Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 40 (02 Jun 2021)
Sequence version 1 (04 Mar 2015)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Trichohyalin

Gene

Tchh

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi62 – 73PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TrichohyalinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TchhImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2177944, Tchh

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A0B4J1F9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
306181

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052415, Expressed in skin of back and 196 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000069525

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A0A0B4J1F9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0B4J1F9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 84EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 142DisorderedSequence analysisAdd BLAST40
Regioni181 – 222DisorderedSequence analysisAdd BLAST42
Regioni418 – 448DisorderedSequence analysisAdd BLAST31
Regioni484 – 525DisorderedSequence analysisAdd BLAST42
Regioni537 – 560DisorderedSequence analysisAdd BLAST24
Regioni636 – 951DisorderedSequence analysisAdd BLAST316
Regioni960 – 979DisorderedSequence analysisAdd BLAST20
Regioni1209 – 1229DisorderedSequence analysisAdd BLAST21
Regioni1488 – 1525DisorderedSequence analysisAdd BLAST38
Regioni1546 – 1585DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili233 – 368Sequence analysisAdd BLAST136
Coiled coili1083 – 1103Sequence analysisAdd BLAST21
Coiled coili1105 – 1192Sequence analysisAdd BLAST88
Coiled coili1314 – 1413Sequence analysisAdd BLAST100
Coiled coili1425 – 1452Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1546 – 1569Basic and acidic residuesSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQH0, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164620

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001958_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRDLKWQ

Database of Orthologous Groups

More...
OrthoDBi
1367189at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00213, S-100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR034325, S-100_dom
IPR013787, S100_Ca-bd_sub
IPR033200, TCHH

The PANTHER Classification System

More...
PANTHERi
PTHR34855, PTHR34855, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01023, S_100, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01394, S_100, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0B4J1F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPLIRSIVD ITEVFNQYAS QSCDGASLSK KDLKNLLERE LGDVLQRPHD
60 70 80 90 100
PETIDLTLEL LDRDCNGRVD FNEFLLFLFK IAQACYYALD QAAELGEKRA
110 120 130 140 150
LPNEKRNLSQ DRRQEDQRRF EPRSRQLDEE PGRRSWQKRR EQEERAEEQR
160 170 180 190 200
LEQRYRQHRD EEQRLQRREL QELEERLAEK EPLGWSKGRD AEEFSEVEEQ
210 220 230 240 250
QRQERQELKG KGQTEERRLQ KRRQEELREP LLRRDLELRR EQELRREQEL
260 270 280 290 300
RQEQRREQEL RREQELRQEL RREQELNRRQ ELRREQELRR EQELRQELRR
310 320 330 340 350
EQELRREQEL RQELRREQEL RREQELRQEL RREQELRREQ ELRQELRREQ
360 370 380 390 400
ELRREQELRQ ELAEEDELTR IREPDESITQ RWQWQLENEA DARQNKVYSR
410 420 430 440 450
PSRQEQRLRQ ELGERQLREQ EEQRRDLQQE RPAEEARQRN QWERPQRAEE
460 470 480 490 500
RLEQEQRFRD REEQRFREEK LQRAELQDSL LDEEQRRLQE ERREPNRSRQ
510 520 530 540 550
LREESQRRRT LYAKPSQRQR REEELREERL LQEEQRQQRE RKHRREEDLQ
560 570 580 590 600
QEEKRLQQDE EQLQRERRRL QRERQYQEED LQQEEERLQQ EEERLQRERR
610 620 630 640 650
RLQQERQYQE EDLQRLRDED QRRDLKWQWQ PRKENEVRSN RLFTKRRGDE
660 670 680 690 700
EPIQQLEDSQ ERERRQDRRP LQDEEEEKRE LEQERRRRQQ RDRQILEEEQ
710 720 730 740 750
FQREHQREAR RRDETFQEEE QLQGESRRRQ QEREGKFLEE ERQLRTEREE
760 770 780 790 800
QRRRQEQERE FQEEEEHLQE REKELRQECD RKSREQERRQ QREEEQLRRQ
810 820 830 840 850
ERDQRFRREQ ERHLEREEEQ LRDRPSRREQ ERHQEREEEQ LRDRPSRREQ
860 870 880 890 900
ERHQEREEEQ LRDRPSRREQ ERHQEREEEQ LRDRPFRREQ ERRLEREEEQ
910 920 930 940 950
LRDRPSRREQ ERHQEREEEQ LRDRPSRREQ ERRLEREEEQ LRDRSFRREQ
960 970 980 990 1000
ELRRDRKFHE EEERREELEE EQRGQERDRL RVEEQLRGQR EEEQRRRQEC
1010 1020 1030 1040 1050
DRKLHRELEV RQELEEERLR DRKLRREQEL RRDRKFHEEE ERRHEEFEEK
1060 1070 1080 1090 1100
QLRLQEPDRR FRREQELRQE CVEEERLRDS KIRREQELRR EREEERLRDR
1110 1120 1130 1140 1150
KIRRDQELRQ GLEEEQLRRQ ELDRKFREEQ ELDQELEEER LRDRKIRREQ
1160 1170 1180 1190 1200
ELRREQELRR EQEFRREQEL RREQEFRREQ ELRQEREEER LRDRKIRRDQ
1210 1220 1230 1240 1250
ELRQGLEEEQ LRRQERDRKV REEQELDQEL EEERLRDRKI RREQELRREQ
1260 1270 1280 1290 1300
ELRREQEFRR EQGLRREREE ERLRDRKIRR DQELRQGLEE EQLRRQERDR
1310 1320 1330 1340 1350
KFREEQELGQ ELEEERLRDR KIRREQELRR EREQEQRRRL EREEEQQRLH
1360 1370 1380 1390 1400
EREEEQRRRQ EREQEQQRCL EREEEQFRFE EQQRRRQERE QQLRQERDRR
1410 1420 1430 1440 1450
VLEEEELRQE REELLHRQVG GRKFREEERL RLEREEQQRR LQERDNRRFR
1460 1470 1480 1490 1500
EEVELRQERE GQQLRQERDR KFREVEELRQ EEQRRRQERD RKFREEKHPR
1510 1520 1530 1540 1550
EEREEQQLRR EKRDGQYLAE EQFARDTIRR QEQELRQEEE QRRRQERERK
1560 1570 1580 1590
FQEEQIRRRQ EEQRRRQILE PGTRQFANVP VRSSPLYEYI QEQRSQYRP
Length:1,599
Mass (Da):208,219
Last modified:March 4, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE12B79226D21578
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001156570.1, NM_001163098.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000064257; ENSMUSP00000069525; ENSMUSG00000052415

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
99681

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:99681

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001156570.1, NM_001163098.1

3D structure databases

SMRiA0A0B4J1F9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069525

Proteomic databases

PaxDbiA0A0B4J1F9
ProteomicsDBi306181

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34083, 35 antibodies

Genome annotation databases

EnsembliENSMUST00000064257; ENSMUSP00000069525; ENSMUSG00000052415
GeneIDi99681
KEGGimmu:99681

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7062
MGIiMGI:2177944, Tchh

Phylogenomic databases

eggNOGiENOG502QQH0, Eukaryota
GeneTreeiENSGT00940000164620
HOGENOMiCLU_001958_0_0_1
OMAiRRDLKWQ
OrthoDBi1367189at2759

Enzyme and pathway databases

ReactomeiR-MMU-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
99681, 1 hit in 52 CRISPR screens
RNActiA0A0B4J1F9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000052415, Expressed in skin of back and 196 other tissues

Family and domain databases

CDDicd00213, S-100, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR034325, S-100_dom
IPR013787, S100_Ca-bd_sub
IPR033200, TCHH
PANTHERiPTHR34855, PTHR34855, 4 hits
PfamiView protein in Pfam
PF01023, S_100, 1 hit
SMARTiView protein in SMART
SM01394, S_100, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0B4J1F9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0B4J1F9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 4, 2015
Last sequence update: March 4, 2015
Last modified: June 2, 2021
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again