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Entry version 37 (11 Dec 2019)
Sequence version 1 (04 Mar 2015)
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Protein
Submitted name:

Tetratricopeptide repeat protein 21A

Gene

TTC21A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tetratricopeptide repeat protein 21AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC21AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168026.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30761 TTC21A

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000168026

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A0B4J1Y2

PeptideAtlas

More...
PeptideAtlasi
A0A0B4J1Y2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168026 Expressed in 122 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0B4J1Y2 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A0A0B4J1Y2, 4 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 180TPR_REGIONInterPro annotationAdd BLAST71
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati110 – 143TPRPROSITE-ProRule annotationAdd BLAST34
Domaini326 – 359TPR_REGIONInterPro annotationAdd BLAST34
Repeati326 – 359TPRPROSITE-ProRule annotationAdd BLAST34
Domaini494 – 598TPR_REGIONInterPro annotationAdd BLAST105
Repeati494 – 527TPRPROSITE-ProRule annotationAdd BLAST34
Domaini721 – 1017TPR_REGIONInterPro annotationAdd BLAST297
Repeati721 – 754TPRPROSITE-ProRule annotationAdd BLAST34
Repeati755 – 788TPRPROSITE-ProRule annotationAdd BLAST34
Repeati882 – 915TPRPROSITE-ProRule annotationAdd BLAST34
Repeati950 – 983TPRPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1108 – 1143DisorderedSequence analysisAdd BLAST36

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEX1 Eukaryota
ENOG410XV69 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005979

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR040364 TTC21A/TTC21B

The PANTHER Classification System

More...
PANTHERi
PTHR14699 PTHR14699, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A0B4J1Y2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSNDSSLMA GIIYYSQEKY FHHVQQAAAV GLEKFSNDPV LKFFKAYGVL
60 70 80 90 100
KEEHIQDAIS DLESIRHHPD VSLCSTMALI YAHKRCEIID REAIQELEYS
110 120 130 140 150
LKEIRKTVSG TALYYAGLFL WLIGRHDKAK EYIDRMLKIS RGFREAYVLR
160 170 180 190 200
GWVDLTSDKP HTAKKAIEYL EQGIQDTKDV LGLMGKAMYF MMQQNYSEAL
210 220 230 240 250
EVVNQITVTS GSFLPALVLK MQLFLARQDW EQTVEMGHRI LEKDESNIDA
260 270 280 290 300
CQILTVHELA REGNMTTATN HVRNLIKALE TREPENPSLH LKKIIVVSRL
310 320 330 340 350
CGSHQVILGL VCSFIERTFM ATPSYVHVAT ELGYLFILKN QVKEALLWYS
360 370 380 390 400
EAMKLDKDGM AGLTGIILCH ILEGHLEEAE YRLEFLKEVQ KSLGKSEVLI
410 420 430 440 450
FLQALLMSRK HKGEEETTAL LKEAVELHFS SMQGIPLGSE YFEKLDPYFL
460 470 480 490 500
VCIAKEYLLF CPKQPRLPGQ IVSPLLKQVA VILNPVVKAA PALIDPLYLM
510 520 530 540 550
AQVRYYSGEL ENAQSILQRC LELDPASVDA HLLMCQIYLA QGNFGMCFHC
560 570 580 590 600
LELGVSHNFQ VRDHPLYHLI KARALNKAGD YPEAIKTLKM VIKLPALKKE
610 620 630 640 650
EGRKFLRPSV QPSQRASILL ELVEALRLNG ELHEATKVMQ DTINEFGGTP
660 670 680 690 700
EENRITIANV DLVLSKGNVD VALNMLRNIL PKQSCYMEAR EKMANIYLQT
710 720 730 740 750
LRDRRLYIRC YRELCEHLPG PHTSLLLGDA LMSILEPEKA LEVYDEAYRQ
760 770 780 790 800
NPHDASLASR IGHAYVKAHQ YTEAIEYYEA AQKINGQDFL CCDLGKLLLK
810 820 830 840 850
LKKVNKAEKV LKQALEHDIV QDIPSMMNDV KCLLLLAKVY KSHKKEAVIE
860 870 880 890 900
TLNKALDLQS RILKRVPLEQ PEMIPSQKQL AASICIQFAE HYLAEKEYDK
910 920 930 940 950
AVQSYKDVFS YLPTDNKVML ELAQLYLLQG HLDLCEQHCA ILLQTEQNHE
960 970 980 990 1000
TASVLMADLM FRKQKHEAAI NLYHQVLEKA PDNFLVLHKL IDLLRRSGKL
1010 1020 1030 1040 1050
EDIPAFFELA KKVSSRVPLE PGFNYCRGIY CWHIGQPNEA LKFLNKARKD
1060 1070 1080 1090 1100
STWGQSAIYH MVQICLNPDN EVVGGEAFEN QGAESNYMEK KELEQQGVST
1110 1120 1130 1140
AEKLLQGQRP CPAGLGTSLR VPEADPQGAY AVEAPGQDPL GAE
Length:1,143
Mass (Da):129,686
Last modified:March 4, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49BCC87B7EA8BD57
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NDW8TT21A_HUMAN
Tetratricopeptide repeat protein 21...
TTC21A STI2
1,320Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH51A0A0C4DH51_HUMAN
Tetratricopeptide repeat protein 21...
TTC21A
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDN4F8WDN4_HUMAN
Tetratricopeptide repeat protein 21...
TTC21A
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC092053 Genomic DNA No translation available.
AC138124 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000430597; ENSP00000405396; ENSG00000168026

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092053 Genomic DNA No translation available.
AC138124 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA0A0B4J1Y2, 4 interactors

Proteomic databases

jPOSTiA0A0B4J1Y2
PeptideAtlasiA0A0B4J1Y2

Genome annotation databases

EnsembliENST00000430597; ENSP00000405396; ENSG00000168026

Organism-specific databases

EuPathDBiHostDB:ENSG00000168026.16
HGNCiHGNC:30761 TTC21A
OpenTargetsiENSG00000168026

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEX1 Eukaryota
ENOG410XV69 LUCA
GeneTreeiENSGT00390000005979

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTC21A human

Gene expression databases

BgeeiENSG00000168026 Expressed in 122 organ(s), highest expression level in right uterine tube
ExpressionAtlasiA0A0B4J1Y2 baseline and differential

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR040364 TTC21A/TTC21B
PANTHERiPTHR14699 PTHR14699, 1 hit
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 12 hits
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B4J1Y2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4J1Y2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 4, 2015
Last sequence update: March 4, 2015
Last modified: December 11, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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