UniProtKB - A0A0C4DFM0 (A0A0C4DFM0_HUMAN)
Protein
Maleylacetoacetate isomerase
Gene
GSTZ1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:5.2.1.2ARBA annotation
Cofactori
glutathioneARBA annotation
: L-phenylalanine degradation Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.ARBA annotationProteins known to be involved in the 6 steps of the subpathway in this organism are:
- Phe-4-monooxygenase (PAH), Phe-4-monooxygenase (PAH), Phe-4-monooxygenase (PAH), Phenylalanine-4-hydroxylase (PAH), Phe-4-monooxygenase
- Tyrosine aminotransferase (TAT), Tyrosine aminotransferase, Tyrosine aminotransferase (TAT)
- 4-hydroxyphenylpyruvate dioxygenase (HPD)
- Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase (HGD), Homogentisate 1,2-dioxygenase, Homogentisate 1,2-dioxygenase (HGD)
- Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase, Maleylacetoacetate isomerase (GSTZ1), Maleylacetoacetate isomerase (GSTZ1)
- Fumarylacetoacetase, Fumarylacetoacetase, Fumarylacetoacetase (FAH), Fumarylacetoacetase (FAH), Fumarylacetoacetase (FAH)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.
GO - Molecular functioni
- maleylacetoacetate isomerase activity Source: UniProtKB-EC
- transferase activity Source: UniProtKB-KW
GO - Biological processi
- L-phenylalanine catabolic process Source: UniProtKB-UniPathway
- tyrosine catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | IsomeraseImportedARBA annotation, TransferaseImported |
Biological process | Phenylalanine catabolismARBA annotation, Tyrosine catabolismARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00340 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GSTZ1Imported ORF Names:hCG_22265Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100577.18 |
HGNCi | HGNC:4643, GSTZ1 |
Subcellular locationi
Other locations
- cytoplasm Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000100577, Expressed in right lobe of liver and 221 other tissues |
ExpressionAtlasi | A0A0C4DFM0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 87 | GST N-terminalInterPro annotationAdd BLAST | 84 | |
Domaini | 92 – 212 | GST C-terminalInterPro annotationAdd BLAST | 121 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000006580 |
Family and domain databases
CDDi | cd03191, GST_C_Zeta, 1 hit cd03042, GST_N_Zeta, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR005955, GST_Zeta IPR034330, GST_Zeta_C IPR034333, GST_Zeta_N IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF13417, GST_N_3, 1 hit |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01262, maiA, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
A0A0C4DFM0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQAGKPILYS YFRSSCSWRV RIALALKGID YETVPINLIK DGGQQFSKDF
60 70 80 90 100
QALNPMKQVP TLKIDGITIH QSLAIIEYLE EMRPTPRLLP QDPKKRASVR
110 120 130 140 150
MISDLIAGGI QPLQNLSVLK QVGEEMQLTW AQNAITCGFN ALEQILQSTA
160 170 180 190 200
GIYCVGDEVT MADLCLVPQV ANAERFKVDL TPYPTISSIN KRLLVLEAFQ
210
VSHPCRQPDT PTELRA
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO43708 | MAAI_HUMAN | Maleylacetoacetate isomerase | GSTZ1 MAAI | 216 | Annotation score: | ||
G3V4T6 | G3V4T6_HUMAN | Maleylacetoacetate isomerase | GSTZ1 | 217 | Annotation score: | ||
G3V267 | G3V267_HUMAN | Maleylacetoacetate isomerase | GSTZ1 | 189 | Annotation score: | ||
G3V5T0 | G3V5T0_HUMAN | Maleylacetoacetate isomerase | GSTZ1 | 202 | Annotation score: | ||
A0A0A0MR33 | A0A0A0MR33_HUMAN | Maleylacetoacetate isomerase | GSTZ1 | 174 | Annotation score: | ||
G3V5G8 | G3V5G8_HUMAN | Maleylacetoacetate isomerase | GSTZ1 | 38 | Annotation score: | ||
G3V3B9 | G3V3B9_HUMAN | Maleylacetoacetate isomerase | GSTZ1 | 119 | Annotation score: | ||
G3V5U6 | G3V5U6_HUMAN | Maleylacetoacetate isomerase | GSTZ1 | 59 | Annotation score: | ||
H0YJN8 | H0YJN8_HUMAN | Maleylacetoacetate isomerase | GSTZ1 | 70 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007954 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81280.1 |
RefSeqi | NP_665877.1, NM_145870.2 |
Genome annotation databases
Ensembli | ENST00000216465; ENSP00000216465; ENSG00000100577 |
GeneIDi | 2954 |
KEGGi | hsa:2954 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007954 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81280.1 |
RefSeqi | NP_665877.1, NM_145870.2 |
3D structure databases
SMRi | A0A0C4DFM0 |
ModBasei | Search... |
Proteomic databases
MaxQBi | A0A0C4DFM0 |
Protocols and materials databases
Antibodypediai | 188, 204 antibodies |
Genome annotation databases
Ensembli | ENST00000216465; ENSP00000216465; ENSG00000100577 |
GeneIDi | 2954 |
KEGGi | hsa:2954 |
Organism-specific databases
CTDi | 2954 |
EuPathDBi | HostDB:ENSG00000100577.18 |
HGNCi | HGNC:4643, GSTZ1 |
OpenTargetsi | ENSG00000100577 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000006580 |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00340 |
Miscellaneous databases
BioGRID-ORCSi | 2954, 7 hits in 845 CRISPR screens |
ChiTaRSi | GSTZ1, human |
GenomeRNAii | 2954 |
Gene expression databases
Bgeei | ENSG00000100577, Expressed in right lobe of liver and 221 other tissues |
ExpressionAtlasi | A0A0C4DFM0, baseline and differential |
Family and domain databases
CDDi | cd03191, GST_C_Zeta, 1 hit cd03042, GST_N_Zeta, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR005955, GST_Zeta IPR034330, GST_Zeta_C IPR034333, GST_Zeta_N IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF13417, GST_N_3, 1 hit |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR01262, maiA, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0C4DFM0_HUMAN | |
Accessioni | A0A0C4DFM0Primary (citable) accession number: A0A0C4DFM0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 1, 2015 |
Last sequence update: | April 1, 2015 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |