Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 21 (11 Dec 2019)
Sequence version 1 (04 Mar 2015)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Ryanodine receptor 44F

Gene

Rya-r44F_3

Organism
Lygus hesperus (Western plant bug)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ryanodine receptor 44FImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rya-r44F_3Imported
ORF Names:CM83_98488Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLygus hesperus (Western plant bug)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri30085 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraHeteropteraPanheteropteraCimicomorphaMiridaeMiriniLygus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 149MIRInterPro annotationAdd BLAST55
Domaini156 – 201MIRInterPro annotationAdd BLAST46
Domaini211 – 265MIRInterPro annotationAdd BLAST55
Domaini271 – 329MIRInterPro annotationAdd BLAST59
Domaini337 – 397MIRInterPro annotationAdd BLAST61
Domaini577 – 805B30.2/SPRYInterPro annotationAdd BLAST229
Domaini1034 – 1218B30.2/SPRYInterPro annotationAdd BLAST185
Domaini1472 – 1685B30.2/SPRYInterPro annotationAdd BLAST214

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1378 – 1516DisorderedSequence analysisAdd BLAST139
Regioni2282 – 2303DisorderedSequence analysisAdd BLAST22
Regioni2916 – 2943DisorderedSequence analysisAdd BLAST28
Regioni3001 – 3022DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili461 – 481Sequence analysisAdd BLAST21
Coiled coili1317 – 1337Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1414 – 1430PolarSequence analysisAdd BLAST17
Compositional biasi1431 – 1472PolyampholyteSequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR014821 Ins145_P3_rcpt
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF02815 MIR, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00795 RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A0A9WDJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDTEGGSEQ DDVSFLRTED MVCLSCTATG ERVCLAAEGF GNRHCFLENI
60 70 80 90 100
ADKNIPPDLS TCVFVIEQAL SVRALQELVT AAGTEEGKGG TGSGHRTLLY
110 120 130 140 150
GNAILLRHQN SDMYLACLST SSSNDKLSFD VGLQEHSQGE ACWWTVHPAS
160 170 180 190 200
KQRSEGEKVR VGDDLILVSV ATERYLHTTK ENDQSIVNAS FHVTHWSVQP
210 220 230 240 250
YGTGISKMKY VGYVFGGDVL RFFHGGDECL TIPSTWSQDA SQNVVVYEGG
260 270 280 290 300
SVLSQARSLW RLELARTKWS GGFINWYHPM RIRHLTTGRY LGVNEANELH
310 320 330 340 350
LVPREEATTA LSTFILRVEK DDQKVVMEDK DLEVIGAPII KYGDTTVLVQ
360 370 380 390 400
HCESGLWVTY KSFETKKKGV GKVEEKQAVL HEEGKMDDGL DFSRSQEEES
410 420 430 440 450
RTARVIRKCS SLFHKFIKGL EELQLNRRHS LFCATVNLNE MVMCLEDLIN
460 470 480 490 500
YFAQPEEDTE HEEKQNRLRA LRNRQDLFQE EGILNLILEA IDKINVITSQ
510 520 530 540 550
GFLVNLAGDE SGHSWDIISG FLYQLLAAII KGNHTNCAQF ANTNRLNWLF
560 570 580 590 600
SRLGSQASGE GSGMLDVLHC VLIDSPEALN MMRDEHIKVI ISLLEKHGRD
610 620 630 640 650
PKVLDVLCSL CVGNGVAVRS SQNNICDFLL PGKNLLLQTQ LVDHVASVRP
660 670 680 690 700
NIFVGRVEGS AVYQKWYFEV TLDHMEQTTH MTPHLRIGWA NTAGYVPYPG
710 720 730 740 750
GGEKWGGNGV GDDLYSFSFD GSALWTGGRK TVVLLNNNAP NGPFIRKGDV
760 770 780 790 800
IGCALDLTVP AIRFTFNGAP ISGCFTNFNL EGMFFPCISC SSKLSCRFLL
810 820 830 840 850
GGDHGRLKYA PPEEFSPLVE SLQPQQVLSI DPCFYFGQLS KTILSGPFPI
860 870 880 890 900
ESDTAFVPVP VDTTSVSLPN LVETIRDRLA ENIHEMWAMN KIEAGWIFGE
910 920 930 940 950
LRDDIRRVHP CLVQFEKLPA AEKRYDTQLA VQTLKTIIAL GYHITVDKPP
960 970 980 990 1000
SRIKNVRLPN EPFLQPNGYK PAPLDLSAIS LTPKMEELVD QLAENTHNLW
1010 1020 1030 1040 1050
AKERIQQGWT YGLNEDPDYC RSPHLVPYCK VDELIKKANR DTASETVRTL
1060 1070 1080 1090 1100
LVYGYNLDPP TGEQTEALLA EAGRLRQMSF RTYRAEKTYA VTSGKWYFEF
1110 1120 1130 1140 1150
EILTAGPMRV GWAAADCPPG HQLGADDHSW AFDGYNEEKV TSGVAESFGR
1160 1170 1180 1190 1200
QWTVGDVVGV FLDLLDHTIS FSLNGELLMD TLGGETTFGD VQGEAGFVPA
1210 1220 1230 1240 1250
FTLGVGQKAR LVYGQDVNAL KFFTTCGLQE GYEPFCVNMN RQVTYWYTKD
1260 1270 1280 1290 1300
QPIFENTDDY ADTRIDVTRI PPGSDTPPCL KVSHNLFETM EKANWEFLRL
1310 1320 1330 1340 1350
SLPVICESTF IDENEKIRRW KEIRMRQQRL MNEAEQQYTT NAQMEQIMRS
1360 1370 1380 1390 1400
GFSMSDIKGL TSYPEDAVES DEVMGRSLPA RNAKGQPPAP PRPPRKGSLS
1410 1420 1430 1440 1450
RPDDVIMNGT MESGIGAMNR STSELDFNRY NGELSDSDKS QKKRGRSPFR
1460 1470 1480 1490 1500
FFSRKNRDTS GSAERPKKGR TPEPQMLEPQ VTPTLQRGGL RATKGPGDMK
1510 1520 1530 1540 1550
PPSPLAERTN KGGGMSMSVP AASGIETVGN EMYDAECLKL INEYYYAVRI
1560 1570 1580 1590 1600
FPGQDPTHVY VGWVTTQFHQ HAAHFNQNCV LKSTVTVEDS YNRVFDRIER
1610 1620 1630 1640 1650
QNCYVVRADE LYNEVTQDAS GKSASQGMII GCSIDTATGY ITFTCEGKDT
1660 1670 1680 1690 1700
KHKYRMEPET KLFPAIFVEA TSKEILQIEL GRTSTTLPLS AAVLRNSEKH
1710 1720 1730 1740 1750
VIPQFPPRFK VQCLIPHQWA RVPNVSLHVH ALKLSDIRGW SMLCEDPVSM
1760 1770 1780 1790 1800
IALHIPEEDR CIDVLELIEM EKLLSFHAHT LGLYAALCFQ SNYRAAHALC
1810 1820 1830 1840 1850
HHVDQKQLQY AIRAEYMSGP LRRGFYDLLI ALHIESHANT MEICKNEFII
1860 1870 1880 1890 1900
PLGPELKELY EDPDMGNSLK SLQAVSVVPN MKMSDIVIES TENIQTLYSP
1910 1920 1930 1940 1950
YFPLDAVRDY VMVALHEAVE ISQVHNRDPI GGSNENFFLP LLKLTDRLLL
1960 1970 1980 1990 2000
VGMLRDEDVM KLLIMFDPET WDPTFEKEGK DEHRKGLLQM KMAEGAKLQM
2010 2020 2030 2040 2050
CYILQHLCDI QLRHRIEQII AFSFDYCGEI QNDQLRRYIE IKQTDLPASV
2060 2070 2080 2090 2100
AAKKTREFRC PPKEQMNAII SFKNLEEDDE ACPVGTELKE KLNGFHEQLL
2110 2120 2130 2140 2150
VKVSLSALQE PQEEEEETDA NKPGMFKKMY NFINRVKELD EPPKVEPEPE
2160 2170 2180 2190 2200
KKTPEEVFRK VLIKTIVRWA EEHQIETPKL VREMFSLLVR QYDTIGEIMR
2210 2220 2230 2240 2250
SLKTTYAINY KTRDDVALMW VALSQIRALL PVQMSHEEEA LMRMRLKKFV
2260 2270 2280 2290 2300
NNHTFFQHPD LIRVLRVHEN VMAVMINTLG RRSQAQSDTP QTGEGGEPVA
2310 2320 2330 2340 2350
KEKDTSHEMV VSCCRFLCYF CRSSRQNQKA MFDHLAFLLE NSNILLSRPS
2360 2370 2380 2390 2400
LRGCTPLDVA YSSVMENTEL ALALREHYLE KIAIYLSRCG LQSNSELVEK
2410 2420 2430 2440 2450
GYPDLGWDPV EGERYLDFLR FCVWVNGESV EENSNLVIRL LIRRPECLGP
2460 2470 2480 2490 2500
ALRGEGEGLL QAIIEANKMS ERLQDRRKMM DEGQDLTGFE HPLPESDEDE
2510 2520 2530 2540 2550
DYIDTGAAIL AFYCTLIDLL GRCAPDASVI AQGKNESLRA RAILRSLVPL
2560 2570 2580 2590 2600
EDLFGVLSLR FTLTHPAVGE VAPISDIPSG LIPSHKQSIV LFLERVYGIE
2610 2620 2630 2640 2650
SADLFFRLLE EAFLPDLRAA TMLDKADGGE SEMALAMNRY IGNSILPLLI
2660 2670 2680 2690 2700
SHSNFYGNAD NYASLLDATL HTAYRMSKNR MLTKGQREAV SDFLVALTSQ
2710 2720 2730 2740 2750
LQPNMLLKLL RKLTVDVSQL SEYTTVALRL LTLHYDRCGK YYGMSGQGGS
2760 2770 2780 2790 2800
SDEEKRLTMM LFSNIFDSLS KMDYDPELFG KALPCLTAIG CALPPDYSLT
2810 2820 2830 2840 2850
KNYDDEWEAN SGESSNAQYN PQPINTSSVS LSNDFNTIVQ KFSEHYHDAW
2860 2870 2880 2890 2900
ASRKMENGWQ YGEQWSDSSK THPRLKPYTM LSDYEKERYK EPVRESLKAL
2910 2920 2930 2940 2950
LAIGWGVEHT EVDIPSNNRG NSVRRQSKGA MGEAGSPFSY HPNPIDMSNL
2960 2970 2980 2990 3000
TLSREMQNMA ERLAENSHDI WAKKKKEELN HWEEPCRPSL CPTTYSQIKR
3010 3020 3030 3040 3050
RKKIEKGPRS SSSTCNIKDS NFTNPTVVET KQIKLPLLQL PENPGSLTVF
3060
SKNFYNTRTR LPST
Length:3,064
Mass (Da):345,723
Last modified:March 4, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB53CF19F87FAACF8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GBHO01038148 Transcribed RNA Translation: JAG05456.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GBHO01038148 Transcribed RNA Translation: JAG05456.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd12877 SPRY1_RyR, 1 hit
cd12878 SPRY2_RyR, 1 hit
cd12879 SPRY3_RyR, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR014821 Ins145_P3_rcpt
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR000699 RIH_dom
IPR013333 Ryan_recept
IPR003032 Ryanodine_rcpt
IPR035910 RyR/IP3R_RIH_dom_sf
IPR035761 SPRY1_RyR
IPR035764 SPRY2_RyR
IPR035762 SPRY3_RyR
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF02815 MIR, 1 hit
PF01365 RYDR_ITPR, 2 hits
PF02026 RyR, 4 hits
PF00622 SPRY, 3 hits
PRINTSiPR00795 RYANODINER
SMARTiView protein in SMART
SM00472 MIR, 4 hits
SM00449 SPRY, 3 hits
SUPFAMiSSF100909 SSF100909, 1 hit
SSF49899 SSF49899, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 3 hits
PS50919 MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A9WDJ1_LYGHE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A9WDJ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 4, 2015
Last sequence update: March 4, 2015
Last modified: December 11, 2019
This is version 21 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again