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UniProtKB - A0A0C4DG40 (A0A0C4DG40_HUMAN)

Entry version 56 (19 Jan 2022)
Sequence version 1 (01 Apr 2015)
Previous versions | rss
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Protein
Submitted name:

Nesprin-1

Gene

SYNE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nesprin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17089, SYNE1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131018

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8698CytoplasmicPROSITE-ProRule annotationAdd BLAST8698
Topological domaini8720 – 8749Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000131018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		A0A0C4DG40

PeptideAtlas

More...PeptideAtlasi		A0A0C4DG40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131018, Expressed in cerebellum and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A0C4DG40, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141Calponin-homology (CH)InterPro annotationAdd BLAST115
Domaini185 – 290Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8690 – 8749KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5788 – 5815DisorderedSequence analysisAdd BLAST28
Regioni8175 – 8210DisorderedSequence analysisAdd BLAST36
Regioni8623 – 8686DisorderedSequence analysisAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili334 – 354Sequence analysisAdd BLAST21
Coiled coili629 – 656Sequence analysisAdd BLAST28
Coiled coili936 – 956Sequence analysisAdd BLAST21
Coiled coili1321 – 1348Sequence analysisAdd BLAST28
Coiled coili1420 – 1454Sequence analysisAdd BLAST35
Coiled coili1561 – 1581Sequence analysisAdd BLAST21
Coiled coili1633 – 1667Sequence analysisAdd BLAST35
Coiled coili1909 – 1929Sequence analysisAdd BLAST21
Coiled coili1987 – 2014Sequence analysisAdd BLAST28
Coiled coili2021 – 2041Sequence analysisAdd BLAST21
Coiled coili2091 – 2111Sequence analysisAdd BLAST21
Coiled coili2244 – 2271Sequence analysisAdd BLAST28
Coiled coili2349 – 2383Sequence analysisAdd BLAST35
Coiled coili2489 – 2509Sequence analysisAdd BLAST21
Coiled coili2969 – 2989Sequence analysisAdd BLAST21
Coiled coili3168 – 3188Sequence analysisAdd BLAST21
Coiled coili3412 – 3432Sequence analysisAdd BLAST21
Coiled coili3473 – 3493Sequence analysisAdd BLAST21
Coiled coili3675 – 3695Sequence analysisAdd BLAST21
Coiled coili3768 – 3788Sequence analysisAdd BLAST21
Coiled coili4037 – 4057Sequence analysisAdd BLAST21
Coiled coili4075 – 4095Sequence analysisAdd BLAST21
Coiled coili4702 – 4736Sequence analysisAdd BLAST35
Coiled coili4780 – 4800Sequence analysisAdd BLAST21
Coiled coili4997 – 5017Sequence analysisAdd BLAST21
Coiled coili5081 – 5108Sequence analysisAdd BLAST28
Coiled coili5286 – 5313Sequence analysisAdd BLAST28
Coiled coili5339 – 5369Sequence analysisAdd BLAST31
Coiled coili5434 – 5461Sequence analysisAdd BLAST28
Coiled coili5498 – 5518Sequence analysisAdd BLAST21
Coiled coili5528 – 5548Sequence analysisAdd BLAST21
Coiled coili5556 – 5583Sequence analysisAdd BLAST28
Coiled coili5662 – 5689Sequence analysisAdd BLAST28
Coiled coili5700 – 5737Sequence analysisAdd BLAST38
Coiled coili5932 – 5952Sequence analysisAdd BLAST21
Coiled coili5987 – 6014Sequence analysisAdd BLAST28
Coiled coili6091 – 6118Sequence analysisAdd BLAST28
Coiled coili6156 – 6183Sequence analysisAdd BLAST28
Coiled coili6513 – 6537Sequence analysisAdd BLAST25
Coiled coili6986 – 7020Sequence analysisAdd BLAST35
Coiled coili7092 – 7122Sequence analysisAdd BLAST31
Coiled coili7576 – 7596Sequence analysisAdd BLAST21
Coiled coili7741 – 7768Sequence analysisAdd BLAST28
Coiled coili7848 – 7868Sequence analysisAdd BLAST21
Coiled coili8420 – 8440Sequence analysisAdd BLAST21
Coiled coili8594 – 8618Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5791 – 5815Polar residuesSequence analysisAdd BLAST25
Compositional biasi8176 – 8196Polar residuesSequence analysisAdd BLAST21
Compositional biasi8623 – 8683Polar residuesSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154481

Database of Orthologous Groups

More...OrthoDBi		47at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 24 potential isoforms that are computationally mapped.Show allAlign All

A0A0C4DG40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV 
        60         70         80         90        100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE 
       110        120        130        140        150
GRKSMHRGSP IKLVNINSTD IADGRPSIVL GLMWTIILYF QIEELTSNLP 
       160        170        180        190        200
QLQSLSSSAS SVDSIVSSET PSPPSKRKVT TKIQGNAKKA LLKWVQYTAG 
       210        220        230        240        250
KQTGIEVKDF GKSWRSGVAF HSVIHAIRPE LVDLETVKGR SNRENLEDAF 
       260        270        280        290        300
TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKHYP DIHNASTDGQ 
       310        320        330        340        350
EDDEILPGFP SFANSVQNFK REDRVIFKEM KVWIEQFERD LTRAQMVESN 
       360        370        380        390        400
LQDKYQSFKH FRVQYEMKRK QIEHLIQPLH RDGKLSLDQA LVKQSWDRVT 
       410        420        430        440        450
SRLFDWHIQL DKSLPAPLGT IGAWLYRAEV ALREEITVQQ VHEETANTIQ 
       460        470        480        490        500
RKLEQHKDLL QNTDAHKRAF HEIYRTRSVN GIPVPPDQLE DMAERFHFVS 
       510        520        530        540        550
STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGRR ESVEQLLQNY 
       560        570        580        590        600
VSFIENSKFF EQYEVTYQIL KQTAEMYVKA DGSVEEAENV MKFMNETTAQ 
       610        620        630        640        650
WRNLSVEVRS VRSMLEEVIS NWDRYGNTVA SLQAWLEDAE KMLNQSENAK 
       660        670        680        690        700
KDFFRNLPHW IQQHTAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL 
       710        720        730        740        750
FMEVKQYAQA DEMDRMKKEY TDCVVTLSAF ATEAHKKLSE PLEVSFMNVK 
       760        770        780        790        800
LLIQDLEDIE QRVPVMDAQY KIITKTAHLI TKESPQEEGK EMFATMSKLK 
       810        820        830        840        850
EQLTKVKECY SPLLYESQQL LIPLEELEKQ MTSFYDSLGK INEIITVLER 
       860        870        880        890        900
EAQSSALFKQ KHQELLACQE NCKKTLTLIE KGSQSVQKFV TLSNVLKHFD 
       910        920        930        940        950
QTRLQRQIAD IHVAFQSMVK KTGDWKKHVE TNSRLMKKFE ESRAELEKVL 
       960        970        980        990       1000
RIAQEGLEEK GDPEELLRRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE 
      1010       1020       1030       1040       1050
QQGLQEAVRK LHKQWKDLQG EAPYHLLHLK IDVEKNRFLA SVEECRTELD 
      1060       1070       1080       1090       1100
RETKLMPQEG SEKIIKEHRV FFSDKGPHHL CEKRLQLIEE LCVKLPVRDP 
      1110       1120       1130       1140       1150
VRDTPGTCHV TLKELRAAID STYRKLMEDP DKWKDYTSRF SEFSSWISTN 
      1160       1170       1180       1190       1200
ETQLKGIKGE AIDTANHGEV KRAVEEIRNG VTKRGETLSW LKSRLKVLTE 
      1210       1220       1230       1240       1250
VSSENEAQKQ GDELAKLSSS FKALVTLLSE VEKMLSNFGD CVQYKEIVKN 
      1260       1270       1280       1290       1300
SLEELISGSK EVQEQAEKIL DTENLFEAQQ LLLHHQQKTK RISAKKRDVQ 
      1310       1320       1330       1340       1350
QQIAQAQQGE GGLPDRGHEE LRKLESTLDG LERSRERQER RIQVTLRKWE 
      1360       1370       1380       1390       1400
RFETNKETVV RYLFQTGSSH ERFLSFSSLE SLSSELEQTK EFSKRTESIA 
      1410       1420       1430       1440       1450
VQAENLVKEA SEIPLGPQNK QLLQQQAKSI KEQVKKLEDT LEEDIKTMEM 
      1460       1470       1480       1490       1500
VKTKWDHFGS NFETLSVWIT EKEKELNALE TSSSAMDMQI SQIKVTIQEI 
      1510       1520       1530       1540       1550
ESKLSSIVGL EEEAQSFAQF VTTGESARIK AKLTQIRRYG EELREHAQCL 
      1560       1570       1580       1590       1600
EGTILGHLSQ QQKFEENLRK IQQSVSEFED KLAVPIKICS SATETYKVLQ 
      1610       1620       1630       1640       1650
EHMDLCQALE SLSSAITAFS ASARKVVNRD SCVQEAAALQ QQYEDILRRA 
      1660       1670       1680       1690       1700
KERQTALENL LAHWQRLEKE LSSFLTWLER GEAKASSPEM DISADRVKVE 
      1710       1720       1730       1740       1750
GELQLIQALQ NEVVSQASFY SKLLQLKESL FSVASKDDVK MMKLHLEQLD 
      1760       1770       1780       1790       1800
ERWRDLPQII NKRINFLQSV VAEHQQFDEL LLSFSVWIKL FLSELQTTSE 
      1810       1820       1830       1840       1850
ISIMDHQVAL TRHKDHAAEV ESKKGELQSL QGHLAKLGSL GRAEDLHLLQ 
      1860       1870       1880       1890       1900
GKAEDCFQLF EEASQVVERR QLALSHLAEF LQSHASLSGI LRQLRQTVEA 
      1910       1920       1930       1940       1950
TNSMNKNESD LIEKDLNDAL QNAKALESAA VSLDGILSKA QYHLKIGSSE 
      1960       1970       1980       1990       2000
QRTSCRATAD QLCGEVERIQ NLLGTKQSEA DALAVLKKAF QDQKEELLKS 
      2010       2020       2030       2040       2050
IEDIEERTDK ERLKEPTRQA LQQRLRVFNQ LEDELNSHEH ELCWLKDKAK 
      2060       2070       2080       2090       2100
QIAQKDVAFA PEVDREINRL EVTWDDTKRL IHENQGQCCG LIDLMREYQN 
      2110       2120       2130       2140       2150
LKSAVSKVLE NASSVIVTRT TIKDQEDLKW AFSKHETAKN KMNYKQKDLD 
      2160       2170       2180       2190       2200
NFTSKGKHLL SELKKIHSSD FSLVKTDMES TVDKWLDVSE KLEENMDRLR 
      2210       2220       2230       2240       2250
VSLSIWDDVL STRDEIEGWS NNCVPQMAEN ISNLDNHLRA EELLKEFESE 
      2260       2270       2280       2290       2300
VKNKALRLEE LHSKVNDLKE LTKNLETPPD LQFIEADLMQ KLEHAKEITE 
      2310       2320       2330       2340       2350
VAKGTLKDFT AQSTQVEKFI NDITTWFTKV EESLMNCAQN ETCEALKKVK 
      2360       2370       2380       2390       2400
DIQKELQSQQ SNISSTQENL NSLCRKYHSA ELESLGRAMT GLIKKHEAVS 
      2410       2420       2430       2440       2450
QLCSKTQASL QESLEKHFSE SMQEFQEWFL GAKAAAKESS DRTGDSKVLE 
      2460       2470       2480       2490       2500
AKLHDLQNIL DSVSDGQSKL DAVTQEGQTL YAHLSKQIVS SIQEQITKAN 
      2510       2520       2530       2540       2550
EEFQAFLKQC LKDKQALQDC ASELGSFEDQ HRKLNLWIHE MEERFNTENL 
      2560       2570       2580       2590       2600
GESKQHIPEK KNEVHKVEMF LGELLAARES LDKLSQRGQL LSEEGHGAGQ 
      2610       2620       2630       2640       2650
EGRLCSQLLT SHQNLLRMTK EKLRSCQVAL QEHEALEEAL QSMWFWVKAI 
      2660       2670       2680       2690       2700
QDRLACAEST LGSKDTLEKR LSQIQDILLM KGEGEVKLNM AIGKGEQALR 
      2710       2720       2730       2740       2750
SSNKEGQRVI QTQLETLKEV WADIMSSSVH AQSTLESVIS QWNDYVERKN 
      2760       2770       2780       2790       2800
QLEQWMESVD QKIEHPLQPQ PGLKEKFVLL DHLQSILSEA EDHTRALHRL 
      2810       2820       2830       2840       2850
IAKSRELYEK TEDESFKDTA QEELKTQFND IMTVAKEKMR KVEEIVKDHL 
      2860       2870       2880       2890       2900
MYLDAVHEFT DWLHSAKEEL HRWSDMSGDS SATQKKLSKI KELIDSREIG 
      2910       2920       2930       2940       2950
ASRLSRVESL APEVKQNTTA SGCELMHTEM QALRADWKQW EDSVFQTQSC 
      2960       2970       2980       2990       3000
LENLVSQMAL SEQEFSGQVA QLEQALEQFS ALLKTWAQQL TLLEGKNTDE 
      3010       3020       3030       3040       3050
EIVECWHKGQ EILDALQKAE PRTEDLKSQL NELCRFSRDL STYSGKVSGL 
      3060       3070       3080       3090       3100
IKEYNCLCLQ ASKGCQNKEQ ILQQRFRKAF RDFQQWLVNA KITTAKCFDI 
      3110       3120       3130       3140       3150
PQNISEVSTS LQKIQEFLSE SENGQHKLNM MLSKGELLST LLTKEKAKGI 
      3160       3170       3180       3190       3200
QAKVTAAKED WKNFHSNLHQ KESALENLKI QMKDFEVSAE PIQDWLSKTE 
      3210       3220       3230       3240       3250
KMVHESSNRL YDLPAKRREQ QKLQSVLEEI HCYEPQLNRL KEKAQQLWEG 
      3260       3270       3280       3290       3300
QAASKSFRHR VSQLSSQYLA LSNLTKEKVS RLDRIVAEHN QFSLGIKELQ 
      3310       3320       3330       3340       3350
DWMTDAIHML DSYCHPTSDK SVLDSRTLKL EALLSVKQEK EIQMKMIVTR 
      3360       3370       3380       3390       3400
GESVLQNTSP EGIPTIQQQL QSVKDMWASL LSAGIRCKSQ LEGALSKWTS 
      3410       3420       3430       3440       3450
YQDGVRQFSG WMDSMEANLN ESERQHAELR DKTTMLGKAK LLNEEVLSYS 
      3460       3470       3480       3490       3500
SLLETIEVKG AGMTEHYVTQ LELQDLQERY RAIQERAKEA VTKSEKLVRL 
      3510       3520       3530       3540       3550
HQEYQRDLKA FEVWLGQEQE KLDQYSVLEG DAHTHETTLR DLQELQVHCA 
      3560       3570       3580       3590       3600
EGQALLNSVL HTREDVIPSG IPQAEDRALE SLRQDWQAYQ HRLSETRTQF 
      3610       3620       3630       3640       3650
NNVVNKLRLM EQKFQQVDEW LKTAEEKKWH EEVTAYRDEV EEVGARAQEI 
      3660       3670       3680       3690       3700
LDESHVNSRM GCQATQLTSR YQALLLQVLE QIKFLEEEIQ SLEESESSLS 
      3710       3720       3730       3740       3750
SYSDWYGSTH KNFKNVATKI DKVDTVMMGK KLKTLEVLLK DMEKGHSLLK 
      3760       3770       3780       3790       3800
SAREKGERAV KYLEEGEAER LRKEIHDHME QLKELTSTVR KEHMTLEKGL 
      3810       3820       3830       3840       3850
HLAKEFSDKC KALTQWIAEY QEILHVPEEP KMELYEKKAQ LSKYKSLQQT 
      3860       3870       3880       3890       3900
VLSHEPSVKS VREKGEALLE LVQDVTLKDK IDQLQSDYQD LCSIGKAMME 
      3910       3920       3930       3940       3950
EIAGFEDRLN NLQMKGDTLI GQCADHLQAK LKQNVHAHLQ GTKDSYSAIC 
      3960       3970       3980       3990       4000
STAQRMYQSL EHELQKHVSR QDTLQQCQAW LSAVQPDLEP SPQPPLSRAE 
      4010       4020       4030       4040       4050
AIKQVKHFRA LQEQARTYLD LLCSMCDLSN ASVKTTAKDI QQTEQTIEQK 
      4060       4070       4080       4090       4100
LVQAQNLTQG WEEIKHLKSE LWIYLQDADQ QLQNMKRRHS ELELNIAQNM 
      4110       4120       4130       4140       4150
VSQVKDFVKK LQSKQASVNT IIEKVNKLTK KEESPEHKEI NHLNDQWLDL 
      4160       4170       4180       4190       4200
CRQSNNLCLQ REEDLQRTRD YHDCMNVVEV FLEKFTTEWD NLARSDAEST 
      4210       4220       4230       4240       4250
AVHLEALKKL ALALQERKYA IEDLKDQKQK MIEHLNLDDK ELVKEQTSHL 
      4260       4270       4280       4290       4300
EQRWFQLEDL IKRKIQVSVT NLEELNVVQS RFQELMEWAE EQQPNIAEAL 
      4310       4320       4330       4340       4350
KQSPPPDMAQ NLLMDHLAIC SELEAKQMLL KSLIKDADRV MADLGLNERQ 
      4360       4370       4380       4390       4400
VIQKALSDAQ SHVNCLSDLV GQRRKYLNKA LSEKTQFLMA VFQATSQIQQ 
      4410       4420       4430       4440       4450
HERKIMFREH ICLLPDDVSK QVKTCKSAQA SLKTYQNEVT GLWAQGRELM 
      4460       4470       4480       4490       4500
KEVTEQEKSE VLGKLQELQS VYDSVLQKCS HRLQELEKNL VSRKHFKEDF 
      4510       4520       4530       4540       4550
DKACHWLKQA DIVTFPEINL MNESSELHTQ LAKYQNILEQ SPEYENLLLT 
      4560       4570       4580       4590       4600
LQRTGQTILP SLNEVDHSYL SEKLNALPRQ FNVIVALAKD KFYKVQEAIL 
      4610       4620       4630       4640       4650
ARKEYASLIE LTTQSLSELE AQFLRMSKVP TDLAVEEALS LQDGCRAILD 
      4660       4670       4680       4690       4700
EVAGLGEAVD ELNQKKEGFR STGQPWQPDK MLHLVTLYHR LKRQTEQRVS 
      4710       4720       4730       4740       4750
LLEDTTSAYQ EHEKMCQQLE RQLKSVKEEQ SKVNEETLPA EEKLKMYHSL 
      4760       4770       4780       4790       4800
AGSLQDSGIV LKRVTIHLED LAPHLDPLAY EKARHQIQSW QGELKLLTSA 
      4810       4820       4830       4840       4850
IGETVTECES RMVQSIDFQT EMSRSLDWLR RVKAELSGPV YLDLNLQDIQ 
      4860       4870       4880       4890       4900
EEIRKIQIHQ EEVQSSLRIM NALSHKEKEK FTKAKELISA DLEHSLAELS 
      4910       4920       4930       4940       4950
ELDGDIQEAL RTRQATLTEI YSQCQRYYQV FQAANDWLED AQELLQLAGN 
      4960       4970       4980       4990       5000
GLDVESAEEN LKSHMEFFST EDQFHSNLEE LHSLVATLDP LIKPTGKEDL 
      5010       5020       5030       5040       5050
EQKVASLELR SQRMSRDSGA QVDLLQRCTA QWHDYQKARE EVIELMNDTE 
      5060       5070       5080       5090       5100
KKLSEFSLLK TSSSHEAEEK LSEHKALVSV VNSFHEKIVA LEEKASQLEK 
      5110       5120       5130       5140       5150
TGNDASKATL SRSMTTVWQR WTRLRAVAQD QEKILEDAVD EWTGFNNKVK 
      5160       5170       5180       5190       5200
KATEMIDQLQ DKLPGSSAEK ASKAELLTLL EYHDTFVLEL EQQQSALGML 
      5210       5220       5230       5240       5250
RQQTLSMLQD GAAPTPGEEP PLMQEITAMQ DRCLNMQEKV KTNGKLVKQE 
      5260       5270       5280       5290       5300
LKDREMVETQ INSVKCWVQE TKEYLGNPTI EIDAQLEELQ ILLTEATNHR 
      5310       5320       5330       5340       5350
QNIEKMAEEQ KEKYLGLYTI LPSELSLQLA EVALDLKIRD QIQDKIKEVE 
      5360       5370       5380       5390       5400
QSKATSQELS RQIQKLAKDL TTILTKLKAK TDNVVQAKTD QKVLGEELDG 
      5410       5420       5430       5440       5450
CNSKLMELDA AVQKFLEQNG QLGKPLAKKI GKLTELHQQT IRQAENRLSK 
      5460       5470       5480       5490       5500
LNQAASHLEE YNEMLELILK WIEKAKVLAH GTIAWNSASQ LREQYILHQT 
      5510       5520       5530       5540       5550
LLEESKEIDS ELEAMTEKLQ YLTSVYCTEK MSQQVAELGR ETEELRQMIK 
      5560       5570       5580       5590       5600
IRLQNLQDAA KDMKKFEAEL KKLQAALEQA QATLTSPEVG RLSLKEQLSH 
      5610       5620       5630       5640       5650
RQHLLSEMES LKPKVQAVQL CQSALRIPED VVASLPLCHA ALRLQEEASR 
      5660       5670       5680       5690       5700
LQHTAIQQCN IMQAAVVQYE QYEQEMKHLQ QLIEGAHREI EDKPVATSNI 
      5710       5720       5730       5740       5750
QELQAQISRH EELAQKIKGY QEQIASLNSK CKMLTMKAKH ATMLLTVTEV 
      5760       5770       5780       5790       5800
EGLAEGTEDL DGELLPTPSA HPSVVMMTAG RCHTLLSPVT EESGEEGTNS 
      5810       5820       5830       5840       5850
EISSPPACRS PSPVANTDAS VNQDIAYYQA LSAERLQTDA AKIHPSTSAS 
      5860       5870       5880       5890       5900
QEFYEPGLEP SATAKLGDLQ RSWETLKNVI SEKQRTLYEA LERQQKYQDS 
      5910       5920       5930       5940       5950
LQSISTKMEA IELKLSESPE PGRSPESQMA EHQALMDEIL MLQDEINELQ 
      5960       5970       5980       5990       6000
SSLAEELVSE SCEADPAEQL ALQSTLTVLA ERMSTIRMKA SGKRQLLEEK 
      6010       6020       6030       6040       6050
LNDQLEEQRQ EQALQRYRCE ADELDSWLLS TKATLDTALS PPKEPMDMEA 
      6060       6070       6080       6090       6100
QLMDCQNMLV EIEQKVVALS ELSVHNENLL LEGKAHTKDE AEQLAGKLRR 
      6110       6120       6130       6140       6150
LKGSLLELQR ALHDKQLNMQ GTAQEKEESD VDLTATQSPG VQEWLAQART 
      6160       6170       6180       6190       6200
TWTQQRQSSL QQQKELEQEL AEQKSLLRSV ASRGEEILIQ HSAAETSGDA 
      6210       6220       6230       6240       6250
GEKPDVLSQE LGMEGEKSSA EDQMRMKWES LHQEFSTKQK LLQNVLEQEQ 
      6260       6270       6280       6290       6300
EQVLYSRPNR LLSGVPLYKG DVPTQDKSAV TSLLDGLNQA FEEVSSQSGG 
      6310       6320       6330       6340       6350
AKRQSIHLEQ KLYDGVSATS TWLDDVEERL FVATALLPEE TETCLFNQEI 
      6360       6370       6380       6390       6400
LAKDIKEMSE EMDKNKNLFS QAFPENGDNR DVIEDTLGCL LGRLSLLDSV 
      6410       6420       6430       6440       6450
VNQRCHQMKE RLQQILNFQN DLKVLFTSLA DNKYIILQKL ANVFEQPVAE 
      6460       6470       6480       6490       6500
QIEAIQQAED GLKEFDAGII ELKRRGDKLQ VEQPSMQELS KLQDMYDELM 
      6510       6520       6530       6540       6550
MIIGSRRSGL NQNLTLKSQY ERALQDLADL LETGQEKMAG DQKIIVSSKE 
      6560       6570       6580       6590       6600
EIQQLLDKHK EYFQGLESHM ILTETLFRKI ISFAVQKETQ FHTELMAQAS 
      6610       6620       6630       6640       6650
AVLKRAHKRG VELEYILETW SHLDEDQQEL SRQLEVVESS IPSVGLVEEN 
      6660       6670       6680       6690       6700
EDRLIDRITL YQHLKSSLNE YQPKLYQVLD DGKRLLISIS CSDLESQLNQ 
      6710       6720       6730       6740       6750
LGECWLSNTN KMSKELHRLE TILKHWTRYQ SESADLIHWL QSAKDRLEFW 
      6760       6770       6780       6790       6800
TQQSVTVPQE LEMVRDHLNA FLEFSKEVDA QSSLKSSVLS TGNQLLRLKK 
      6810       6820       6830       6840       6850
VDTATLRSEL SRIDSQWTDL LTNIPAVQEK LHQLQMDKLP SRHAISEVMS 
      6860       6870       6880       6890       6900
WISLMENVIQ KDEDNIKNSI GYKAIHEYLQ KYKGFKIDIN CKQLTVDFVN 
      6910       6920       6930       6940       6950
QSVLQISSQD VESKRSDKTD FAEQLGAMNK SWQILQGLVT EKIQLLEGLL 
      6960       6970       6980       6990       7000
ESWSEYENNV QCLKTWFETQ EKRLKQQHRI GDQASVQNAL KDCQDLEDLI 
      7010       7020       7030       7040       7050
KAKEKEVEKI EQNGLALIQN KKEDVSSIVM STLRELGQTW ANLDHMVGQL 
      7060       7070       7080       7090       7100
KILLKSVLDQ WSSHKVAFDK INSYLMEARY SLSRFRLLTG SLEAVQVQVD 
      7110       7120       7130       7140       7150
NLQNLQDDLE KQERSLQKFG SITNQLLKEC HPPVTETLTN TLKEVNMRWN 
      7160       7170       7180       7190       7200
NLLEEIAEQL QSSKALLQLW QRYKDYSKQC ASTVQQQEDR TNELLKAATN 
      7210       7220       7230       7240       7250
KDIADDEVAT WIQDCNDLLK GLGTVKDSLF FLHELGEQLK QQVDASAASA 
      7260       7270       7280       7290       7300
IQSDQLSLSQ HLCALEQALC KQQTSLQAGV LDYETFAKSL EALEAWIVEA 
      7310       7320       7330       7340       7350
EEILQGQDPS HSSDLSTIQE RMEELKGQML KFSSMAPDLD RLNELGYRLP 
      7360       7370       7380       7390       7400
LNDKEIKRMQ NLNRHWSLIS SQTTERFSKL QSFLLQHQTF LEKCETWMEF 
      7410       7420       7430       7440       7450
LVQTEQKLAV EISGNYQHLL EQQRAHELFQ AEMFSRQQIL HSIIIDGQRL 
      7460       7470       7480       7490       7500
LEQGQVDDRD EFNLKLTLLS NQWQGVIRRA QQRRGIIDSQ IRQWQRYREM 
      7510       7520       7530       7540       7550
AEKLRKWLVE VSYLPMSGLG SVPIPLQQAR TLFDEVQFKE KVFLRQQGSY 
      7560       7570       7580       7590       7600
ILTVEAGKQL LLSADSGAEA ALQAELAEIQ EKWKSASMRL EEQKKKLAFL 
      7610       7620       7630       7640       7650
LKDWEKCEKG IADSLEKLRT FKKKLSQSLP DHHEELHAEQ MRCKELENAV 
      7660       7670       7680       7690       7700
GSWTDDLTQL SLLKDTLSAY ISADDISILN ERVELLQRQW EELCHQLSLR 
      7710       7720       7730       7740       7750
RQQIGERLNE WAVFSEKNKE LCEWLTQMES KVSQNGDILI EEMIEKLKKD 
      7760       7770       7780       7790       7800
YQEEIAIAQE NKIQLQQMGE RLAKASHESK ASEIEYKLGK VNDRWQHLLD 
      7810       7820       7830       7840       7850
LIAARVKKLK ETLVAVQQLD KNMSSLRTWL AHIESELAKP IVYDSCNSEE 
      7860       7870       7880       7890       7900
IQRKLNEQQE LQRDIEKHST GVASVLNLCE VLLHDCDACA TDAECDSIQQ 
      7910       7920       7930       7940       7950
ATRNLDRRWR NICAMSMERR LKIEETWRLW QKFLDDYSRF EDWLKSSERT 
      7960       7970       7980       7990       8000
AAFPSSSGVI YTVAKEELKK FEAFQRQVHE CLTQLELINK QYRRLARENR 
      8010       8020       8030       8040       8050
TDSACSLKQM VHEGNQRWDN LQKRVTSILR RLKHFIGQRE EFETARDSIL 
      8060       8070       8080       8090       8100
VWLTEMDLQL TNIEHFSECD VQAKIKQLKA FQQEISLNHN KIEQIIAQGE 
      8110       8120       8130       8140       8150
QLIEKSEPLD AAIIEEELDE LRRYCQEVFG RVERYHKKLI RLPLPDDEHD 
      8160       8170       8180       8190       8200
LSDRELELED SAALSDLHWH DRSADSLLSP QPSSNLSLSL AQPLRSERSG 
      8210       8220       8230       8240       8250
RDTPASVDSI PLEWDHDYDL SRDLESAMSR ALPSEDEEGQ DDKDFYLRGA 
      8260       8270       8280       8290       8300
VGLSDVMIPE SPEAYVKLTE NAIKNTSGDH SALESQIRQL GKALDDSRFQ 
      8310       8320       8330       8340       8350
IQQTENIIRS KTPTGPELDT SYKGYMKLLG ECSSSIDSVK RLEHKLKEEE 
      8360       8370       8380       8390       8400
ESLPGFVNLH STETQTAGVI DRWELLQAQA LSKELRMKQN LQKWQQFNSD 
      8410       8420       8430       8440       8450
LNSIWAWLGD TEEELEQLQR LELSTDIQTI ELQIKKLKEL QKAVDHRKAI 
      8460       8470       8480       8490       8500
ILSINLCSPE FTQADSKESR DLQDRLSQMN GRWDRVCSLL EEWRGLLQDA 
      8510       8520       8530       8540       8550
LMQCQGFHEM SHGLLLMLEN IDRRKNEIVP IDSNLDAEIL QDHHKQLMQI 
      8560       8570       8580       8590       8600
KHELLESQLR VASLQDMSCQ LLVNAEGTDC LEAKEKVHVI GNRLKLLLKE 
      8610       8620       8630       8640       8650
VSRHIKELEK LLDVSSSQQD LSSWSSADEL DTSGSVSPTS GRSTPNRQKT 
      8660       8670       8680       8690       8700
PRGKCSLSQP GPSVSSPHSR STKGGSDSSL SEPGPGRSGR GFLFRVLRAA 
      8710       8720       8730       8740 
LPLQLLLLLL IGLACLVPMS EEDYSCALSN NFARSFHPML RYTNGPPPL
Length:8,749
Mass (Da):1,005,181
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CFD0A58FCC46064
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 24 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NF91SYNE1_HUMAN
Nesprin-1
SYNE1 C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1
8,797Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAI0F8WAI0_HUMAN
Nesprin-1
SYNE1
975Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JV20Q5JV20_HUMAN
Nesprin-1
SYNE1
952Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y326H0Y326_HUMAN
Nesprin-1
SYNE1
1,355Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y325H0Y325_HUMAN
Nesprin-1
SYNE1
1,654Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ83F5GZ83_HUMAN
Nesprin-1
SYNE1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH87A0A5F9ZH87_HUMAN
Nesprin-1
SYNE1
542Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH86A0A5F9ZH86_HUMAN
Nesprin-1
SYNE1
510Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHB2A0A5F9ZHB2_HUMAN
Nesprin-1
SYNE1
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHE1A0A5F9ZHE1_HUMAN
Nesprin-1
SYNE1
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL049548 Genomic DNA No translation available.
AL078582 Genomic DNA No translation available.
AL136079 Genomic DNA No translation available.
AL138832 Genomic DNA No translation available.
AL357081 Genomic DNA No translation available.
AL450401 Genomic DNA No translation available.
AL589963 Genomic DNA No translation available.
AL591507 Genomic DNA No translation available.
KF458330 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_149062.1, NM_033071.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000423061; ENSP00000396024; ENSG00000131018

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23345

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049548 Genomic DNA No translation available.
AL078582 Genomic DNA No translation available.
AL136079 Genomic DNA No translation available.
AL138832 Genomic DNA No translation available.
AL357081 Genomic DNA No translation available.
AL450401 Genomic DNA No translation available.
AL589963 Genomic DNA No translation available.
AL591507 Genomic DNA No translation available.
KF458330 Genomic DNA No translation available.
RefSeqiNP_149062.1, NM_033071.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

MaxQBiA0A0C4DG40
PeptideAtlasiA0A0C4DG40

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19931, 157 antibodies from 25 providers

Genome annotation databases

EnsembliENST00000423061; ENSP00000396024; ENSG00000131018
GeneIDi23345

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23345
HGNCiHGNC:17089, SYNE1
OpenTargetsiENSG00000131018
VEuPathDBiHostDB:ENSG00000131018

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000154481
OrthoDBi47at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23345, 5 hits in 1041 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYNE1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23345

Gene expression databases

BgeeiENSG00000131018, Expressed in cerebellum and 239 other tissues
ExpressionAtlasiA0A0C4DG40, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 10 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0C4DG40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0C4DG40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: January 19, 2022
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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