UniProtKB - A0A0C4DFW9 (A0A0C4DFW9_HUMAN)
Protein
Cellular tumor antigen p53
Gene
TP73
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- transcription regulatory region sequence-specific DNA binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle arrest Source: InterPro
- protein tetramerization Source: InterPro
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation |
Biological process | ApoptosisUniRule annotationARBA annotation, Cell cycleUniRule annotation, Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Cellular tumor antigen p53UniRule annotation |
Gene namesi | Name:TP73Imported ORF Names:hCG_19088Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000078900.14 |
HGNCi | HGNC:12003, TP73 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotation, Ubl conjugationARBA annotationProteomic databases
MaxQBi | A0A0C4DFW9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000078900, Expressed in right uterine tube and 94 other tissues |
ExpressionAtlasi | A0A0C4DFW9, baseline and differential |
Interactioni
Subunit structurei
Binds DNA as a homotetramer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 259 | P53InterPro annotationAdd BLAST | 191 | |
Domaini | 296 – 334 | P53_tetramerInterPro annotationAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 68 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 265 – 296 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 343 – 395 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 47 – 66 | PolarSequence analysisAdd BLAST | 20 | |
Compositional biasi | 343 – 365 | PolarSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
HOGENOMi | CLU_019621_0_0_1 |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor IPR032646, Tp73 |
PANTHERi | PTHR11447, PTHR11447, 1 hit PTHR11447:SF21, PTHR11447:SF21, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A0C4DFW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLYVGDPARH LATAQFNLLS STMDQMSSRA ASASPYTPEH AASVPTHSPY
60 70 80 90 100
AQPSSTFDTM SPAPVIPSNT DYPGPHHFEV TFQQSSTAKS ATWTYSPLLK
110 120 130 140 150
KLYCQIAKTC PIQIKVSTPP PPGTAIRAMP VYKKAEHVTD VVKRCPNHEL
160 170 180 190 200
GRDFNEGQSA PASHLIRVEG NNLSQYVDDP VTGRQSVVVP YEPPQVGTEF
210 220 230 240 250
TTILYNFMCN SSCVGGMNRR PILIIITLEM RDGQVLGRRS FEGRICACPG
260 270 280 290 300
RDRKADEDHY REQQALNESS AKNGAASKRA FKQSPPAVPA LGAGVKKRRH
310 320 330 340 350
GDEDTYYLQV RGRENFEILM KLKESLELME LVPQPLVDSY RQQQQLLQRP
360 370 380 390 400
PRDAQQPWPR SASQRRDEQQ PQRPVHGLGV PLHSATPLPR RPQPRQFFNR
410 420
IGVSKLHRVF HLPRVTEHLP PAEPDH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO15350 | P73_HUMAN | Tumor protein p73 | TP73 P73 | 636 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136528 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71465.1 |
RefSeqi | NP_001119714.1, NM_001126242.2 |
Genome annotation databases
Ensembli | ENST00000378280; ENSP00000367529; ENSG00000078900 |
GeneIDi | 7161 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136528 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71465.1 |
RefSeqi | NP_001119714.1, NM_001126242.2 |
3D structure databases
SMRi | A0A0C4DFW9 |
ModBasei | Search... |
Proteomic databases
MaxQBi | A0A0C4DFW9 |
Protocols and materials databases
Antibodypediai | 3467, 1100 antibodies |
Genome annotation databases
Ensembli | ENST00000378280; ENSP00000367529; ENSG00000078900 |
GeneIDi | 7161 |
Organism-specific databases
CTDi | 7161 |
EuPathDBi | HostDB:ENSG00000078900.14 |
HGNCi | HGNC:12003, TP73 |
OpenTargetsi | ENSG00000078900 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
HOGENOMi | CLU_019621_0_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 7161, 10 hits in 870 CRISPR screens |
ChiTaRSi | TP73, human |
GenomeRNAii | 7161 |
Gene expression databases
Bgeei | ENSG00000078900, Expressed in right uterine tube and 94 other tissues |
ExpressionAtlasi | A0A0C4DFW9, baseline and differential |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR002117, p53_tumour_suppressor IPR032646, Tp73 |
PANTHERi | PTHR11447, PTHR11447, 1 hit PTHR11447:SF21, PTHR11447:SF21, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF07710, P53_tetramer, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0C4DFW9_HUMAN | |
Accessioni | A0A0C4DFW9Primary (citable) accession number: A0A0C4DFW9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 1, 2015 |
Last sequence update: | April 1, 2015 | |
Last modified: | December 2, 2020 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |