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Protein

Low affinity immunoglobulin gamma Fc region receptor IV

Gene

Fcgr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059).6 Publications

GO - Molecular functioni

  • IgE binding Source: UniProtKB-KW
  • IgE receptor activity Source: UniProtKB
  • IgG binding Source: UniProtKB-KW
  • IgG receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein, IgG-binding protein, Receptor

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-2029481 FCGR activation
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485 Role of phospholipids in phagocytosis
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor IVImported
Alternative name(s):
CD16-21 Publication
FcgammaRIV1 Publication
Gene namesi
Name:Fcgr4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2179523 Fcgr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 203ExtracellularCuratedAdd BLAST183
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 249CytoplasmicCuratedAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi235Y → W: Abolishes receptor ligation-induced phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500820482421 – 249Low affinity immunoglobulin gamma Fc region receptor IVSequence analysisAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 88PROSITE-ProRule annotation
Glycosylationi62N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi127 ↔ 171PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi179N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Modified residuei235PhosphotyrosineCombined sources1 Publication1

Post-translational modificationi

N-glycosylated.2 Publications
Phosphorylated following receptor ligation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiA0A0B4J1G0
PRIDEiA0A0B4J1G0

PTM databases

iPTMnetiA0A0B4J1G0
PhosphoSitePlusiA0A0B4J1G0

Expressioni

Tissue specificityi

Detected on myeloid cells, peripheral blood monocytes, splenic and bone marrow dendritic cells, and thioglycollate-elicited macrophages and neutrophils but absent from lymphoid populations with no expression observed on T cells, B cells, NK cells or other granulocytes (at protein level) (PubMed:16039578, PubMed:19795417). Expressed in peripheral blood leukocytes, spleen, liver, thymus and small intestine (PubMed:12389094, PubMed:17558411).4 Publications

Inductioni

By lipopolysaccharide, interferon beta and IFNG.1 Publication

Gene expression databases

BgeeiENSMUSG00000059089 Expressed in 59 organ(s), highest expression level in bone marrow macrophage

Interactioni

Subunit structurei

Interacts with the Fc receptor gamma chain Fcerg; Fcerg is required for the cell surface expression of Fcrg4.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077873

Structurei

3D structure databases

ProteinModelPortaliA0A0B4J1G0
SMRiA0A0B4J1G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 102Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST81
Domaini119 – 188Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST70

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYD Eukaryota
ENOG41114N1 LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
KOiK06463
OMAiPWHQITF
OrthoDBiEOG091G0JSA
PhylomeDBiA0A0B4J1G0

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0A0B4J1G0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWQLLLPTAL VLTAFSGIQA GLQKAVVNLD PKWVRVLEED SVTLRCQGTF
60 70 80 90 100
SPEDNSIKWF HNESLIPHQD ANYVIQSARV KDSGMYRCQT ALSTISDPVQ
110 120 130 140 150
LEVHMGWLLL QTTKWLFQEG DPIHLRCHSW QNRPVRKVTY LQNGKGKKYF
160 170 180 190 200
HENSELLIPK ATHNDSGSYF CRGLIGHNNK SSASFRISLG DPGSPSMFPP
210 220 230 240
WHQITFCLLI GLLFAIDTVL YFSVRRGLQS PVADYEEPKI QWSKEPQDK
Length:249
Mass (Da):28,398
Last modified:March 4, 2015 - v1
Checksum:i99BBA7992862E80C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57I → T in ABS89131 (PubMed:18292508).Curated1
Sequence conflicti57I → T in BAE42113 (PubMed:16141072).Curated1
Sequence conflicti141L → S in AAH27310 (PubMed:15489334).Curated1
Sequence conflicti157L → P in AAM19249 (PubMed:12389094).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF499613 mRNA Translation: AAM19249.1
EU050648 mRNA Translation: ABS89131.1
AK170920 mRNA Translation: BAE42113.1
AC115959 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39140.1
BC027310 mRNA Translation: AAH27310.1
CCDSiCCDS15476.1
RefSeqiNP_653142.2, NM_144559.2
UniGeneiMm.251254

Genome annotation databases

EnsembliENSMUST00000078825; ENSMUSP00000077873; ENSMUSG00000059089
GeneIDi246256
KEGGimmu:246256
UCSCiuc007dmw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF499613 mRNA Translation: AAM19249.1
EU050648 mRNA Translation: ABS89131.1
AK170920 mRNA Translation: BAE42113.1
AC115959 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39140.1
BC027310 mRNA Translation: AAH27310.1
CCDSiCCDS15476.1
RefSeqiNP_653142.2, NM_144559.2
UniGeneiMm.251254

3D structure databases

ProteinModelPortaliA0A0B4J1G0
SMRiA0A0B4J1G0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077873

PTM databases

iPTMnetiA0A0B4J1G0
PhosphoSitePlusiA0A0B4J1G0

Proteomic databases

PaxDbiA0A0B4J1G0
PRIDEiA0A0B4J1G0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078825; ENSMUSP00000077873; ENSMUSG00000059089
GeneIDi246256
KEGGimmu:246256
UCSCiuc007dmw.2 mouse

Organism-specific databases

CTDi246256
MGIiMGI:2179523 Fcgr4

Phylogenomic databases

eggNOGiENOG410IKYD Eukaryota
ENOG41114N1 LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
KOiK06463
OMAiPWHQITF
OrthoDBiEOG091G0JSA
PhylomeDBiA0A0B4J1G0

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-MMU-2029481 FCGR activation
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485 Role of phospholipids in phagocytosis
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:A0A0B4J1G0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059089 Expressed in 59 organ(s), highest expression level in bone marrow macrophage

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCGR4_MOUSE
AccessioniPrimary (citable) accession number: A0A0B4J1G0
Secondary accession number(s): Q3TC44, Q8R2R4, Q8R477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 18, 2017
Last sequence update: March 4, 2015
Last modified: November 7, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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