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Immunoglobulin heavy joining 1



Homo sapiens (Human)
Reviewed-Annotation score: -Protein predictedi


J region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications


There are several genes encoding the J region in the immunoglobulin heavy locus. The peptide described in this entry is a representative for all the peptides encoded by these genes. For examples of full-length immunoglobulin heavy chains (of different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC P0DOX5 and AC P0DOX6.Curated

GO - Biological processi


Biological processAdaptive immunity, Immunity

Protein family/group databases


Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin heavy joining 12 Publications
Gene namesi
Name:IGHJ12 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases


Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000439096‹1 – ›17Immunoglobulin heavy joining 1Add BLAST›17


Gene expression databases

BgeeiENSG00000211905 Expressed in 73 organ(s), highest expression level in lymph node


Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
SUPFAMiSSF48726 SSF48726, 1 hit


Sequence statusi: Complete.

A0A0C4DH62-1 [UniParc]FASTAAdd to basket
« Hide
Mass (Da):1,910
Last modified:April 1, 2015 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei171


The sequence shown is that of IMGT allele IGHJ1*01.Curated

Sequence databases

Select the link destinations:
Links Updated
AC246787 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000390565; ENSP00000418050; ENSG00000211905
ENST00000634062; ENSP00000488542; ENSG00000282409

Keywords - Coding sequence diversityi


Similar proteinsi

Entry informationi

Entry nameiHJ01_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DH62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: April 1, 2015
Last modified: September 12, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.


Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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