UniProtKB - A0A0B4J1G6 (A0A0B4J1G6_MOUSE)
Protein
Submitted name:
T-cell immunoreceptor with Ig and ITIM domains
Gene
Tigit
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- signaling receptor binding Source: Ensembl
GO - Biological processi
- negative regulation of interleukin-12 production Source: Ensembl
- negative regulation of T cell activation Source: Ensembl
- positive regulation of interleukin-10 production Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: T-cell immunoreceptor with Ig and ITIM domainsImported |
Gene namesi | Name:TigitImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3642260, Tigit |
Subcellular locationi
Other locations
- cell surface Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 140 – 162 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_5002092569 | 17 – 241 | Sequence analysisAdd BLAST | 225 |
Proteomic databases
EPDi | A0A0B4J1G6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000071552, Expressed in spleen and 32 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
- signaling receptor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 110 | Ig-likeInterPro annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 176 – 214 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 185 – 206 | PolarSequence analysisAdd BLAST | 22 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00390000012671 |
HOGENOMi | CLU_073090_0_0_1 |
OMAi | LGRSMRW |
OrthoDBi | 1484731at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR042948, TIGIT |
PANTHERi | PTHR47734, PTHR47734, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A0B4J1G6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHGWLLLVWV QGLIQAAFLA TGATAGTIDT KRNISAEEGG SVILQCHFSS
60 70 80 90 100
DTAEVTQVDW KQQDQLLAIY SVDLGWHVAS VFSDRVVPGP SLGLTFQSLT
110 120 130 140 150
MNDTGEYFCT YHTYPGGIYK GRIFLKVQES SVAQFQTAPL GGTMAAVLGL
160 170 180 190 200
ICLMVTGVTV LARKKSIRMH SIESGLGRTE AEPQEWNLRS LSSPGSPVQT
210 220 230 240
QTAPAGPCGE QAEDDYADPQ EYFNVLSYRS LESFIAVSKT G
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP86176 | TIGIT_MOUSE | T-cell immunoreceptor with Ig and I... | Tigit Vstm3 | 249 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120871 Genomic DNA No translation available. AC154408 Genomic DNA No translation available. |
RefSeqi | NP_001139797.1, NM_001146325.1 |
Genome annotation databases
Ensembli | ENSMUST00000096065; ENSMUSP00000093770; ENSMUSG00000071552 |
GeneIDi | 100043314 |
KEGGi | mmu:100043314 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC120871 Genomic DNA No translation available. AC154408 Genomic DNA No translation available. |
RefSeqi | NP_001139797.1, NM_001146325.1 |
3D structure databases
SMRi | A0A0B4J1G6 |
ModBasei | Search... |
Proteomic databases
EPDi | A0A0B4J1G6 |
Protocols and materials databases
Antibodypediai | 53759, 355 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000096065; ENSMUSP00000093770; ENSMUSG00000071552 |
GeneIDi | 100043314 |
KEGGi | mmu:100043314 |
Organism-specific databases
CTDi | 201633 |
MGIi | MGI:3642260, Tigit |
Phylogenomic databases
GeneTreei | ENSGT00390000012671 |
HOGENOMi | CLU_073090_0_0_1 |
OMAi | LGRSMRW |
OrthoDBi | 1484731at2759 |
Miscellaneous databases
BioGRID-ORCSi | 100043314, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000071552, Expressed in spleen and 32 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR042948, TIGIT |
PANTHERi | PTHR47734, PTHR47734, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0B4J1G6_MOUSE | |
Accessioni | A0A0B4J1G6Primary (citable) accession number: A0A0B4J1G6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 4, 2015 |
Last sequence update: | March 4, 2015 | |
Last modified: | December 2, 2020 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |