ATPUniRule annotation1
Binding sitei225ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi6 – 13ATPUniRule annotation8
Nucleotide bindingi121 – 125ATPUniRule annotation5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processCoenzyme A biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
GCF_001546605-HMP:HMPREF3211_RS13070-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00241;UER00352

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type II pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIUniRule annotation
Pantothenic acid kinaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:coaWUniRule annotationImported
ORF Names:BTN44_13005Imported, EP54_10775Imported, EQ90_06670Imported, FA040_09625Imported, HMPREF3211_02599Imported, NCTC10654_02293Imported, NCTC13131_01465Imported, RK64_11310Imported, SAMEA1708674_02555Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000070177 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000298587 Componenti: Unassembled WGS sequence
  • UP000249308 Componenti: Unassembled WGS sequence
  • UP000255075 Componenti: Unassembled WGS sequence
  • UP000251686 Componenti: Unassembled WGS sequence
  • UP000035281 Componenti: Chromosome
  • UP000236484 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type II pantothenate kinase family.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K09680

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01273 Pantothen_kinase_2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004567 Type_II_PanK
IPR011602 Type_II_PanK_bac

The PANTHER Classification System

More...
PANTHERi
PTHR12280:SF27 PTHR12280:SF27, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03630 Fumble, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036940 PanK_bac_aCoA, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00555 panK_eukar, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0D6HHM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVGIDAGGT LIKIVQEQDN QRTFKTELTK NIDQVVEWLN QQQIEKLCLT
60 70 80 90 100
GGNAGVIAEN INIPAQIFVE FDAASQGLGI LLKEQGHDLA DYIFANVGTG
110 120 130 140 150
TSLHYFDGQS QRRVGGIGTG GGMIQGLGYL LSQITDYKQL TDMAQHGDRN
160 170 180 190 200
TIDLKVRHIY KDTEPPIPGD LTAANFGHVL HHLDADFTPS NKLAAVIGVV
210 220 230 240 250
GEVVTTMAIT VAREFKTENI VYIGSSFHNN ALLRKVVEDY TVLRGCKPYY
260
VENGAFSGAI GALYLEK
Length:267
Mass (Da):29,097
Last modified:May 27, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3663BBC6DFBC2D9A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP018629 Genomic DNA Translation: AUS76089.1
CP026962 Genomic DNA Translation: AVG64720.1
LALJ01000010 Genomic DNA Translation: KMR36775.1
LALQ01000048 Genomic DNA Translation: KMR56423.1
LRQH01000193 Genomic DNA Translation: KXA32669.1
FMPP01000014 Genomic DNA Translation: SCT27107.1
UAUZ01000002 Genomic DNA Translation: SQA08437.1
UHBX01000004 Genomic DNA Translation: SUL30404.1
SWED01000011 Genomic DNA Translation: TKC11150.1

NCBI Reference Sequences

More...
RefSeqi
WP_000862727.1, NZ_VSZH01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CFG07339; CFG07339; ERS093009_02327
CXE77586; CXE77586; ERS074020_01878
CXM24703; CXM24703; ERS072738_01917
CZQ30288; CZQ30288; ERS1058648_01972
KXA32669; KXA32669; HMPREF3211_02599
OAP74084; OAP74084; A4U86_07065
SCR60749; SCR60749; SAMEA2298760_02228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
saur:SABB_02455

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1280.10758.peg.1911

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP018629 Genomic DNA Translation: AUS76089.1
CP026962 Genomic DNA Translation: AVG64720.1
LALJ01000010 Genomic DNA Translation: KMR36775.1
LALQ01000048 Genomic DNA Translation: KMR56423.1
LRQH01000193 Genomic DNA Translation: KXA32669.1
FMPP01000014 Genomic DNA Translation: SCT27107.1
UAUZ01000002 Genomic DNA Translation: SQA08437.1
UHBX01000004 Genomic DNA Translation: SUL30404.1
SWED01000011 Genomic DNA Translation: TKC11150.1
RefSeqiWP_000862727.1, NZ_VSZH01000002.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6EBVX-ray3.00A/B/C/D1-267[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Genome annotation databases

EnsemblBacteriaiCFG07339; CFG07339; ERS093009_02327
CXE77586; CXE77586; ERS074020_01878
CXM24703; CXM24703; ERS072738_01917
CZQ30288; CZQ30288; ERS1058648_01972
KXA32669; KXA32669; HMPREF3211_02599
OAP74084; OAP74084; A4U86_07065
SCR60749; SCR60749; SAMEA2298760_02228
KEGGisaur:SABB_02455
PATRICifig|1280.10758.peg.1911

Phylogenomic databases

KOiK09680

Enzyme and pathway databases

UniPathwayiUPA00241;UER00352
BioCyciGCF_001546605-HMP:HMPREF3211_RS13070-MONOMER

Family and domain databases

HAMAPiMF_01273 Pantothen_kinase_2, 1 hit
InterProiView protein in InterPro
IPR004567 Type_II_PanK
IPR011602 Type_II_PanK_bac
PANTHERiPTHR12280:SF27 PTHR12280:SF27, 1 hit
PfamiView protein in Pfam
PF03630 Fumble, 1 hit
PIRSFiPIRSF036940 PanK_bac_aCoA, 1 hit
TIGRFAMsiTIGR00555 panK_eukar, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0D6HHM8_STAAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0D6HHM8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 27, 2015
Last sequence update: May 27, 2015
Last modified: November 13, 2019
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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