Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Planococcus sp. PAMC 21323
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Biotin carboxylase (Plano_1347), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseImported, TransferaseUniRule annotationSAAS annotationImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:2.1.3.15UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
ORF Names:Plano_1104Imported
OrganismiPlanococcus sp. PAMC 21323Imported
Taxonomic identifieri1526927 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPlanococcaceaePlanococcus
Proteomesi
  • UP000031496 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 297CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili34 – 54Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK01962

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0B4RAB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKKNGKKTL AFEEPLIQLR AKISELKEYT TTAEVDLSSE IKSLEDRFSK
60 70 80 90 100
LEEEIYENMK PWDRVQVARH PERPTTLDYI PMIFDDFIEL HGDRLYGDDE
110 120 130 140 150
AIVSGIASFN GQPVTIIGHQ RGKDTKENVR RNFGMPHPEG YRKALRLMKQ
160 170 180 190 200
AEKFKRPIIC LIDTKGAYPG KAAEERGQSE AIARNLVEMA GLEVPVLSIV
210 220 230 240 250
IGEGGSGGAL ALGVGNQILM LENSTFSVIS PEGAASILWK DSALAQTAAE
260 270 280 290 300
AMKITAPDLL EMKIIEHMIP EVRGGAHHNP QKQAAIMTEA IRRSLEELNG
310 320
LSGKELVEQR YNKFKSIGVF SE
Length:322
Mass (Da):35,787
Last modified:April 1, 2015 - v1
Checksum:iA8CDFB69DCDC5AEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009129 Genomic DNA Translation: AIY05069.1
RefSeqiWP_038703526.1, NZ_CP009129.1

Genome annotation databases

EnsemblBacteriaiAIY05069; AIY05069; Plano_1104
KEGGipln:Plano_1104

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009129 Genomic DNA Translation: AIY05069.1
RefSeqiWP_038703526.1, NZ_CP009129.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAIY05069; AIY05069; Plano_1104
KEGGipln:Plano_1104

Phylogenomic databases

KOiK01962

Enzyme and pathway databases

UniPathwayi
UPA00655;UER00711

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0B4RAB5_9BACL
AccessioniPrimary (citable) accession number: A0A0B4RAB5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: November 7, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again