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Entry version 25 (10 Apr 2019)
Sequence version 1 (29 Apr 2015)
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Protein

Bifunctional protein PutA

Gene

putA

Organism
Sphingobium sp. YBL2
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidizes proline to glutamate for use as a carbon and nitrogen source.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADUniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Bifunctional protein PutA (putA)
  2. Bifunctional protein PutA (putA)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei792UniRule annotation1
Active sitei826UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, OxidoreductaseUniRule annotationImported, RepressorUniRule annotation
Biological processProline metabolismUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00261;UER00373
UPA00261;UER00374

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional protein PutAUniRule annotation
Including the following 2 domains:
Proline dehydrogenaseUniRule annotation (EC:1.5.5.2UniRule annotation)
Alternative name(s):
Proline oxidaseUniRule annotation
Delta-1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:putAImported
ORF Names:TZ53_07765Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSphingobium sp. YBL2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri484429 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingobium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000032302 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 65PRODHInterPro annotationAdd BLAST48
Domaini73 – 184Pro_dh-DNA_bdgInterPro annotationAdd BLAST112
Domaini194 – 491Pro_dhInterPro annotationAdd BLAST298
Domaini574 – 1008AldedhInterPro annotationAdd BLAST435

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the proline dehydrogenase family.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K13821

Database of Orthologous Groups

More...
OrthoDBi
14333at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR025703 Bifunct_PutA
IPR005933 Delta1-pyrroline-5-COlate_DH-3
IPR029041 FAD-linked_oxidoreductase-like
IPR041349 PRODH
IPR024089 PRODH_PutA_dom_I/II
IPR024082 PRODH_PutA_dom_II
IPR002872 Proline_DH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00171 Aldedh, 1 hit
PF01619 Pro_dh, 1 hit
PF14850 Pro_dh-DNA_bdg, 1 hit
PF18327 PRODH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000197 Bifunct_PutA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51730 SSF51730, 1 hit
SSF53720 SSF53720, 1 hit
SSF81935 SSF81935, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01238 D1pyr5carbox3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0C5XAA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNPPPFIDF APAIRPQSPL RQAITAAYRR DEAECLAPLL EAAALPDAMR
60 70 80 90 100
QGVRDMARRL VTTLRANGKG SGVEALVQEY SLSSQEGVAL MCLAEALLRI
110 120 130 140 150
PDDATRDALI RDKIADGDWG GHLGGGKSLF VNAATWGLVV TGKLVGSVDD
160 170 180 190 200
RGLGAALTRL MARLGEPVIR RGVDLAMRMM GEQFVTGETI GEALKRARTE
210 220 230 240 250
EAKGFQYSYD MLGEAAATAA DAARYLEDYR QAIHAIGRAS DGRGVYAGPG
260 270 280 290 300
ISIKLSALHP RYSRAQAERV MGELLPRVKE LALLAKSYDI GLNIDAEEAD
310 320 330 340 350
RLELSLDLLE SLALDPDLAG WNGLGFVVQA YGKRCPFVID WIVDLAQRAG
360 370 380 390 400
RRIMVRLVKG AYWDAEIKRA QVDGMADFPV YTRKVHTDVA YIACAKKLLA
410 420 430 440 450
ARDRVFPQFA THNAQTLATV HHLAGPGFTL GDYEFQCLHG MGEPLYEQVV
460 470 480 490 500
GKGNLDRPCR IYAPVGTHET LLAYLVRRLL ENGANSSFVH RIADPAVPVE
510 520 530 540 550
EMIADPVEQV LAMPHPGARH AEIALPSGLY PDRRNSDGID LSDENALAML
560 570 580 590 600
AQALAESAQI NWTAAPQGEE GTARLVLNPA NRRDVVGTVF EACADHARAA
610 620 630 640 650
VMRADESEWA QVPVAERAAM LERAADAMQA RMPILLGLIV REAGKSLPNA
660 670 680 690 700
IAEVREAIDF LRYYAAQARA AFGAAQTALG PVVCISPWNF PLAIFTGQVA
710 720 730 740 750
AALVAGNAVL AKPAEETPLI AAEAVRLLYE AGVPGDALQL VPGAGEIGAA
760 770 780 790 800
LVAAPQTAGV LFTGSTEVAR LIQRQLAARL SASGRPIPLI AETGGQNAMI
810 820 830 840 850
VDSSALAEQV VADVIASAFD SAGQRCSALR ILCLQEDVAD RTLAMLKGAL
860 870 880 890 900
RELQIGRTDR LAVDIGPVIT DEAKEGIERH IEAMRALGCA VEQQPLPQET
910 920 930 940 950
AHGSFVPPTI IEIDDIAQLR REVFGPVLHV IRFPRTGLNA LVDAINATGY
960 970 980 990 1000
GLTFGLHTRL DDTVAQVTGR VKAGNLYVNR NVIGAIVGVQ PFGGRGLSGT
1010 1020 1030 1040 1050
GPKAGGPLYL GRLVAVPPVF AERAGSLRSP LSDFADWLAA KGEAEASAMA
1060 1070 1080 1090 1100
RRCGDASALG VEMTLPGPVG ERNLYALHPR GLIGMRPATR QGLLQQMAAV
1110 1120 1130 1140 1150
LATGNRGVLR DMELPLGLPA PIAAHFTSQA DGLLRAVLVE GDAARIGAAV
1160 1170 1180 1190 1200
RDVAGMPGPV VSVHAAGADG GYPLDWLLEE VSTSINTTAA GGNASLMMIG
Length:1,200
Mass (Da):127,341
Last modified:April 29, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97B9E072D99154A4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP010954 Genomic DNA Translation: AJR26254.1

NCBI Reference Sequences

More...
RefSeqi
WP_044662936.1, NZ_CP010954.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AJR26254; AJR26254; TZ53_07765

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
syb:TZ53_07765

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|484429.4.peg.1640

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP010954 Genomic DNA Translation: AJR26254.1
RefSeqiWP_044662936.1, NZ_CP010954.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAJR26254; AJR26254; TZ53_07765
KEGGisyb:TZ53_07765
PATRICifig|484429.4.peg.1640

Phylogenomic databases

KOiK13821
OrthoDBi14333at2

Enzyme and pathway databases

UniPathwayiUPA00261;UER00373
UPA00261;UER00374

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR025703 Bifunct_PutA
IPR005933 Delta1-pyrroline-5-COlate_DH-3
IPR029041 FAD-linked_oxidoreductase-like
IPR041349 PRODH
IPR024089 PRODH_PutA_dom_I/II
IPR024082 PRODH_PutA_dom_II
IPR002872 Proline_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PF01619 Pro_dh, 1 hit
PF14850 Pro_dh-DNA_bdg, 1 hit
PF18327 PRODH, 1 hit
PIRSFiPIRSF000197 Bifunct_PutA, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit
SSF53720 SSF53720, 1 hit
SSF81935 SSF81935, 1 hit
TIGRFAMsiTIGR01238 D1pyr5carbox3, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0C5XAA3_9SPHN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0C5XAA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2015
Last sequence update: April 29, 2015
Last modified: April 10, 2019
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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