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Entry version 50 (02 Dec 2020)
Sequence version 1 (01 Apr 2015)
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Protein

E3 SUMO-protein ligase RanBP2

Gene

Nup358

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope (PubMed:17682050). Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway (PubMed:27979731, PubMed:17682050, PubMed:17682050). Plays a role in nuclear mRNA export by recruiting the mRNA transport complex composed of Nxt1 and sbr/Nxf1 to the NPC (PubMed:14729961). Essential during germline development for transposon silencing and piRNA biogenesis probably by regulating piwi localization to the nucleus (PubMed:29735528). During oogenesis, required to form granules that modulate the biogenesis of annulate lamellae containing nuclear pore complex components (PubMed:31626769).By similarity6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1770 – 1799RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri1890 – 1919RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processmRNA transport, Protein transport, Translocation, Transport, Ubl conjugation pathway
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 SUMO-protein ligase RanBP2Curated (EC:2.3.2.-By similarity)
Alternative name(s):
358 kDa nucleoporinImported
Nuclear pore complex protein Nup358Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nup358Imported
Synonyms:RanBP21 Publication
ORF Names:CG11856Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0039302, Nup358

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown abolishes embryonic development (PubMed:31626769). RNAi-mediated knockdown in the larval fat body reduces the levels of importin beta and disrupts the nuclear import of the sesquiterpenoid juvenile hormone receptor Met and juvenile hormone signal transduction (PubMed:27979731). RNAi-mediated knockdown in the germarium results in failed piwi localization to the nucleus, failed transposon silencing and piRNA biogenesis, increased DNA damage levels and overall defective ovaries (PubMed:29735528). RNAi-mediated knockdown in egg chambers reduces numbers of annulate lamellae containing nuclear pore complex components (PubMed:31626769).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004437331 – 2718E3 SUMO-protein ligase RanBP2Add BLAST2718

Keywords - PTMi

Isopeptide bond, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A0B4K7J2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in both oocytes and nurse cells (at protein level).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during embryogenesis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0039302, Expressed in eye disc (Drosophila) and 38 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VBU7, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the nuclear pore complex (By similarity).

Forms a complex with Nxt1, sbr/Nxf1 and RanGAP (PubMed:14729961).

Interacts (via TPR repeats) with Hsp83; the interaction is required for the nuclear import of the sesquiterpenoid juvenile hormone receptor Met (PubMed:27979731).

Interacts (via N-terminus) with piwi (PubMed:29735528).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A0A0B4K7J2, 3 interactors

Molecular INTeraction database

More...
MINTi
A0A0B4K7J2

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0293235

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0B4K7J2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati26 – 58TPR 1Sequence analysisAdd BLAST33
Repeati59 – 94TPR 2Sequence analysisAdd BLAST36
Repeati808 – 8091Curated2
Repeati1028 – 10292Curated2
Repeati1035 – 10363Curated2
Repeati1104 – 11054Curated2
Repeati1252 – 12535Curated2
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1309 – 1445RanBD1 1PROSITE-ProRule annotationAdd BLAST137
Repeati1506 – 15076Curated2
Repeati1539 – 15407Curated2
Repeati1547 – 15488Curated2
Repeati1552 – 15539Curated2
Domaini1605 – 1742RanBD1 2PROSITE-ProRule annotationAdd BLAST138
Repeati1763 – 176410Curated2
Repeati1826 – 182711Curated2
Repeati1842 – 184312Curated2
Repeati1874 – 187513Curated2
Repeati1883 – 188414Curated2
Repeati1942 – 194315Curated2
Repeati1944 – 194516Curated2
Domaini2019 – 2151RanBD1 3PROSITE-ProRule annotationAdd BLAST133
Repeati2260 – 226117Curated2
Repeati2313 – 231418Curated2
Repeati2332 – 233319Curated2
Repeati2352 – 235320Curated2
Repeati2360 – 236121Curated2
Repeati2366 – 236722Curated2
Repeati2393 – 239423Curated2
Repeati2399 – 240024Curated2
Repeati2415 – 241625Curated2
Repeati2421 – 242226Curated2
Domaini2556 – 2699RanBD1 4PROSITE-ProRule annotationAdd BLAST144
Repeati2580 – 258127Curated2

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 200Sufficient for interaction with piwi1 PublicationAdd BLAST200
Regioni1 – 100Sufficient for interaction with Hsp831 PublicationAdd BLAST100
Regioni808 – 258127 X 2 AA repeats of F-GCuratedAdd BLAST1774

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi939 – 1011Gln-richPROSITE-ProRule annotationAdd BLAST73
Compositional biasi1016 – 1240Pro-richPROSITE-ProRule annotationAdd BLAST225

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RanBP2 E3 ligase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1770 – 1799RanBP2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri1890 – 1919RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0864, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141073

Identification of Orthologs from Complete Genome Data

More...
OMAi
FRFVDKE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A0A0B4K7J2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
2.30.29.30, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993, PH-like_dom_sf
IPR000156, Ran_bind_dom
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00638, Ran_BP1, 4 hits
PF00641, zf-RanBP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00160, RanBD, 4 hits
SM00547, ZnF_RBZ, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit
SSF90209, SSF90209, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50196, RANBD1, 4 hits
PS50293, TPR_REGION, 1 hit
PS01358, ZF_RANBP2_1, 2 hits
PS50199, ZF_RANBP2_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform BImported (identifier: A0A0B4K7J2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFTTRKEVDA HVHKMLGKLQ PGRERDIKGL AVARLYMKVQ EYPKAIEYLN
60 70 80 90 100
GYLRVRDDAV GHNMIATCYS RLNPPDVTEA LQHYQRSIQI DPRQSEVVID
110 120 130 140 150
ACELLVKENN ASITECARYW LDQANSLDLS GNKQVFNLRM RVNLADSNGE
160 170 180 190 200
RDDTSGGDGE QNTLEILMYK ELQARPQDVN IRIQLLRSYV EKMKIDQAFN
210 220 230 240 250
YALKTELESK NCTSQSNEWY EQIWMVLFKI EMAKDVKKNW RFWHFALHTL
260 270 280 290 300
DRLVQLSLEG SGLADSSKQL FRLDQYLFKF STSIERSGDA PQRDLHQACI
310 320 330 340 350
DHFTGQLLLH AVTLIFKREV LANKNKWMST LRSALPLLLL GYQVRPIDDS
360 370 380 390 400
STNQWIKHCD AEQKQLIQMW RPQGAFRCAQ LGRTLLGCLD RSQMEIKNDR
410 420 430 440 450
ENAEFDENKN SGNSMPGLFA DSEELLASAH QQCLDKSWRS QIYQQLFTHA
460 470 480 490 500
EHKLKDTSSH LVRNLRLQLP LFEWPNLAHI ENYELQALVL PPHSLAQHVY
510 520 530 540 550
LALGTDPNKL GDAPRVVFYE GFQRDVKQNL NYCGQDSISQ VDVDLYLYAT
560 570 580 590 600
TIQTRRKLQI QREVYDSSNL GNRNAAARPH MMPFANLVGQ LGAPEQSNWW
610 620 630 640 650
DLVVRLNSNQ LITEGNRAEQ RAQLQHGLEA VRGVNGPKAD AIIIFQLGKI
660 670 680 690 700
LNSRSDRSSL EARIDTLYRQ GFSILRHQHN QQMESYVRVF KYGSAGSTAA
710 720 730 740 750
WQDLQSLAEE AVTYFSEKMF RIGQYEQFLD EVRGLHLPMA YFLQSEACHH
760 770 780 790 800
LEESSKLPRT SRDRYSERRR ECLQKTQKLI KNDDKHPLIA AMHRHQQDRN
810 820 830 840 850
SRGIDNSFGS PDVHNNSSAY EDAEDDFYSH AAFSANRSRR QLEVTPVTPI
860 870 880 890 900
VMAQPSQEME QAVKQISKSL CVLKDDVSVG MEAMRQDIKV LTEKFTGLED
910 920 930 940 950
LLKKIKISSR DTPTRDVDPA AALGLDDLFI IEDALAEHQQ QQQHQQQQSH
960 970 980 990 1000
NQGAIHPVVP NPYTSGFYNG MPNTPSAQER FLQGPYGSPM FNQNQMYNYY
1010 1020 1030 1040 1050
AAQAQAQAQA QFLRTPPAPG SIPPPNMFGP RNPNFGLPSM FPPPTVPSVA
1060 1070 1080 1090 1100
PYIDAMGNFT QPPPSLIPPP AQPAAPPAPL NILESKPVVA LPTPGFFNTT
1110 1120 1130 1140 1150
TPVFGASPIQ VPQSKPLTVP TVPIPSTAPA PPIAGTVNPP ATTAVPPPVH
1160 1170 1180 1190 1200
IPQVAPSVPA QPPAPAPVSV PSMFNRALNN QPVEKEPPAN VVITSSDPLP
1210 1220 1230 1240 1250
KPTTASVQPT LSVTIPAQHI KPSLVQAPEQ PAQSAQPAQP SVSGVGSLSF
1260 1270 1280 1290 1300
NFGSKSSESP FSFKTQVAKA AAEKQKEQEE AEQNQSGATD PNKTLPQDTS
1310 1320 1330 1340 1350
ADDYDPRPDF KPIIPLPDEV EVRTGEEGED IKFTSRAKLF RYVDKEWKER
1360 1370 1380 1390 1400
GTGVIKILCD KATGVSRVLM RRDQTHKVCA NHTITADITI NVANQDKDKK
1410 1420 1430 1440 1450
SLLWAANDFA DEQVTLERFL VRFKTGELAE EFRVAFTKAS EAAKSKETVK
1460 1470 1480 1490 1500
PTVNTAEKGS TATAPAAFKS FVTSTPAANS LINKPQEQTK TQPNPDPPAT
1510 1520 1530 1540 1550
AAKSLFGTLS VSAAPATSAP ASATPFASFS FTPNGSSGFG TSTASPFGNL
1560 1570 1580 1590 1600
SFGTASAVGS GNNTTLFTTA LIKDNTVQGK TLQQESQLNK SNSSDAEEEY
1610 1620 1630 1640 1650
VPTAQFVPVI ALPDIVEVVT GEENEDVLFE HRAKLLRWDK EANEWKERGL
1660 1670 1680 1690 1700
GNMKLLRDRT DPNKVRLLMR REQVHKLCCN QRLLPETKFT YATNCKAAVT
1710 1720 1730 1740 1750
WGAQDYSDEE LTTALLAVRF KSQDICQQFL EAVQKAQQSI GNEPKKEEVP
1760 1770 1780 1790 1800
SAAGEKEKPI KGFGDAFKPK AGSWNCQACY TNNGQDQLYC LACQEPKDAT
1810 1820 1830 1840 1850
VPPKQSGLDQ GNALNLTTSS SNKFSFGFAS SATLPATGGF SFGGATQPKE
1860 1870 1880 1890 1900
KPAVAVVTAS ASAPTSVQTA ALGFGKSSMT SGFGDAFKPA VGSWSCSACY
1910 1920 1930 1940 1950
VNNPGESLYC SACDAPKNDT VPQKEKSLGS GLNLPPTSKF SFGFGAAAAG
1960 1970 1980 1990 2000
DKDQAGDGAT FNFAAMPAAV APTTSIGSSS FTFSMTKPKP DQQQPNSTAA
2010 2020 2030 2040 2050
KEDEDNDSQE VEEEENNTYF SPVIPLPDKI DVKTGEEDEE LLYVHKAKLY
2060 2070 2080 2090 2100
RLNESDWKER GLGDVKILRH RQTKKLRVVM RREQVFKICL NHVLNENVVY
2110 2120 2130 2140 2150
REKTETSWMF AVHDFSEGES VLERFTLRFK NKEVAQGFME AIKNALNETA
2160 2170 2180 2190 2200
KPIEDSPVVG SVSQSTEANK PSQKNDGAAK SRGGESEVLD VGKTSSVRPT
2210 2220 2230 2240 2250
THEVIPPLPM TLPLLTLPQP LAKPNDYQTP ATILFKGSSL SRNNSSASEA
2260 2270 2280 2290 2300
SKTPSSAFIF GSTDKSEPGK DAGPLANLQK LASGEGQGNV LGSIFRSGSS
2310 2320 2330 2340 2350
NENSSDGSVK FFFGGGNKAA EQQKKDSSES VFGGNKADSQ SPATQEAPKL
2360 2370 2380 2390 2400
AFGGIAAPVF GDANPFGGHK VNLQKSDGKE EPKSIIGGTP LLFGGSNAFG
2410 2420 2430 2440 2450
IPKIETQSPA KDFVFGSAPA FGQMATFSFT AAKNEKEKDI TSNNTTDLKA
2460 2470 2480 2490 2500
EGKEKKELVP ETTSTFADLA KTGSTFADLA SNPGGTFADL ANKTGNDFAN
2510 2520 2530 2540 2550
LSANSQGTTV GFNKSAGGGF YNLTHQNAFK NFESPQATEE CDDDGDATTD
2560 2570 2580 2590 2600
DNYDPHYDAI VELPDEIVVT TGEENETKLF GERAKLYRYD AESKQWKERG
2610 2620 2630 2640 2650
VGEIKVLEHP ELQTFRLIMR QEQIHKLVLN MNISASLQMD YMNAQMKSFL
2660 2670 2680 2690 2700
WAGYNYAVDA EGKVDTEGVL ERLACRFAKE EIASEFLNTV NSCIKRAKAL
2710
QGDEENKNDD APEEQASS
Length:2,718
Mass (Da):298,931
Last modified:April 1, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9921196A7C964A7C
GO
Isoform AImported (identifier: A0A0B4K7J2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2197-2219: Missing.

Show »
Length:2,695
Mass (Da):296,385
Checksum:i85F6B929E4261BAA
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM11383 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0595172197 – 2219Missing in isoform A. Add BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014297 Genomic DNA Translation: AFH06619.1
AE014297 Genomic DNA Translation: AAF56430.2
BT100062 mRNA Translation: ACX61603.1
AY095055 mRNA Translation: AAM11383.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_001247302.1, NM_001260373.2 [A0A0B4K7J2-1]
NP_651361.2, NM_143104.3 [A0A0B4K7J2-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0084813; FBpp0084188; FBgn0039302 [A0A0B4K7J2-2]
FBtr0304692; FBpp0293235; FBgn0039302 [A0A0B4K7J2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
43041

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG11856

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AFH06619.1
AE014297 Genomic DNA Translation: AAF56430.2
BT100062 mRNA Translation: ACX61603.1
AY095055 mRNA Translation: AAM11383.1 Different initiation.
RefSeqiNP_001247302.1, NM_001260373.2 [A0A0B4K7J2-1]
NP_651361.2, NM_143104.3 [A0A0B4K7J2-2]

3D structure databases

SMRiA0A0B4K7J2
ModBaseiSearch...

Protein-protein interaction databases

IntActiA0A0B4K7J2, 3 interactors
MINTiA0A0B4K7J2
STRINGi7227.FBpp0293235

Proteomic databases

PaxDbiA0A0B4K7J2

Genome annotation databases

EnsemblMetazoaiFBtr0084813; FBpp0084188; FBgn0039302 [A0A0B4K7J2-2]
FBtr0304692; FBpp0293235; FBgn0039302 [A0A0B4K7J2-1]
GeneIDi43041
KEGGidme:Dmel_CG11856

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43041
FlyBaseiFBgn0039302, Nup358

Phylogenomic databases

eggNOGiKOG0864, Eukaryota
GeneTreeiENSGT00900000141073
OMAiFRFVDKE
PhylomeDBiA0A0B4K7J2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
43041, 2 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nup358, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43041

Protein Ontology

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PROi
PR:A0A0B4K7J2

Gene expression databases

BgeeiFBgn0039302, Expressed in eye disc (Drosophila) and 38 other tissues
GenevisibleiQ9VBU7, DM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.30.29.30, 4 hits
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR000156, Ran_bind_dom
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PfamiView protein in Pfam
PF00638, Ran_BP1, 4 hits
PF00641, zf-RanBP, 2 hits
SMARTiView protein in SMART
SM00160, RanBD, 4 hits
SM00547, ZnF_RBZ, 2 hits
SUPFAMiSSF48452, SSF48452, 1 hit
SSF90209, SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50196, RANBD1, 4 hits
PS50293, TPR_REGION, 1 hit
PS01358, ZF_RANBP2_1, 2 hits
PS50199, ZF_RANBP2_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBP2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4K7J2
Secondary accession number(s): D3DMF2, Q8SWV7, Q9VBU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2018
Last sequence update: April 1, 2015
Last modified: December 2, 2020
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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