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Entry version 51 (25 May 2022)
Sequence version 1 (29 Apr 2015)
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Protein

Superoxide dismutase

Gene

sodA

Organism
Staphylococcus aureus
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+ARBA annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi27Divalent metal cationUniRule annotation1
Metal bindingi81Divalent metal cationUniRule annotation1
Metal bindingi161Divalent metal cationUniRule annotation1
Metal bindingi165Divalent metal cationUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationARBA annotation
LigandManganeseARBA annotation, Metal-bindingUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotationARBA annotation (EC:1.15.1.1UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sodAImported
ORF Names:A6762_07710Imported, BN1321_260190Imported, BTN44_04405Imported, C7P97_02450Imported, CSC87_02560Imported, CV021_16580Imported, DD547_01639Imported, E3A28_00705Imported, E3K14_07850Imported, E4U00_05525Imported, EDCC5055_01475Imported, EP54_01115Imported, EQ90_12445Imported, FA040_08410Imported, G6Y24_00940Imported, GO782_10880Imported, GO788_01395Imported, GO793_15860Imported, GO814_12680Imported, GO941_07540Imported, GO942_05385Imported, GQX37_09830Imported, GZ128_01850Imported, GZ156_06685Imported, HK402_06725Imported, HMPREF3211_01704Imported, HUW54_07815Imported, NCTC7972_00374Imported, QU38_09165Imported, SA0759_01304Imported, SA950122_01277Imported, SAGV69_00893Imported, SAHC1335_02575Imported, SAJPND4_01507Imported, SAMEA2077334_01656Imported, SAMEA2078260_01302Imported, SAMEA2078588_01411Imported, SAMEA2080344_01587Imported, SAMEA2081063_01151Imported, SAMEA2081470_01326Imported, SAMEA70146418_01116Imported, SAMEA70245418_00872Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 89Sod_Fe_NInterPro annotationAdd BLAST87
Domaini95 – 193Sod_Fe_CInterPro annotationAdd BLAST99

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWGSFDK

Database of Orthologous Groups

More...
OrthoDBi
1440645at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.990, 1 hit
3.55.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001189, Mn/Fe_SOD
IPR019833, Mn/Fe_SOD_BS
IPR019832, Mn/Fe_SOD_C
IPR019831, Mn/Fe_SOD_N
IPR036324, Mn/Fe_SOD_N_sf
IPR036314, SOD_C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02777, Sod_Fe_C, 1 hit
PF00081, Sod_Fe_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000349, SODismutase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01703, MNSODISMTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46609, SSF46609, 1 hit
SSF54719, SSF54719, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00088, SOD_MN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0D1GRH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFELPKLPY AFDALEPHFD KETMEIHHDR HHNTYVTKLN AAVEGTDLES
60 70 80 90 100
KSIEEIVANL DSVPANIQTA VRNNGGGHLN HSLFWELLSP NSEEKGTVVE
110 120 130 140 150
KIKEQWGSLE EFKKEFADKA AARFGSGWAW LVVNNGQLEI VTTPNQDNPL
160 170 180 190
TEGKTPILGL DVWEHAYYLK YQNKRPDYIG AFWNVVNWEK VDELYNATK
Length:199
Mass (Da):22,711
Last modified:April 29, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2CEC7B4701AC559
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP009681 Genomic DNA Translation: AIU84686.1
CP012012 Genomic DNA Translation: ALY21159.1
CP018629 Genomic DNA Translation: AUS74503.1
CP031670 Genomic DNA Translation: AXP71502.1
AP014653 Genomic DNA Translation: BAR11742.1
CACTQT010000006 Genomic DNA Translation: CAA4371491.1
CACTWD010000006 Genomic DNA Translation: CAA4679935.1
CACUCZ010000006 Genomic DNA Translation: CAA5256268.1
CACUNS010000007 Genomic DNA Translation: CAA6081056.1
CACURZ010000007 Genomic DNA Translation: CAA6355940.1
CACUTQ010000007 Genomic DNA Translation: CAA6523990.1
CAIIGD010000003 Genomic DNA Translation: CAC8207559.1
CAIIKR010000002 Genomic DNA Translation: CAC8504763.1
CVOQ01000019 Genomic DNA Translation: CRI11734.1
JXIG01000627 Genomic DNA Translation: KIT96742.1
LALJ01000033 Genomic DNA Translation: KMR35467.1
LALQ01000003 Genomic DNA Translation: KMR58402.1
LRQH01000132 Genomic DNA Translation: KXA34986.1
WPRT01000162 Genomic DNA Translation: MVH49118.1
WPRH01000849 Genomic DNA Translation: MVI57319.1
WPRM01000020 Genomic DNA Translation: MVI77198.1
WPTS01000037 Genomic DNA Translation: MVK35996.1
WPVZ01000431 Genomic DNA Translation: MVL45341.1
WPXC01000010 Genomic DNA Translation: MVM10120.1
JAAFLQ010000003 Genomic DNA Translation: NDP78588.1
JAAFKS010000010 Genomic DNA Translation: NDQ60223.1
JAALTR010000009 Genomic DNA Translation: NGW66073.1
JAANEC010000100 Genomic DNA Translation: NUY12811.1
LXGQ01000008 Genomic DNA Translation: OCQ35359.1
PGWZ01000663 Genomic DNA Translation: PPJ68728.1
PDVL01000012 Genomic DNA Translation: PPK16100.1
PZSP01000003 Genomic DNA Translation: PZJ51617.1
CP053075 Genomic DNA Translation: QJR32455.1
CP054876 Genomic DNA Translation: QKV60130.1
CP045439 Genomic DNA Translation: QLH98261.1
CP045441 Genomic DNA Translation: QLI00853.1
LT671859 Genomic DNA Translation: SIN04774.1
UHAI01000002 Genomic DNA Translation: SUK15218.1
SOPO01000001 Genomic DNA Translation: TFE15746.1
SOPD01000001 Genomic DNA Translation: TFE21298.1
SPPY01000001 Genomic DNA Translation: TFU37170.1
SWED01000009 Genomic DNA Translation: TKC11395.1

NCBI Reference Sequences

More...
RefSeqi
WP_000863556.1, NZ_WWFR01000004.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
KIT96742; KIT96742; QU38_09165
QBZ85822; QBZ85822; E5491_08485
TJX35272; TJX35272; FAF19_12660
TJX39658; TJX39658; FAF18_07180
TJX47775; TJX47775; FAF15_03350
TJX51070; TJX51070; FAF22_03165
TJX54781; TJX54781; FAF13_04125
TJX58271; TJX58271; FAF16_04720
TJX61980; TJX61980; FAF14_04315
TJX77291; TJX77291; FAF10_09605
TJX79708; TJX79708; FAF38_05575
TJX97053; TJX97053; FAF37_08740
TJY14378; TJY14378; FAF17_00690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sams:NI36_08375
saud:CH52_11305

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1280.10341.peg.1677
fig|46170.102.peg.1530

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009681 Genomic DNA Translation: AIU84686.1
CP012012 Genomic DNA Translation: ALY21159.1
CP018629 Genomic DNA Translation: AUS74503.1
CP031670 Genomic DNA Translation: AXP71502.1
AP014653 Genomic DNA Translation: BAR11742.1
CACTQT010000006 Genomic DNA Translation: CAA4371491.1
CACTWD010000006 Genomic DNA Translation: CAA4679935.1
CACUCZ010000006 Genomic DNA Translation: CAA5256268.1
CACUNS010000007 Genomic DNA Translation: CAA6081056.1
CACURZ010000007 Genomic DNA Translation: CAA6355940.1
CACUTQ010000007 Genomic DNA Translation: CAA6523990.1
CAIIGD010000003 Genomic DNA Translation: CAC8207559.1
CAIIKR010000002 Genomic DNA Translation: CAC8504763.1
CVOQ01000019 Genomic DNA Translation: CRI11734.1
JXIG01000627 Genomic DNA Translation: KIT96742.1
LALJ01000033 Genomic DNA Translation: KMR35467.1
LALQ01000003 Genomic DNA Translation: KMR58402.1
LRQH01000132 Genomic DNA Translation: KXA34986.1
WPRT01000162 Genomic DNA Translation: MVH49118.1
WPRH01000849 Genomic DNA Translation: MVI57319.1
WPRM01000020 Genomic DNA Translation: MVI77198.1
WPTS01000037 Genomic DNA Translation: MVK35996.1
WPVZ01000431 Genomic DNA Translation: MVL45341.1
WPXC01000010 Genomic DNA Translation: MVM10120.1
JAAFLQ010000003 Genomic DNA Translation: NDP78588.1
JAAFKS010000010 Genomic DNA Translation: NDQ60223.1
JAALTR010000009 Genomic DNA Translation: NGW66073.1
JAANEC010000100 Genomic DNA Translation: NUY12811.1
LXGQ01000008 Genomic DNA Translation: OCQ35359.1
PGWZ01000663 Genomic DNA Translation: PPJ68728.1
PDVL01000012 Genomic DNA Translation: PPK16100.1
PZSP01000003 Genomic DNA Translation: PZJ51617.1
CP053075 Genomic DNA Translation: QJR32455.1
CP054876 Genomic DNA Translation: QKV60130.1
CP045439 Genomic DNA Translation: QLH98261.1
CP045441 Genomic DNA Translation: QLI00853.1
LT671859 Genomic DNA Translation: SIN04774.1
UHAI01000002 Genomic DNA Translation: SUK15218.1
SOPO01000001 Genomic DNA Translation: TFE15746.1
SOPD01000001 Genomic DNA Translation: TFE21298.1
SPPY01000001 Genomic DNA Translation: TFU37170.1
SWED01000009 Genomic DNA Translation: TKC11395.1
RefSeqiWP_000863556.1, NZ_WWFR01000004.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiKIT96742; KIT96742; QU38_09165
QBZ85822; QBZ85822; E5491_08485
TJX35272; TJX35272; FAF19_12660
TJX39658; TJX39658; FAF18_07180
TJX47775; TJX47775; FAF15_03350
TJX51070; TJX51070; FAF22_03165
TJX54781; TJX54781; FAF13_04125
TJX58271; TJX58271; FAF16_04720
TJX61980; TJX61980; FAF14_04315
TJX77291; TJX77291; FAF10_09605
TJX79708; TJX79708; FAF38_05575
TJX97053; TJX97053; FAF37_08740
TJY14378; TJY14378; FAF17_00690
KEGGisams:NI36_08375
saud:CH52_11305
PATRICifig|1280.10341.peg.1677
fig|46170.102.peg.1530

Phylogenomic databases

OMAiKWGSFDK
OrthoDBi1440645at2

Family and domain databases

Gene3Di1.10.287.990, 1 hit
3.55.40.20, 1 hit
InterProiView protein in InterPro
IPR001189, Mn/Fe_SOD
IPR019833, Mn/Fe_SOD_BS
IPR019832, Mn/Fe_SOD_C
IPR019831, Mn/Fe_SOD_N
IPR036324, Mn/Fe_SOD_N_sf
IPR036314, SOD_C_sf
PfamiView protein in Pfam
PF02777, Sod_Fe_C, 1 hit
PF00081, Sod_Fe_N, 1 hit
PIRSFiPIRSF000349, SODismutase, 1 hit
PRINTSiPR01703, MNSODISMTASE
SUPFAMiSSF46609, SSF46609, 1 hit
SSF54719, SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088, SOD_MN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0D1GRH1_STAAU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0D1GRH1
Secondary accession number(s): A0A1E8X1S8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2015
Last sequence update: April 29, 2015
Last modified: May 25, 2022
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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