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Protein

Cellular tumor antigen p53

Gene

TP73

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation
Biological processApoptosisUniRule annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53UniRule annotation
Gene namesi
Name:TP73Imported
ORF Names:hCG_19088Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000078900.14
HGNCiHGNC:12003 TP73

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078900

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

MaxQBiA0A0C4DFW9
PRIDEiA0A0C4DFW9

Expressioni

Gene expression databases

BgeeiENSG00000078900

Interactioni

Subunit structurei

Binds DNA as a homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 260P53InterPro annotationAdd BLAST196
Domaini296 – 334P53_tetramerInterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the p53 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IGE4 Eukaryota
ENOG410XV9W LUCA
GeneTreeiENSGT00390000015092

Family and domain databases

CDDicd08367 P53, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR002117 p53_tumour_suppressor
IPR032646 Tp73
PANTHERiPTHR11447 PTHR11447, 1 hit
PTHR11447:SF21 PTHR11447:SF21, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF07710 P53_tetramer, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SUPFAMiSSF47719 SSF47719, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0C4DFW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYVGDPARH LATAQFNLLS STMDQMSSRA ASASPYTPEH AASVPTHSPY
60 70 80 90 100
AQPSSTFDTM SPAPVIPSNT DYPGPHHFEV TFQQSSTAKS ATWTYSPLLK
110 120 130 140 150
KLYCQIAKTC PIQIKVSTPP PPGTAIRAMP VYKKAEHVTD VVKRCPNHEL
160 170 180 190 200
GRDFNEGQSA PASHLIRVEG NNLSQYVDDP VTGRQSVVVP YEPPQVGTEF
210 220 230 240 250
TTILYNFMCN SSCVGGMNRR PILIIITLEM RDGQVLGRRS FEGRICACPG
260 270 280 290 300
RDRKADEDHY REQQALNESS AKNGAASKRA FKQSPPAVPA LGAGVKKRRH
310 320 330 340 350
GDEDTYYLQV RGRENFEILM KLKESLELME LVPQPLVDSY RQQQQLLQRP
360 370 380 390 400
PRDAQQPWPR SASQRRDEQQ PQRPVHGLGV PLHSATPLPR RPQPRQFFNR
410 420
IGVSKLHRVF HLPRVTEHLP PAEPDH
Length:426
Mass (Da):47,696
Last modified:April 1, 2015 - v1
Checksum:i18BB215365AED592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136528 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71465.1
RefSeqiNP_001119714.1, NM_001126242.2
UniGeneiHs.192132

Genome annotation databases

EnsembliENST00000378280; ENSP00000367529; ENSG00000078900
GeneIDi7161

Similar proteinsi

Entry informationi

Entry nameiA0A0C4DFW9_HUMAN
AccessioniPrimary (citable) accession number: A0A0C4DFW9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: July 18, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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