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UniProtKB - A0A0B4K7J2 (RBP2_DROME)

Entry version 50 (02 Dec 2020)
Sequence version 1 (01 Apr 2015)
Previous versions | rss
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Protein

E3 SUMO-protein ligase RanBP2

Gene

Nup358

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope (PubMed:17682050). Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway (PubMed:27979731, PubMed:17682050, PubMed:17682050). Plays a role in nuclear mRNA export by recruiting the mRNA transport complex composed of Nxt1 and sbr/Nxf1 to the NPC (PubMed:14729961). Essential during germline development for transposon silencing and piRNA biogenesis probably by regulating piwi localization to the nucleus (PubMed:29735528). During oogenesis, required to form granules that modulate the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769).By similarity6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1770 – 1799RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri1890 – 1919RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processmRNA transport, Protein transport, Translocation, Transport, Ubl conjugation pathway
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 SUMO-protein ligase RanBP2Curated (EC:2.3.2.-By similarity)
Alternative name(s):
358 kDa nucleoporinImported
Nuclear pore complex protein Nup358Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup358Imported
Synonyms:RanBP21 Publication
ORF Names:CG11856Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0039302, Nup358

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown abolishes embryonic development (PubMed:31626769). RNAi-mediated knockdown in the larval fat body reduces the levels of importin beta and disrupts the nuclear import of the sesquiterpenoid juvenile hormone receptor Met and juvenile hormone signal transduction (PubMed:27979731). RNAi-mediated knockdown in the germarium results in failed piwi localization to the nucleus, failed transposon silencing and piRNA biogenesis, increased DNA damage levels and overall defective ovaries (PubMed:29735528). RNAi-mediated knockdown in egg chambers reduces numbers of annulate lamellae containing nuclear pore complex components (PubMed:31626769).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004437331 – 2718E3 SUMO-protein ligase RanBP2Add BLAST2718

Keywords - PTMi

Isopeptide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A0A0B4K7J2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in both oocytes and nurse cells (at protein level).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during embryogenesis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0039302, Expressed in eye disc (Drosophila) and 38 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VBU7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the nuclear pore complex (By similarity).

Forms a complex with Nxt1, sbr/Nxf1 and RanGAP (PubMed:14729961).

Interacts (via TPR repeats) with Hsp83; the interaction is required for the nuclear import of the sesquiterpenoid juvenile hormone receptor Met (PubMed:27979731).

Interacts (via N-terminus) with piwi (PubMed:29735528).

By similarity3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A0A0B4K7J2, 3 interactors

Molecular INTeraction database

More...MINTi		A0A0B4K7J2

STRING: functional protein association networks

More...STRINGi		7227.FBpp0293235

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A0B4K7J2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati26 – 58TPR 1Sequence analysisAdd BLAST33
Repeati59 – 94TPR 2Sequence analysisAdd BLAST36
Repeati808 – 8091Curated2
Repeati1028 – 10292Curated2
Repeati1035 – 10363Curated2
Repeati1104 – 11054Curated2
Repeati1252 – 12535Curated2
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1309 – 1445RanBD1 1PROSITE-ProRule annotationAdd BLAST137
Repeati1506 – 15076Curated2
Repeati1539 – 15407Curated2
Repeati1547 – 15488Curated2
Repeati1552 – 15539Curated2
Domaini1605 – 1742RanBD1 2PROSITE-ProRule annotationAdd BLAST138
Repeati1763 – 176410Curated2
Repeati1826 – 182711Curated2
Repeati1842 – 184312Curated2
Repeati1874 – 187513Curated2
Repeati1883 – 188414Curated2
Repeati1942 – 194315Curated2
Repeati1944 – 194516Curated2
Domaini2019 – 2151RanBD1 3PROSITE-ProRule annotationAdd BLAST133
Repeati2260 – 226117Curated2
Repeati2313 – 231418Curated2
Repeati2332 – 233319Curated2
Repeati2352 – 235320Curated2
Repeati2360 – 236121Curated2
Repeati2366 – 236722Curated2
Repeati2393 – 239423Curated2
Repeati2399 – 240024Curated2
Repeati2415 – 241625Curated2
Repeati2421 – 242226Curated2
Domaini2556 – 2699RanBD1 4PROSITE-ProRule annotationAdd BLAST144
Repeati2580 – 258127Curated2

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 200Sufficient for interaction with piwi1 PublicationAdd BLAST200
Regioni1 – 100Sufficient for interaction with Hsp831 PublicationAdd BLAST100
Regioni808 – 258127 X 2 AA repeats of F-GCuratedAdd BLAST1774

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi939 – 1011Gln-richPROSITE-ProRule annotationAdd BLAST73
Compositional biasi1016 – 1240Pro-richPROSITE-ProRule annotationAdd BLAST225

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RanBP2 E3 ligase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1770 – 1799RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri1890 – 1919RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0864, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00900000141073

Identification of Orthologs from Complete Genome Data

More...OMAi		FRFVDKE

Database for complete collections of gene phylogenies

More...PhylomeDBi		A0A0B4K7J2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit
2.30.29.30, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993, PH-like_dom_sf
IPR000156, Ran_bind_dom
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00638, Ran_BP1, 4 hits
PF00641, zf-RanBP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00160, RanBD, 4 hits
SM00547, ZnF_RBZ, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit
SSF90209, SSF90209, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50196, RANBD1, 4 hits
PS50293, TPR_REGION, 1 hit
PS01358, ZF_RANBP2_1, 2 hits
PS50199, ZF_RANBP2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform BImported (identifier: A0A0B4K7J2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFTTRKEVDA HVHKMLGKLQ PGRERDIKGL AVARLYMKVQ EYPKAIEYLN 
        60         70         80         90        100
GYLRVRDDAV GHNMIATCYS RLNPPDVTEA LQHYQRSIQI DPRQSEVVID 
       110        120        130        140        150
ACELLVKENN ASITECARYW LDQANSLDLS GNKQVFNLRM RVNLADSNGE 
       160        170        180        190        200
RDDTSGGDGE QNTLEILMYK ELQARPQDVN IRIQLLRSYV EKMKIDQAFN 
       210        220        230        240        250
YALKTELESK NCTSQSNEWY EQIWMVLFKI EMAKDVKKNW RFWHFALHTL 
       260        270        280        290        300
DRLVQLSLEG SGLADSSKQL FRLDQYLFKF STSIERSGDA PQRDLHQACI 
       310        320        330        340        350
DHFTGQLLLH AVTLIFKREV LANKNKWMST LRSALPLLLL GYQVRPIDDS 
       360        370        380        390        400
STNQWIKHCD AEQKQLIQMW RPQGAFRCAQ LGRTLLGCLD RSQMEIKNDR 
       410        420        430        440        450
ENAEFDENKN SGNSMPGLFA DSEELLASAH QQCLDKSWRS QIYQQLFTHA 
       460        470        480        490        500
EHKLKDTSSH LVRNLRLQLP LFEWPNLAHI ENYELQALVL PPHSLAQHVY 
       510        520        530        540        550
LALGTDPNKL GDAPRVVFYE GFQRDVKQNL NYCGQDSISQ VDVDLYLYAT 
       560        570        580        590        600
TIQTRRKLQI QREVYDSSNL GNRNAAARPH MMPFANLVGQ LGAPEQSNWW 
       610        620        630        640        650
DLVVRLNSNQ LITEGNRAEQ RAQLQHGLEA VRGVNGPKAD AIIIFQLGKI 
       660        670        680        690        700
LNSRSDRSSL EARIDTLYRQ GFSILRHQHN QQMESYVRVF KYGSAGSTAA 
       710        720        730        740        750
WQDLQSLAEE AVTYFSEKMF RIGQYEQFLD EVRGLHLPMA YFLQSEACHH 
       760        770        780        790        800
LEESSKLPRT SRDRYSERRR ECLQKTQKLI KNDDKHPLIA AMHRHQQDRN 
       810        820        830        840        850
SRGIDNSFGS PDVHNNSSAY EDAEDDFYSH AAFSANRSRR QLEVTPVTPI 
       860        870        880        890        900
VMAQPSQEME QAVKQISKSL CVLKDDVSVG MEAMRQDIKV LTEKFTGLED 
       910        920        930        940        950
LLKKIKISSR DTPTRDVDPA AALGLDDLFI IEDALAEHQQ QQQHQQQQSH 
       960        970        980        990       1000
NQGAIHPVVP NPYTSGFYNG MPNTPSAQER FLQGPYGSPM FNQNQMYNYY 
      1010       1020       1030       1040       1050
AAQAQAQAQA QFLRTPPAPG SIPPPNMFGP RNPNFGLPSM FPPPTVPSVA 
      1060       1070       1080       1090       1100
PYIDAMGNFT QPPPSLIPPP AQPAAPPAPL NILESKPVVA LPTPGFFNTT 
      1110       1120       1130       1140       1150
TPVFGASPIQ VPQSKPLTVP TVPIPSTAPA PPIAGTVNPP ATTAVPPPVH 
      1160       1170       1180       1190       1200
IPQVAPSVPA QPPAPAPVSV PSMFNRALNN QPVEKEPPAN VVITSSDPLP 
      1210       1220       1230       1240       1250
KPTTASVQPT LSVTIPAQHI KPSLVQAPEQ PAQSAQPAQP SVSGVGSLSF 
      1260       1270       1280       1290       1300
NFGSKSSESP FSFKTQVAKA AAEKQKEQEE AEQNQSGATD PNKTLPQDTS 
      1310       1320       1330       1340       1350
ADDYDPRPDF KPIIPLPDEV EVRTGEEGED IKFTSRAKLF RYVDKEWKER 
      1360       1370       1380       1390       1400
GTGVIKILCD KATGVSRVLM RRDQTHKVCA NHTITADITI NVANQDKDKK 
      1410       1420       1430       1440       1450
SLLWAANDFA DEQVTLERFL VRFKTGELAE EFRVAFTKAS EAAKSKETVK 
      1460       1470       1480       1490       1500
PTVNTAEKGS TATAPAAFKS FVTSTPAANS LINKPQEQTK TQPNPDPPAT 
      1510       1520       1530       1540       1550
AAKSLFGTLS VSAAPATSAP ASATPFASFS FTPNGSSGFG TSTASPFGNL 
      1560       1570       1580       1590       1600
SFGTASAVGS GNNTTLFTTA LIKDNTVQGK TLQQESQLNK SNSSDAEEEY 
      1610       1620       1630       1640       1650
VPTAQFVPVI ALPDIVEVVT GEENEDVLFE HRAKLLRWDK EANEWKERGL 
      1660       1670       1680       1690       1700
GNMKLLRDRT DPNKVRLLMR REQVHKLCCN QRLLPETKFT YATNCKAAVT 
      1710       1720       1730       1740       1750
WGAQDYSDEE LTTALLAVRF KSQDICQQFL EAVQKAQQSI GNEPKKEEVP 
      1760       1770       1780       1790       1800
SAAGEKEKPI KGFGDAFKPK AGSWNCQACY TNNGQDQLYC LACQEPKDAT 
      1810       1820       1830       1840       1850
VPPKQSGLDQ GNALNLTTSS SNKFSFGFAS SATLPATGGF SFGGATQPKE 
      1860       1870       1880       1890       1900
KPAVAVVTAS ASAPTSVQTA ALGFGKSSMT SGFGDAFKPA VGSWSCSACY 
      1910       1920       1930       1940       1950
VNNPGESLYC SACDAPKNDT VPQKEKSLGS GLNLPPTSKF SFGFGAAAAG 
      1960       1970       1980       1990       2000
DKDQAGDGAT FNFAAMPAAV APTTSIGSSS FTFSMTKPKP DQQQPNSTAA 
      2010       2020       2030       2040       2050
KEDEDNDSQE VEEEENNTYF SPVIPLPDKI DVKTGEEDEE LLYVHKAKLY 
      2060       2070       2080       2090       2100
RLNESDWKER GLGDVKILRH RQTKKLRVVM RREQVFKICL NHVLNENVVY 
      2110       2120       2130       2140       2150
REKTETSWMF AVHDFSEGES VLERFTLRFK NKEVAQGFME AIKNALNETA 
      2160       2170       2180       2190       2200
KPIEDSPVVG SVSQSTEANK PSQKNDGAAK SRGGESEVLD VGKTSSVRPT 
      2210       2220       2230       2240       2250
THEVIPPLPM TLPLLTLPQP LAKPNDYQTP ATILFKGSSL SRNNSSASEA 
      2260       2270       2280       2290       2300
SKTPSSAFIF GSTDKSEPGK DAGPLANLQK LASGEGQGNV LGSIFRSGSS 
      2310       2320       2330       2340       2350
NENSSDGSVK FFFGGGNKAA EQQKKDSSES VFGGNKADSQ SPATQEAPKL 
      2360       2370       2380       2390       2400
AFGGIAAPVF GDANPFGGHK VNLQKSDGKE EPKSIIGGTP LLFGGSNAFG 
      2410       2420       2430       2440       2450
IPKIETQSPA KDFVFGSAPA FGQMATFSFT AAKNEKEKDI TSNNTTDLKA 
      2460       2470       2480       2490       2500
EGKEKKELVP ETTSTFADLA KTGSTFADLA SNPGGTFADL ANKTGNDFAN 
      2510       2520       2530       2540       2550
LSANSQGTTV GFNKSAGGGF YNLTHQNAFK NFESPQATEE CDDDGDATTD 
      2560       2570       2580       2590       2600
DNYDPHYDAI VELPDEIVVT TGEENETKLF GERAKLYRYD AESKQWKERG 
      2610       2620       2630       2640       2650
VGEIKVLEHP ELQTFRLIMR QEQIHKLVLN MNISASLQMD YMNAQMKSFL 
      2660       2670       2680       2690       2700
WAGYNYAVDA EGKVDTEGVL ERLACRFAKE EIASEFLNTV NSCIKRAKAL 
      2710 
QGDEENKNDD APEEQASS
Length:2,718
Mass (Da):298,931
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9921196A7C964A7C
GO
Isoform AImported (identifier: A0A0B4K7J2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2197-2219: Missing.

Show »
Length:2,695
Mass (Da):296,385
Checksum:i85F6B929E4261BAA
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM11383 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0595172197 – 2219Missing in isoform A. Add BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014297 Genomic DNA Translation: AFH06619.1
AE014297 Genomic DNA Translation: AAF56430.2
BT100062 mRNA Translation: ACX61603.1
AY095055 mRNA Translation: AAM11383.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_001247302.1, NM_001260373.2 [A0A0B4K7J2-1]
NP_651361.2, NM_143104.3 [A0A0B4K7J2-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0084813; FBpp0084188; FBgn0039302 [A0A0B4K7J2-2]
FBtr0304692; FBpp0293235; FBgn0039302 [A0A0B4K7J2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		43041

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG11856

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AFH06619.1
AE014297 Genomic DNA Translation: AAF56430.2
BT100062 mRNA Translation: ACX61603.1
AY095055 mRNA Translation: AAM11383.1 Different initiation.
RefSeqiNP_001247302.1, NM_001260373.2 [A0A0B4K7J2-1]
NP_651361.2, NM_143104.3 [A0A0B4K7J2-2]

3D structure databases

SMRiA0A0B4K7J2
ModBaseiSearch...

Protein-protein interaction databases

IntActiA0A0B4K7J2, 3 interactors
MINTiA0A0B4K7J2
STRINGi7227.FBpp0293235

Proteomic databases

PaxDbiA0A0B4K7J2

Genome annotation databases

EnsemblMetazoaiFBtr0084813; FBpp0084188; FBgn0039302 [A0A0B4K7J2-2]
FBtr0304692; FBpp0293235; FBgn0039302 [A0A0B4K7J2-1]
GeneIDi43041
KEGGidme:Dmel_CG11856

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		43041
FlyBaseiFBgn0039302, Nup358

Phylogenomic databases

eggNOGiKOG0864, Eukaryota
GeneTreeiENSGT00900000141073
OMAiFRFVDKE
PhylomeDBiA0A0B4K7J2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		43041, 2 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Nup358, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		43041

Protein Ontology

More...PROi		PR:A0A0B4K7J2

Gene expression databases

BgeeiFBgn0039302, Expressed in eye disc (Drosophila) and 38 other tissues
GenevisibleiQ9VBU7, DM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.30.29.30, 4 hits
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR000156, Ran_bind_dom
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PfamiView protein in Pfam
PF00638, Ran_BP1, 4 hits
PF00641, zf-RanBP, 2 hits
SMARTiView protein in SMART
SM00160, RanBD, 4 hits
SM00547, ZnF_RBZ, 2 hits
SUPFAMiSSF48452, SSF48452, 1 hit
SSF90209, SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50196, RANBD1, 4 hits
PS50293, TPR_REGION, 1 hit
PS01358, ZF_RANBP2_1, 2 hits
PS50199, ZF_RANBP2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBP2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4K7J2
Secondary accession number(s): D3DMF2, Q8SWV7, Q9VBU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2018
Last sequence update: April 1, 2015
Last modified: December 2, 2020
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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