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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Radix balthica (Wandering pond snail) (Radix ovata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:COIImported
Encoded oniMitochondrionImported
OrganismiRadix balthica (Wandering pond snail) (Radix ovata)Imported
Taxonomic identifieri582868 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataHygrophilaLymnaeoideaLymnaeidaeRadix

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei39 – 68HelicalSequence analysisAdd BLAST30
Transmembranei89 – 113HelicalSequence analysisAdd BLAST25
Transmembranei133 – 158HelicalSequence analysisAdd BLAST26
Transmembranei170 – 197HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 226COX1InterPro annotationAdd BLAST226

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A0B5EHT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KDIGTLYMIF GVWCGLVGTG LSLLIRLELG TSMVLIDEHF YNVIVTAHAF
60 70 80 90 100
VMIFFMVMPM MIGGFGNWMV PLLIGAPDMS FPRMNNMSFW LLPPSFVLLL
110 120 130 140 150
CSSMVEGGVG TGWTVYPPLS GPIAHGGSSV DLAIFSLHLA GLSSILGAIN
160 170 180 190 200
FITTIFNMRS PGITLERMSL FVWSVLITAF LLLLSLPVLA GAITMLLTDR
210 220
NFNTTFFDPA GGGDPILYQH LFWFFG
Length:226
Mass (Da):24,700
Last modified:April 1, 2015 - v1
Checksum:i67B16023BFDC92CC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei226Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP242441 Genomic DNA Translation: AJE70409.1
KP242606 Genomic DNA Translation: AJE70574.1
KP242634 Genomic DNA Translation: AJE70602.1
KP242639 Genomic DNA Translation: AJE70607.1
KP242666 Genomic DNA Translation: AJE70634.1
KP242683 Genomic DNA Translation: AJE70651.1
KP242779 Genomic DNA Translation: AJE70746.1
KP242781 Genomic DNA Translation: AJE70748.1
KP242782 Genomic DNA Translation: AJE70749.1

Similar proteinsi

Entry informationi

Entry nameiA0A0B5EHT0_RADBA
AccessioniPrimary (citable) accession number: A0A0B5EHT0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: May 23, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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