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Protein
Submitted name:

Nesprin-2

Gene

SYNE2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nesprin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000054654.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17084 SYNE2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3490CytoplasmicPROSITE-ProRule annotationAdd BLAST3490
Topological domaini3512 – 3541Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000054654

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A0C4DGK3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000054654 Expressed in 221 organ(s), highest expression level in left ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0C4DGK3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A0A0C4DGK3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3482 – 3541KASHInterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 139Sequence analysisAdd BLAST21
Coiled coili195 – 215Sequence analysisAdd BLAST21
Coiled coili326 – 353Sequence analysisAdd BLAST28
Coiled coili491 – 511Sequence analysisAdd BLAST21
Coiled coili519 – 539Sequence analysisAdd BLAST21
Coiled coili632 – 652Sequence analysisAdd BLAST21
Coiled coili666 – 693Sequence analysisAdd BLAST28
Coiled coili1132 – 1159Sequence analysisAdd BLAST28
Coiled coili1302 – 1329Sequence analysisAdd BLAST28
Coiled coili1467 – 1487Sequence analysisAdd BLAST21
Coiled coili1792 – 1826Sequence analysisAdd BLAST35
Coiled coili1846 – 1866Sequence analysisAdd BLAST21
Coiled coili1944 – 1964Sequence analysisAdd BLAST21
Coiled coili2140 – 2160Sequence analysisAdd BLAST21
Coiled coili2446 – 2466Sequence analysisAdd BLAST21
Coiled coili2471 – 2512Sequence analysisAdd BLAST42
Coiled coili3396 – 3416Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, TransmembranePROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154656

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012315 KASH
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR030266 SYNE2

The PANTHER Classification System

More...
PANTHERi
PTHR45487 PTHR45487, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10541 KASH, 1 hit
PF00435 Spectrin, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01249 KASH, 1 hit
SM00150 SPEC, 14 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51049 KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

A0A0C4DGK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEDIYTNLS KMETVLGQSM SSLPLSYREA LERLEQSKAL VSNLISTKEE
60 70 80 90 100
LMKLRQILRL LRLRCTENDG ICLLKIVSAL WEKWLSLLEA AKEWEMWCEE
110 120 130 140 150
LKQEWKFVSE EIEREAIILD NLQEELPEIS KTKEAATTEE LSELLDCLCQ
160 170 180 190 200
YGENVEKQQL LLTLLLQRIR SIQNVPESSG AVETVPAFQE ITSMKERCNK
210 220 230 240 250
LLQKVQKNKE LVQTEIQERH SFTKEIIALK NFFQQTTTSF QNMAFQDHPE
260 270 280 290 300
KSEQFEELQS ILKKGKLTFE NIMEKLRIKY SEMYTIVPAE IESQVEECRK
310 320 330 340 350
ALEDIDEKIS NEVLKSSPSY AMRRKIEEIN NGLHNVEKML QQKSKNIEKA
360 370 380 390 400
QEIQKKMWDE LDLWHSKLNE LDSEVQDIVE QDPGQAQEWM DNLMIPFQQY
410 420 430 440 450
QQVSQRAECR TSQLNKATVK MEEYSDLLKS TEAWIENTSH LLANPADYDS
460 470 480 490 500
LRTLSHHAST VQMALEDSEQ KHNLLHSIFM DLEDLSIIFE TDELTQSIQE
510 520 530 540 550
LSNQVTALQQ KIMESLPQIQ RMADDVVAIE SEVKSMEKRV SKIKTILLSK
560 570 580 590 600
EIFDFSPEEH LKHGEVILEN IRPMKKTIAE IVSYQVELRL PQTGMKPLPV
610 620 630 640 650
FQRTNQLLQD IKLLENVTQE QNELLKVVIK QTNEWDEEIE NLKQILNNYS
660 670 680 690 700
AQFSLEHMSP DQADKLPQLQ GEIERMEKQI LSLNQRKEDL LVDLKATVLN
710 720 730 740 750
LHQHLKQEQE GVERDRLPAV TSEEGGVAER DASERKLNRR GSMSYLAAVE
760 770 780 790 800
EEVEESSVKS DNGDEKAEPS PQSWSSLWKH DKDMEEDRAS SSSGTIVQEA
810 820 830 840 850
YGKISTSDNS MAQILTPDSL NTEQGPECSL RPNQTEEGTT PPIEADTLDS
860 870 880 890 900
SDAQGGLEPR VEKTRPEPTE VLHACKTQVA ELELWLQQAN VAVEPETLNA
910 920 930 940 950
DMQQVLEQQL VGCQAMLTEI EHKVAFLLET CKDQGLGDNG ATQHEAEALS
960 970 980 990 1000
LKLKTVKCNL EKVQMMLQEK HSEDQHPTIL KKSSEPEHQE ALQPVNLSEL
1010 1020 1030 1040 1050
ESIVTERPQF SRQKDFQQQQ VLELKPMEQK DFIKFIEFNA KKMWPQYCQH
1060 1070 1080 1090 1100
DNDTTQESSA SNQASSPEND VPDSILSPQG QNGDKWQYLH HELSSKIKLP
1110 1120 1130 1140 1150
LPQLVEPQVS TNMGILPSVT MYNFRYPTTE ELKTYTTQLE DLRQEASNLQ
1160 1170 1180 1190 1200
TQENMTEEAY INLDKKLFEL FLTLSQCLSS VEEMLEMPRL YREDGSGQQV
1210 1220 1230 1240 1250
HYETLALELK KLYLALSDKK GDLLKAMTWP GENTNLLLEC FDNLQVCLEH
1260 1270 1280 1290 1300
TQAAAVCRSK SLKAGLDYNR SYQNEIKRLY HQLIKSKTSL QQSLNEISGQ
1310 1320 1330 1340 1350
SVAEQLQKAD AYTVELENAE SRVAKLRDEG ERLHLPYALL QEVYKLEDVL
1360 1370 1380 1390 1400
DSMWGMLRAR YTELSSPFVT ESQQDALLQG MVELVKIGKE KLAHGHLKQT
1410 1420 1430 1440 1450
KSKVALQAQI ENHKVFFQKL VADMLLIQAY SAKILPSLLQ NRETFWAEQV
1460 1470 1480 1490 1500
TEVKILEEKS RQCGMKLQSL LQKWEEFDEN YASLEKDLEI LISTLPSVSL
1510 1520 1530 1540 1550
VEETEERLVE RISFYQQIKR NIGGKHARLY QTLNEGKQLV ASVSCPELEG
1560 1570 1580 1590 1600
QIAKLEEQWL SLNKKIDHEL HRLQALLKHL LSYNRDSDQL TKWLESSQHT
1610 1620 1630 1640 1650
LNYWKEQSLN VSQDLDTIRS NINNFFEFSK EVDEKSSLKT AVISIGNQLL
1660 1670 1680 1690 1700
HLKETDTATL RASLAQFEQK WTMLITQLPD IQEKLHQLQM EKLPSRKAIT
1710 1720 1730 1740 1750
EMISWMNNVE HQTSDEDSVH SPSSASQVKH LLQKHKEFRM EMDYKQWIVD
1760 1770 1780 1790 1800
FVNQSLLQLS TCDVESKRYE RTEFAEHLGE MNRQWHRVHG MLNRKIQHLE
1810 1820 1830 1840 1850
QLLESITESE NKIQILNNWL EAQEERLKTL QKPESVISVQ KLLLDCQDIE
1860 1870 1880 1890 1900
NQLAIKSKAL DELKQSYLTL ESGAVPLLED TASRIDELFQ KRSSVLTQVN
1910 1920 1930 1940 1950
QLKTSMQSVL QEWKIYDQLY DEVNMMTIRF WYCMEHSKPV VLSLETLRCQ
1960 1970 1980 1990 2000
VENLQSLQDE AESSEGSWEK LQEVIGKLKG LCPSVAEIIE EKCQNTHKRW
2010 2020 2030 2040 2050
TQVNQAIADQ LQKAQSLLQL WKAYSNAHGE AAARLKQQEA KFQQLANISM
2060 2070 2080 2090 2100
SGNNLAEILP PALQDIKELQ HDVQKTKEAF LQNSSVLDRL PQPAESSTHM
2110 2120 2130 2140 2150
LLPGPLHSLQ RAAYLEKMLL VKANEFEFVL SQFKDFGVRL ESLKGLIMHE
2160 2170 2180 2190 2200
EENLDRLHQQ EKENPDSFLN HVLALTAQSP DIEHLNEVSL KLPLSDVAVK
2210 2220 2230 2240 2250
TLQNMNRQWI RATATALERC SELQGIGLNE KFLYCCEKWI QLLEKIEEAL
2260 2270 2280 2290 2300
KVDVANSLPE LLEQQKTYKM LEAEVSINQT IADSYVTQSL QLLDTTEIEN
2310 2320 2330 2340 2350
RPEFITEFSK LTDRWQNAVQ GVRQRKGDVD GLVRQWQDFT TSVENLFRFL
2360 2370 2380 2390 2400
TDTSHLLSAV KGQERFSLYQ TRSLIHELKN KEIHFQRRRT TCALTLEAGE
2410 2420 2430 2440 2450
KLLLTTDLKT KESVGRRISQ LQDSWKDMEP QLAEMIKQFQ STVETWDQCE
2460 2470 2480 2490 2500
KKIKELKSRL QVLKAQSEDP LPELHEDLHN EKELIKELEQ SLASWTQNLK
2510 2520 2530 2540 2550
ELQTMKADLT RHVLVEDVMV LKEQIEHLHR QWEDLCLRVA IRKQEIEDRL
2560 2570 2580 2590 2600
NTWVVFNEKN KELCAWLVQM ENKVLQTADI SIEEMIEKLQ KDCMEEINLF
2610 2620 2630 2640 2650
SENKLQLKQM GDQLIKASNK SRAAEIDDKL NKINDRWQHL FDVIGSRVKK
2660 2670 2680 2690 2700
LKETFAFIQQ LDKNMSNLRT WLARIESELS KPVVYDVCDD QEIQKRLAEQ
2710 2720 2730 2740 2750
QDLQRDIEQH SAGVESVFNI CDVLLHDSDA CANETECDSI QQTTRSLDRR
2760 2770 2780 2790 2800
WRNICAMSME RRMKIEETWR LWQKFLDDYS RFEDWLKSAE RTAACPNSSE
2810 2820 2830 2840 2850
VLYTSAKEEL KRFEAFQRQI HERLTQLELI NKQYRRLARE NRTDTASRLK
2860 2870 2880 2890 2900
QMVHEGNQRW DNLQRRVTAV LRRLRHFTNQ REEFEGTRES ILVWLTEMDL
2910 2920 2930 2940 2950
QLTNVEHFSE SDADDKMRQL NGFQQEITLN TNKIDQLIVF GEQLIQKSEP
2960 2970 2980 2990 3000
LDAVLIEDEL EELHRYCQEV FGRVSRFHRR LTSCTPGLED EKEASENETD
3010 3020 3030 3040 3050
MEDPREIQTD SWRKRGESEE PSSPQSLCHL VAPGHERSGC ETPVSVDSIP
3060 3070 3080 3090 3100
LEWDHTGDVG GSSSHEEDEE GPYYSALSDV EIPENPEAYL KMTTKTLKAS
3110 3120 3130 3140 3150
SGKSISDGHS WHVPDSPSCP EHHYKQMEGD RNVPPVPPAS STPYKPPYGK
3160 3170 3180 3190 3200
LLLPPGTDGG KEGPRVLNGN PQQEDGGLAG ITEQQSGAFD RWEMIQAQEL
3210 3220 3230 3240 3250
HNKLKIKQNL QQLNSDISAI TTWLKKTEAE LEMLKMAKPP SDIQEIELRV
3260 3270 3280 3290 3300
KRLQEILKAF DTYKALVVSV NVSSKEFLQT ESPESTELQS RLRQLSLLWE
3310 3320 3330 3340 3350
AAQGAVDSWR GGLRQSLMQC QDFHQLSQNL LLWLASAKNR RQKAHVTDPK
3360 3370 3380 3390 3400
ADPRALLECR RELMQLEKEL VERQPQVDML QEISNSLLIK GHGEDCIEAE
3410 3420 3430 3440 3450
EKVHVIEKKL KQLREQVSQD LMALQGTQNP ASPLPSFDEV DSGDQPPATS
3460 3470 3480 3490 3500
VPAPRAKFRA VRTTEGEEET ESRVPGSTRP QRSFLSRVVR AALPLQLLLL
3510 3520 3530 3540
LLLLLACLLP SSEEDYSCTQ ANNFARSFYP MLRYTNGPPP T
Length:3,541
Mass (Da):408,729
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB9CF87A5A1A397C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8WXH0SYNE2_HUMAN
Nesprin-2
SYNE2 KIAA1011, NUA
6,885Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRE3A0A0A0MRE3_HUMAN
Nesprin-2
SYNE2
6,824Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5X4G3V5X4_HUMAN
Nesprin-2
SYNE2
6,818Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4T3G3V4T3_HUMAN
Nesprin-2
SYNE2
1,127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3D4G3V3D4_HUMAN
Nesprin-2
SYNE2
607Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5N1G3V5N1_HUMAN
Nesprin-2
SYNE2
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2Q0G3V2Q0_HUMAN
Nesprin-2
SYNE2
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRN9A0A1W2PRN9_HUMAN
Nesprin-2
SYNE2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PS37A0A1W2PS37_HUMAN
Nesprin-2
SYNE2
16Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL162832 Genomic DNA No translation available.
AL355094 Genomic DNA No translation available.
AL359235 Genomic DNA No translation available.

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.745014

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000555002; ENSP00000450831; ENSG00000054654

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162832 Genomic DNA No translation available.
AL355094 Genomic DNA No translation available.
AL359235 Genomic DNA No translation available.
UniGeneiHs.745014

3D structure databases

ProteinModelPortaliA0A0C4DGK3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0C4DGK3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555002; ENSP00000450831; ENSG00000054654

Organism-specific databases

EuPathDBiHostDB:ENSG00000054654.15
HGNCiHGNC:17084 SYNE2
OpenTargetsiENSG00000054654

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000154656

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SYNE2 human

Gene expression databases

BgeeiENSG00000054654 Expressed in 221 organ(s), highest expression level in left ovary
ExpressionAtlasiA0A0C4DGK3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR012315 KASH
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
IPR030266 SYNE2
PANTHERiPTHR45487 PTHR45487, 1 hit
PfamiView protein in Pfam
PF10541 KASH, 1 hit
PF00435 Spectrin, 4 hits
SMARTiView protein in SMART
SM01249 KASH, 1 hit
SM00150 SPEC, 14 hits
PROSITEiView protein in PROSITE
PS51049 KASH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0C4DGK3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0C4DGK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: December 5, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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