Fcgr4

Functionⁱ

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059).6 Publications

GO - Molecular functionⁱ

IgE binding Source: UniProtKB-KW
IgE receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17558411
- 18949059
IgG binding Source: UniProtKB-KW
IgG receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16039578
- 17558411

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to lipopolysaccharide Source: MGI
neutrophil activation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18097064
positive regulation of bone resorption
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25824719
regulation of sensory perception of pain Source: MGI
wound healing Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	IgE-binding protein, IgG-binding protein, Receptor

Molecular function

IgE-binding protein, IgG-binding protein, Receptor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins R-MMU-2029481 FCGR activation R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-2029485 Role of phospholipids in phagocytosis R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-2029481 FCGR activation
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485 Role of phospholipids in phagocytosis
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Low affinity immunoglobulin gamma Fc region receptor IVImported Alternative name(s): CD16-21 Publication FcgammaRIV1 Publication
Gene namesⁱ	Name:Fcgr4Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:2179523 Fcgr4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 203	ExtracellularCuratedAdd BLAST	183
Transmembraneⁱ	204 – 224	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	225 – 249	CytoplasmicCuratedAdd BLAST	25

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	235	Y → W: Abolishes receptor ligation-induced phosphorylation. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_5008204824	21 – 249	Low affinity immunoglobulin gamma Fc region receptor IVSequence analysisAdd BLAST		229

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	46 ↔ 88	PROSITE-ProRule annotation
Glycosylationⁱ	62	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	127 ↔ 171	PROSITE-ProRule annotation
Glycosylationⁱ	164	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	179	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Modified residueⁱ	235	PhosphotyrosineCombined sources1 Publication	1

Post-translational modificationⁱ

N-glycosylated.2 Publications

Phosphorylated following receptor ligation.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	A0A0B4J1G0
PRIDEⁱ	A0A0B4J1G0

PTM databases

iPTMnetⁱ	A0A0B4J1G0
PhosphoSitePlusⁱ	A0A0B4J1G0

Expressionⁱ

Tissue specificityⁱ

Detected on myeloid cells, peripheral blood monocytes, splenic and bone marrow dendritic cells, and thioglycollate-elicited macrophages and neutrophils but absent from lymphoid populations with no expression observed on T cells, B cells, NK cells or other granulocytes (at protein level) (PubMed:16039578, PubMed:19795417). Expressed in peripheral blood leukocytes, spleen, liver, thymus and small intestine (PubMed:12389094, PubMed:17558411).4 Publications

Inductionⁱ

By lipopolysaccharide, interferon beta and IFNG.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000059089 Expressed in 59 organ(s), highest expression level in bone marrow macrophage

Bgeeⁱ

ENSMUSG00000059089 Expressed in 59 organ(s), highest expression level in bone marrow macrophage

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000077873

STRINGⁱ

10090.ENSMUSP00000077873

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0A0B4J1G0
SMRⁱ	A0A0B4J1G0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 102	Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST		81
Domainⁱ	119 – 188	Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST		70

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IKYD Eukaryota ENOG41114N1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119130
HOGENOMⁱ	HOG000251632
HOVERGENⁱ	HBG051602
KEGG Orthology (KO) More...KOⁱ	K06463
OMAⁱ	FCRGIIG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JSA
PhylomeDBⁱ	A0A0B4J1G0

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13895 Ig_2, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

A0A0B4J1G0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWQLLLPTAL VLTAFSGIQA GLQKAVVNLD PKWVRVLEED SVTLRCQGTF 
        60         70         80         90        100
SPEDNSIKWF HNESLIPHQD ANYVIQSARV KDSGMYRCQT ALSTISDPVQ 
       110        120        130        140        150
LEVHMGWLLL QTTKWLFQEG DPIHLRCHSW QNRPVRKVTY LQNGKGKKYF 
       160        170        180        190        200
HENSELLIPK ATHNDSGSYF CRGLIGHNNK SSASFRISLG DPGSPSMFPP 
       210        220        230        240 
WHQITFCLLI GLLFAIDTVL YFSVRRGLQS PVADYEEPKI QWSKEPQDK

Length:249

Mass (Da):28,398

Last modified:March 4, 2015 - v1

Checksum:ⁱ99BBA7992862E80C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	57	I → T in ABS89131 (PubMed:18292508).Curated	1
Sequence conflictⁱ	57	I → T in BAE42113 (PubMed:16141072).Curated	1
Sequence conflictⁱ	141	L → S in AAH27310 (PubMed:15489334).Curated	1
Sequence conflictⁱ	157	L → P in AAM19249 (PubMed:12389094).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF499613 mRNA Translation: AAM19249.1 EU050648 mRNA Translation: ABS89131.1 AK170920 mRNA Translation: BAE42113.1 AC115959 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39140.1 BC027310 mRNA Translation: AAH27310.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15476.1
NCBI Reference Sequences More...RefSeqⁱ	NP_653142.2, NM_144559.2
UniGeneⁱ	Mm.251254

Genome annotation databases

Ensemblⁱ	ENSMUST00000078825; ENSMUSP00000077873; ENSMUSG00000059089
GeneIDⁱ	246256
KEGGⁱ	mmu:246256
UCSC genome browser More...UCSCⁱ	uc007dmw.2 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A0B4J1G0	Low affinity immunoglobulin gamma Fc region receptor III-B	)	HUMAN		233	UniRef50_O75015
Low affinity immunoglobulin gamma Fc region receptor IV		CAVPO		254
Low affinity immunoglobulin gamma Fc region receptor III		PIG		257
Uncharacterized protein		PANTR		233
low affinity immunoglobulin gamma Fc region receptor III-like isoform X1		DELLE		278
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF499613 mRNA Translation: AAM19249.1 EU050648 mRNA Translation: ABS89131.1 AK170920 mRNA Translation: BAE42113.1 AC115959 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39140.1 BC027310 mRNA Translation: AAH27310.1
CCDSⁱ	CCDS15476.1
RefSeqⁱ	NP_653142.2, NM_144559.2
UniGeneⁱ	Mm.251254

3D structure databases

ProteinModelPortalⁱ	A0A0B4J1G0
SMRⁱ	A0A0B4J1G0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000077873

STRINGⁱ

10090.ENSMUSP00000077873

PTM databases

iPTMnetⁱ	A0A0B4J1G0
PhosphoSitePlusⁱ	A0A0B4J1G0

Proteomic databases

PaxDbⁱ	A0A0B4J1G0
PRIDEⁱ	A0A0B4J1G0

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000078825; ENSMUSP00000077873; ENSMUSG00000059089
GeneIDⁱ	246256
KEGGⁱ	mmu:246256
UCSCⁱ	uc007dmw.2 mouse

Organism-specific databases

CTDⁱ	246256
MGIⁱ	MGI:2179523 Fcgr4

Phylogenomic databases

eggNOGⁱ	ENOG410IKYD Eukaryota ENOG41114N1 LUCA
GeneTreeⁱ	ENSGT00760000119130
HOGENOMⁱ	HOG000251632
HOVERGENⁱ	HBG051602
KOⁱ	K06463
OMAⁱ	FCRGIIG
OrthoDBⁱ	EOG091G0JSA
PhylomeDBⁱ	A0A0B4J1G0

Enzyme and pathway databases

Reactomeⁱ	R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins R-MMU-2029481 FCGR activation R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-2029485 Role of phospholipids in phagocytosis R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-2029481 FCGR activation
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485 Role of phospholipids in phagocytosis
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:A0A0B4J1G0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000059089 Expressed in 59 organ(s), highest expression level in bone marrow macrophage

Bgeeⁱ

ENSMUSG00000059089 Expressed in 59 organ(s), highest expression level in bone marrow macrophage

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2
Pfamⁱ	View protein in Pfam PF13895 Ig_2, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 2 hits SM00408 IGc2, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FCGR4_MOUSE
Accessionⁱ	A0A0B4J1G0Primary (citable) accession number: A0A0B4J1G0 Secondary accession number(s): Q3TC44, Q8R2R4, Q8R477
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 18, 2017
	Last sequence update:	March 4, 2015
	Last modified:	September 12, 2018
	This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A0B4J1G0 (FCGR4_MOUSE)

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Low affinity immunoglobulin gamma Fc region receptor IV

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ