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Entry version 45 (10 Feb 2021)
Sequence version 1 (01 Apr 2015)
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Protein
Submitted name:

Shavenoid, isoform C

Gene

sha

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Shavenoid, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:shaImported
Synonyms:Dmel\CG13209Imported, kojImported, lincRNA.286Imported, ShaImported
ORF Names:CG13209Imported, Dmel_CG13209Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003382, sha

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei351 – 374HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500210724426 – 1618Sequence analysisAdd BLAST1593

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0B4KEL5, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 125DisorderedSequence analysisAdd BLAST23
Regioni463 – 499DisorderedSequence analysisAdd BLAST37
Regioni634 – 727DisorderedSequence analysisAdd BLAST94
Regioni848 – 868DisorderedSequence analysisAdd BLAST21
Regioni896 – 931DisorderedSequence analysisAdd BLAST36
Regioni954 – 975DisorderedSequence analysisAdd BLAST22
Regioni989 – 1019DisorderedSequence analysisAdd BLAST31
Regioni1136 – 1193DisorderedSequence analysisAdd BLAST58
Regioni1216 – 1237DisorderedSequence analysisAdd BLAST22
Regioni1267 – 1297DisorderedSequence analysisAdd BLAST31
Regioni1495 – 1608DisorderedSequence analysisAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili51 – 71Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi689 – 727PolarSequence analysisAdd BLAST39
Compositional biasi905 – 926PolarSequence analysisAdd BLAST22
Compositional biasi993 – 1019PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1169 – 1183Pro-richSequence analysisAdd BLAST15
Compositional biasi1223 – 1237PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1495 – 1522PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1547 – 1588PolarSequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPTMFNI

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0B4KEL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLQSLPLLL LLAVVTLPPA TPTSAARPLT HPRARNHYPS EDLAEEPLMP
60 70 80 90 100
ASLLLEELQQ TNGQLVNLTR QHDGDTFHTS GLSSACNADT CIGLSSGTAS
110 120 130 140 150
LVRSTGDGSG QGNDGLNPAT SSLGGGQMEL LTRRLKLQKG RGQVANIDAS
160 170 180 190 200
GETGCTCRCL PYQRAYREDL GICVDDIHEC SLSPFVSGSS SEKIPFVFLP
210 220 230 240 250
LKGQIIYPSR EISFASIHTP VCAVTGAQYL GSNGWSDLRN PIDTDYPFRM
260 270 280 290 300
FRDEGRSFLL WLGEADLRQK MQGRLIVVHL VCRDMTVALN ASNHVKGEPL
310 320 330 340 350
MPPRNVHSPC VAFRVNGSPV KYAHNVPEVF FQPANSTTLA STSDGMTMRE
360 370 380 390 400
YVVIGICSLL LGLIYVASVF LYLYMKKRKR HSSRHSLDNL TNDINYPKND
410 420 430 440 450
QVTYGAPFSR VGSIYSSNSM GLGNGNESNT RTSIGSLKED MGIVKNNPLL
460 470 480 490 500
QHFPQLSERE HNSGFASDIS NSNSECEMEE KIKLSKSPKP SGGTDNAAMD
510 520 530 540 550
VDDFLQDNEC LPAENVAVID ELMSEEKLEN LRAMVSGNVR KKLYFNPAYF
560 570 580 590 600
EPHLLAEPPQ AAIEFLQKIR EVIAIAKYKM ASKRYQPSLN IIPEEQHPES
610 620 630 640 650
SSSSPMFNIP LQQSLAGKGM GDKRNSIEQW LQSVPNSDAT PAPKTLDRPA
660 670 680 690 700
PPTAKKPSSG SPNKGSLRKE ISAPKERPPP PPMQKSKADE GNAKSSSPAP
710 720 730 740 750
SGPHSSRSTG KSSPEQSPKP KTNVGSTYEG FSAFSVAANV YGFAETGGEI
760 770 780 790 800
YNNPKFMLAD SPAASLRSAS SRSKSMKKRS EVLDQFAAAN STPTSLTSFD
810 820 830 840 850
RQHYNMLRNM KAPEVIYDSL KREFAAHIPT PDYDSTIEKR IKDIYSSTQS
860 870 880 890 900
SIPSVPTPDY SSLSRKSLKQ FQPDSPIYRR KSPQYLIVDY ETDSLERLEP
910 920 930 940 950
SKRKSSHSSS SPSSDVSSQL SPSLSTALPL EEEMEISHTV YDRMNGFRKE
960 970 980 990 1000
GEMKKRLAAK HQHPHPGQQQ RQKEAAARIK YDTPFRGSMT IEVEHEPPSD
1010 1020 1030 1040 1050
LERTDSDQFE PDTLDRKPKK QSFCDISAWD GHKPIDSDFS QISSLPDLSR
1060 1070 1080 1090 1100
QISPAPNQGI KPRTASFILR SSNSFRNLRE IYESPLIAQD NIKYEKKVAQ
1110 1120 1130 1140 1150
TPEEEGRILT LEAKHSRRQR LMETSPTHSV MDITKVNKTT ITISSPKPAD
1160 1170 1180 1190 1200
KAPPTRPKVN QHYCPPLVQS KRPLPPPPPN SSEHQAPDED AYSLHSEITG
1210 1220 1230 1240 1250
TSEFENSCNN TMSSAISATT EERTHAKGSR SPKINAKIPE EDYEGMYNKK
1260 1270 1280 1290 1300
INSLRNDYSL TKYLNRRKSQ REEVSKAGPD SPKDVAPEPE FGGSNKSVKE
1310 1320 1330 1340 1350
VDVAQFDALS ISSRSNRSSS HLSERTKEMY RNAGVPVGIA YPQRAASSSG
1360 1370 1380 1390 1400
NASAGGNVQT VYRCEIEQAQ LTAGMQIAIG LKDRAKKAKD LKNAWRKFVT
1410 1420 1430 1440 1450
MAANKFSPSQ SPAPTYGSKT AAGFLEDDGI ASIIEDAAQS AGMGQPGSQT
1460 1470 1480 1490 1500
YYEQRFGQLD SGYMSTDSTE LYKRNVYDRY NFKMPCGRGQ IIRVDTIEDN
1510 1520 1530 1540 1550
EEESGPNDNR FEDLEHMVSP SHSRRSPENN AVVACDLSDA ESDKTLTRSH
1560 1570 1580 1590 1600
SQTNSQERNV RGSTTTMSSY SSDENGRGRS TCCGSSETDE ETNAEDMWES
1610
GAESIETHSV LYKMIRKS
Length:1,618
Mass (Da):178,450
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4FF4A698393D018
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7YZF2B7YZF2_DROME
Shavenoid, isoform B
sha Dmel\CG13209, koj, lincRNA.286, Sha, CG13209
1,633Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A1Z8J5A1Z8J5_DROME
Shavenoid, isoform A
sha Dmel\CG13209, koj, lincRNA.286, Sha, CG13209
1,626Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AGB93422.1

NCBI Reference Sequences

More...
RefSeqi
NP_001260889.1, NM_001273960.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0332463; FBpp0304736; FBgn0003382

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36213

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AGB93422.1
RefSeqiNP_001260889.1, NM_001273960.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiFBtr0332463; FBpp0304736; FBgn0003382
GeneIDi36213

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
109556
FlyBaseiFBgn0003382, sha

Phylogenomic databases

OMAiSPTMFNI

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36213, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sh, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36213

Gene expression databases

ExpressionAtlasiA0A0B4KEL5, baseline and differential

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B4KEL5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4KEL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: February 10, 2021
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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