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Entry version 42 (11 Dec 2019)
Sequence version 1 (01 Apr 2015)
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Protein
Submitted name:

Tripeptidyl-peptidase II, isoform F

Gene

TppII

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tripeptidyl-peptidase II, isoform FImported (EC:3.4.14.-Imported, EC:3.4.21.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TppIIImported
Synonyms:anon-WO0118547.127Imported, Dmel\CG3991Imported, dTPP IIImported, dTPPIIImported, l(2)k14301Imported, TPP IIImported, TPP2Imported, TPPIIImported
ORF Names:CG3991Imported, Dmel_CG3991Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0020370 TppII

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0B4LGC0 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 513Peptidase_S8InterPro annotationAdd BLAST479
Domaini806 – 989TPPIIInterPro annotationAdd BLAST184
Domaini1032 – 1169TPPII_NInterPro annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1052 – 1103DisorderedSequence analysisAdd BLAST52
Regioni1168 – 1187DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1064 – 1090PolarSequence analysisAdd BLAST27

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1114 Eukaryota
COG1404 LUCA

Database of Orthologous Groups

More...
OrthoDBi
156304at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04857 Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.200, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022229 Peptidase_S8A_TPPII
IPR022232 Peptidase_S8A_TPPII_art
IPR034051 TPP_II_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00082 Peptidase_S8, 1 hit
PF12580 TPPII, 1 hit
PF12583 TPPII_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00723 SUBTILISIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52743 SSF52743, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0B4LGC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSGIVESF PTGALVPKAE TGVLNFLQKY PEYDGRDVTI AIFDSGVDPR
60 70 80 90 100
ATGLETLCDG KTVKVIERYD CSGCGDVDMK KKVTPDENGN IKGLSGNSLK
110 120 130 140 150
LSPELMALNT DPEKAVRVGL KSFSDLLPSK VRNNIVAQAK LKHWDKPHKT
160 170 180 190 200
ATANASRKIV EFESQNPGEA SKLPWDKKIL KENLDFELEM LNSYEKVYGD
210 220 230 240 250
IKTSYDCILF PTADGWLTIV DTTEQGDLDQ ALRIGEYSRT HETRNVDDFL
260 270 280 290 300
SISVNVHDEG NVLEVVGMSS PHGTHVSSIA SGNHSSRDVD GVAPNAKIVS
310 320 330 340 350
MTIGDGRLGS METGTALVRA MTKVMELCRD GRRIDVINMS YGEHANWSNS
360 370 380 390 400
GRIGELMNEV VNKYGVVWVA SAGNHGPALC TVGTPPDISQ PSLIGVGAYV
410 420 430 440 450
SPQMMEAEYA MREKLPGNVY TWTSRDPCID GGQGVTVCAP GGAIASVPQF
460 470 480 490 500
TMSKSQLMNG TSMAAPHVAG AVALLISGLK QQNIEYSPYS IKRAISVTAT
510 520 530 540 550
KLGYVDPFAQ GHGLLNVEKA FEHLTEHRQS KDNMLRFSVR VGNNADKGIH
560 570 580 590 600
LRQGVQRNSI DYNVYIEPIF YNDKEADPKD KFNFNVRLNL IASQPWVQCG
610 620 630 640 650
AFLDLSYGTR SIAVRVDPTG LQPGVHSAVI RAYDTDCVQK GSLFEIPVTV
660 670 680 690 700
VQPHVLESDQ NTPVFEPASS KGDNSVEFQP NTIQRDFILV PERATWAELR
710 720 730 740 750
MRITDPNRGE DIGKFFVHTN QLLPKQSCRK LETMKIVSVG SENESIMAFK
760 770 780 790 800
VKSGRILELC IAKYWSNYGQ SHLKYSLRFR GVEAHNPNAY VMHAGRGIHK
810 820 830 840 850
LEIEALVAED VQPQLQLKNA EVVLKPTEAK ISPLSATRDV IPDGRQVYQN
860 870 880 890 900
LLAFNLNVAK AADVSIYAPI FNDLLYEAEF ESQMWMLFDA NKALVATGDA
910 920 930 940 950
HSHTSFTKLD KGEYTIRLQV RHEKRDLLEK ISEANLVASF KLTSPLTLDF
960 970 980 990 1000
YENYNQCIVG GRKYVSSPLR LSTRVLYIAP ITQERLTKAN LPAQCAWLSG
1010 1020 1030 1040 1050
NLVFPQDEVG RRVAQHPFTY ILNPAEKKSH TNGSSNGSSA AGSTATAAAV
1060 1070 1080 1090 1100
TTANGAKPKA PATPQAATSV TNPAAGDGIS VQNDPPVDSS GSPASPKKGK
1110 1120 1130 1140 1150
ANADDYAESF RDFQCSQIVK CELEMAEKIY NDVVAAHPKH LQANLLLIQN
1160 1170 1180 1190 1200
IESNQLKSQL PLTFVNAQKT SPPEAGESAD KQKEDQKKVR SALERIVKLA
1210 1220 1230 1240 1250
DKVIQETDSE ALLSYYGLKN DTRADAAKIK TNMDKQKNTL IEALSKKGIA
1260 1270 1280 1290 1300
VAKLAVLDDC IKDSLAEINE LYTEIIKFVD ANDSKAIQFA LWHAYAHGHY
1310 1320 1330 1340 1350
GRMYKYVVKL IEEKRTRDHF VELAAINGAL GHEHIRTVIN RMMITAFPSS

FRLF
Length:1,354
Mass (Da):148,909
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i525E1FCD6D7CB819
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9V6K1TPP2_DROME
Tripeptidyl-peptidase 2
TppII CG3991
1,441Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4LF88A0A0B4LF88_DROME
Tripeptidyl-peptidase II, isoform E
TppII anon-WO0118547.127, Dmel\CG3991, dTPP II, dTPPII, l(2)k14301
1,375Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AHN56174.1

NCBI Reference Sequences

More...
RefSeqi
NP_001286376.1, NM_001299447.1
NP_477247.1, NM_057899.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0087775; FBpp0086888; FBgn0020370
FBtr0344199; FBpp0310608; FBgn0020370

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36444

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AHN56174.1
RefSeqiNP_001286376.1, NM_001299447.1
NP_477247.1, NM_057899.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiFBtr0087775; FBpp0086888; FBgn0020370
FBtr0344199; FBpp0310608; FBgn0020370
GeneIDi36444

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36444
FlyBaseiFBgn0020370 TppII

Phylogenomic databases

eggNOGiKOG1114 Eukaryota
COG1404 LUCA
OrthoDBi156304at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TppII fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36444

Gene expression databases

ExpressionAtlasiA0A0B4LGC0 baseline and differential

Family and domain databases

CDDicd04857 Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit
Gene3Di3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022229 Peptidase_S8A_TPPII
IPR022232 Peptidase_S8A_TPPII_art
IPR034051 TPP_II_domain
PfamiView protein in Pfam
PF00082 Peptidase_S8, 1 hit
PF12580 TPPII, 1 hit
PF12583 TPPII_N, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B4LGC0_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4LGC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: December 11, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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