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Protein

Dihydrofolate reductase

Gene

C7T97_10755

Organism
Bacillus subtilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.UniRule annotation

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Dihydrofolate reductase (B4122_0334), Dihydrofolate reductase (BS21228_01425), Dihydrofolate reductase (C0W65_20665), Dihydrofolate reductase (B4417_1266), Dihydrofolate reductase (KS08_10090), Dihydrofolate reductase (BMJ37_10305), Dihydrofolate reductase (B4122_2050), Dihydrofolate reductase (AX282_05680), Dihydrofolate reductase (C7T97_10755), Dihydrofolate reductase (dfrD), Dihydrofolate reductase (C7H81_06640)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00077; UER00158

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrofolate reductaseUniRule annotation (EC:1.5.1.3UniRule annotation)
Gene namesi
ORF Names:C7T97_10755Imported, SC09_Contig24orf00237Imported
OrganismiBacillus subtilisImported
Taxonomic identifieri1423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000241428 Componenti: Unassembled WGS sequence
  • UP000032247 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 159DHFRInterPro annotationAdd BLAST159

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YYV Bacteria
COG0262 LUCA

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR012259 DHFR
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PANTHERiPTHR22778:SF16 PTHR22778:SF16, 1 hit
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
PIRSFiPIRSF000194 DHFR, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0C3JBD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISFIFAMDA NRLIGKDNDL PWHLPNDLAY FKKVTSGHSI IMGRKTFESI
60 70 80 90 100
GRPLPNRKNI VVTSAPASEF PGCTVVGSLK DVLDICSGPE ECFVIGGAQL
110 120 130 140 150
YTDLFPYADR LYMTKIHHEF EGDRHFPEFD ESNWKLVSSE QGIKDEKNPY
160
DYEFLMYEKK NSSKAGGF
Length:168
Mass (Da):19,069
Last modified:April 1, 2015 - v1
Checksum:i9BA3EFA999C8F0FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JXBC01000003 Genomic DNA Translation: KIU11303.1
PYBK01000005 Genomic DNA Translation: PSL99692.1
RefSeqiWP_015714128.1, NZ_PYBK01000005.1

Genome annotation databases

EnsemblBacteriaiKIU11303; KIU11303; SC09_Contig24orf00237
PATRICifig|1423.134.peg.184

Similar proteinsi

Entry informationi

Entry nameiA0A0C3JBD2_BACIU
AccessioniPrimary (citable) accession number: A0A0C3JBD2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: July 18, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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