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Protein

RNA polymerase II transcription factor B subunit 2

Gene

UMAG_06296

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:UMAG_06296Imported
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)Imported
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
Proteomesi
  • UP000000561 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:UMAG_06296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5270.UM06296P0

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144
OMAiYLEQYAH

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0D1CUU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQRHTPGP GQGLTSTAKG GTNTALAISE HSRAAGIGAE TIDDFLDRQP
60 70 80 90 100
RSVLIRLYQK PASCLAIFRL LPMMARQLIM HMLFLDVPLA ADDFLAWIKK
110 120 130 140 150
EVKNEFDAAV DKLSRLSIIQ LKASAGKQML LLNAGFTEGM RRALTGGGKH
160 170 180 190 200
RSFGVPCDTE DKNAVDVAFL DQYARTKWET ILHYMVGSDN SSTPREPVLY
210 220 230 240 250
LLRRSNLMQP RTASSSNGGL NITSRGFQFL LEDVNTQLWD LLLQYLDMAE
260 270 280 290 300
ERNMDLVEVL AFLFMLGSLE LGRDYSTEEL PETQLHMLED FRDYGLVYQR
310 320 330 340 350
KASSRRFYPT RLATTLTSSA AVPLLSSNGT EQEERGYIIL ETNYRLYAYT
360 370 380 390 400
SNPLRVAVLS LFVTIKARFP NLVVGSITRD SVKSALANGI TAEQIITYLT
410 420 430 440 450
HHAHLQMHRN DPLLPVTVSD QIRLWEREKN RVQQNLGSLF TDFTSQFDFE
460 470 480 490
EVRNYAKQLG VLVWQDEEKR RFFVDEAGNE PVRDYIRRRR A
Length:491
Mass (Da):55,715
Last modified:April 29, 2015 - v1
Checksum:i9570F6A2AD22C3AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM003143 Genomic DNA Translation: KIS70208.1
RefSeqiXP_011388300.1, XM_011389998.1

Genome annotation databases

EnsemblFungiiKIS70208; KIS70208; UMAG_06296
GeneIDi23565933
KEGGiuma:UMAG_06296

Similar proteinsi

Entry informationi

Entry nameiA0A0D1CUU7_USTMA
AccessioniPrimary (citable) accession number: A0A0D1CUU7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2015
Last sequence update: April 29, 2015
Last modified: March 28, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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