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UniProtKB - A0A0A6YXU9 (A0A0A6YXU9_MOUSE)
Protein
Transforming growth factor beta
Gene
Tgfb2
Organism
Mus musculus (Mouse)
Status
Functioni
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
ARBA annotationGO - Molecular functioni
- amyloid-beta binding Source: Ensembl
- growth factor activity Source: UniProtKB-UniRule
- protein homodimerization activity Source: Ensembl
- type III transforming growth factor beta receptor binding Source: Ensembl
- type II transforming growth factor beta receptor binding Source: Ensembl
GO - Biological processi
- activation of protein kinase activity Source: Ensembl
- cardiac epithelial to mesenchymal transition Source: Ensembl
- cardiac muscle cell proliferation Source: Ensembl
- cardioblast differentiation Source: Ensembl
- cell-cell junction organization Source: Ensembl
- cell morphogenesis Source: Ensembl
- collagen fibril organization Source: Ensembl
- embryonic digestive tract development Source: Ensembl
- extrinsic apoptotic signaling pathway Source: Ensembl
- eye development Source: Ensembl
- glial cell migration Source: Ensembl
- hair follicle development Source: Ensembl
- negative regulation of alkaline phosphatase activity Source: Ensembl
- negative regulation of angiogenesis Source: Ensembl
- negative regulation of cell growth Source: Ensembl
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of macrophage cytokine production Source: Ensembl
- pathway-restricted SMAD protein phosphorylation Source: Ensembl
- positive regulation of cardioblast differentiation Source: Ensembl
- positive regulation of cell adhesion mediated by integrin Source: Ensembl
- positive regulation of cell division Source: UniProtKB-UniRule
- positive regulation of cell growth Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of epithelial cell migration Source: Ensembl
- positive regulation of epithelial to mesenchymal transition Source: Ensembl
- positive regulation of heart contraction Source: Ensembl
- positive regulation of integrin biosynthetic process Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- positive regulation of Notch signaling pathway Source: Ensembl
- positive regulation of ossification Source: Ensembl
- positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
- positive regulation of protein secretion Source: Ensembl
- positive regulation of stress-activated MAPK cascade Source: Ensembl
- positive regulation of timing of catagen Source: Ensembl
- regulation of transforming growth factor beta2 production Source: Ensembl
- response to hypoxia Source: Ensembl
- response to progesterone Source: Ensembl
- response to wounding Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- salivary gland morphogenesis Source: Ensembl
- SMAD protein signal transduction Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | Growth factorUniRule annotationARBA annotation, MitogenUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor betaUniRule annotation |
Gene namesi | Name:Tgfb2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98726, Tgfb2 |
VEuPathDBi | HostDB:ENSMUSG00000039239 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix ARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-UniRule
Other locations
- collagen-containing extracellular matrix Source: Ensembl
Keywords - Cellular componenti
Extracellular matrixARBA annotation, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | UniRule annotationAdd BLAST | 20 | |
ChainiPRO_5016196282 | 21 – 442 | Transforming growth factor betaUniRule annotationAdd BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 337 ↔ 346 | UniRule annotation | ||
Disulfide bondi | 345 ↔ 408 | UniRule annotation | ||
Disulfide bondi | 374 ↔ 439 | UniRule annotation | ||
Disulfide bondi | 378 ↔ 441 | UniRule annotation | ||
Disulfide bondi | 407 | InterchainUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationARBA annotationProteomic databases
ProteomicsDBi | 359669 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039239, Expressed in uterus and 400 other tissues |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
UniRule annotationGO - Molecular functioni
- growth factor activity Source: UniProtKB-UniRule
- protein homodimerization activity Source: Ensembl
- type III transforming growth factor beta receptor binding Source: Ensembl
- type II transforming growth factor beta receptor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 327 – 442 | TGF_BETA_2InterPro annotationAdd BLAST | 116 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000157390 |
OrthoDBi | 643840at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A0A6YXU9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHYCVLSTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
TSPPEDYPEP DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA
110 120 130 140 150
KEVYKIDMPS HLPSETVCPV VTTPSGSLGS FCSRQSQVLC GYLDAIPPTF
160 170 180 190 200
YRPYFRIVRF DVSTMEKNAS NLVKAEFRVF RLQNPKARVA EQRIELYQIL
210 220 230 240 250
KSKDLTSPTQ RYIDSKVVKT RAEGEWLSFD VTDAVQEWLH HKDRNLGFKI
260 270 280 290 300
SLHCPCCTFV PSNNYIIPNK SEELEARFAG IDGTSTYASG DQKTIKSTRK
310 320 330 340 350
KTSGKTPHLL LMLLPSYRLE SQQSSRRKKR ALDAAYCFRN VQDNCCLRPL
360 370 380 390 400
YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHTK VLSLYNTINP
410 420 430 440
EASASPCCVS QDLEPLTILY YIGNTPKIEQ LSNMIVKSCK CS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP27090 | TGFB2_MOUSE | Transforming growth factor beta-2 p... | Tgfb2 | 414 | Annotation score: |
Sequence databases
RefSeqi | NP_001316036.1, NM_001329107.1 |
Genome annotation databases
Ensembli | ENSMUST00000195201; ENSMUSP00000142149; ENSMUSG00000039239 |
GeneIDi | 21808 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001316036.1, NM_001329107.1 |
3D structure databases
SMRi | A0A0A6YXU9 |
ModBasei | Search... |
Proteomic databases
ProteomicsDBi | 359669 |
Protocols and materials databases
Antibodypediai | 20732, 618 antibodies from 37 providers |
DNASUi | 21808 |
Genome annotation databases
Ensembli | ENSMUST00000195201; ENSMUSP00000142149; ENSMUSG00000039239 |
GeneIDi | 21808 |
Organism-specific databases
CTDi | 7042 |
MGIi | MGI:98726, Tgfb2 |
VEuPathDBi | HostDB:ENSMUSG00000039239 |
Phylogenomic databases
GeneTreei | ENSGT00940000157390 |
OrthoDBi | 643840at2759 |
Miscellaneous databases
BioGRID-ORCSi | 21808, 0 hits in 66 CRISPR screens |
ChiTaRSi | Tgfb2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039239, Expressed in uterus and 400 other tissues |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A6YXU9_MOUSE | |
Accessioni | A0A0A6YXU9Primary (citable) accession number: A0A0A6YXU9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 4, 2015 |
Last sequence update: | February 4, 2015 | |
Last modified: | January 19, 2022 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |