UniProtKB - A0A0A6YX50 (A0A0A6YX50_MOUSE)
Protein
Protoporphyrinogen oxidase
Gene
Ppox
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.UniRule annotationARBA annotation
Catalytic activityi
- EC:1.3.3.4UniRule annotationARBA annotation
Cofactori
FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation
: protoporphyrin-IX biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes protoporphyrin-IX from protoporphyrinogen-IX.UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- Protoporphyrinogen oxidase (Ppox), Protoporphyrinogen oxidase (Ppox), Protoporphyrinogen oxidase (Ppox)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoporphyrin-IX from protoporphyrinogen-IX, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.
GO - Molecular functioni
- oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-UniRule
GO - Biological processi
- protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | OxidoreductaseUniRule annotationARBA annotation |
Biological process | Heme biosynthesisUniRule annotationARBA annotation, Porphyrin biosynthesisUniRule annotationARBA annotation |
Ligand | FADUniRule annotationARBA annotation, Flavoprotein |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00324 |
Names & Taxonomyi
Protein namesi | Recommended name: Protoporphyrinogen oxidaseUniRule annotationARBA annotation (EC:1.3.3.4UniRule annotationARBA annotation) |
Gene namesi | Name:PpoxImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104968, Ppox |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane UniRule annotation
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000062729, Expressed in fetal liver hematopoietic progenitor cell and 295 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 117 | Amino_oxidaseInterPro annotationAdd BLAST | 106 | |
Domaini | 135 – 385 | Amino_oxidaseInterPro annotationAdd BLAST | 251 |
Sequence similaritiesi
Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.UniRule annotationARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00390000008744 |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR002937, Amino_oxidase IPR036188, FAD/NAD-bd_sf IPR004572, Protoporphyrinogen_oxidase |
Pfami | View protein in Pfam PF01593, Amino_oxidase, 2 hits |
SUPFAMi | SSF51905, SSF51905, 1 hit |
TIGRFAMsi | TIGR00562, proto_IX_ox, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A0A6YX50-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRTVIVLGG GISGLAASYH LIRGPSPPKV ILVEGSKRLG GWIRSIRGSD
60 70 80 90 100
GAIFELGPRG IRPAGALGAR TLLLFLLFLR ACGEQVSELG LESEVLPVRG
110 120 130 140 150
DHPAAQNRFL YVGGTLHPLP SGLSPSLTLK VASLAMDSLC RGVFAGNSRE
160 170 180 190 200
LSIRSCFPSL FQAEQTHRSI LLGLLLGAGQ SPQPDSSLIR QARAERWSQW
210 220 230 240 250
SLRGGLEVLP QALHNHLASK GVTVLSGQPV CGLSLQPEGR WKVSLGDSSL
260 270 280 290 300
EADHIISAIP ASELSKLLPA EAAPLARILS TIKAVSVAVV NLQYRGACLP
310 320 330 340 350
VQGFGHLVPS SEDPTVLGIV YDSVAFPEQD GNPPSLRVTV MLGGYWLQKL
360 370 380
KAAGHQLSPE LFQQQAQEAA ATQLGLKEPP SHCLVHLHK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP51175 | PPOX_MOUSE | Protoporphyrinogen oxidase | Ppox | 477 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 389 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084821 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000192956; ENSMUSP00000141835; ENSMUSG00000062729 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC084821 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A0A6YX50 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 34299, 252 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000192956; ENSMUSP00000141835; ENSMUSG00000062729 |
Organism-specific databases
MGIi | MGI:104968, Ppox |
Phylogenomic databases
GeneTreei | ENSGT00390000008744 |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00324 |
Miscellaneous databases
ChiTaRSi | Ppox, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000062729, Expressed in fetal liver hematopoietic progenitor cell and 295 other tissues |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
InterProi | View protein in InterPro IPR002937, Amino_oxidase IPR036188, FAD/NAD-bd_sf IPR004572, Protoporphyrinogen_oxidase |
Pfami | View protein in Pfam PF01593, Amino_oxidase, 2 hits |
SUPFAMi | SSF51905, SSF51905, 1 hit |
TIGRFAMsi | TIGR00562, proto_IX_ox, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A0A6YX50_MOUSE | |
Accessioni | A0A0A6YX50Primary (citable) accession number: A0A0A6YX50 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 4, 2015 |
Last sequence update: | February 4, 2015 | |
Last modified: | October 7, 2020 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |