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Entry version 42 (11 Dec 2019)
Sequence version 1 (01 Apr 2015)
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Protein
Submitted name:

Ryanodine receptor, isoform G

Gene

RyR

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor, isoform GImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RyRImported
Synonyms:D-RyRImported, Dmel\CG10844Imported, DRRImported, DRYImported, dryImported, dRyRImported, dRyrImported, dyaImported, l(2)k00424Imported, l(2)k04913Imported, Rya-44FImported, Rya-r4Imported, Rya-R44FImported, Rya-r44FImported, rya-r44FImported, Rya-r76CDImported, RYRImported, RyrImported, ryrImported, RyRsImported
ORF Names:CG10844Imported, Dmel_CG10844Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011286 RyR

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4455 – 4475HelicalSequence analysisAdd BLAST21
Transmembranei4646 – 4664HelicalSequence analysisAdd BLAST19
Transmembranei4729 – 4751HelicalSequence analysisAdd BLAST23
Transmembranei4918 – 4940HelicalSequence analysisAdd BLAST23
Transmembranei4994 – 5017HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0B4K7U9 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0B4K7U9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 148MIRInterPro annotationAdd BLAST55
Domaini155 – 200MIRInterPro annotationAdd BLAST46
Domaini210 – 264MIRInterPro annotationAdd BLAST55
Domaini270 – 328MIRInterPro annotationAdd BLAST59
Domaini336 – 394MIRInterPro annotationAdd BLAST59
Domaini577 – 803B30.2/SPRYInterPro annotationAdd BLAST227
Domaini1032 – 1217B30.2/SPRYInterPro annotationAdd BLAST186
Domaini1452 – 1673B30.2/SPRYInterPro annotationAdd BLAST222

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1416 – 1453DisorderedSequence analysisAdd BLAST38
Regioni1477 – 1511DisorderedSequence analysisAdd BLAST35
Regioni2286 – 2306DisorderedSequence analysisAdd BLAST21
Regioni2930 – 2953DisorderedSequence analysisAdd BLAST24
Regioni3590 – 3611DisorderedSequence analysisAdd BLAST22
Regioni3805 – 3827DisorderedSequence analysisAdd BLAST23
Regioni3860 – 3890DisorderedSequence analysisAdd BLAST31
Regioni4539 – 4565DisorderedSequence analysisAdd BLAST27
Regioni4589 – 4619DisorderedSequence analysisAdd BLAST31
Regioni4686 – 4710DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili460 – 480Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1421 – 1453PolyampholyteSequence analysisAdd BLAST33
Compositional biasi2933 – 2953PolarSequence analysisAdd BLAST21
Compositional biasi3805 – 3821PolyampholyteSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2243 Eukaryota
ENOG410YCNW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168850

Database of Orthologous Groups

More...
OrthoDBi
5161at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 1 hit
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A0B4K7U9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAEGGSEQ DDVSFLRTED MVTLSCTATG ERVCLAAEGF GNRHCFLENI
60 70 80 90 100
ADKNVPPDLS QCVFVIEQAL SVRALQELVT AAGSETGKGT GSGHRTLLYG
110 120 130 140 150
NAILLRHHNS DMYLACLSTS SSNDKLSFDV GLQEHSQGEA CWWTVHPASK
160 170 180 190 200
QRSEGEKVRV GDDLILVSVA TERYLHTTKE NEQSIVNASF HVTHWSVQPY
210 220 230 240 250
GTGISRMKYV GYVFGGDVLR FFHGGDECLT IPSTWGREAG QNIVIYEGGV
260 270 280 290 300
VMAQARSLWR LELARTKWTG GFINWYHPMR IRHITTGRYL GVNDSNELIL
310 320 330 340 350
VKKEEASIAT TTFCLRQEKD DEKKVLEDKD LEVIGSPIIK YGDTTVIVQH
360 370 380 390 400
CETSLWLSYK SYETKKKGVG KVEEKQAILH EEGKMDDCLD FSRSQEEESK
410 420 430 440 450
TARVIRKCSS LFTQFITALE TLQSNRRHSI FFQKVNLNEM VMCLEDLINY
460 470 480 490 500
FSQPEDDMEH EEKQNRFRAL RNRQDLFQEE GVLNLILEAI DKINIITSQG
510 520 530 540 550
FLASFLAGDE TGQSWDLIST YLYQLLAAII KGNHTNCAQF ANSNRLNWLF
560 570 580 590 600
SRLGSQASSE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
610 620 630 640 650
PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTL LVDHVASIRP
660 670 680 690 700
NIFVGRVDGS SMYQKWYFEV TMDHIEQTTH MMPHLRIGWA NTSGYVPYPG
710 720 730 740 750
GGKKWGGNGV GDDLYSFGFD GAFLWTGGRK TLVVDALPEE PFIRKGDVIG
760 770 780 790 800
VAIDLSVPII TFTFNGVKVR GSFRDFNLDG MFFPVMSCSS KLSCRFLFGG
810 820 830 840 850
DHGRLKFAPP MGFSALVQCL MPQQILSLDP CFYFGNLAKN VLAGPWLIED
860 870 880 890 900
DTAFVPKPVD TTGVTLPSSV DQIKEKLAEN IHEMWALNKI EAGWSWGEHR
910 920 930 940 950
DDYHRIHPCL THFEKLPAAE KRYDNQLAVQ TLKTIISLGY YITMDKPPAR
960 970 980 990 1000
IRPVRLPNEI FMQGNGYKPA PLDLSAVTLT PKLEELVDQL AENTHNLWAR
1010 1020 1030 1040 1050
ERIQQGWTYG LNEDSENHRS PHLVPYAKVD EAIKKANRDT ASETVRTLLV
1060 1070 1080 1090 1100
YGYVLDPPTG EGTEALLAEA QRLKFAGFRT YRVERNYAVT SGKWYFEFEV
1110 1120 1130 1140 1150
LTSGPMRVGW ARADCYPGAM LGSEDTSWAF DGHNVTKMHA GSIEHFGVRY
1160 1170 1180 1190 1200
EAGDVIGCFI DVKEQTISFS LNGELLMDAL GGETTFADVT AEGVGFVPAC
1210 1220 1230 1240 1250
TLGVGQKARL IYGQDVDSLK FFTTCGLQEG YEPFCVNMRR PVTHWYTKDQ
1260 1270 1280 1290 1300
PIFENTEEMP DCRIDVTRIP GGADTPPHLK ISHNTFETME KANWEFLRLS
1310 1320 1330 1340 1350
LPVTCMGEFI SEQEKARRWD EIKNRQYRLM REAEIAAQMQ VQTQAAHMDH
1360 1370 1380 1390 1400
MLKGGFNMND IKGLTRNFDE HADAEADHMM RGPNRPPRKG SLTRNITFET
1410 1420 1430 1440 1450
DMSAALDEMQ RSTSVLDMNG LGEEMDDKKK RGRSPFKFFS KKSRDQSREK
1460 1470 1480 1490 1500
MGARTLDTSL ERRNTVAHGR NVVNQQMTTR APTLRLNNAE IPPSPVPQGP
1510 1520 1530 1540 1550
KQLSGSNLGQ QPVETSGDEM FDAECLKLIN EYFYGVRIFP GQDPTHVYVG
1560 1570 1580 1590 1600
WVTTQYHLHS REFNKNKVRR GSVYIEDDYE MAIERIDRQS CYVVRADELF
1610 1620 1630 1640 1650
NEVTQDASGK GASQGMFVGC FVDTATGIIR FTCEGKDTSH RWMMEPDTKL
1660 1670 1680 1690 1700
FPAIFVEATS KEILQIELGR TPTTLPLSAA VLPTSDKHIN PQSPPRLKVQ
1710 1720 1730 1740 1750
CLRPHQWARV PNTALQVHAL KLSDVRGWSM LCEDPVSMLA LHIPEEDRCI
1760 1770 1780 1790 1800
DILELIEMDK LLSFHAHSLT LYAALCYQSN YRAAHALCQH VDQKQLLYAI
1810 1820 1830 1840 1850
RSEYMSGPLR QGFYDLLIAL HLESHATTME VCKNEYITPL GAELKELYSD
1860 1870 1880 1890 1900
EEMQHSLRSL VTESVRPQLR MTEITPPVIA TSSMPSVSSE PIPDIDQLYS
1910 1920 1930 1940 1950
PKFPLEVVRQ FVMEALKDAV EINQVHNRDP IGWTNENLFL PLIKLTDRLL
1960 1970 1980 1990 2000
LVGVLTDEDV QRLLVMIDPE TWDQAFEREG KDEHRKGLLT MKMAEGAKLQ
2010 2020 2030 2040 2050
MCYLLHHLYD TQLRHRVESI IAFSHDFVGD LQTDQLRRYI EIKQSDLPSA
2060 2070 2080 2090 2100
VAAKKTKEFR CPPREQMNQI LCFKNLEPDD QDNCTCGLEL RGRLGDFHDS
2110 2120 2130 2140 2150
LMQKVSLNAL QEPDGVEGTA IEEVKTGPIT KIYNFINTVK ELEEGPKEVE
2160 2170 2180 2190 2200
EPEKKTPEEV FRKVLIKTIV SWAEESQIEN PKLVREMFSL LLRQYDTVGE
2210 2220 2230 2240 2250
LVRALEKTYV INTRARDDVA EMWVGLSQIR ALLPVQMSQE EEELMRKRLW
2260 2270 2280 2290 2300
KLVNNATFFQ HPDLIRILRV HENVMAVMMN TLGRRAQAQS DAPTQSEVAE
2310 2320 2330 2340 2350
GAPSKEKDTS HEMVVACCRF LCYFCRTGRQ NQKAMFDHFD FLLDNANILL
2360 2370 2380 2390 2400
ARPSLRGSTP LDVAYSSLME NTELALALRE HYLEKIAVYL SRCGLQSNSE
2410 2420 2430 2440 2450
LVEKGYPDLG WDPVEGERYL DFLRYCVWVN GESVEENANL VIRLLIRRPE
2460 2470 2480 2490 2500
CLGPALRGEG EGLFRAIVEA NRMSERISDR CKMQDEAEGT IAGLNFTHPL
2510 2520 2530 2540 2550
PEGEEDEDYI DTGAAILNFY CTLVDLLGRC APDASVIEQG KNESLRARAI
2560 2570 2580 2590 2600
LRSLVPLEDL QGVLSLKFTL SQTAPGEEKP KSDMPSGLLP NNKQSIVLFL
2610 2620 2630 2640 2650
ERVYGIEAQD LFYRLLEDAF LPDLRTATIL DKSDGSESDM ALAMNRYIGN
2660 2670 2680 2690 2700
SILPLLIKHS KFYNEAENYA SLLDATLHTV YRLSKNRMLT KGQREAVSDF
2710 2720 2730 2740 2750
LVALTSQMQP AMLLKLLRKL TVDVSKLSEY TTVALRLLTL HFDRCAKYYG
2760 2770 2780 2790 2800
STQGQGSYGA SSDEEKRLTM LLFSNIFDSL SNMDYDPELF GKALPCLIAI
2810 2820 2830 2840 2850
GCALPPDYSL SKNTDEDYYG RQMGAPDQPQ YMPNPIDTNN VHLDNDLNSL
2860 2870 2880 2890 2900
VQKFSEHYHD AWASRRLEGG WTYGDIRSDN DRKHPRLKPY NMLSEYERER
2910 2920 2930 2940 2950
YRDPVRECLK GLLAIGWTVE HSEVEVALNH RGSTRRQSKP QINEGSPFNY
2960 2970 2980 2990 3000
NPHPVDMSNL TLSREMQNMA ERLAENSHDI WAKKKNEELN GCGGVIHPQL
3010 3020 3030 3040 3050
VPYDLLTDKE KKKDRERSQE FLKYMQYQGY KLHKPSKGGA VEEGGATQAA
3060 3070 3080 3090 3100
VELRFSYSLL EKLIQYLDRA TINMKLLKPS TTFSRRSSFK TATRDIKFFS
3110 3120 3130 3140 3150
KVVLPLMEKY FSTHRNYFIA IATATNNIGA ASLKEKEMVA SIFCKLAALL
3160 3170 3180 3190 3200
RNRLSAFGPD VRITVRCLQV LVKGIDARTL TKNCPEFIRT SMLTFFNQTS
3210 3220 3230 3240 3250
DDLGNTILNL QDGKYSHLRG THLKTSTSLG YVNQVVLPVL TAMFDHLAAC
3260 3270 3280 3290 3300
DYGSDLLLDE IQVASYKILA ALYHLGTDGT LTHDRKYLKT EIERHRPALG
3310 3320 3330 3340 3350
SCLGAYSSCF PVAFLEPHLN KHNQYSLLNR IADHSLEAQD IMVKMESCMP
3360 3370 3380 3390 3400
NLETILAEVD QFVESDKTYN DAPHIIDVIL PLLCAYLPFW WSQGPDNVSP
3410 3420 3430 3440 3450
TSGNHVTMVT ADHMNPLLRN VLKMIKKNIG NDNAPWMTRI AAYTQQIIIN
3460 3470 3480 3490 3500
TSEELLKDPF LPLAERVKKR TENMLHKEDS MRGFIKSATD DTSQVETQLQ
3510 3520 3530 3540 3550
EDWNLLVRDI YSFYPLLIKY VDLQRNHWLK DNIPEAEELY NHVAEIFNIW
3560 3570 3580 3590 3600
SKSQYFLKEE QNFISANEID NMALIMPTAT RRSAISEGAP AVGGKVKKKK
3610 3620 3630 3640 3650
KNRDKKRDKD KEVQASLMVA CLKRLLPVGL NLFAGREQEL VQHCKDRYLK
3660 3670 3680 3690 3700
KMPEYDVIEF ARNQLTLPDK LDPSDEMSWQ HYLYSKLGKT EEPVDEQALE
3710 3720 3730 3740 3750
KANVNSNEKG KDKTQETVDR IVAMAKVLFG LHMIDHPQQQ SKNVYRSVVS
3760 3770 3780 3790 3800
IQRKRAVIAC FRQTSLHSLP RHRACNIFAR SYYEQWLQEE NVGQEVMVED
3810 3820 3830 3840 3850
LTQTFEDSEK SKKEGEETDS KPDPLTQLVT TFCRGAMTER SGALQEDLLY
3860 3870 3880 3890 3900
MSYAQIAAKS TGKEEEEGGD EEGGEGGEEG EGTSIHEQEM EKQKLLFHQA
3910 3920 3930 3940 3950
RLSNRGVAEM VLLHISASKG IPSEMVMTTL NLGIAILRGG NIDIQMGMLN
3960 3970 3980 3990 4000
HLKEKKDVGF FTSIAGLMNS CSVLDLDAFE RNTKAEGLGV GSEGAAGEKN
4010 4020 4030 4040 4050
MHDAEFTCAL FRFIQLTCEG HNLEWQNYLR TQAGNTTTVN VVICTVDYLL
4060 4070 4080 4090 4100
RLQESIMDFY WHYSSKEIID PAGKANFFKA IEVASQVFNT LTEVIQGPCT
4110 4120 4130 4140 4150
LNQQALAHSR LWDAVGGFLF LFSHMQDKLS KHSSQVDLLK ELLNLQKDMI
4160 4170 4180 4190 4200
TMMLSMLEGN VVNGTIGKQM VDTLVESASN VELILKYFDM FLKLADLIES
4210 4220 4230 4240 4250
PSFHEVDMKN EGWVTPKDFR EKMEQSKNYT PEEMDFLLAC CERNHEGKID
4260 4270 4280 4290 4300
YRAFVEHFHE PSKEIGFNLA VLLTNLSEHM PNEPRLARFL ETAGSVLNYF
4310 4320 4330 4340 4350
EPFLGRIEIL GSSKRIERVY FEIKDSNIEQ WEKPQIRESK RAFFYSIVTE
4360 4370 4380 4390 4400
GGDKEKLEAF VNFCEDAIFE MTHASGLMAT DDGGGNVKRD TAYSSYMSEE
4410 4420 4430 4440 4450
EEERAARDPI RRTITAVKEG LKFGVHMLSP ANIKHQIGVM QTKSIPELIV
4460 4470 4480 4490 4500
GFFKIIFYIF YYTGYAHFCV VRYIFGILLN LMRGPAPEQE EEPVVEEETF
4510 4520 4530 4540 4550
GRALPPLPLE EPPGTVQAFG LDINKEENGM YKVVVHESPA NSSMEEGGES
4560 4570 4580 4590 4600
SPEDGAAASG ELVEGEPHQE PISIVDLLGG EAAKKAAQER QEAQKAQEAA
4610 4620 4630 4640 4650
MASIEAEAKK SSSAPQETPA VHQIDFSQYT HRAVSFLARN FYNLKYVALV
4660 4670 4680 4690 4700
LAFSINFMLL FYKVTSFTEE ADSSAEEELI LGSGSGGGAD ITGSGFGGSG
4710 4720 4730 4740 4750
DGGSGDGEME DEIPELVHVD EDFFYMEHVL RIAACLHSLV SLAMLIAYYH
4760 4770 4780 4790 4800
LKVPLAIFKR EKEIARRLEF EGLFIAEQPE DDDFKSHWDK LVISAKSFPV
4810 4820 4830 4840 4850
NYWDKFVKKK VRQKYSETYD FDSISNLLGM EKSTFAAQES EETGIFKYIM
4860 4870 4880 4890 4900
NIDWRYQVWK AGVTFTDNAF LYSLWYFSFS VMGNFNNFFF AAHLLDVAVG
4910 4920 4930 4940 4950
FKTLRTILQS VTHNGKQLVL TVMLLTIIVY IYTVIAFNFF RKFYIQEEDE
4960 4970 4980 4990 5000
EVDKKCHDML TCFVFHLYKG VRAGGGIGDE IGDPDGDDYE VYRIIFDITF
5010 5020 5030 5040 5050
FFFVIIILLA IIQGLIIDAF GELRDQLESV KDNMESNCFI CGMGKDFFDI
5060 5070 5080 5090 5100
VPHGFDTHVQ KEHNLANYMF FLMHLINKPD TEYTGQETYV WNMYQQRSWD
5110 5120
FFPVGDCFRK QYEDELSGGG GGG
Length:5,123
Mass (Da):580,494
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD285E1503A170E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q24498RYR_DROME
Ryanodine receptor
RyR dry, Rya-r44F, CG10844
5,127Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K715A0A0B4K715_DROME
Ryanodine receptor, isoform J
RyR D-RyR, Dmel\CG10844, DRR, DRY, dry
5,115Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6T5A0A0B4K6T5_DROME
Ryanodine receptor, isoform H
RyR D-RyR, Dmel\CG10844, DRR, DRY, dry
5,130Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K719A0A0B4K719_DROME
Ryanodine receptor, isoform I
RyR D-RyR, Dmel\CG10844, DRR, DRY, dry
5,134Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7K0A0A0B4K7K0_DROME
Ryanodine receptor, isoform F
RyR D-RyR, Dmel\CG10844, DRR, DRY, dry
5,119Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K837A0A0B4K837_DROME
Ryanodine receptor, isoform E
RyR D-RyR, Dmel\CG10844, DRR, DRY, dry
5,117Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AFH07964.1

NCBI Reference Sequences

More...
RefSeqi
NP_001246209.1, NM_001259280.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0304570; FBpp0293112; FBgn0011286

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
49090

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AFH07964.1
RefSeqiNP_001246209.1, NM_001259280.1

3D structure databases

SMRiA0A0B4K7U9
ModBaseiSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0304570; FBpp0293112; FBgn0011286
GeneIDi49090

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
49090
FlyBaseiFBgn0011286 RyR

Phylogenomic databases

eggNOGiKOG2243 Eukaryota
ENOG410YCNW LUCA
GeneTreeiENSGT00940000168850
OrthoDBi5161at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
49090

Gene expression databases

ExpressionAtlasiA0A0B4K7U9 baseline and differential

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR011992 EF-hand-dom_pair
IPR014821 Ins145_P3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR009460 Ryanrecept_TM4-6
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF06459 RR_TM4-6, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 1 hit
SSF47473 SSF47473, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B4K7U9_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4K7U9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: December 11, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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