UniProtKB - A0A0D3QS97 (NOTU2_XENLA)
Protein
Palmitoleoyl-protein carboxylesterase notum2
Gene
notum2
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleylation of WNT proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.By similarity
Catalytic activityi
- [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = (9Z)-hexadecenoate + [Wnt protein]-L-serine + H+By similarityEC:3.1.1.98By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 223 | Charge relay systemBy similarity | 1 | |
Active sitei | 331 | Charge relay systemBy similarity | 1 | |
Active sitei | 380 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- carboxylic ester hydrolase activity Source: UniProtKB-KW
GO - Biological processi
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Serine esterase |
Biological process | Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Palmitoleoyl-protein carboxylesterase notum2By similarity (EC:3.1.1.98By similarity) |
Gene namesi | Name:notum21 Publication |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000433429 | 19 – 486 | Palmitoleoyl-protein carboxylesterase notum2Sequence analysisAdd BLAST | 468 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 183 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Keywords - PTMi
GlycoproteinFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
OrthoDBi | 610784at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004963, PAE/NOTUM |
PANTHERi | PTHR21562, PTHR21562, 1 hit |
Pfami | View protein in Pfam PF03283, PAE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A0A0D3QS97-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRILEIFAIL LILKEVRPQT KRSHKVNMKT PFQKRKNHHL NTDSRATLMS
60 70 80 90 100
PADLHSVEHS IVQIRDPTLI PHYDQKSQED MKLHFLKNTL VTCNDGTTAG
110 120 130 140 150
YYLRETKGSK RWIIFLEGGW CCYSKETCGV RYDNVKRLMS SSNWPQTRKG
160 170 180 190 200
TGILSPRQDE NPYWWNVNAV FVPYCSSDVW SGNVSKTQDG YAFMGSVIIQ
210 220 230 240 250
EVIRDLVPRG MKQAKSVILA GSSAGGTGVL INIDRVAALV EETTSESVQV
260 270 280 290 300
RGLVDSGWFL DSRHSKQSDC LDISKCALTE AIKKGLKLWN GILPENCKQQ
310 320 330 340 350
FKKGDEWRCF YGPRLFTSMK SPIFVVQWLY DQEQLRIENI QTEFQSMTEN
360 370 380 390 400
QWNSIQNIGR EFKKSLREVP AVFAPACLSH TLITKSNWLE FQVKSVTLAK
410 420 430 440 450
ALHCWDRSLQ ENRAPKGVIR GCPFHLVDNC QWPHCNPTCP AIYDATSGQE
460 470 480
LSILQMFLKL RLESQRRGQE PKGDLGPLMS MLRNSG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KP781857 mRNA Translation: AJQ30103.1 |
RefSeqi | XP_018091827.1, XM_018236338.1 |
Genome annotation databases
GeneIDi | 108701542 |
KEGGi | xla:108701542 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KP781857 mRNA Translation: AJQ30103.1 |
RefSeqi | XP_018091827.1, XM_018236338.1 |
3D structure databases
SMRi | A0A0D3QS97 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 108701542 |
KEGGi | xla:108701542 |
Phylogenomic databases
OrthoDBi | 610784at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004963, PAE/NOTUM |
PANTHERi | PTHR21562, PTHR21562, 1 hit |
Pfami | View protein in Pfam PF03283, PAE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOTU2_XENLA | |
Accessioni | A0A0D3QS97Primary (citable) accession number: A0A0D3QS97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 24, 2015 |
Last sequence update: | May 27, 2015 | |
Last modified: | December 2, 2020 | |
This is version 11 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |