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Entry version 56 (19 Jan 2022)
Sequence version 1 (01 Apr 2015)
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Protein
Submitted name:

Nesprin-1

Gene

SYNE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nesprin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17089, SYNE1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000131018

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8698CytoplasmicPROSITE-ProRule annotationAdd BLAST8698
Topological domaini8720 – 8749Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000131018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A0A0C4DG40

PeptideAtlas

More...
PeptideAtlasi
A0A0C4DG40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131018, Expressed in cerebellum and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0C4DG40, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141Calponin-homology (CH)InterPro annotationAdd BLAST115
Domaini185 – 290Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8690 – 8749KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5788 – 5815DisorderedSequence analysisAdd BLAST28
Regioni8175 – 8210DisorderedSequence analysisAdd BLAST36
Regioni8623 – 8686DisorderedSequence analysisAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili334 – 354Sequence analysisAdd BLAST21
Coiled coili629 – 656Sequence analysisAdd BLAST28
Coiled coili936 – 956Sequence analysisAdd BLAST21
Coiled coili1321 – 1348Sequence analysisAdd BLAST28
Coiled coili1420 – 1454Sequence analysisAdd BLAST35
Coiled coili1561 – 1581Sequence analysisAdd BLAST21
Coiled coili1633 – 1667Sequence analysisAdd BLAST35
Coiled coili1909 – 1929Sequence analysisAdd BLAST21
Coiled coili1987 – 2014Sequence analysisAdd BLAST28
Coiled coili2021 – 2041Sequence analysisAdd BLAST21
Coiled coili2091 – 2111Sequence analysisAdd BLAST21
Coiled coili2244 – 2271Sequence analysisAdd BLAST28
Coiled coili2349 – 2383Sequence analysisAdd BLAST35
Coiled coili2489 – 2509Sequence analysisAdd BLAST21
Coiled coili2969 – 2989Sequence analysisAdd BLAST21
Coiled coili3168 – 3188Sequence analysisAdd BLAST21
Coiled coili3412 – 3432Sequence analysisAdd BLAST21
Coiled coili3473 – 3493Sequence analysisAdd BLAST21
Coiled coili3675 – 3695Sequence analysisAdd BLAST21
Coiled coili3768 – 3788Sequence analysisAdd BLAST21
Coiled coili4037 – 4057Sequence analysisAdd BLAST21
Coiled coili4075 – 4095Sequence analysisAdd BLAST21
Coiled coili4702 – 4736Sequence analysisAdd BLAST35
Coiled coili4780 – 4800Sequence analysisAdd BLAST21
Coiled coili4997 – 5017Sequence analysisAdd BLAST21
Coiled coili5081 – 5108Sequence analysisAdd BLAST28
Coiled coili5286 – 5313Sequence analysisAdd BLAST28
Coiled coili5339 – 5369Sequence analysisAdd BLAST31
Coiled coili5434 – 5461Sequence analysisAdd BLAST28
Coiled coili5498 – 5518Sequence analysisAdd BLAST21
Coiled coili5528 – 5548Sequence analysisAdd BLAST21
Coiled coili5556 – 5583Sequence analysisAdd BLAST28
Coiled coili5662 – 5689Sequence analysisAdd BLAST28
Coiled coili5700 – 5737Sequence analysisAdd BLAST38
Coiled coili5932 – 5952Sequence analysisAdd BLAST21
Coiled coili5987 – 6014Sequence analysisAdd BLAST28
Coiled coili6091 – 6118Sequence analysisAdd BLAST28
Coiled coili6156 – 6183Sequence analysisAdd BLAST28
Coiled coili6513 – 6537Sequence analysisAdd BLAST25
Coiled coili6986 – 7020Sequence analysisAdd BLAST35
Coiled coili7092 – 7122Sequence analysisAdd BLAST31
Coiled coili7576 – 7596Sequence analysisAdd BLAST21
Coiled coili7741 – 7768Sequence analysisAdd BLAST28
Coiled coili7848 – 7868Sequence analysisAdd BLAST21
Coiled coili8420 – 8440Sequence analysisAdd BLAST21
Coiled coili8594 – 8618Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5791 – 5815Polar residuesSequence analysisAdd BLAST25
Compositional biasi8176 – 8196Polar residuesSequence analysisAdd BLAST21
Compositional biasi8623 – 8683Polar residuesSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154481

Database of Orthologous Groups

More...
OrthoDBi
47at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 10 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 24 potential isoforms that are computationally mapped.Show allAlign All

A0A0C4DG40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSRGASRC PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV
60 70 80 90 100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE
110 120 130 140 150
GRKSMHRGSP IKLVNINSTD IADGRPSIVL GLMWTIILYF QIEELTSNLP
160 170 180 190 200
QLQSLSSSAS SVDSIVSSET PSPPSKRKVT TKIQGNAKKA LLKWVQYTAG
210 220 230 240 250
KQTGIEVKDF GKSWRSGVAF HSVIHAIRPE LVDLETVKGR SNRENLEDAF
260 270 280 290 300
TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKHYP DIHNASTDGQ
310 320 330 340 350
EDDEILPGFP SFANSVQNFK REDRVIFKEM KVWIEQFERD LTRAQMVESN
360 370 380 390 400
LQDKYQSFKH FRVQYEMKRK QIEHLIQPLH RDGKLSLDQA LVKQSWDRVT
410 420 430 440 450
SRLFDWHIQL DKSLPAPLGT IGAWLYRAEV ALREEITVQQ VHEETANTIQ
460 470 480 490 500
RKLEQHKDLL QNTDAHKRAF HEIYRTRSVN GIPVPPDQLE DMAERFHFVS
510 520 530 540 550
STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGRR ESVEQLLQNY
560 570 580 590 600
VSFIENSKFF EQYEVTYQIL KQTAEMYVKA DGSVEEAENV MKFMNETTAQ
610 620 630 640 650
WRNLSVEVRS VRSMLEEVIS NWDRYGNTVA SLQAWLEDAE KMLNQSENAK
660 670 680 690 700
KDFFRNLPHW IQQHTAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL
710 720 730 740 750
FMEVKQYAQA DEMDRMKKEY TDCVVTLSAF ATEAHKKLSE PLEVSFMNVK
760 770 780 790 800
LLIQDLEDIE QRVPVMDAQY KIITKTAHLI TKESPQEEGK EMFATMSKLK
810 820 830 840 850
EQLTKVKECY SPLLYESQQL LIPLEELEKQ MTSFYDSLGK INEIITVLER
860 870 880 890 900
EAQSSALFKQ KHQELLACQE NCKKTLTLIE KGSQSVQKFV TLSNVLKHFD
910 920 930 940 950
QTRLQRQIAD IHVAFQSMVK KTGDWKKHVE TNSRLMKKFE ESRAELEKVL
960 970 980 990 1000
RIAQEGLEEK GDPEELLRRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE
1010 1020 1030 1040 1050
QQGLQEAVRK LHKQWKDLQG EAPYHLLHLK IDVEKNRFLA SVEECRTELD
1060 1070 1080 1090 1100
RETKLMPQEG SEKIIKEHRV FFSDKGPHHL CEKRLQLIEE LCVKLPVRDP
1110 1120 1130 1140 1150
VRDTPGTCHV TLKELRAAID STYRKLMEDP DKWKDYTSRF SEFSSWISTN
1160 1170 1180 1190 1200
ETQLKGIKGE AIDTANHGEV KRAVEEIRNG VTKRGETLSW LKSRLKVLTE
1210 1220 1230 1240 1250
VSSENEAQKQ GDELAKLSSS FKALVTLLSE VEKMLSNFGD CVQYKEIVKN
1260 1270 1280 1290 1300
SLEELISGSK EVQEQAEKIL DTENLFEAQQ LLLHHQQKTK RISAKKRDVQ
1310 1320 1330 1340 1350
QQIAQAQQGE GGLPDRGHEE LRKLESTLDG LERSRERQER RIQVTLRKWE
1360 1370 1380 1390 1400
RFETNKETVV RYLFQTGSSH ERFLSFSSLE SLSSELEQTK EFSKRTESIA
1410 1420 1430 1440 1450
VQAENLVKEA SEIPLGPQNK QLLQQQAKSI KEQVKKLEDT LEEDIKTMEM
1460 1470 1480 1490 1500
VKTKWDHFGS NFETLSVWIT EKEKELNALE TSSSAMDMQI SQIKVTIQEI
1510 1520 1530 1540 1550
ESKLSSIVGL EEEAQSFAQF VTTGESARIK AKLTQIRRYG EELREHAQCL
1560 1570 1580 1590 1600
EGTILGHLSQ QQKFEENLRK IQQSVSEFED KLAVPIKICS SATETYKVLQ
1610 1620 1630 1640 1650
EHMDLCQALE SLSSAITAFS ASARKVVNRD SCVQEAAALQ QQYEDILRRA
1660 1670 1680 1690 1700
KERQTALENL LAHWQRLEKE LSSFLTWLER GEAKASSPEM DISADRVKVE
1710 1720 1730 1740 1750
GELQLIQALQ NEVVSQASFY SKLLQLKESL FSVASKDDVK MMKLHLEQLD
1760 1770 1780 1790 1800
ERWRDLPQII NKRINFLQSV VAEHQQFDEL LLSFSVWIKL FLSELQTTSE
1810 1820 1830 1840 1850
ISIMDHQVAL TRHKDHAAEV ESKKGELQSL QGHLAKLGSL GRAEDLHLLQ
1860 1870 1880 1890 1900
GKAEDCFQLF EEASQVVERR QLALSHLAEF LQSHASLSGI LRQLRQTVEA
1910 1920 1930 1940 1950
TNSMNKNESD LIEKDLNDAL QNAKALESAA VSLDGILSKA QYHLKIGSSE
1960 1970 1980 1990 2000
QRTSCRATAD QLCGEVERIQ NLLGTKQSEA DALAVLKKAF QDQKEELLKS
2010 2020 2030 2040 2050
IEDIEERTDK ERLKEPTRQA LQQRLRVFNQ LEDELNSHEH ELCWLKDKAK
2060 2070 2080 2090 2100
QIAQKDVAFA PEVDREINRL EVTWDDTKRL IHENQGQCCG LIDLMREYQN
2110 2120 2130 2140 2150
LKSAVSKVLE NASSVIVTRT TIKDQEDLKW AFSKHETAKN KMNYKQKDLD
2160 2170 2180 2190 2200
NFTSKGKHLL SELKKIHSSD FSLVKTDMES TVDKWLDVSE KLEENMDRLR
2210 2220 2230 2240 2250
VSLSIWDDVL STRDEIEGWS NNCVPQMAEN ISNLDNHLRA EELLKEFESE
2260 2270 2280 2290 2300
VKNKALRLEE LHSKVNDLKE LTKNLETPPD LQFIEADLMQ KLEHAKEITE
2310 2320 2330 2340 2350
VAKGTLKDFT AQSTQVEKFI NDITTWFTKV EESLMNCAQN ETCEALKKVK
2360 2370 2380 2390 2400
DIQKELQSQQ SNISSTQENL NSLCRKYHSA ELESLGRAMT GLIKKHEAVS
2410 2420 2430 2440 2450
QLCSKTQASL QESLEKHFSE SMQEFQEWFL GAKAAAKESS DRTGDSKVLE
2460 2470 2480 2490 2500
AKLHDLQNIL DSVSDGQSKL DAVTQEGQTL YAHLSKQIVS SIQEQITKAN
2510 2520 2530 2540 2550
EEFQAFLKQC LKDKQALQDC ASELGSFEDQ HRKLNLWIHE MEERFNTENL
2560 2570 2580 2590 2600
GESKQHIPEK KNEVHKVEMF LGELLAARES LDKLSQRGQL LSEEGHGAGQ
2610 2620 2630 2640 2650
EGRLCSQLLT SHQNLLRMTK EKLRSCQVAL QEHEALEEAL QSMWFWVKAI
2660 2670 2680 2690 2700
QDRLACAEST LGSKDTLEKR LSQIQDILLM KGEGEVKLNM AIGKGEQALR
2710 2720 2730 2740 2750
SSNKEGQRVI QTQLETLKEV WADIMSSSVH AQSTLESVIS QWNDYVERKN
2760 2770 2780 2790 2800
QLEQWMESVD QKIEHPLQPQ PGLKEKFVLL DHLQSILSEA EDHTRALHRL
2810 2820 2830 2840 2850
IAKSRELYEK TEDESFKDTA QEELKTQFND IMTVAKEKMR KVEEIVKDHL
2860 2870 2880 2890 2900
MYLDAVHEFT DWLHSAKEEL HRWSDMSGDS SATQKKLSKI KELIDSREIG
2910 2920 2930 2940 2950
ASRLSRVESL APEVKQNTTA SGCELMHTEM QALRADWKQW EDSVFQTQSC
2960 2970 2980 2990 3000
LENLVSQMAL SEQEFSGQVA QLEQALEQFS ALLKTWAQQL TLLEGKNTDE
3010 3020 3030 3040 3050
EIVECWHKGQ EILDALQKAE PRTEDLKSQL NELCRFSRDL STYSGKVSGL
3060 3070 3080 3090 3100
IKEYNCLCLQ ASKGCQNKEQ ILQQRFRKAF RDFQQWLVNA KITTAKCFDI
3110 3120 3130 3140 3150
PQNISEVSTS LQKIQEFLSE SENGQHKLNM MLSKGELLST LLTKEKAKGI
3160 3170 3180 3190 3200
QAKVTAAKED WKNFHSNLHQ KESALENLKI QMKDFEVSAE PIQDWLSKTE
3210 3220 3230 3240 3250
KMVHESSNRL YDLPAKRREQ QKLQSVLEEI HCYEPQLNRL KEKAQQLWEG
3260 3270 3280 3290 3300
QAASKSFRHR VSQLSSQYLA LSNLTKEKVS RLDRIVAEHN QFSLGIKELQ
3310 3320 3330 3340 3350
DWMTDAIHML DSYCHPTSDK SVLDSRTLKL EALLSVKQEK EIQMKMIVTR
3360 3370 3380 3390 3400
GESVLQNTSP EGIPTIQQQL QSVKDMWASL LSAGIRCKSQ LEGALSKWTS
3410 3420 3430 3440 3450
YQDGVRQFSG WMDSMEANLN ESERQHAELR DKTTMLGKAK LLNEEVLSYS
3460 3470 3480 3490 3500
SLLETIEVKG AGMTEHYVTQ LELQDLQERY RAIQERAKEA VTKSEKLVRL
3510 3520 3530 3540 3550
HQEYQRDLKA FEVWLGQEQE KLDQYSVLEG DAHTHETTLR DLQELQVHCA
3560 3570 3580 3590 3600
EGQALLNSVL HTREDVIPSG IPQAEDRALE SLRQDWQAYQ HRLSETRTQF
3610 3620 3630 3640 3650
NNVVNKLRLM EQKFQQVDEW LKTAEEKKWH EEVTAYRDEV EEVGARAQEI
3660 3670 3680 3690 3700
LDESHVNSRM GCQATQLTSR YQALLLQVLE QIKFLEEEIQ SLEESESSLS
3710 3720 3730 3740 3750
SYSDWYGSTH KNFKNVATKI DKVDTVMMGK KLKTLEVLLK DMEKGHSLLK
3760 3770 3780 3790 3800
SAREKGERAV KYLEEGEAER LRKEIHDHME QLKELTSTVR KEHMTLEKGL
3810 3820 3830 3840 3850
HLAKEFSDKC KALTQWIAEY QEILHVPEEP KMELYEKKAQ LSKYKSLQQT
3860 3870 3880 3890 3900
VLSHEPSVKS VREKGEALLE LVQDVTLKDK IDQLQSDYQD LCSIGKAMME
3910 3920 3930 3940 3950
EIAGFEDRLN NLQMKGDTLI GQCADHLQAK LKQNVHAHLQ GTKDSYSAIC
3960 3970 3980 3990 4000
STAQRMYQSL EHELQKHVSR QDTLQQCQAW LSAVQPDLEP SPQPPLSRAE
4010 4020 4030 4040 4050
AIKQVKHFRA LQEQARTYLD LLCSMCDLSN ASVKTTAKDI QQTEQTIEQK
4060 4070 4080 4090 4100
LVQAQNLTQG WEEIKHLKSE LWIYLQDADQ QLQNMKRRHS ELELNIAQNM
4110 4120 4130 4140 4150
VSQVKDFVKK LQSKQASVNT IIEKVNKLTK KEESPEHKEI NHLNDQWLDL
4160 4170 4180 4190 4200
CRQSNNLCLQ REEDLQRTRD YHDCMNVVEV FLEKFTTEWD NLARSDAEST
4210 4220 4230 4240 4250
AVHLEALKKL ALALQERKYA IEDLKDQKQK MIEHLNLDDK ELVKEQTSHL
4260 4270 4280 4290 4300
EQRWFQLEDL IKRKIQVSVT NLEELNVVQS RFQELMEWAE EQQPNIAEAL
4310 4320 4330 4340 4350
KQSPPPDMAQ NLLMDHLAIC SELEAKQMLL KSLIKDADRV MADLGLNERQ
4360 4370 4380 4390 4400
VIQKALSDAQ SHVNCLSDLV GQRRKYLNKA LSEKTQFLMA VFQATSQIQQ
4410 4420 4430 4440 4450
HERKIMFREH ICLLPDDVSK QVKTCKSAQA SLKTYQNEVT GLWAQGRELM
4460 4470 4480 4490 4500
KEVTEQEKSE VLGKLQELQS VYDSVLQKCS HRLQELEKNL VSRKHFKEDF
4510 4520 4530 4540 4550
DKACHWLKQA DIVTFPEINL MNESSELHTQ LAKYQNILEQ SPEYENLLLT
4560 4570 4580 4590 4600
LQRTGQTILP SLNEVDHSYL SEKLNALPRQ FNVIVALAKD KFYKVQEAIL
4610 4620 4630 4640 4650
ARKEYASLIE LTTQSLSELE AQFLRMSKVP TDLAVEEALS LQDGCRAILD
4660 4670 4680 4690 4700
EVAGLGEAVD ELNQKKEGFR STGQPWQPDK MLHLVTLYHR LKRQTEQRVS
4710 4720 4730 4740 4750
LLEDTTSAYQ EHEKMCQQLE RQLKSVKEEQ SKVNEETLPA EEKLKMYHSL
4760 4770 4780 4790 4800
AGSLQDSGIV LKRVTIHLED LAPHLDPLAY EKARHQIQSW QGELKLLTSA
4810 4820 4830 4840 4850
IGETVTECES RMVQSIDFQT EMSRSLDWLR RVKAELSGPV YLDLNLQDIQ
4860 4870 4880 4890 4900
EEIRKIQIHQ EEVQSSLRIM NALSHKEKEK FTKAKELISA DLEHSLAELS
4910 4920 4930 4940 4950
ELDGDIQEAL RTRQATLTEI YSQCQRYYQV FQAANDWLED AQELLQLAGN
4960 4970 4980 4990 5000
GLDVESAEEN LKSHMEFFST EDQFHSNLEE LHSLVATLDP LIKPTGKEDL
5010 5020 5030 5040 5050
EQKVASLELR SQRMSRDSGA QVDLLQRCTA QWHDYQKARE EVIELMNDTE
5060 5070 5080 5090 5100
KKLSEFSLLK TSSSHEAEEK LSEHKALVSV VNSFHEKIVA LEEKASQLEK
5110 5120 5130 5140 5150
TGNDASKATL SRSMTTVWQR WTRLRAVAQD QEKILEDAVD EWTGFNNKVK
5160 5170 5180 5190 5200
KATEMIDQLQ DKLPGSSAEK ASKAELLTLL EYHDTFVLEL EQQQSALGML
5210 5220 5230 5240 5250
RQQTLSMLQD GAAPTPGEEP PLMQEITAMQ DRCLNMQEKV KTNGKLVKQE
5260 5270 5280 5290 5300
LKDREMVETQ INSVKCWVQE TKEYLGNPTI EIDAQLEELQ ILLTEATNHR
5310 5320 5330 5340 5350
QNIEKMAEEQ KEKYLGLYTI LPSELSLQLA EVALDLKIRD QIQDKIKEVE
5360 5370 5380 5390 5400
QSKATSQELS RQIQKLAKDL TTILTKLKAK TDNVVQAKTD QKVLGEELDG
5410 5420 5430 5440 5450
CNSKLMELDA AVQKFLEQNG QLGKPLAKKI GKLTELHQQT IRQAENRLSK
5460 5470 5480 5490 5500
LNQAASHLEE YNEMLELILK WIEKAKVLAH GTIAWNSASQ LREQYILHQT
5510 5520 5530 5540 5550
LLEESKEIDS ELEAMTEKLQ YLTSVYCTEK MSQQVAELGR ETEELRQMIK
5560 5570 5580 5590 5600
IRLQNLQDAA KDMKKFEAEL KKLQAALEQA QATLTSPEVG RLSLKEQLSH
5610 5620 5630 5640 5650
RQHLLSEMES LKPKVQAVQL CQSALRIPED VVASLPLCHA ALRLQEEASR
5660 5670 5680 5690 5700
LQHTAIQQCN IMQAAVVQYE QYEQEMKHLQ QLIEGAHREI EDKPVATSNI
5710 5720 5730 5740 5750
QELQAQISRH EELAQKIKGY QEQIASLNSK CKMLTMKAKH ATMLLTVTEV
5760 5770 5780 5790 5800
EGLAEGTEDL DGELLPTPSA HPSVVMMTAG RCHTLLSPVT EESGEEGTNS
5810 5820 5830 5840 5850
EISSPPACRS PSPVANTDAS VNQDIAYYQA LSAERLQTDA AKIHPSTSAS
5860 5870 5880 5890 5900
QEFYEPGLEP SATAKLGDLQ RSWETLKNVI SEKQRTLYEA LERQQKYQDS
5910 5920 5930 5940 5950
LQSISTKMEA IELKLSESPE PGRSPESQMA EHQALMDEIL MLQDEINELQ
5960 5970 5980 5990 6000
SSLAEELVSE SCEADPAEQL ALQSTLTVLA ERMSTIRMKA SGKRQLLEEK
6010 6020 6030 6040 6050
LNDQLEEQRQ EQALQRYRCE ADELDSWLLS TKATLDTALS PPKEPMDMEA
6060 6070 6080 6090 6100
QLMDCQNMLV EIEQKVVALS ELSVHNENLL LEGKAHTKDE AEQLAGKLRR
6110 6120 6130 6140 6150
LKGSLLELQR ALHDKQLNMQ GTAQEKEESD VDLTATQSPG VQEWLAQART
6160 6170 6180 6190 6200
TWTQQRQSSL QQQKELEQEL AEQKSLLRSV ASRGEEILIQ HSAAETSGDA
6210 6220 6230 6240 6250
GEKPDVLSQE LGMEGEKSSA EDQMRMKWES LHQEFSTKQK LLQNVLEQEQ
6260 6270 6280 6290 6300
EQVLYSRPNR LLSGVPLYKG DVPTQDKSAV TSLLDGLNQA FEEVSSQSGG
6310 6320 6330 6340 6350
AKRQSIHLEQ KLYDGVSATS TWLDDVEERL FVATALLPEE TETCLFNQEI
6360 6370 6380 6390 6400
LAKDIKEMSE EMDKNKNLFS QAFPENGDNR DVIEDTLGCL LGRLSLLDSV
6410 6420 6430 6440 6450
VNQRCHQMKE RLQQILNFQN DLKVLFTSLA DNKYIILQKL ANVFEQPVAE
6460 6470 6480 6490 6500
QIEAIQQAED GLKEFDAGII ELKRRGDKLQ VEQPSMQELS KLQDMYDELM
6510 6520 6530 6540 6550
MIIGSRRSGL NQNLTLKSQY ERALQDLADL LETGQEKMAG DQKIIVSSKE
6560 6570 6580 6590 6600
EIQQLLDKHK EYFQGLESHM ILTETLFRKI ISFAVQKETQ FHTELMAQAS
6610 6620 6630 6640 6650
AVLKRAHKRG VELEYILETW SHLDEDQQEL SRQLEVVESS IPSVGLVEEN
6660 6670 6680 6690 6700
EDRLIDRITL YQHLKSSLNE YQPKLYQVLD DGKRLLISIS CSDLESQLNQ
6710 6720 6730 6740 6750
LGECWLSNTN KMSKELHRLE TILKHWTRYQ SESADLIHWL QSAKDRLEFW
6760 6770 6780 6790 6800
TQQSVTVPQE LEMVRDHLNA FLEFSKEVDA QSSLKSSVLS TGNQLLRLKK
6810 6820 6830 6840 6850
VDTATLRSEL SRIDSQWTDL LTNIPAVQEK LHQLQMDKLP SRHAISEVMS
6860 6870 6880 6890 6900
WISLMENVIQ KDEDNIKNSI GYKAIHEYLQ KYKGFKIDIN CKQLTVDFVN
6910 6920 6930 6940 6950
QSVLQISSQD VESKRSDKTD FAEQLGAMNK SWQILQGLVT EKIQLLEGLL
6960 6970 6980 6990 7000
ESWSEYENNV QCLKTWFETQ EKRLKQQHRI GDQASVQNAL KDCQDLEDLI
7010 7020 7030 7040 7050
KAKEKEVEKI EQNGLALIQN KKEDVSSIVM STLRELGQTW ANLDHMVGQL
7060 7070 7080 7090 7100
KILLKSVLDQ WSSHKVAFDK INSYLMEARY SLSRFRLLTG SLEAVQVQVD
7110 7120 7130 7140 7150
NLQNLQDDLE KQERSLQKFG SITNQLLKEC HPPVTETLTN TLKEVNMRWN
7160 7170 7180 7190 7200
NLLEEIAEQL QSSKALLQLW QRYKDYSKQC ASTVQQQEDR TNELLKAATN
7210 7220 7230 7240 7250
KDIADDEVAT WIQDCNDLLK GLGTVKDSLF FLHELGEQLK QQVDASAASA
7260 7270 7280 7290 7300
IQSDQLSLSQ HLCALEQALC KQQTSLQAGV LDYETFAKSL EALEAWIVEA
7310 7320 7330 7340 7350
EEILQGQDPS HSSDLSTIQE RMEELKGQML KFSSMAPDLD RLNELGYRLP
7360 7370 7380 7390 7400
LNDKEIKRMQ NLNRHWSLIS SQTTERFSKL QSFLLQHQTF LEKCETWMEF
7410 7420 7430 7440 7450
LVQTEQKLAV EISGNYQHLL EQQRAHELFQ AEMFSRQQIL HSIIIDGQRL
7460 7470 7480 7490 7500
LEQGQVDDRD EFNLKLTLLS NQWQGVIRRA QQRRGIIDSQ IRQWQRYREM
7510 7520 7530 7540 7550
AEKLRKWLVE VSYLPMSGLG SVPIPLQQAR TLFDEVQFKE KVFLRQQGSY
7560 7570 7580 7590 7600
ILTVEAGKQL LLSADSGAEA ALQAELAEIQ EKWKSASMRL EEQKKKLAFL
7610 7620 7630 7640 7650
LKDWEKCEKG IADSLEKLRT FKKKLSQSLP DHHEELHAEQ MRCKELENAV
7660 7670 7680 7690 7700
GSWTDDLTQL SLLKDTLSAY ISADDISILN ERVELLQRQW EELCHQLSLR
7710 7720 7730 7740 7750
RQQIGERLNE WAVFSEKNKE LCEWLTQMES KVSQNGDILI EEMIEKLKKD
7760 7770 7780 7790 7800
YQEEIAIAQE NKIQLQQMGE RLAKASHESK ASEIEYKLGK VNDRWQHLLD
7810 7820 7830 7840 7850
LIAARVKKLK ETLVAVQQLD KNMSSLRTWL AHIESELAKP IVYDSCNSEE
7860 7870 7880 7890 7900
IQRKLNEQQE LQRDIEKHST GVASVLNLCE VLLHDCDACA TDAECDSIQQ
7910 7920 7930 7940 7950
ATRNLDRRWR NICAMSMERR LKIEETWRLW QKFLDDYSRF EDWLKSSERT
7960 7970 7980 7990 8000
AAFPSSSGVI YTVAKEELKK FEAFQRQVHE CLTQLELINK QYRRLARENR
8010 8020 8030 8040 8050
TDSACSLKQM VHEGNQRWDN LQKRVTSILR RLKHFIGQRE EFETARDSIL
8060 8070 8080 8090 8100
VWLTEMDLQL TNIEHFSECD VQAKIKQLKA FQQEISLNHN KIEQIIAQGE
8110 8120 8130 8140 8150
QLIEKSEPLD AAIIEEELDE LRRYCQEVFG RVERYHKKLI RLPLPDDEHD
8160 8170 8180 8190 8200
LSDRELELED SAALSDLHWH DRSADSLLSP QPSSNLSLSL AQPLRSERSG
8210 8220 8230 8240 8250
RDTPASVDSI PLEWDHDYDL SRDLESAMSR ALPSEDEEGQ DDKDFYLRGA
8260 8270 8280 8290 8300
VGLSDVMIPE SPEAYVKLTE NAIKNTSGDH SALESQIRQL GKALDDSRFQ
8310 8320 8330 8340 8350
IQQTENIIRS KTPTGPELDT SYKGYMKLLG ECSSSIDSVK RLEHKLKEEE
8360 8370 8380 8390 8400
ESLPGFVNLH STETQTAGVI DRWELLQAQA LSKELRMKQN LQKWQQFNSD
8410 8420 8430 8440 8450
LNSIWAWLGD TEEELEQLQR LELSTDIQTI ELQIKKLKEL QKAVDHRKAI
8460 8470 8480 8490 8500
ILSINLCSPE FTQADSKESR DLQDRLSQMN GRWDRVCSLL EEWRGLLQDA
8510 8520 8530 8540 8550
LMQCQGFHEM SHGLLLMLEN IDRRKNEIVP IDSNLDAEIL QDHHKQLMQI
8560 8570 8580 8590 8600
KHELLESQLR VASLQDMSCQ LLVNAEGTDC LEAKEKVHVI GNRLKLLLKE
8610 8620 8630 8640 8650
VSRHIKELEK LLDVSSSQQD LSSWSSADEL DTSGSVSPTS GRSTPNRQKT
8660 8670 8680 8690 8700
PRGKCSLSQP GPSVSSPHSR STKGGSDSSL SEPGPGRSGR GFLFRVLRAA
8710 8720 8730 8740
LPLQLLLLLL IGLACLVPMS EEDYSCALSN NFARSFHPML RYTNGPPPL
Length:8,749
Mass (Da):1,005,181
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CFD0A58FCC46064
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 24 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NF91SYNE1_HUMAN
Nesprin-1
SYNE1 C6orf98, KIAA0796, KIAA1262, KIAA1756, MYNE1
8,797Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAI0F8WAI0_HUMAN
Nesprin-1
SYNE1
975Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JV20Q5JV20_HUMAN
Nesprin-1
SYNE1
952Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y326H0Y326_HUMAN
Nesprin-1
SYNE1
1,355Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y325H0Y325_HUMAN
Nesprin-1
SYNE1
1,654Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZ83F5GZ83_HUMAN
Nesprin-1
SYNE1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH87A0A5F9ZH87_HUMAN
Nesprin-1
SYNE1
542Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH86A0A5F9ZH86_HUMAN
Nesprin-1
SYNE1
510Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHB2A0A5F9ZHB2_HUMAN
Nesprin-1
SYNE1
591Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHE1A0A5F9ZHE1_HUMAN
Nesprin-1
SYNE1
635Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL049548 Genomic DNA No translation available.
AL078582 Genomic DNA No translation available.
AL136079 Genomic DNA No translation available.
AL138832 Genomic DNA No translation available.
AL357081 Genomic DNA No translation available.
AL450401 Genomic DNA No translation available.
AL589963 Genomic DNA No translation available.
AL591507 Genomic DNA No translation available.
KF458330 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_149062.1, NM_033071.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000423061; ENSP00000396024; ENSG00000131018

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23345

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049548 Genomic DNA No translation available.
AL078582 Genomic DNA No translation available.
AL136079 Genomic DNA No translation available.
AL138832 Genomic DNA No translation available.
AL357081 Genomic DNA No translation available.
AL450401 Genomic DNA No translation available.
AL589963 Genomic DNA No translation available.
AL591507 Genomic DNA No translation available.
KF458330 Genomic DNA No translation available.
RefSeqiNP_149062.1, NM_033071.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiA0A0C4DG40
PeptideAtlasiA0A0C4DG40

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19931, 157 antibodies from 25 providers

Genome annotation databases

EnsembliENST00000423061; ENSP00000396024; ENSG00000131018
GeneIDi23345

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23345
HGNCiHGNC:17089, SYNE1
OpenTargetsiENSG00000131018
VEuPathDBiHostDB:ENSG00000131018

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154481
OrthoDBi47at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23345, 5 hits in 1041 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SYNE1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23345

Gene expression databases

BgeeiENSG00000131018, Expressed in cerebellum and 239 other tissues
ExpressionAtlasiA0A0C4DG40, baseline and differential

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 10 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0C4DG40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0C4DG40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: January 19, 2022
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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