UniProtKB - A0A0D3MU51 (A0A0D3MU51_MERS)
Protein
Nucleoprotein
Gene
N
Organism
Middle East respiratory syndrome-related coronavirus (MERS-CoV)
Status
Functioni
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- RNA binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | RibonucleoproteinUniRule annotationARBA annotation, RNA-bindingUniRule annotationARBA annotation, Viral nucleoproteinUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: NucleoproteinUniRule annotationAlternative name(s): Nucleocapsid proteinUniRule annotation Short name: NCUniRule annotation Short name: Protein NUniRule annotation |
Gene namesi | Name:NUniRule annotation |
Organismi | Middle East respiratory syndrome-related coronavirus (MERS-CoV)Imported |
Taxonomic identifieri | 1335626 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Merbecovirus |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation
- Host endoplasmic reticulum-Golgi intermediate compartment UniRule annotation
- Host Golgi apparatus UniRule annotation Note: Located inside the virion, complexed with the viral RNA. Probably associates with ER-derived membranes where it participates in viral RNA synthesis and virus budding.UniRule annotation
Keywords - Cellular componenti
Host Golgi apparatusUniRule annotation, VirionPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 143 | Phosphoserine; by hostUniRule annotation | 1 | |
Modified residuei | 158 | Phosphothreonine; by hostUniRule annotation | 1 | |
Modified residuei | 406 | Phosphothreonine; by hostUniRule annotation | 1 |
Post-translational modificationi
ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection.UniRule annotation
Phosphorylated on serine and threonine residues.UniRule annotation
Keywords - PTMi
ADP-ribosylationUniRule annotationARBA annotation, PhosphoproteinUniRule annotationARBA annotationInteractioni
Subunit structurei
Homooligomer. Both monomeric and oligomeric forms interact with RNA.
Interacts with protein M.
Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.
UniRule annotationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 216 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 372 – 423 | DisorderedSequence analysisAdd BLAST | 52 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 173 – 212 | PolarSequence analysisAdd BLAST | 40 | |
Compositional biasi | 372 – 391 | PolyampholyteSequence analysisAdd BLAST | 20 | |
Compositional biasi | 392 – 423 | PolarSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the betacoronavirus nucleocapsid protein family.UniRule annotation
Family and domain databases
CDDi | cd21595, CoV_N-CTD, 1 hit cd21554, CoV_N-NTD, 1 hit |
HAMAPi | MF_04096, BETA_CORONA_NCAP, 1 hit |
InterProi | View protein in InterPro IPR044344, N_prot_C_CoV IPR044345, N_prot_N_CoV IPR043505, NCAP_bCoV IPR001218, Nucleocap_CoV IPR037179, Nucleocapsid_C IPR037195, Nucleocapsid_N |
Pfami | View protein in Pfam PF00937, CoV_nucleocap, 1 hit |
PIRSFi | PIRSF003888, Corona_nucleocap, 1 hit |
SUPFAMi | SSF103068, SSF103068, 1 hit SSF110304, SSF110304, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A0D3MU51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILTNLNFIV MAAPAAPRAV SFADNNDITN TNLSRGRGRN PKPRAAPNNT
60 70 80 90 100
VSWYTGLTQH GKVPLTFPPG QGVPLNANST PAQNAGYWRR QDRKINTGNG
110 120 130 140 150
IKQLAPRWYF YYTGTGPEAA LPFRAVKDGI VWVHEDGATD APSTFGTRNP
160 170 180 190 200
NNDSAIVTQF APGTKLPKNF HIEGTGGNSQ SSSRASSVSR NSSRSSSQGS
210 220 230 240 250
RSGNSTRGTS PGPSGIGAVG GDLLYLDLLN RLQALESGKV KQSQPKVITK
260 270 280 290 300
KDAAAAKNKM RHKRTSTKSF NMVQAFGLRG PGDLQGNFGD LQLNKLGTED
310 320 330 340 350
PRWPQIAELA PTASAFMGMS QFKLTHQNND DHGNPVYFLR YSGAIKLDPK
360 370 380 390 400
NPNYNKWLEL LEQNIDAYKT FPKKEKKQKA PKEESTDQMS EPPKEQRVQG
410 420
SITQRTRTRP SVQPGPMIDV NTD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ361501 Genomic RNA Translation: AIZ74430.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KJ361501 Genomic RNA Translation: AIZ74430.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6G13 | X-ray | 1.97 | A/B/C/D | 249-372 | [»] | |
SMRi | A0A0D3MU51 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Family and domain databases
CDDi | cd21595, CoV_N-CTD, 1 hit cd21554, CoV_N-NTD, 1 hit |
HAMAPi | MF_04096, BETA_CORONA_NCAP, 1 hit |
InterProi | View protein in InterPro IPR044344, N_prot_C_CoV IPR044345, N_prot_N_CoV IPR043505, NCAP_bCoV IPR001218, Nucleocap_CoV IPR037179, Nucleocapsid_C IPR037195, Nucleocapsid_N |
Pfami | View protein in Pfam PF00937, CoV_nucleocap, 1 hit |
PIRSFi | PIRSF003888, Corona_nucleocap, 1 hit |
SUPFAMi | SSF103068, SSF103068, 1 hit SSF110304, SSF110304, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0D3MU51_MERS | |
Accessioni | A0A0D3MU51Primary (citable) accession number: A0A0D3MU51 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 27, 2015 |
Last sequence update: | May 27, 2015 | |
Last modified: | April 7, 2021 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |