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Entry version 52 (02 Jun 2021)
Sequence version 1 (01 Apr 2015)
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Protein
Submitted name:

Gartenzwerg, isoform C

Gene

garz

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: FlyBase

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Gartenzwerg, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:garzImported
Synonyms:angImported, ARF1GEFImported, ArfGEFImported, CG 8487Imported, Dmel\CG8487Imported, GarzImported, GBF1Imported, GEFImported
ORF Names:CG8487Imported, Dmel_CG8487Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0264560, garz

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0B4K7N0, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0B4K7N0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini636 – 828SEC7InterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni226 – 261DisorderedSequence analysisAdd BLAST36
Regioni561 – 589DisorderedSequence analysisAdd BLAST29
Regioni1243 – 1287DisorderedSequence analysisAdd BLAST45
Regioni1388 – 1418DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi228 – 259Polar residuesSequence analysisAdd BLAST32
Compositional biasi1388 – 1405Basic and acidic residuesSequence analysisAdd BLAST18

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
DESVCEM

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00171, Sec7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1000.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
IPR032691, Sec7_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01369, Sec7, 1 hit
PF12783, Sec7_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222, Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48425, SSF48425, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50190, SEC7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0B4K7N0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPGNGIYV VRGEMATLMT AMRRGTRWNA TAYVDDENDS LLKLFIDLKH
60 70 80 90 100
ELNRIEDLRQ IEPQVFLAPF LEVIRTADAT GPLTSLALAS VNKLLSYGLI
110 120 130 140 150
DPTSPNLADI VERIADAVTH ARFMGTDQSS DGVTFMRVIE VLHTLIRSPE
160 170 180 190 200
GAAVSNVSMC EVMLSCFKIS FEPRLSELLR RSAEKSLKDM VLLFFMRLPQ
210 220 230 240 250
FAEERSDTML QKRFTIGDAA SGATQEKLKR KTVAQAQTAP RKSSAVEEPP
260 270 280 290 300
QTPQSANLTV PGHLKAPILA TTPASPAGNI LDMQGKITQT PTTTASTGED
310 320 330 340 350
ETTVPETPVI QVESTESEPL LDGETGEATS TLAEANSSEY INSVGVRFTQ
360 370 380 390 400
QSTDHDVTSL SPYGLPFIQE LFRFLIILCN PLDKQNSDSM MHTGLSLLTV
410 420 430 440 450
AFEVAADNIG KYEGLLELVK DDLCRNLISL LSSERLSIFA ADLQLCFLLF
460 470 480 490 500
ESLRGHLKFQ LEAYLRKLSE IIASDNPKTP YEMRELALDN LLQLWRIPGF
510 520 530 540 550
VTELYINYDC DLYCTDMFES LTNLLSKYTL SATNAVYSTH IISMDTLLSV
560 570 580 590 600
IDSIERNCAA SKNSSNNRES LPEAAPATGG SRHSRHNSGL EGIVIDSGNS
610 620 630 640 650
VAAEEKVENI ASFINASSHR LRLQSGGEGV GITSEQLAKV KQKKRLLSQG
660 670 680 690 700
TERFNQRPEK GIQYLQEHGI LNAELDPMQV ALFLRENPGL DKKMIGEYIS
710 720 730 740 750
KKKNVDSKIL INFVDSFDFT GLRVDQALRL YLETFRLPGE APLIFLVLEH
760 770 780 790 800
FSDHWHKQNQ DPFANVDAAF RLAYAIIMLN MDQHNSNAKR LNVPMTLEDF
810 820 830 840 850
TKNLRGLNGG EDFDQEMLAQ VFNAIKNEEI VMPAEQTGLV RENYQWKVLL
860 870 880 890 900
RRGDTHDGHF HYVHDASYDV EIFNIVWGAS LSALSFMFDK STETGYQRTL
910 920 930 940 950
AGFSKSAAIS AHYNLHSDFD ALVLTLCKFT TLLSSVEQHE PAPANNETQQ
960 970 980 990 1000
AVNFGLNGKA QAAMRTVFLL VHDYGDCLRE SWKHILDLYL QLFRLKLLPK
1010 1020 1030 1040 1050
SLIEVEDFCE ANGKAMLILE KPREKQESGL FSSLYSFISS EGQREPTYEE
1060 1070 1080 1090 1100
QDFIKLGRKC IKECQLDQML QESKFVQLES LQELLKCVLA LLKAPQGHKS
1110 1120 1130 1140 1150
IGLPYAEDQT VFWMEFLVKI VVHNRDRMIP LWPAVRDQMY LLLMGSASCG
1160 1170 1180 1190 1200
YDYLLNRCIV AVLKLAIYLM RNEELCPIVL QSLKMLLMLK PALLLRISKQ
1210 1220 1230 1240 1250
ISIGIYELLK TSAQNIHSEQ DWQIIFNLLE CVGAGAVPPN YDDAQLPLPP
1260 1270 1280 1290 1300
NGSAKSDGAI SGEEDATAVP ERGYTSDSEI TKASAAPAVS SPSAENWILV
1310 1320 1330 1340 1350
NNKDSELTTA SRPQSPPSLS APPVNTLVYN CQLLDHAPFA LFKCWDSLAF
1360 1370 1380 1390 1400
IVRSVAHITP YNFEACVRCI RIFVEACRDG GIRQRRKLES AAKQKSSKKR
1410 1420 1430 1440 1450
SERKPGMASS ASSSNLTLLT GDPSDNQING NAAEQEDLAQ RYEQLSIQLL
1460 1470 1480 1490 1500
DLMYTLYTRT AQIFRWWAEE GCTVPQSAAL WSPGWCPLLQ GIARLAMDRR
1510 1520 1530 1540 1550
REVRTHAISC LQQRALLVHD LQTLSGTEWC SCFHQVLFPL LNELLPESNA
1560 1570 1580 1590 1600
AGQLDAALLE ESRIRTATIM SKVFLQHLTT LIELGNAFNE LWLDILDYIE
1610 1620 1630 1640 1650
RFMKVGSDTL SEQMQEILKN MLLVMHSVRV FHNQDGSLQQ ALWELTWRRI
1660 1670 1680 1690 1700
GEFLPNLKEE LFHDEADSIT PAVSLDYTQI RFAHSTGTTD YSLSLPLYGY
1710 1720 1730 1740
SPKISSISAS KCDTLPATQR KKPWAKLRSK LKLLKKVGKK N
Length:1,741
Mass (Da):194,940
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE388661246BA920
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A1Z8W8A1Z8W8_DROME
Gartenzwerg, isoform B
garz ang, ARF1GEF, ArfGEF, CG 8487, Dmel\CG8487
1,983Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A1Z8W9A1Z8W9_DROME
Gartenzwerg, isoform A
garz ang, ARF1GEF, ArfGEF, CG 8487, Dmel\CG8487
1,740Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AFH08032.1

NCBI Reference Sequences

More...
RefSeqi
NP_001246278.1, NM_001259349.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0305075; FBpp0293612; FBgn0264560

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
36337

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8487

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AFH08032.1
RefSeqiNP_001246278.1, NM_001259349.2

3D structure databases

SMRiA0A0B4K7N0
ModBaseiSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0305075; FBpp0293612; FBgn0264560
GeneIDi36337
KEGGidme:Dmel_CG8487

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
36337
FlyBaseiFBgn0264560, garz

Phylogenomic databases

OMAiDESVCEM

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
36337, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
36337

Gene expression databases

ExpressionAtlasiA0A0B4K7N0, baseline and differential

Family and domain databases

CDDicd00171, Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR023394, Sec7_C_sf
IPR000904, Sec7_dom
IPR035999, Sec7_dom_sf
IPR032691, Sec7_N
PfamiView protein in Pfam
PF01369, Sec7, 1 hit
PF12783, Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222, Sec7, 1 hit
SUPFAMiSSF48425, SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190, SEC7, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B4K7N0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4K7N0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 1, 2015
Last sequence update: April 1, 2015
Last modified: June 2, 2021
This is version 52 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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