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Entry version 35 (07 Oct 2020)
Sequence version 1 (01 Apr 2015)
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Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Sus scrofa domesticus (domestic pig)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3582S-adenosyl-L-methionineUniRule annotation1
Binding sitei3584S-adenosyl-L-methionineUniRule annotation1
Binding sitei3626S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3652ZincUniRule annotation1
Metal bindingi3700ZincUniRule annotation1
Binding sitei3701S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3702ZincUniRule annotation1
Metal bindingi3707ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri892 – 940CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotationARBA annotation, DNA-bindingARBA annotation, MethyltransferaseUniRule annotationImportedARBA annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa domesticus (domestic pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9825 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini892 – 940CXXC-typeInterPro annotationAdd BLAST49
Domaini1176 – 1227PHD-typeInterPro annotationAdd BLAST52
Domaini1224 – 1278PHD-typeInterPro annotationAdd BLAST55
Domaini1311 – 1372PHD-typeInterPro annotationAdd BLAST62
Domaini1448 – 1493BromoInterPro annotationAdd BLAST46
Domaini1615 – 1723PHD-typeInterPro annotationAdd BLAST109
Domaini1763 – 1819FYR N-terminalInterPro annotationAdd BLAST57
Domaini3409 – 3490FYR C-terminalInterPro annotationAdd BLAST82
Domaini3572 – 3688SETInterPro annotationAdd BLAST117
Domaini3696 – 3712Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 89DisorderedSequence analysisAdd BLAST23
Regioni190 – 347DisorderedSequence analysisAdd BLAST158
Regioni458 – 691DisorderedSequence analysisAdd BLAST234
Regioni783 – 812DisorderedSequence analysisAdd BLAST30
Regioni850 – 910DisorderedSequence analysisAdd BLAST61
Regioni945 – 1120DisorderedSequence analysisAdd BLAST176
Regioni1408 – 1449DisorderedSequence analysisAdd BLAST42
Regioni1551 – 1614DisorderedSequence analysisAdd BLAST64
Regioni1826 – 1878DisorderedSequence analysisAdd BLAST53
Regioni1891 – 1919DisorderedSequence analysisAdd BLAST29
Regioni1992 – 2080DisorderedSequence analysisAdd BLAST89
Regioni2106 – 2207DisorderedSequence analysisAdd BLAST102
Regioni2245 – 2364DisorderedSequence analysisAdd BLAST120
Regioni2390 – 2421DisorderedSequence analysisAdd BLAST32
Regioni2458 – 2542DisorderedSequence analysisAdd BLAST85
Regioni2547 – 2566DisorderedSequence analysisAdd BLAST20
Regioni2681 – 2790DisorderedSequence analysisAdd BLAST110
Regioni2877 – 2991DisorderedSequence analysisAdd BLAST115
Regioni3213 – 3387DisorderedSequence analysisAdd BLAST175
Regioni3528 – 3551DisorderedSequence analysisAdd BLAST24
Regioni3649 – 3650S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili118 – 138Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi70 – 89PolyampholyteSequence analysisAdd BLAST20
Compositional biasi190 – 240PolarSequence analysisAdd BLAST51
Compositional biasi280 – 300PolarSequence analysisAdd BLAST21
Compositional biasi301 – 321Pro-richSequence analysisAdd BLAST21
Compositional biasi458 – 476PolarSequence analysisAdd BLAST19
Compositional biasi492 – 590PolarSequence analysisAdd BLAST99
Compositional biasi591 – 643PolyampholyteSequence analysisAdd BLAST53
Compositional biasi669 – 691PolarSequence analysisAdd BLAST23
Compositional biasi791 – 806PolarSequence analysisAdd BLAST16
Compositional biasi979 – 993PolarSequence analysisAdd BLAST15
Compositional biasi994 – 1017PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1047 – 1062Pro-richSequence analysisAdd BLAST16
Compositional biasi1071 – 1085Pro-richSequence analysisAdd BLAST15
Compositional biasi1567 – 1592Pro-richSequence analysisAdd BLAST26
Compositional biasi1841 – 1863PolarSequence analysisAdd BLAST23
Compositional biasi1993 – 2065PolarSequence analysisAdd BLAST73
Compositional biasi2147 – 2163PolarSequence analysisAdd BLAST17
Compositional biasi2164 – 2190PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2271 – 2339PolarSequence analysisAdd BLAST69
Compositional biasi2466 – 2491PolarSequence analysisAdd BLAST26
Compositional biasi2492 – 2529PolyampholyteSequence analysisAdd BLAST38
Compositional biasi2681 – 2696PolarSequence analysisAdd BLAST16
Compositional biasi2707 – 2722PolarSequence analysisAdd BLAST16
Compositional biasi2756 – 2790PolarSequence analysisAdd BLAST35
Compositional biasi2877 – 2893PolarSequence analysisAdd BLAST17
Compositional biasi2909 – 2928PolarSequence analysisAdd BLAST20
Compositional biasi2941 – 2960PolarSequence analysisAdd BLAST20
Compositional biasi2975 – 2991PolarSequence analysisAdd BLAST17
Compositional biasi3213 – 3272PolarSequence analysisAdd BLAST60
Compositional biasi3283 – 3308PolyampholyteSequence analysisAdd BLAST26
Compositional biasi3309 – 3349PolarSequence analysisAdd BLAST41
Compositional biasi3356 – 3372PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri892 – 940CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2, PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0B8RVR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRTPSATFQ QATKIKKLRA GKLSPLKSKF KTGKLQIGRK GVQIVRRRGR
60 70 80 90 100
PPSTERIKTP AGLLINSELE KPQKVRKDKE GTPPLTKEDK TVVRQSPRRI
110 120 130 140 150
KPVRIIPSSK RTDATIAKQL LQRAKKGAQK KIEKEAAQLQ GRKVKTQVKN
160 170 180 190 200
IRQFIMPVVS AISSRIIKTP RRFIEDEDYD PPIKIARLES TPNSRFSATS
210 220 230 240 250
CGSSEKSSAA SQHSSQMSSD SSRSSSPSVD TSTDSQASEE IQVLPEERSD
260 270 280 290 300
TPEVHTPLPI SQSPENESTD RRSRRYSVSE RSFGSRTTKK LSTLQSAPPQ
310 320 330 340 350
QTSSSPPPPL LTPPPPLQPA SSISDHTPWL MPPTIPLASP FLPTSAAPMQ
360 370 380 390 400
GKRKSILREP TFRWTSLKHS RSEPQYFSSA KYAKEGLIRK PIFDNFRPPP
410 420 430 440 450
LTPEDVGFAS GFSTSGTAAS ARLFSPLHSG TRFDMHKRSP LLRAPRFTPS
460 470 480 490 500
EAHSRIFESV TLPSNRTSAG TSSSGLSNRK RKRKVFSPIR SEPRSPSHSM
510 520 530 540 550
RTRSGRLSTS ELSPLTPPSS VSSSLSISVS PLATSALNPT FTFPSHSLTQ
560 570 580 590 600
SGESAEKNQR PRKQTSAPAE PFSSSSPTPL FPWFTPGSQT ERGRNKDKAP
610 620 630 640 650
EELSKERDAD KSVEKDKSRE RDREREKENK RESRKEKRKK GSEIQSSSAL
660 670 680 690 700
YPVGRVSKEK VVDEDVATSS SAKKATGRKK SSSLDSGTDI ASVTLGDTTA
710 720 730 740 750
VKTKILIKKG RGNLEKNNLD LGPTAPSLEK EKTLCLSTPS SSTVKHSTSS
760 770 780 790 800
IGSMLAQADK LPMTDKRVAS LLKKAKAQLC KIEKSKSLKQ TDQPKAQGQE
810 820 830 840 850
SDSSETSVRG PRIKHVCRRA AVALGRKRAV FPDDMPTLSA LPWEEREKIL
860 870 880 890 900
SSMGNDDKSS IAGSEDAEPL APPIKPIKPV TRNKAPQEPP VKKGRRSRRC
910 920 930 940 950
GQCPGCQVPE DCGVCTNCLD KPKFGGRNIK KQCCKMRKCQ NLQWMPSKAY
960 970 980 990 1000
LQKQAKAVKK KEKKSKTSEK KESKESSVVK NLVDSSQKST PAAREDPTPK
1010 1020 1030 1040 1050
KSNSEPPPRK PVEDKSEEGN ASASAPEAKQ VAAPTSRKSN KQASQPTPAI
1060 1070 1080 1090 1100
PPQPPSTAPP RKEVPKTTPS EPKKKQPPPP EPGPEQSKQK KVAPRPSIPV
1110 1120 1130 1140 1150
KQKPKEKEKP PPVNKQENAG TLNILSTFSN GNSSKQKIPA DGVHRIRVDF
1160 1170 1180 1190 1200
KEDCEAENVW EMGGLGILTS VPITPRVVCF LCASSGHVEF VYCQVCCEPF
1210 1220 1230 1240 1250
HKFCLEENER PLEDQLENWC CRRCKFCHVC GRQHQATKQL LECNKCRNSY
1260 1270 1280 1290 1300
HPECLGPNYP TKPTKKKKVW ICTKCVRCKS CGSTTPGKGW DAQWSHDFSL
1310 1320 1330 1340 1350
CHDCAKLFAK GNFCPLCDKC YDDDDYESKM MQCGKCDRWV HSKCENLSDE
1360 1370 1380 1390 1400
MYEILSNLPE SVAYTCVNCT ERHPAEWRLA LEKELQISLK QVLTALLNSR
1410 1420 1430 1440 1450
TTSHLLRYRQ AAKPPDLNPE TEESIPSRSS PEGPDPPVLT EVSKQEDQQP
1460 1470 1480 1490 1500
LDLEGVKRKM DQGNYTSVLE FSDDIVKIIQ AAINSDGGQP EIKKANSMVK
1510 1520 1530 1540 1550
SFFIRQMERV FPWFSVKKSR FWEPNKVSSN SGMLPNAVLP PSLDHNYAQW
1560 1570 1580 1590 1600
QEREENSHTE QPPLMKKIIP APKPKGPGEP DSPTPLHPPT PPILSTDRSR
1610 1620 1630 1640 1650
EDSPELNPPP GIEDNRQCAL CLTYGDDSAN DAGRLLYIGQ NEWTHVNCAL
1660 1670 1680 1690 1700
WSAEVFEDDD GSLKNVHMAV IRGKQLRCEF CQKPGATVGC CLTSCTSNYH
1710 1720 1730 1740 1750
FMCSRAKNCV FLDDKKVYCQ RHRDLIKGEV VPENGFEVFR RVFVDFEGIS
1760 1770 1780 1790 1800
LRRKFLNGLE PENIHMMIGS MTIDCLGILN DLSDCEDKLF PIGYQCSRVY
1810 1820 1830 1840 1850
WSTTDARKRC VYTCKIVECR PPVVEPDINS TVEHDENRTI AHSPSSFAEI
1860 1870 1880 1890 1900
SSKESQNTAE IVSPPSPDRP PHSQTSGSCF YHVISKVPRI RTPSYSPTQR
1910 1920 1930 1940 1950
SPGCRPLPSA GSPTPTTHEI VTVGDPLLSS GLRSIGSRRH STSSLSPQRS
1960 1970 1980 1990 2000
KLRIMSPMRT GGTYSRNSVS SLSTIGTTTD LESSAKAADH VLGPLNSNTN
2010 2020 2030 2040 2050
LGQNTPTSSN LQRTVVTLGT KTSHLDGPSS SEMKHSSASD STSKSSSLKG
2060 2070 2080 2090 2100
EKTKMPSSKN SEGSAHNVAY PGIPKLAPQV HNTTSGELNV SKMGTFAELS
2110 2120 2130 2140 2150
SVPFSSKEAL PFPPLHLRGQ RNDRDQQPDS NQLANPPPDE DTEVKTLKLS
2160 2170 2180 2190 2200
GVSSRASTIS EHVGSSSRDR RQKGKKSGKD TFKEKHSSKS FLEPGQVTTG
2210 2220 2230 2240 2250
EEGNLKPEFM DEVLTPEFMG QRPCNNVSSD KIGDKVHSIA GVPKAASMQV
2260 2270 2280 2290 2300
EGSAKELQTP RKRTVKVTLT PLKMESESQS KNTLKESSPV SPLQIEPASP
2310 2320 2330 2340 2350
TEPVSASESP GDGPVAQPSP NNTSSQDSQS NSYQNLPVQD RNLMLPDGPK
2360 2370 2380 2390 2400
PQEDGSFKRR YPRRSARARS NMFFGLTPLY GVRSYGEEDI PFYSSSTGKK
2410 2420 2430 2440 2450
RGKRSAEGQV DGADDLSTSD EDDLYYYNFT RTVIASGGEE RLASHNLFRE
2460 2470 2480 2490 2500
EEQCDLPKIS QLDGVDDGTE SDTSVTATTR KSSQIPKRNS KENGTENLKM
2510 2520 2530 2540 2550
DRPEDAGEKE HVIKSSVGHK NEPKMDNCHS VSRVKTQGQD SLEAQLSSLE
2560 2570 2580 2590 2600
SGRRVHTSTP SDKNLLDTYN TELLKSDSDN NNSDDCGNIL PSDIMDFVLK
2610 2620 2630 2640 2650
NTPSMQALGE SPESSSSELL NLGEGLGLDS NREKDMGLFE VFSQQLPTAE
2660 2670 2680 2690 2700
PVDSSVSSSI SAEEQFELPL ELPSDLSVLT TRSPTVPSQN PSRLAVISDS
2710 2720 2730 2740 2750
GEKRVSITEK SVASSESDSA LLSPGVDPTP EGHMTPDHFI QGHMDADHIS
2760 2770 2780 2790 2800
SPPCGSVEQG HGNNQDLTRN SSTPGLQVPV SPTVPIQNQK YVPNSTDSPG
2810 2820 2830 2840 2850
PSQISNAAVQ TTPPHLKPAT EKLIVVNQNM QPLYVLQTLP NGVTQKIQLT
2860 2870 2880 2890 2900
SSVSSAPNVM ETNTSVLGPM GSGLTLTTGL NPSLPTSQSL FPPASKGLLP
2910 2920 2930 2940 2950
MPHHQHLHSF PAATQSSFPT NISSPPSGLL IGVQPPPDPQ LLVSEASQRT
2960 2970 2980 2990 3000
DLSTTVATPP SGLKKRPISR LQNRKNKKLA PSSTPSNIAP SDVVSNMTLI
3010 3020 3030 3040 3050
NFTPSQLPNH PNLLDLGSLN ASSHRTVPNI IKRSKSSIMY FEQAPLLPQS
3060 3070 3080 3090 3100
VGGSAAPAAG TSTISQDAGH LTSGPVSGLA SGSSVLNVVS MQTTTAPTSS
3110 3120 3130 3140 3150
ASVPGHVALT NPRLLGTPDI GSISNLLIKA SQQSLGIQDQ SVALPPSSGM
3160 3170 3180 3190 3200
FPQLGTSQTP STAAMTAASS ICVLPSTQTA GITAASPSGD TDEHYQLQHV
3210 3220 3230 3240 3250
NQLLASKTGI LSSQRDLDSA PGTQGSNFTQ TVDAPNNMGL EQNKTLSSAM
3260 3270 3280 3290 3300
QASSTSPGGS PSSGQQSASP SVPAPTKPKP KSKRIQLPLD KGSGKKHKVS
3310 3320 3330 3340 3350
HLRTSSEAHI PDQEASTTAL TSVTGTPGAE AEQQETASVE QSSQKGCGQP
3360 3370 3380 3390 3400
AGQVAVLPEI QTTQNPVNEQ ENSEPKTAEE EESNFSSPLM LWLQQEQKRK
3410 3420 3430 3440 3450
ESIAEKKPKK GLVFEISSDD GFQICAESIE DAWKSLTDKV QEARSNARLK
3460 3470 3480 3490 3500
QLSFAGVNGL RMLGILHDAV VFLIEQLSGA KHCRNYKFRF HKPEEANEPP
3510 3520 3530 3540 3550
LNPHGSARAE VHLRKSAFDM FNFLASKHRQ PPEYNPNDEE EEEVQLKSAR
3560 3570 3580 3590 3600
RATSMDLPMP MRFRHLKKTS KEAVGVYRSP IHGRGLFCKR NIDAGEMVIE
3610 3620 3630 3640 3650
YAGNVIRSIQ TDKREKYYDS KGIGCYMFRI DDSEVVDATM HGNAARFINH
3660 3670 3680 3690 3700
SCEPNCYSRV INIDGQKHIV IFAMRKIYRG EELTYDYKFP IEDASNKLPC
3710
NCGAKKCRKF LN
Length:3,712
Mass (Da):405,787
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i765D4ADE0208290A
GO

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
GBZA01000347 Transcribed RNA Translation: JAG69421.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GBZA01000347 Transcribed RNA Translation: JAG69421.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Family and domain databases

CDDicd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2, PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 1 hit
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B8RVR8_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B8RVR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: October 7, 2020
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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