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Protein

Ribonuclease PH

Gene

rph

Organism
Bacillus anthracis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86Phosphate (substrate) bindingUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotation, RNA-binding, Transferase, tRNA-bindingUniRule annotationSAAS annotation
Biological processrRNA processingUniRule annotationSAAS annotation, tRNA processingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease PHUniRule annotationSAAS annotation (EC:2.7.7.56UniRule annotationSAAS annotation)
Short name:
RNase PHUniRule annotation
Alternative name(s):
tRNA nucleotidyltransferaseUniRule annotation
Gene namesi
Name:rphUniRule annotation
ORF Names:A9486_16110Imported, ABW01_28535Imported, BVG01_28035Imported, COL95_13945Imported
OrganismiBacillus anthracisImported
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000181973 Componenti: Unassembled WGS sequence
  • UP000224851 Componenti: Unassembled WGS sequence
  • UP000191148 Componenti: Unassembled WGS sequence
  • UP000035904 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homohexameric ring arranged as a trimer of dimers.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiA0A0B5PNC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 139RNase_PHInterPro annotationAdd BLAST130
Domaini159 – 224RNase_PH_CInterPro annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 126Phosphate (substrate) bindingUniRule annotation3

Sequence similaritiesi

Belongs to the RNase PH family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108FK2 Bacteria
COG0689 LUCA
KOiK00989
OMAiKGKGQGW

Family and domain databases

CDDicd11362 RNase_PH_bact, 1 hit
Gene3Di3.30.230.70, 1 hit
HAMAPiMF_00564 RNase_PH, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR002381 RNase_PH_bac-type
IPR018336 RNase_PH_CS
PfamiView protein in Pfam
PF01138 RNase_PH, 1 hit
PF03725 RNase_PH_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55666 SSF55666, 1 hit
TIGRFAMsiTIGR01966 RNasePH, 1 hit
PROSITEiView protein in PROSITE
PS01277 RIBONUCLEASE_PH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0B5PNC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVDGREKTE LRHIHIHTNY LKHPEGSVLI EVGDTKVICS ATIEERVPPF
60 70 80 90 100
MRGEGKGWVT AEYAMIPRAT EQRTIRESSK GKVTGRTMEI QRLIGRALRA
110 120 130 140 150
VVDLEALGER TVWIDCDVIQ ADGGTRTASI TGAYVAMVLA FEKLLQAEKV
160 170 180 190 200
SKIPVKDYLA ATSVGIVEEQ GVVLDLNYAE DSKADVDMNV IMTGKGQFVE
210 220 230 240
VQGTGEEATF SRAQLNELLD AAEQGIFQLI DIQKEALGDI VSHIE
Length:245
Mass (Da):26,983
Last modified:April 1, 2015 - v1
Checksum:i00053DA2C582D0E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDPG01000036 Genomic DNA Translation: KLV14200.1
LZQX01000046 Genomic DNA Translation: OJD88489.1
MTAU01000031 Genomic DNA Translation: OPD55699.1
NVHS01000030 Genomic DNA Translation: PGB53374.1
RefSeqiWP_001261764.1, NZ_QANP01000006.1

Genome annotation databases

EnsemblBacteriaiANH88621; ANH88621; A8C77_22905
KLV14200; KLV14200; ABW01_28535
KEGGibanh:HYU01_22990
PATRICifig|1392.230.peg.4648

Similar proteinsi

Entry informationi

Entry nameiA0A0B5PNC6_BACAN
AccessioniPrimary (citable) accession number: A0A0B5PNC6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: July 18, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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