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Entry version 46 (10 Apr 2019)
Sequence version 1 (01 Apr 2015)
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Protein
Submitted name:

Aminotransferase class-V

Gene

iscS_1

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminotransferaseImported, Transferase
LigandPyridoxal phosphateSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Aminotransferase class-VImported (EC:2.8.1.7Imported)
Submitted name:
Cysteine desulfuraseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:iscS_1Imported
Synonyms:iscS_2Imported, iscS_4Imported
ORF Names:CHL73_07715Imported, CWI01_08795Imported, CWI64_01155Imported, ERS019166_01294Imported, ERS019499_01323Imported, ERS020408_01491Imported, ERS020521_01914Imported, ERS020692_02617Imported, ERS021300_01509Imported, ERS021360_01446Imported, ERS021368_02072Imported, ERS021449_01903Imported, ERS021634_05777Imported, ERS043879_00769Imported, ERS096107_00332Imported, ERS232471_01346Imported, ERS232499_01906Imported, ERS409064_01401Imported, ERS409405_03193Imported, KK0981_30400Imported, NCTC12140_02099Imported, NCTC13735_01333Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus pneumoniaeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1313 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000046356 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000277064 Componenti: Unassembled WGS sequence
  • UP000046964 Componenti: Unassembled WGS sequence
  • UP000039303 Componenti: Unassembled WGS sequence
  • UP000044493 Componenti: Unassembled WGS sequence
  • UP000255473 Componenti: Unassembled WGS sequence
  • UP000040885 Componenti: Unassembled WGS sequence
  • UP000045409 Componenti: Unassembled WGS sequence
  • UP000046154 Componenti: Unassembled WGS sequence
  • UP000042802 Componenti: Unassembled WGS sequence
  • UP000044228 Componenti: Unassembled WGS sequence
  • UP000249761 Componenti: Unassembled WGS sequence
  • UP000216187 Componenti: Unassembled WGS sequence
  • UP000039362 Componenti: Unassembled WGS sequence
  • UP000040760 Componenti: Unassembled WGS sequence
  • UP000254469 Componenti: Unassembled WGS sequence
  • UP000218786 Componenti: Chromosome
  • UP000232067 Componenti: Chromosome
  • UP000235698 Componenti: Unassembled WGS sequence
  • UP000038546 Componenti: Unassembled WGS sequence
  • UP000042569 Componenti: Unassembled WGS sequence
  • UP000074995 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 361Aminotran_5InterPro annotationAdd BLAST360

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili244 – 264Sequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C3J Bacteria
COG1104 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR016454 Cysteine_dSase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00266 Aminotran_5, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005572 NifS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53383 SSF53383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0B7LHP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIYLDNAATT PMSAVAISAM TKVMQETHGN PSSIHGHGRQ AGKLLREARQ
60 70 80 90 100
ELAQLLRTKP QHIFFTSGGT EGNNTTIIGY CLRHQEQGKH IITTAIEHHA
110 120 130 140 150
VLETIDYLVQ HFGFEATIIQ PENQEITAQQ IQKALRDDTI LVSTMFANNE
160 170 180 190 200
TGNLLPIAEI GQILKQHPAA YHVDAVQAIG KIPIHSEELG IDFLTASAHK
210 220 230 240 250
FHGPKGIGFL YASSMDFDSY LHGGDQEQKK RAGTENLPAI VGMVAALKED
260 270 280 290 300
LEKQEEHFQH VQNLETAFLA ELEGIQYYLN RGKHHLPYVL NIGFPGQKND
310 320 330 340 350
LLLLRLDLAG ISISTGSACT AGVVQSSHVL EAMYGANSER LKESLRISLS
360 370
PQNTVEDLQT LAKTLKEIIG G
Length:371
Mass (Da):40,735
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i136E618E39E21F4D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP025076 Genomic DNA Translation: AUB32376.1
AP017971 Genomic DNA Translation: BAW84532.1
CFGX01000044 Genomic DNA Translation: CEY69396.1
CKAB01000018 Genomic DNA Translation: CIO44923.1
CKHR01000019 Genomic DNA Translation: CIT07332.1
CKOR01000016 Genomic DNA Translation: CIX32568.1
CKTJ01000022 Genomic DNA Translation: CJA11578.1
CKVP01000031 Genomic DNA Translation: CJC41110.1
CLBL01000018 Genomic DNA Translation: CJF62245.1
CLFU01000061 Genomic DNA Translation: CJJ90227.1
CMOR01000019 Genomic DNA Translation: CKE19930.1
CMQD01000045 Genomic DNA Translation: CKF14951.1
CMTS01000004 Genomic DNA Translation: CKH33343.1
CRPE01000038 Genomic DNA Translation: CON82609.1
CGXO01000054 Genomic DNA Translation: COP56436.1
CNOG02000124 Genomic DNA Translation: CTO25475.1
FDEX01000010 Genomic DNA Translation: CVT16076.1
FEGY01000025 Genomic DNA Translation: CWJ16253.1
NOIL01000050 Genomic DNA Translation: OZS29631.1
PHTV01000120 Genomic DNA Translation: RRR95170.1
UHGD01000001 Genomic DNA Translation: SUN93919.1
UHGR01000001 Genomic DNA Translation: SUO27217.1

NCBI Reference Sequences

More...
RefSeqi
WP_000639662.1, NZ_UHHG01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CEY69396; CEY69396; ERS021368_02072
CFP94847; CFP94847; ERS013931_01974
CIO44923; CIO44923; ERS019166_01294
CIT07332; CIT07332; ERS019499_01323
CIT93058; CIT93058; ERS019595_01223
CIX32568; CIX32568; ERS020408_01491
CJA11578; CJA11578; ERS021360_01446
CJC41110; CJC41110; ERS021449_01903
CJF62245; CJF62245; ERS021300_01509
CJJ90227; CJJ90227; ERS021634_05777
CJK67019; CJK67019; ERS022016_02061
CJP28644; CJP28644; ERS021996_02065
CJY68136; CJY68136; ERS022329_02048
CKE19930; CKE19930; ERS232471_01346
CKF14951; CKF14951; ERS232499_01906
CMX33000; CMX33000; ERS077238_02152
CNB05173; CNB05173; ERS077235_02190
CNB26841; CNB26841; ERS077244_02154
CNY96539; CNY96539; ERS020873_00655
CON82609; CON82609; ERS020692_02617
CTO25475; CTO25475; ERS043879_00769
CVO84949; CVO84949; ERS408893_01653
CVP44284; CVP44284; ERS367764_02002
CVT16076; CVT16076; ERS409064_01401
CWE66382; CWE66382; ERS367337_01309
CWI60455; CWI60455; ERS409444_00968
CWM45981; CWM45981; ERS515182_01916
CYN30089; CYN30089; ERS455152_01703
KWX84601; KWX84601; AWW74_00380

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1313.6472.peg.1870

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025076 Genomic DNA Translation: AUB32376.1
AP017971 Genomic DNA Translation: BAW84532.1
CFGX01000044 Genomic DNA Translation: CEY69396.1
CKAB01000018 Genomic DNA Translation: CIO44923.1
CKHR01000019 Genomic DNA Translation: CIT07332.1
CKOR01000016 Genomic DNA Translation: CIX32568.1
CKTJ01000022 Genomic DNA Translation: CJA11578.1
CKVP01000031 Genomic DNA Translation: CJC41110.1
CLBL01000018 Genomic DNA Translation: CJF62245.1
CLFU01000061 Genomic DNA Translation: CJJ90227.1
CMOR01000019 Genomic DNA Translation: CKE19930.1
CMQD01000045 Genomic DNA Translation: CKF14951.1
CMTS01000004 Genomic DNA Translation: CKH33343.1
CRPE01000038 Genomic DNA Translation: CON82609.1
CGXO01000054 Genomic DNA Translation: COP56436.1
CNOG02000124 Genomic DNA Translation: CTO25475.1
FDEX01000010 Genomic DNA Translation: CVT16076.1
FEGY01000025 Genomic DNA Translation: CWJ16253.1
NOIL01000050 Genomic DNA Translation: OZS29631.1
PHTV01000120 Genomic DNA Translation: RRR95170.1
UHGD01000001 Genomic DNA Translation: SUN93919.1
UHGR01000001 Genomic DNA Translation: SUO27217.1
RefSeqiWP_000639662.1, NZ_UHHG01000005.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCEY69396; CEY69396; ERS021368_02072
CFP94847; CFP94847; ERS013931_01974
CIO44923; CIO44923; ERS019166_01294
CIT07332; CIT07332; ERS019499_01323
CIT93058; CIT93058; ERS019595_01223
CIX32568; CIX32568; ERS020408_01491
CJA11578; CJA11578; ERS021360_01446
CJC41110; CJC41110; ERS021449_01903
CJF62245; CJF62245; ERS021300_01509
CJJ90227; CJJ90227; ERS021634_05777
CJK67019; CJK67019; ERS022016_02061
CJP28644; CJP28644; ERS021996_02065
CJY68136; CJY68136; ERS022329_02048
CKE19930; CKE19930; ERS232471_01346
CKF14951; CKF14951; ERS232499_01906
CMX33000; CMX33000; ERS077238_02152
CNB05173; CNB05173; ERS077235_02190
CNB26841; CNB26841; ERS077244_02154
CNY96539; CNY96539; ERS020873_00655
CON82609; CON82609; ERS020692_02617
CTO25475; CTO25475; ERS043879_00769
CVO84949; CVO84949; ERS408893_01653
CVP44284; CVP44284; ERS367764_02002
CVT16076; CVT16076; ERS409064_01401
CWE66382; CWE66382; ERS367337_01309
CWI60455; CWI60455; ERS409444_00968
CWM45981; CWM45981; ERS515182_01916
CYN30089; CYN30089; ERS455152_01703
KWX84601; KWX84601; AWW74_00380
PATRICifig|1313.6472.peg.1870

Phylogenomic databases

eggNOGiENOG4105C3J Bacteria
COG1104 LUCA

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR016454 Cysteine_dSase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF005572 NifS, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B7LHP5_STREE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B7LHP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: April 10, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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