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Entry version 33 (26 Feb 2020)
Sequence version 1 (01 Apr 2015)
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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

PARPA_12471.1 scaffold 45109

Organism
Parasitella parasitica
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase
LigandS-adenosyl-L-methionineUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PARPA_12471.1 scaffold 45109Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParasitella parasiticaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri35722 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotaMucoromycotinaMucoromycetesMucoralesMucorineaeMucoraceaeParasitella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000054107 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini366 – 463SWIRMInterPro annotationAdd BLAST98
Domaini570 – 621SANTInterPro annotationAdd BLAST52
Domaini1097 – 1446DOT1InterPro annotationAdd BLAST350

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni277 – 326DisorderedSequence analysisAdd BLAST50
Regioni680 – 749DisorderedSequence analysisAdd BLAST70
Regioni848 – 869DisorderedSequence analysisAdd BLAST22
Regioni890 – 934DisorderedSequence analysisAdd BLAST45
Regioni975 – 1061DisorderedSequence analysisAdd BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili762 – 803Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi294 – 315PolarSequence analysisAdd BLAST22
Compositional biasi688 – 749PolyampholyteSequence analysisAdd BLAST62
Compositional biasi905 – 927PolarSequence analysisAdd BLAST23
Compositional biasi975 – 1034PolarSequence analysisAdd BLAST60
Compositional biasi1035 – 1059PolyampholyteSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
683891at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036420 BRCT_dom_sf
IPR025789 DOT1_dom
IPR009057 Homeobox-like_sf
IPR029063 SAM-dependent_MTases
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR032450 SMARCC_N
IPR007526 SWIRM
IPR036388 WH-like_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08123 DOT1, 1 hit
PF00249 Myb_DNA-binding, 1 hit
PF04433 SWIRM, 1 hit
PF16496 SWIRM-assoc_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717 SANT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits
SSF52113 SSF52113, 1 hit
SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51569 DOT1, 1 hit
PS51293 SANT, 1 hit
PS50934 SWIRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0B7NT54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTTTEQPPK IDFNFYEQPS TISYFDAIVE DLRNDLGSIG VDTAFTAPEL
60 70 80 90 100
AYFTARFLQF QQDTLRLNRN QTKPLPARIP THFFNVETLS KPSPLYTILQ
110 120 130 140 150
AAYTFQSDND ISDWQFDAPE ERDIYLELIR VITKQLIQDG FYMPPVVAFD
160 170 180 190 200
ETVTNKSDID EWSRIVIALG GQVVDVIPSA THIIYNNVEP VFNSENCSFY
210 220 230 240 250
IEEQKNGKAL IHYIGLPDSY NTWVTEIGAG QVSKPTLSSP WHVRATWILD
260 270 280 290 300
SYRYSEWMSP IDYDYPEKHL SRMNLKRSAD ESSVLDKNSP LKKVKTPTGE
310 320 330 340 350
QPTLQVDSEG SALMTEGNAP SGPEPIAKTE NIETVIQAPL MPVDLSAIPL
360 370 380 390 400
PEEDPQRYLT IQSHEIVIPS YAAWFDITTV NIIESRSLPE FFNDRNKSKT
410 420 430 440 450
PTVYKTYRDF MVNTYRMNPV EYLTITACRR NLTGDVCAIL RVHSFLEQWG
460 470 480 490 500
LINYQVDPEA KLSSLSPPFD SQFKVVIDKV IEKQIKEEEK EEDVCMKDEP
510 520 530 540 550
VVSRYSFGKE KKPQKCSSCE TKCTSEQFCS TTRTDFYLCR SCLVAGKYPM
560 570 580 590 600
DQDSGNFVWE RFGNENGSTE DDDAWDDKEE SLFKKGLRLY QDDWEKISDH
610 620 630 640 650
VGTRTHDECI LHYLQLPTND PFTDAEIQKL GLLQYDFAQH QENPVMAAVA
660 670 680 690 700
FLASGVQPKV AAAAGHIDIE KFEDESIIEV EAEDDDTLVK EEEKKANGAK
710 720 730 740 750
EDREVESEKK SVLDVEKENE KEQDKEPKTE EKATVEEHKS SRTEEEENEL
760 770 780 790 800
CNLTNTLIRF KLAQYEQQAS HYESLEEVVE DQKRQLEKEK HQLDLDQSSL
810 820 830 840 850
KKKILSIHLE MTRRGSSATA IANSITPAQL QQQLAGASPS MFLNAQQPHL
860 870 880 890 900
HQHPQQQPHP QQSPQVIQQM QLQQQQYQLR MQMQLQQQHL QLQQQQHHQQ
910 920 930 940 950
HHQQHHQQQQ QQQQPGPPGF NNMMSFSSKK DDRSHLLIEK DQNKQTVALP
960 970 980 990 1000
PKKVMASKLA AAAAAAAAAA AATSTSQKQQ SQSQIQTSTT VSHTVRTSAT
1010 1020 1030 1040 1050
VTTNSTTTVA SNKTETSGHL SKSESTVTKR RLSSSAFDNT REKKIAKDKT
1060 1070 1080 1090 1100
PHSKPGKSIT HSDRVVQAEI IQYRPYFTEP DSDNPNETAP THKEKHLRVT
1110 1120 1130 1140 1150
LEYPGSIEPE NFLLLKPVIK NAAGKYEEEE EDQDEYNPIT DLMRTAELIY
1160 1170 1180 1190 1200
DCYLTPEEQT LLGNQSHGIM RNLTKYRNRR NGAGFAQAIK EFNKVMRQFK
1210 1220 1230 1240 1250
ADGVLSKNAK DMCHPNYDLA CHILFQVYSR TVARQADALN NYQAFSNNVY
1260 1270 1280 1290 1300
GEINPILVKD FITKTGVNSR SVFMDLGCGI GNVVLQVAAQ TGCEAYGIEI
1310 1320 1330 1340 1350
METPCKFAKR QLKEYAARMK AWRLPTGKIH FRHGDFLDVA ANDLYSTLKR
1360 1370 1380 1390 1400
SDVLLVNNYA FDAATNQALA QLFLDLKEGT KIISLKSFVP KHHKINQRTL
1410 1420 1430 1440
NMPESILRVE EFEYYSEAVS WTNNGGQYYI GTVDRSRLAP YFEEMYGR
Length:1,448
Mass (Da):164,940
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31455D8EE6C1CBE2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN733769 Genomic DNA Translation: CEP18169.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN733769 Genomic DNA Translation: CEP18169.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

OrthoDBi683891at2759

Family and domain databases

CDDicd00167 SANT, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR036420 BRCT_dom_sf
IPR025789 DOT1_dom
IPR009057 Homeobox-like_sf
IPR029063 SAM-dependent_MTases
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR032450 SMARCC_N
IPR007526 SWIRM
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF08123 DOT1, 1 hit
PF00249 Myb_DNA-binding, 1 hit
PF04433 SWIRM, 1 hit
PF16496 SWIRM-assoc_2, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
SSF52113 SSF52113, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51569 DOT1, 1 hit
PS51293 SANT, 1 hit
PS50934 SWIRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B7NT54_9FUNG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B7NT54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: February 26, 2020
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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