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Protein

Hydroxyacylglutathione hydrolase

Gene

gloB

Organism
Mameliella alba
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: methylglyoxal degradation

This protein is involved in step 2 of the subpathway that synthesizes (R)-lactate from methylglyoxal.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxyacylglutathione hydrolase (gloB)
This subpathway is part of the pathway methylglyoxal degradation, which is itself part of Secondary metabolite metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-lactate from methylglyoxal, the pathway methylglyoxal degradation and in Secondary metabolite metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Zinc 1UniRule annotation1
Metal bindingi56Zinc 1UniRule annotation1
Metal bindingi58Zinc 2UniRule annotation1
Metal bindingi59Zinc 2UniRule annotation1
Metal bindingi112Zinc 1UniRule annotation1
Metal bindingi131Zinc 1UniRule annotation1
Metal bindingi131Zinc 2UniRule annotation1
Metal bindingi169Zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00619;UER00676

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyacylglutathione hydrolaseUniRule annotation (EC:3.1.2.6UniRule annotation)
Alternative name(s):
Glyoxalase IIUniRule annotation
Short name:
Glx IIUniRule annotation
Gene namesi
Name:gloBUniRule annotationImported
ORF Names:OA50_02814Imported
OrganismiMameliella albaImported
Taxonomic identifieri561184 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeMameliella
Proteomesi
  • UP000030960 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 169Lactamase_BInterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd07723 hydroxyacylglutathione_hydrola, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01374 Glyoxalase_2, 1 hit
InterProiView protein in InterPro
IPR035680 Clx_II_MBL
IPR032282 HAGH_C
IPR017782 Hydroxyacylglutathione_Hdrlase
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF16123 HAGH_C, 1 hit
PF00753 Lactamase_B, 1 hit
PIRSFiPIRSF005457 Glx, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR03413 GSH_gloB, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0B3RXF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLEIVTVPC LSDNYAYLVH GPDGVALIDA PEAGPIIEAL EARGWSLGVI
60 70 80 90 100
MITHHHHDHV GGVAELREKY GCPVMGPKAE VDKLPKLDMA LDPGFSGGTG
110 120 130 140 150
DGLCEVIAVP GHTLGHIAYY YPRGGAVFTA DSLMALGCGR IFEGTPQMMW
160 170 180 190 200
DSLEKLASLP PETVVYSGHE YTTANAAFAL TIEPENQALI SRKREIDAAR
210 220 230 240 250
AEGRPTAQVP LSVELETNPF LRATTDSVKR AVGLPGGTDA EVFAEVRARK

DRF
Length:253
Mass (Da):27,102
Last modified:March 4, 2015 - v1
Checksum:iF9149ED9572FDA07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUQ01000010 Genomic DNA Translation: KHQ52777.1
RefSeqiWP_043142508.1, NZ_QAOY01000007.1

Genome annotation databases

EnsemblBacteriaiKHQ52777; KHQ52777; OA50_02814
PATRICifig|1515334.3.peg.2832

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUQ01000010 Genomic DNA Translation: KHQ52777.1
RefSeqiWP_043142508.1, NZ_QAOY01000007.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKHQ52777; KHQ52777; OA50_02814
PATRICifig|1515334.3.peg.2832

Enzyme and pathway databases

UniPathwayi
UPA00619;UER00676

Family and domain databases

CDDicd07723 hydroxyacylglutathione_hydrola, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01374 Glyoxalase_2, 1 hit
InterProiView protein in InterPro
IPR035680 Clx_II_MBL
IPR032282 HAGH_C
IPR017782 Hydroxyacylglutathione_Hdrlase
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PfamiView protein in Pfam
PF16123 HAGH_C, 1 hit
PF00753 Lactamase_B, 1 hit
PIRSFiPIRSF005457 Glx, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR03413 GSH_gloB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A0B3RXF2_9RHOB
AccessioniPrimary (citable) accession number: A0A0B3RXF2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 4, 2015
Last sequence update: March 4, 2015
Last modified: November 7, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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