UniProtKB - A0A0B5A8P8 (INS2_CONIM)
Protein
Con-Ins Im2
Gene
N/A
Organism
Conus imperialis (Imperial cone)
Status
Functioni
This venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock. Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In vivo, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.By similarity
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- glucose metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hormone, Toxin |
Biological process | Carbohydrate metabolism, Glucose metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Con-Ins Im21 PublicationAlternative name(s): Insulin 2Imported Cleaved into the following 2 chains: Con-Ins I2 B chain1 Publication Con-Ins I2 A chain1 Publication |
Organismi | Conus imperialis (Imperial cone) |
Taxonomic identifieri | 35631 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Stephanoconus |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
PeptideiPRO_5002099638 | 30 – 63 | Con-Ins I2 B chainBy similarityAdd BLAST | 34 | |
PropeptideiPRO_0000439324 | 64 – 110 | C peptideBy similarityAdd BLAST | 47 | |
PeptideiPRO_0000439325 | 111 – 140 | Con-Ins I2 A chainBy similarityAdd BLAST | 30 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 35 ↔ 123 | Curated | ||
Disulfide bondi | 50 ↔ 126 | Interchain (between B and A chains)By similarity | ||
Disulfide bondi | 62 ↔ 139 | Interchain (between B and A chains)By similarity | ||
Disulfide bondi | 125 ↔ 130 | By similarity | ||
Modified residuei | 134 | 4-carboxyglutamate; partialBy similarity | 1 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acidExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the insulin family.
Keywords - Domaini
SignalFamily and domain databases
InterProi | View protein in InterPro IPR016179 Insulin-like IPR036438 Insulin-like_sf IPR016724 Insulin-rel_pep IPR022353 Insulin_CS IPR022352 Insulin_family |
Pfami | View protein in Pfam PF00049 Insulin, 1 hit |
PIRSFi | PIRSF018431 Molluscan_insulin_rel_peptide, 1 hit |
PRINTSi | PR00276 INSULINFAMLY |
SMARTi | View protein in SMART SM00078 IlGF, 1 hit |
SUPFAMi | SSF56994 SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262 INSULIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A0A0B5A8P8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALTWPSSPP VLLTLLLSLL ALQLCAVYGS YEHTCTLATR SRGAHPSGIC
60 70 80 90 100
GRNLARIVSV LCTPRGYVSN WFTKRSAPNK PAETFVDQNL RGVLLNKREA
110 120 130 140
LSYLRPREPR ATRGTFGSQG ITCECCFNQC TYYELLQYCN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KP268612 mRNA Translation: AJD85825.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KP268612 mRNA Translation: AJD85825.1 |
3D structure databases
SMRi | A0A0B5A8P8 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR016179 Insulin-like IPR036438 Insulin-like_sf IPR016724 Insulin-rel_pep IPR022353 Insulin_CS IPR022352 Insulin_family |
Pfami | View protein in Pfam PF00049 Insulin, 1 hit |
PIRSFi | PIRSF018431 Molluscan_insulin_rel_peptide, 1 hit |
PRINTSi | PR00276 INSULINFAMLY |
SMARTi | View protein in SMART SM00078 IlGF, 1 hit |
SUPFAMi | SSF56994 SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262 INSULIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | INS2_CONIM | |
Accessioni | A0A0B5A8P8Primary (citable) accession number: A0A0B5A8P8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2017 |
Last sequence update: | April 1, 2015 | |
Last modified: | November 7, 2018 | |
This is version 20 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |