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UniProtKB - A0A0B4J184 (T3A_TERVA)
Protein
Venom peptide Tv1
Gene
N/A
Organism
Terebra variegata (Variegate auger snail)
Status
Functioni
Injections of 20 µM of this synthetic peptide (Ile) causes partial paralysis to polychaete worms (Nereis virens), the natural prey of terebrid snails (PubMed:24713808).
This paralysis may be due to an inhibition of nicotinic receptors at the neuromuscular junction (Probable).
1 Publication1 PublicationCaution
It is unsure whether the 3rd residue is an Ile or a Leu. NMR structural calculations were carried out using only the Ile-3 form of the peptide.1 Publication
GO - Molecular functioni
- acetylcholine receptor inhibitor activity Source: UniProtKB-KW
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Acetylcholine receptor inhibiting toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Venom peptide Tv11 PublicationAlternative name(s): Teretoxin v3aCurated |
Organismi | Terebra variegata (Variegate auger snail) |
Taxonomic identifieri | 1167563 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Terebridae › Terebra |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- host cell postsynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000435098 | 1 – 21 | Venom peptide Tv1Add BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 4 ↔ 20 | 1 Publication | ||
Disulfide bondi | 5 ↔ 21 | 1 Publication | ||
Disulfide bondi | 7 ↔ 16 | 1 Publication |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the salivary gland. This peptide is considered as a venom peptide.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | A0A0B4J184 |
SMRi | A0A0B4J184 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domaini
The cysteine framework is III (CC-C-C-CC). Classified in the M-3 branch, since 3 residues stand between the fourth and the fifth cysteine residues. This peptide has a cysteine scaffold similar to the M superfamily of conotoxins, but it displays a disulfide pattern previously unknown in native cone snail peptides.1 Publication
i Sequence
Sequence statusi: Complete.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence uncertaintyi | 3 | I or L1 Publication | 1 |
Cross-referencesi
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MIX | NMR | - | A | 1-21 | [»] | |
AlphaFoldDBi | A0A0B4J184 | |||||
SMRi | A0A0B4J184 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | T3A_TERVA | |
Accessioni | A0A0B4J184Primary (citable) accession number: A0A0B4J184 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 9, 2015 |
Last sequence update: | March 4, 2015 | |
Last modified: | May 25, 2022 | |
This is version 17 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references