Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 52 (29 Sep 2021)
Sequence version 1 (01 Apr 2015)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Ryanodine receptor, isoform E

Gene

RyR

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorImported
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RyRImported
Synonyms:D-RyRImported, Dmel\CG10844Imported, DmRyRImported, DRRImported, DRYImported, dryImported, dRyRImported, dRyrImported, dyaImported, l(2)k00424Imported, l(2)k04913Imported, Rya-44FImported, Rya-r4Imported, Rya-R44FImported, Rya-r44FImported, rya-r44FImported, Rya-r76CDImported, RYRImported, RyrImported, ryrImported, RyRsImported
ORF Names:CG10844Imported, Dmel_CG10844Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011286, RyR

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0011286

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4449 – 4469HelicalSequence analysisAdd BLAST21
Transmembranei4640 – 4658HelicalSequence analysisAdd BLAST19
Transmembranei4723 – 4745HelicalSequence analysisAdd BLAST23
Transmembranei4912 – 4934HelicalSequence analysisAdd BLAST23
Transmembranei4988 – 5011HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulumARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0B4K837, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 152MIRInterPro annotationAdd BLAST55
Domaini581 – 807B30.2/SPRYInterPro annotationAdd BLAST227
Domaini1036 – 1221B30.2/SPRYInterPro annotationAdd BLAST186
Domaini1456 – 1677B30.2/SPRYInterPro annotationAdd BLAST222

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1420 – 1457DisorderedSequence analysisAdd BLAST38
Regioni1481 – 1515DisorderedSequence analysisAdd BLAST35
Regioni2276 – 2296DisorderedSequence analysisAdd BLAST21
Regioni3584 – 3605DisorderedSequence analysisAdd BLAST22
Regioni3799 – 3821DisorderedSequence analysisAdd BLAST23
Regioni3854 – 3884DisorderedSequence analysisAdd BLAST31
Regioni4533 – 4559DisorderedSequence analysisAdd BLAST27
Regioni4594 – 4613DisorderedSequence analysisAdd BLAST20
Regioni4680 – 4704DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili464 – 484Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1425 – 1457Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi3799 – 3815Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168850

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A0B4K837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAEGGSEQ DDVSFLRTED MVTLSCTATG ERVCLAAEGF GNRHCFLENI
60 70 80 90 100
ADKNVPPDLS QCVFVIEQAL SVRALQELVT AAGSETDSRL GKGTGSGHRT
110 120 130 140 150
LLYGNAILLR HHNSDMYLAC LSTSSSNDKL SFDVGLQEHS QGEACWWTVH
160 170 180 190 200
PASKQRSEGE KVRVGDDLIL VSVATERYLH TTKENEQSIV NASFHVTHWS
210 220 230 240 250
VQPYGTGISR MKYVGYVFGG DVLRFFHGGD ECLTIPSTWG REAGQNIVIY
260 270 280 290 300
EGGVVMAQAR SLWRLELART KWTGGFINWY HPMRIRHITT GRYLGVNDSN
310 320 330 340 350
ELILVKKEEA SIATTTFCLR QEKDDEKKVL EDKDLEVIGS PIIKYGDTTV
360 370 380 390 400
IVQHCETSLW LSYKSYETKK KGVGKVEEKQ AILHEEGKMD DCLDFSRSQE
410 420 430 440 450
EESKTARVIR KCSSLFTQFI TALETLQSNR RHSIFFQKVN LNEMVMCLED
460 470 480 490 500
LINYFSQPED DMEHEEKQNR FRALRNRQDL FQEEGVLNLI LEAIDKINII
510 520 530 540 550
TSQGFLASFL AGDETGQSWD LISTYLYQLL AAIIKGNHTN CAQFANSNRL
560 570 580 590 600
NWLFSRLGSQ ASSEGSGMLD VLHCVLIDSP EALNMMRDEH IKVIISLLEK
610 620 630 640 650
HGRDPKVLDV LCSLCVGNGV AVRSSQNNIC DFLLPGKNLL LQTLLVDHVA
660 670 680 690 700
SIRPNIFVGR VDGSSMYQKW YFEVTMDHIE QTTHMMPHLR IGWANTSGYV
710 720 730 740 750
PYPGGGKKWG GNGVGDDLYS FGFDGAFLWT GGRKTLVVDA LPEEPFIRKG
760 770 780 790 800
DVIGVAIDLS VPIITFTFNG VKVRGSFRDF NLDGMFFPVM SCSSKLSCRF
810 820 830 840 850
LFGGDHGRLK FAPPMGFSAL VQCLMPQQIL SLDPCFYFGN LAKNVLAGPW
860 870 880 890 900
LIEDDTAFVP KPVDTTGVTL PSSVDQIKEK LAENIHEMWA LNKIEAGWSW
910 920 930 940 950
GEHRDDYHRI HPCLTHFEKL PAAEKRYDNQ LAVQTLKTII SLGYYITMDK
960 970 980 990 1000
PPARIRPVRL PNEIFMQGNG YKPAPLDLSA VTLTPKLEEL VDQLAENTHN
1010 1020 1030 1040 1050
LWARERIQQG WTYGLNEDSE NHRSPHLVPY AKVDEAIKKA NRDTASETVR
1060 1070 1080 1090 1100
TLLVYGYVLD PPTGEGTEAL LAEAQRLKFA GFRTYRVERN YAVTSGKWYF
1110 1120 1130 1140 1150
EFEVLTSGPM RVGWARADCY PGAMLGSEDT SWAFDGHNEE KVYGGVSESF
1160 1170 1180 1190 1200
GKQCGPGDIV GVFLDLADHT ISFSLNGELL MDALGGETTF ADVTAEGVGF
1210 1220 1230 1240 1250
VPACTLGVGQ KARLIYGQDV DSLKFFTTCG LQEGYEPFCV NMRRPVTHWY
1260 1270 1280 1290 1300
TKDQPIFENT EEMPDCRIDV TRIPGGADTP PHLKISHNTF ETMEKANWEF
1310 1320 1330 1340 1350
LRLSLPVTCM GEFISEQEKA RRWDEIKNRQ YRLMREAEIA AQMQVQTQAA
1360 1370 1380 1390 1400
HMDHMLKGGF NMNDIKGLTR NFDEHADAEA DHMMRGPNRP PRKGSLTRNI
1410 1420 1430 1440 1450
TFETDMSAAL DEMQRSTSVL DMNGLGEEMD DKKKRGRSPF KFFSKKSRDQ
1460 1470 1480 1490 1500
SREKMGARTL DTSLERRNTV AHGRNVVNQQ MTTRAPTLRL NNAEIPPSPV
1510 1520 1530 1540 1550
PQGPKQLSGS NLGQQPVETS GDEMFDAECL KLINEYFYGV RIFPGQDPTH
1560 1570 1580 1590 1600
VYVGWVTTQY HLHSREFNKN KVRRGSVYIE DDYEMAIERI DRQSCYVVRA
1610 1620 1630 1640 1650
DELFNEVTQD ASGKGASQGM FVGCFVDTAT GIIRFTCEGK DTSHRWMMEP
1660 1670 1680 1690 1700
DTKLFPAIFV EATSKEILQI ELGRTPTTLP LSAAVLPTSD KHINPQSPPR
1710 1720 1730 1740 1750
LKVQCLRPHQ WARVPNTALQ VHALKLSDVR GWSMLCEDPV SMLALHIPEE
1760 1770 1780 1790 1800
DRCIDILELI EMDKLLSFHA HSLTLYAALC YQSNYRAAHA LCQHVDQKQL
1810 1820 1830 1840 1850
LYAIRSEYMS GPLRQGFYDL LIALHLESHA TTMEVCKNEY ITPLGAELKE
1860 1870 1880 1890 1900
LYSDEEMQHS LRSLVTESVR PQLRMTEITE PIPDIDQLYS PKFPLEVVRQ
1910 1920 1930 1940 1950
FVMEALKDAV EINQVHNRDP IGWTNENLFL PLIKLTDRLL LVGVLTDEDV
1960 1970 1980 1990 2000
QRLLVMIDPE TWDQAFEREG KDEHRKGLLT MKMAEGAKLQ MCYLLHHLYD
2010 2020 2030 2040 2050
TQLRHRVESI IAFSHDFVGD LQTDQLRRYI EIKQSDLPSA VAAKKTKEFR
2060 2070 2080 2090 2100
CPPREQMNQI LCFKNLEPDD QDNCTCGLEL RGRLGDFHDS LMQKVSLNAL
2110 2120 2130 2140 2150
QEPDGVEGTA IEEVKTGPIT KIYNFINTVK ELEEGPKEVE EPEKKTPEEV
2160 2170 2180 2190 2200
FRKVLIKTIV SWAEESQIEN PKLVREMFSL LLRQYDTVGE LVRALEKTYV
2210 2220 2230 2240 2250
INTRARDDVA EMWVGLSQIR ALLPVQMSQE EEELMRKRLW KLVNNATFFQ
2260 2270 2280 2290 2300
HPDLIRILRV HENVMAVMMN TLGRRAQAQS DAPTQSEVAE GAPSKEKDTS
2310 2320 2330 2340 2350
HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD FLLDNANILL ARPSLRGSTP
2360 2370 2380 2390 2400
LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE LVEKGYPDLG
2410 2420 2430 2440 2450
WDPVEGERYL DFLRYCVWVN GESVEENANL VIRLLIRRPE CLGPALRGEG
2460 2470 2480 2490 2500
EGLFRAIVEA NRMSERISDR CKMQDEAEGT IAGLNFTHPL PEGEEDEDYI
2510 2520 2530 2540 2550
DTGAAILNFY CTLVDLLGRC APDASVIEQG KNESLRARAI LRSLVPLEDL
2560 2570 2580 2590 2600
QGVLSLKFTL SQTAPGEEKP KSDMPSGLLP NNKQSIVLFL ERVYGIEAQD
2610 2620 2630 2640 2650
LFYRLLEDAF LPDLRTATIL DKSDGSESDM ALAMNRYIGN SILPLLIKHS
2660 2670 2680 2690 2700
KFYNEAENYA SLLDATLHTV YRLSKNRMLT KGQREAVSDF LVALTSQMQP
2710 2720 2730 2740 2750
AMLLKLLRKL TVDVSKLSEY TTVALRLLTL HFDRCAKYYG STQGQGSYGA
2760 2770 2780 2790 2800
SSDEEKRLTM LLFSNIFDSL SNMDYDPELF GKALPCLIAI GCALPPDYSL
2810 2820 2830 2840 2850
SKNTDEDYYG RQMGAPDQPQ YMPNPIDTNN VHLDNDLNSL VQKFSEHYHD
2860 2870 2880 2890 2900
AWASRRLEGG WTYGDIRSDN DRKHPRLKPY NMLSEYERER YRDPVRECLK
2910 2920 2930 2940 2950
GLLAIGWTVE HSEVEVALNH RGSTRRQSKP QINEFQNEGS PFNYNPHPVD
2960 2970 2980 2990 3000
MSNLTLSREM QNMAERLAEN SHDIWAKKKN EELNGCGGVI HPQLVPYDLL
3010 3020 3030 3040 3050
TDKEKKKDRE RSQEFLKYMQ YQGYKLHKPS KGGAVEEGGA TQAAVELRFS
3060 3070 3080 3090 3100
YSLLEKLIQY LDRATINMKL LKPSTTFSRR SSFKTATRDI KFFSKVVLPL
3110 3120 3130 3140 3150
MEKYFSTHRN YFIAIATATN NIGAASLKEK EMVASIFCKL AALLRNRLSA
3160 3170 3180 3190 3200
FGPDVRITVR CLQVLVKGID ARTLTKNCPE FIRTSMLTFF NQTSDDLGNT
3210 3220 3230 3240 3250
ILNLQDGKYS HLRGTHLKTS TSLGYVNQVV LPVLTAMFDH LAACDYGSDL
3260 3270 3280 3290 3300
LLDEIQVASY KILAALYHLG TDGTLTHDRK YLKTEIERHR PALGSCLGAY
3310 3320 3330 3340 3350
SSCFPVAFLE PHLNKHNQYS LLNRIADHSL EAQDIMVKME SCMPNLETIL
3360 3370 3380 3390 3400
AEVDQFVESD KTYNDAPHII DVILPLLCAY LPFWWSQGPD NVSPTSGNHV
3410 3420 3430 3440 3450
TMVTADHMNP LLRNVLKMIK KNIGNDNAPW MTRIAAYTQQ IIINTSEELL
3460 3470 3480 3490 3500
KDPFLPLAER VKKRTENMLH KEDSMRGFIK SATDDTSQVE TQLQEDWNLL
3510 3520 3530 3540 3550
VRDIYSFYPL LIKYVDLQRN HWLKDNIPEA EELYNHVAEI FNIWSKSQYF
3560 3570 3580 3590 3600
LKEEQNFISA NEIDNMALIM PTATRRSAIS EGAPAVGGKV KKKKKNRDKK
3610 3620 3630 3640 3650
RDKDKEVQAS LMVACLKRLL PVGLNLFAGR EQELVQHCKD RYLKKMPEYD
3660 3670 3680 3690 3700
VIEFARNQLT LPDKLDPSDE MSWQHYLYSK LGKTEEPVDE QALEKANVNS
3710 3720 3730 3740 3750
NEKGKDKTQE TVDRIVAMAK VLFGLHMIDH PQQQSKNVYR SVVSIQRKRA
3760 3770 3780 3790 3800
VIACFRQTSL HSLPRHRACN IFARSYYEQW LQEENVGQEV MVEDLTQTFE
3810 3820 3830 3840 3850
DSEKSKKEGE ETDSKPDPLT QLVTTFCRGA MTERSGALQE DLLYMSYAQI
3860 3870 3880 3890 3900
AAKSTGKEEE EGGDEEGGEG GEEGEGTSIH EQEMEKQKLL FHQARLSNRG
3910 3920 3930 3940 3950
VAEMVLLHIS ASKGIPSEMV MTTLNLGIAI LRGGNIDIQM GMLNHLKEKK
3960 3970 3980 3990 4000
DVGFFTSIAG LMNSCSVLDL DAFERNTKAE GLGVGSEGAA GEKNMHDAEF
4010 4020 4030 4040 4050
TCALFRFIQL TCEGHNLEWQ NYLRTQAGNT TTVNVVICTV DYLLRLQESI
4060 4070 4080 4090 4100
MDFYWHYSSK EIIDPAGKAN FFKAIEVASQ VFNTLTEVIQ GPCTLNQQAL
4110 4120 4130 4140 4150
AHSRLWDAVG GFLFLFSHMQ DKLSKHSSQV DLLKELLNLQ KDMITMMLSM
4160 4170 4180 4190 4200
LEGNVVNGTI GKQMVDTLVE SASNVELILK YFDMFLKLAD LIESPSFHEV
4210 4220 4230 4240 4250
DMKNEGWVTP KDFREKMEQS KNYTPEEMDF LLACCERNHE GKIDYRAFVE
4260 4270 4280 4290 4300
HFHEPSKEIG FNLAVLLTNL SEHMPNEPRL ARFLETAGSV LNYFEPFLGR
4310 4320 4330 4340 4350
IEILGSSKRI ERVYFEIKDS NIEQWEKPQI RESKRAFFYS IVTEGGDKEK
4360 4370 4380 4390 4400
LEAFVNFCED AIFEMTHASG LMATDDGGGN VKRDTAYSSY MSEEEEERAA
4410 4420 4430 4440 4450
RDPIRRTITA VKEGLKFGVH MLSPANIKHQ IGVMQTKSIP ELIVGFFKII
4460 4470 4480 4490 4500
FYIFYYTGYA HFCVVRYIFG ILLNLMRGPA PEQEEEPVVE EETFGRALPP
4510 4520 4530 4540 4550
LPLEEPPGTV QAFGLDINKE ENGMYKVVVH ESPANSSMEE GGESSPEDGA
4560 4570 4580 4590 4600
AASGELVEGE PHQEPISIVD LLGGEAAKKA AQERQEAQKA QEAAMASIEA
4610 4620 4630 4640 4650
EAKKSSSAPQ ETPAVHQIDF SQYTHRAVSF LARNFYNLKY VALVLAFSIN
4660 4670 4680 4690 4700
FMLLFYKVTS FTEEADSSAE EELILGSGSG GGADITGSGF GGSGDGGSGD
4710 4720 4730 4740 4750
GEMEDEIPEL VHVDEDFFYM EHVLRIAACL HSLVSLAMLI AYYHLKVPLA
4760 4770 4780 4790 4800
IFKREKEIAR RLEFEGLFIA EQPEDDDFKS HWDKLVISAK SFPVNYWDKF
4810 4820 4830 4840 4850
VKKKVRQKYS ETYDFDSISN LLGMEKSTFA AQESEETGIF KYIMNIDWRY
4860 4870 4880 4890 4900
QVWKAGVTFT DNAFLYSLWY FSFSVMGNFN NFFFAAHLLD VAVGFKTLRT
4910 4920 4930 4940 4950
ILQSVTHNGK QLVLTVMLLT IIVYIYTVIA FNFFRKFYIQ EEDEEVDKKC
4960 4970 4980 4990 5000
HDMLTCFVFH LYKGVRAGGG IGDEIGDPDG DDYEVYRIIF DITFFFFVII
5010 5020 5030 5040 5050
ILLAIIQGLI IDAFGELRDQ LESVKDNMES NCFICGMGKD FFDIVPHGFD
5060 5070 5080 5090 5100
THVQKEHNLA NYMFFLMHLI NKPDTEYTGQ ETYVWNMYQQ RSWDFFPVGD
5110
CFRKQYEDEL SGGGGGG
Length:5,117
Mass (Da):579,959
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FD8F595F8A57B1D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q24498RYR_DROME
Ryanodine receptor
RyR dry, Rya-r44F, CG10844
5,127Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K715A0A0B4K715_DROME
Ryanodine receptor, isoform J
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,115Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K719A0A0B4K719_DROME
Ryanodine receptor, isoform I
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,134Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7U9A0A0B4K7U9_DROME
Ryanodine receptor, isoform G
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,123Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7K0A0A0B4K7K0_DROME
Ryanodine receptor, isoform F
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,119Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6T5A0A0B4K6T5_DROME
Ryanodine receptor, isoform H
RyR D-RyR, Dmel\CG10844, DmRyR, DRR, DRY
5,130Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AFH07962.1

NCBI Reference Sequences

More...
RefSeqi
NP_001246207.1, NM_001259278.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0304568; FBpp0293110; FBgn0011286

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
49090

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AFH07962.1
RefSeqiNP_001246207.1, NM_001259278.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiFBtr0304568; FBpp0293110; FBgn0011286
GeneIDi49090

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
49090
FlyBaseiFBgn0011286, RyR
VEuPathDBiVectorBase:FBgn0011286

Phylogenomic databases

GeneTreeiENSGT00940000168850

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
49090, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
49090

Gene expression databases

ExpressionAtlasiA0A0B4K837, baseline and differential

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 1 hit
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B4K837_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4K837
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: September 29, 2021
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again