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Protein

Methylenetetrahydrofolate reductase

Gene

metF

Organism
Defluviitoga tunisiensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayi
UPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate reductaseUniRule annotation (EC:1.5.1.20UniRule annotation)
Gene namesi
Name:metFImported
ORF Names:DTL3_0400Imported
OrganismiDefluviitoga tunisiensisImported
Taxonomic identifieri1006576 [NCBI]
Taxonomic lineageiBacteriaThermotogaePetrotogalesPetrotogaceaeDefluviitoga
Proteomesi
  • UP000032809 Componenti: Chromosome I

Family & Domainsi

Sequence similaritiesi

Belongs to the methylenetetrahydrofolate reductase family.UniRule annotation

Phylogenomic databases

KOiK00297

Family and domain databases

CDDicd00537 MTHFR, 1 hit
InterProiView protein in InterPro
IPR029041 FAD-linked_oxidoreductase-like
IPR003171 Mehydrof_redctse
PfamiView protein in Pfam
PF02219 MTHFR, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0C7NIE1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIVDVISQK GKPILSFEII PPNRGGSILD IYNVVDGLMN FSPSFINVTK
60 70 80 90 100
HANEVEYLEN GLEVNKIIVN KRPGTVGISA ALKNRYNVDV VPHLICVGFN
110 120 130 140 150
KYQLEDILID LHYLGIENVF VVRGDKNRYT FREFDEHKYA CDLVEQIVNL
160 170 180 190 200
NKGIYVYPTR YNYSTDFCIG VAGYPEKHFE SPNLEKDLDN LKLKIELGAQ
210 220 230 240 250
FIITQMFFDV NYYINFLDKI SERGINVPVI PGLKPIVSKK SLYNIPKSFF
260 270 280 290 300
VNIPKELVEA FDEAKTPKDE FNVGVKHTIK MIEELLSSGV PGVHIFTMGK
310
GDAVKEVLRE FQNVF
Length:315
Mass (Da):35,877
Last modified:April 29, 2015 - v1
Checksum:i6F02AF5EF370037A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN824141 Genomic DNA Translation: CEP77726.1
RefSeqiWP_045087301.1, NZ_LN824141.1

Genome annotation databases

EnsemblBacteriaiCEP77726; CEP77726; DTL3_0400
KEGGidtn:DTL3_0400
PATRICifig|1006576.9.peg.394

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN824141 Genomic DNA Translation: CEP77726.1
RefSeqiWP_045087301.1, NZ_LN824141.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCEP77726; CEP77726; DTL3_0400
KEGGidtn:DTL3_0400
PATRICifig|1006576.9.peg.394

Phylogenomic databases

KOiK00297

Enzyme and pathway databases

UniPathwayi
UPA00193

Family and domain databases

CDDicd00537 MTHFR, 1 hit
InterProiView protein in InterPro
IPR029041 FAD-linked_oxidoreductase-like
IPR003171 Mehydrof_redctse
PfamiView protein in Pfam
PF02219 MTHFR, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0C7NIE1_9BACT
AccessioniPrimary (citable) accession number: A0A0C7NIE1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2015
Last sequence update: April 29, 2015
Last modified: February 28, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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