Transforming growth factor beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: Ensembl
• growth factor activity Source: UniProtKB-UniRule
• protein homodimerization activity Source: Ensembl
• type III transforming growth factor beta receptor binding Source: Ensembl
• type II transforming growth factor beta receptor binding Source: Ensembl

GO - Biological processⁱ

• activation of protein kinase activity Source: Ensembl
• cardiac epithelial to mesenchymal transition Source: Ensembl
• cardiac muscle cell proliferation Source: Ensembl
• cardioblast differentiation Source: Ensembl
• cell-cell junction organization Source: Ensembl
• cell morphogenesis Source: Ensembl
• collagen fibril organization Source: Ensembl
• embryonic digestive tract development Source: Ensembl
• extrinsic apoptotic signaling pathway Source: Ensembl
• eye development Source: Ensembl
• glial cell migration Source: Ensembl
• hair follicle development Source: Ensembl
• negative regulation of alkaline phosphatase activity Source: Ensembl
• negative regulation of angiogenesis Source: Ensembl
• negative regulation of cell growth Source: Ensembl
• negative regulation of epithelial cell proliferation Source: Ensembl
• negative regulation of macrophage cytokine production Source: Ensembl
• pathway-restricted SMAD protein phosphorylation Source: Ensembl
• positive regulation of cardioblast differentiation Source: Ensembl
• positive regulation of cell adhesion mediated by integrin Source: Ensembl
• positive regulation of cell division Source: UniProtKB-UniRule
• positive regulation of cell growth Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of epithelial cell migration Source: Ensembl
• positive regulation of epithelial to mesenchymal transition Source: Ensembl
• positive regulation of heart contraction Source: Ensembl
• positive regulation of integrin biosynthetic process Source: Ensembl
• positive regulation of neuron apoptotic process Source: Ensembl
• positive regulation of Notch signaling pathway Source: Ensembl
• positive regulation of ossification Source: Ensembl
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• positive regulation of protein secretion Source: Ensembl
• positive regulation of stress-activated MAPK cascade Source: Ensembl
• positive regulation of timing of catagen Source: Ensembl
• regulation of transforming growth factor beta2 production Source: Ensembl
• response to hypoxia Source: Ensembl
• response to progesterone Source: Ensembl
• response to wounding Source: Ensembl
• response to xenobiotic stimulus Source: Ensembl
• salivary gland morphogenesis Source: Ensembl
• SMAD protein signal transduction Source: Ensembl
• transforming growth factor beta receptor signaling pathway Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• growth factor activity Source: UniProtKB-UniRule
• protein homodimerization activity Source: Ensembl
• type III transforming growth factor beta receptor binding Source: Ensembl
• type II transforming growth factor beta receptor binding Source: Ensembl

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MHYCVLSTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL 
        60         70         80         90        100
TSPPEDYPEP DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA 
       110        120        130        140        150
KEVYKIDMPS HLPSETVCPV VTTPSGSLGS FCSRQSQVLC GYLDAIPPTF 
       160        170        180        190        200
YRPYFRIVRF DVSTMEKNAS NLVKAEFRVF RLQNPKARVA EQRIELYQIL 
       210        220        230        240        250
KSKDLTSPTQ RYIDSKVVKT RAEGEWLSFD VTDAVQEWLH HKDRNLGFKI 
       260        270        280        290        300
SLHCPCCTFV PSNNYIIPNK SEELEARFAG IDGTSTYASG DQKTIKSTRK 
       310        320        330        340        350
KTSGKTPHLL LMLLPSYRLE SQQSSRRKKR ALDAAYCFRN VQDNCCLRPL 
       360        370        380        390        400
YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHTK VLSLYNTINP 
       410        420        430        440 
EASASPCCVS QDLEPLTILY YIGNTPKIEQ LSNMIVKSCK CS         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ