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Protein
Submitted name:

Tetratricopeptide repeat domain 8 isoform 1

Gene

TTC8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Tetratricopeptide repeat domain 8 isoform 1Imported
Submitted name:
Tetratricopeptide repeat domain 8, isoform CRA_cImported
Submitted name:
Tetratricopeptide repeat protein 8Imported
Gene namesi
Name:TTC8Imported
ORF Names:hCG_21081Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165533.18
HGNCiHGNC:20087 TTC8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165533

Expressioni

Gene expression databases

BgeeiENSG00000165533 Expressed in 192 organ(s), highest expression level in right ovary

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 274TPR_REGIONInterPro annotationAdd BLAST34
Domaini274 – 514TPR_REGIONInterPro annotationAdd BLAST241
Repeati274 – 307TPRPROSITE-ProRule annotationAdd BLAST34
Repeati308 – 341TPRPROSITE-ProRule annotationAdd BLAST34
Repeati342 – 375TPRPROSITE-ProRule annotationAdd BLAST34
Repeati376 – 409TPRPROSITE-ProRule annotationAdd BLAST34
Repeati413 – 446TPRPROSITE-ProRule annotationAdd BLAST34
Repeati447 – 480TPRPROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063455
KOiK16781
OMAiETADVWY
OrthoDBiEOG091G0FBF

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR028796 BBS8
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR44177 PTHR44177, 1 hit
PfamiView protein in Pfam
PF13176 TPR_7, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 8 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

A0A0C4DGX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEMEPLLL AWSYFRRRKF QLCADLCTQM LEKSPYDQAA WILKARALTE
60 70 80 90 100
MVYIDEIDVD QEGIAEMMLD ENAIAQVPRP GTSLKLPGTN QTGGPSQAVR
110 120 130 140 150
PITQAGRPIT GFLRPSTQSG RPGTMEQAIR TPRTAYTARP ITSSSGRFVR
160 170 180 190 200
LGTASMLTSP DGPFINLSRL NLTKYSQKPK LAKALFEYIF HHENDVKTIH
210 220 230 240 250
LEDVVLHLGI YPFLLRNKNH IEKNALDLAA LSTEHSQYKD WWWKVQIGKC
260 270 280 290 300
YYRLGMYREA EKQFKSALKQ QEMVDTFLYL AKVYVSLDQP VTALNLFKQG
310 320 330 340 350
LDKFPGEVTL LCGIARIYEE MNNMSSAAEY YKEVLKQDNT HVEAIACIGS
360 370 380 390 400
NHFYSDQPEI ALRFYRRLLQ MGIYNGQLFN NLGLCCFYAQ QYDMTLTSFE
410 420 430 440 450
RALSLAENEE EAADVWYNLG HVAVGIGDTN LAHQCFRLAL VNNNNHAEAY
460 470 480 490 500
NNLAVLEMRK GHVEQARALL QTASSLAPHM YEPHFNFATI SDKIGDLQRS
510 520 530
YVAAQKSEAA FPDHVDTQHL IKQLRQHFAM L
Length:531
Mass (Da):60,392
Last modified:April 1, 2015 - v1
Checksum:iD8BCADCDDF8A662A
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TAM2TTC8_HUMAN
Tetratricopeptide repeat protein 8
TTC8 BBS8
541Annotation score:
A0A0C4DFT4A0A0C4DFT4_HUMAN
Tetratricopeptide repeat domain 8, ...
TTC8 hCG_21081
317Annotation score:
A0A0C4DGY3A0A0C4DGY3_HUMAN
Tetratricopeptide repeat domain 8 i...
TTC8
505Annotation score:
H0YJQ3H0YJQ3_HUMAN
Tetratricopeptide repeat protein 8
TTC8
265Annotation score:
H0YJX0H0YJX0_HUMAN
Tetratricopeptide repeat protein 8
TTC8
437Annotation score:
A0A0C4DGH8A0A0C4DGH8_HUMAN
Tetratricopeptide repeat domain 8 i...
TTC8 hCG_21081
475Annotation score:
Q86U25Q86U25_HUMAN
Full-length cDNA clone CS0DA007YG23...
TTC8 hCG_21081
211Annotation score:
G3V324G3V324_HUMAN
Tetratricopeptide repeat protein 8
TTC8
192Annotation score:
G3V2Z9G3V2Z9_HUMAN
Tetratricopeptide repeat protein 8
TTC8
186Annotation score:
G3V2W6G3V2W6_HUMAN
Tetratricopeptide repeat protein 8
TTC8
41Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei531Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121768 Genomic DNA No translation available.
AL133238 Genomic DNA No translation available.
KU178849 mRNA Translation: ALQ34307.1
CH471061 Genomic DNA Translation: EAW81397.1
RefSeqiNP_001275710.1, NM_001288781.1
XP_011534734.1, XM_011536432.1
UniGeneiHs.303055

Genome annotation databases

EnsembliENST00000338104; ENSP00000337653; ENSG00000165533
ENST00000614125; ENSP00000482306; ENSG00000165533
GeneIDi123016
KEGGihsa:123016

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121768 Genomic DNA No translation available.
AL133238 Genomic DNA No translation available.
KU178849 mRNA Translation: ALQ34307.1
CH471061 Genomic DNA Translation: EAW81397.1
RefSeqiNP_001275710.1, NM_001288781.1
XP_011534734.1, XM_011536432.1
UniGeneiHs.303055

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338104; ENSP00000337653; ENSG00000165533
ENST00000614125; ENSP00000482306; ENSG00000165533
GeneIDi123016
KEGGihsa:123016

Organism-specific databases

CTDi123016
EuPathDBiHostDB:ENSG00000165533.18
HGNCiHGNC:20087 TTC8
OpenTargetsiENSG00000165533
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063455
KOiK16781
OMAiETADVWY
OrthoDBiEOG091G0FBF

Miscellaneous databases

GenomeRNAii123016

Gene expression databases

BgeeiENSG00000165533 Expressed in 192 organ(s), highest expression level in right ovary

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR028796 BBS8
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR44177 PTHR44177, 1 hit
PfamiView protein in Pfam
PF13176 TPR_7, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 8 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0C4DGX9_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DGX9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: November 7, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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