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Protein
Submitted name:

Cullin-associated NEDD8-dissociated protein 1

Gene

CAND1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Cullin-associated NEDD8-dissociated protein 1Imported
Gene namesi
Name:CAND1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111530.12
HGNCiHGNC:30688 CAND1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111530

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A0C4DGH5

Expressioni

Gene expression databases

BgeeiENSG00000111530 Expressed in 231 organ(s), highest expression level in kidney
ExpressionAtlasiA0A0C4DGH5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A0C4DGH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini580 – 742TIP120InterPro annotationAdd BLAST163

Phylogenomic databases

eggNOGiKOG1824 Eukaryota
ENOG410XPK4 LUCA
GeneTreeiENSGT00390000017740

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120
PANTHERiPTHR12696 PTHR12696, 2 hits
PfamiView protein in Pfam
PF08623 TIP120, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A0C4DGH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
HVSTIINICL KYLTYDPNYN YDDEDEDENA MDADGGDDDD QGSDDEYSDD
60 70 80 90 100
DDMSWKVRRA AAKCLDAVVS TRHEMLPEFY KTVSPALISR FKEREENVKA
110 120 130 140 150
DVFHAYLSLL KQTRPVQSWL CDPDAMEQGE TPLTMLQSQV PNIVKALHKQ
160 170 180 190 200
MKEKSVKTRQ CCFNMLTTVK ALTLIAGSPL KIDLRPVLGE GVPILASFLR
210 220 230 240 250
KNQRALKLGT LSALDILIKN YSDSLTAAMI DAVLDELPPL ISESDMHVSQ
260 270 280 290 300
MAISFLTTLA KVYPSSLSKI SGSILNELIG LVRSPLLQGG ALSAMLDFFQ
310 320 330 340 350
ALVVTGTNNL GYMDLLRMLT GPVYSQSTAL THKQSYYSIA KCVAALTRAC
360 370 380 390 400
PKEGPAVVGQ FIQDVKNSRS TDSIRLLALL SLGEVGHHID LSGQLELKSV
410 420 430 440 450
ILEAFSSPSE EVKSAASYAL GSISVGNLPE YLPFVLQEIT SQPKRQYLLL
460 470 480 490 500
HSLKEIISSA SVVGLKPYVE NIWALLLKHC ECAEEGTRNV VAECLGKLTL
510 520 530 540 550
IDPETLLPRL KGYLISGSSY ARSSVVTAVK FTISDHPQPI DPLLKNCIGD
560 570 580 590 600
FLKTLEDPDL NVRRVALVTF NSAAHNKPSL IRDLLDTVLP HLYNETKVRK
610 620 630 640 650
ELIREVEMGP FKHTVDDGLD IRKAAFECMY TLLDSCLDRL DIFEFLNHVE
660 670 680 690 700
DGLKDHYDIK MLTFLMLVRL STLCPSAVLQ RLDRLVEPLR ATCTTKVKAN
710 720 730 740 750
SVKQEFEKQD ELKRSAMRAV AALLTIPEAE KSPLMSEFQS QISSNPELAA
760 770
IFESIQKDSS STNLESMDTS
Length:770
Mass (Da):85,409
Last modified:April 1, 2015 - v1
Checksum:iE2C22A6723BC95ED
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q86VP6CAND1_HUMAN
Cullin-associated NEDD8-dissociated...
CAND1 KIAA0829, TIP120, TIP120A
1,230Annotation score:
F5H6I6F5H6I6_HUMAN
Cullin-associated NEDD8-dissociated...
CAND1
54Annotation score:
H0YH27H0YH27_HUMAN
Cullin-associated NEDD8-dissociated...
CAND1
442Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012518 Genomic DNA No translation available.
AC078983 Genomic DNA No translation available.
UniGeneiHs.546407

Genome annotation databases

EnsembliENST00000544619; ENSP00000444089; ENSG00000111530

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012518 Genomic DNA No translation available.
AC078983 Genomic DNA No translation available.
UniGeneiHs.546407

3D structure databases

ProteinModelPortaliA0A0C4DGH5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A0C4DGH5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000544619; ENSP00000444089; ENSG00000111530

Organism-specific databases

EuPathDBiHostDB:ENSG00000111530.12
HGNCiHGNC:30688 CAND1
OpenTargetsiENSG00000111530
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1824 Eukaryota
ENOG410XPK4 LUCA
GeneTreeiENSGT00390000017740

Miscellaneous databases

ChiTaRSiCAND1 human

Gene expression databases

BgeeiENSG00000111530 Expressed in 231 organ(s), highest expression level in kidney
ExpressionAtlasiA0A0C4DGH5 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120
PANTHERiPTHR12696 PTHR12696, 2 hits
PfamiView protein in Pfam
PF08623 TIP120, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0C4DGH5_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DGH5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: November 7, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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