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Entry version 37 (31 Jul 2019)
Sequence version 1 (04 Feb 2015)
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Protein
Submitted name:

Ubiquitin carboxyl-terminal hydrolase 19

Gene

Usp19

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ubiquitin carboxyl-terminal hydrolase 19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp19Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918722 Usp19

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A0A0A6YWX1

PRoteomics IDEntifications database

More...
PRIDEi
A0A0A6YWX1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000006676 Expressed in 290 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0A6YWX1 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A0A6YWX1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 140CSInterPro annotationAdd BLAST90
Domaini323 – 425CSInterPro annotationAdd BLAST103
Domaini538 – 1255USPInterPro annotationAdd BLAST718
Domaini832 – 874MYND-typeInterPro annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni164 – 240DisorderedSequence analysisAdd BLAST77
Regioni434 – 482DisorderedSequence analysisAdd BLAST49
Regioni964 – 987DisorderedSequence analysisAdd BLAST24
Regioni1258 – 1322DisorderedSequence analysisAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 46PolyampholyteSequence analysisAdd BLAST30
Compositional biasi172 – 186PolyampholyteSequence analysisAdd BLAST15
Compositional biasi461 – 479PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1258 – 1274PolyampholyteSequence analysisAdd BLAST17

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1870 Eukaryota
COG5560 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159085

Database of Orthologous Groups

More...
OrthoDBi
1283205at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR002893 Znf_MYND

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04969 CS, 2 hits
PF00443 UCH, 1 hit
PF01753 zf-MYND, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764 SSF49764, 2 hits
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51203 CS, 2 hits
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

A0A0A6YWX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT
60 70 80 90 100
KDELLLDWRQ SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW
110 120 130 140 150
GGVFFAEIQS SCTKVQARKG GLLQLVLPKK VPLLTWPSLL KKPLGTQELV
160 170 180 190 200
PGLQCQENGQ ELSPIALEPG SEPRRAKQEA RNQKRAQGRG EVGSGAGPGT
210 220 230 240 250
QAGPSAKRAV HLRRGPEGEG SMDGPGPQGD APSFLSDSAT QVEAEEKLCA
260 270 280 290 300
PPMNTQTSLL SSEKSLALLT VEKTVSPRND PVAPVMVQDR DPEPEQEDQV
310 320 330 340 350
KEEMALGADP TALVEEPESM VNLAFVKNDS YEKGPDSVVV HVYVKEIRRD
360 370 380 390 400
SSRVLFREQD FTLIFQTRDG NFLRLHPGCG PHTIFRWQVK LRNLIEPEQC
410 420 430 440 450
TFCFTASRID ICLRKRQSQR WGGLEAPATR VGGAKVAVPT GPTPLDSTPP
460 470 480 490 500
GGGPHPLTGQ EEARAVEKEK PKARSEDSGL DGVVARTPLE HVAPKPDPHL
510 520 530 540 550
ASPKPTCMVP PMPHSPVSGD SVEEDEEEEK KVCLPGFTGL VNLGNTCFMN
560 570 580 590 600
SVIQSLSNTR ELRDFFHDRS FEAEINYNNP LGTGGRLAIG FAVLLRALWK
610 620 630 640 650
GTHQAFQPSK LKAIVASKAS QFTGYAQHDA QEFMAFLLDG LHEDLNRIQN
660 670 680 690 700
KPYTETVDSD GRPDEVVAEE AWQRHKMRND SFIVDLFQGQ YKSKLVCPVC
710 720 730 740 750
AKVSITFDPF LYLPVPLPQK QKVLPIFYFA REPHSKPIKF LVSVSKENSS
760 770 780 790 800
ASEVLDSLSQ SVHVKPENLR LAEVIKNRFH RVFLPSHSLD AVSPTDVLLC
810 820 830 840 850
FELLSPELAK ERVVVLEVQQ RPQVPSIPIS KCAACQRKQQ SEEEKLKRCT
860 870 880 890 900
RCYRVGYCNQ FCQKTHWPDH KGLCRPENIG YPFLVSVPAS RLTYARLAQL
910 920 930 940 950
LEGYARYSVS VFQPPFQPGR MALESQSPGC TTLLSTSSLE AGDSEREPIQ
960 970 980 990 1000
PSELQLVTPV AEGDTGAHRV WPPADRGPVP STSGLSSEML ASGPIEGCPL
1010 1020 1030 1040 1050
LAGERVSRPE AAVPGYQHSS ESVNTHTPQF FIYKIDASNR EQRLEDKGET
1060 1070 1080 1090 1100
PLELGDDCSL ALVWRNNERL QEFVLVASKE LECAEDPGSA GEAARAGHFT
1110 1120 1130 1140 1150
LDQCLNLFTR PEVLAPEEAW YCPQCKQHRE ASKQLLLWRL PNVLIVQLKR
1160 1170 1180 1190 1200
FSFRSFIWRD KINDLVEFPV RNLDLSKFCI GQKEEQLPSY DLYAVINHYG
1210 1220 1230 1240 1250
GMIGGHYTAC ARLPNDRSSQ RSDVGWRLFD DSTVTTVDES QVVTRYAYVL
1260 1270 1280 1290 1300
FYRRRNSPVE RPPRASHSEH HPDLGPAAEA AASQGLGPGQ APEVAPTRTA
1310 1320
PERFAPPVDR PAPTYSNMEE VD
Length:1,322
Mass (Da):146,283
Last modified:February 4, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53B30888FAA5BC2D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UJD6UBP19_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp19 Kiaa0891
1,360Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWN9A0A0A6YWN9_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp19
991Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9M5E9Q9M5_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp19
1,299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KMM1J3KMM1_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp19 mCG_16487
1,324Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXT9A0A0A6YXT9_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp19
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YX42A0A0A6YX42_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp19
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT010508 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001161845.1, NM_001168373.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000193678; ENSMUSP00000141738; ENSMUSG00000006676

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71472

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT010508 Genomic DNA No translation available.
RefSeqiNP_001161845.1, NM_001168373.2

3D structure databases

SMRiA0A0A6YWX1
ModBaseiSearch...

Proteomic databases

EPDiA0A0A6YWX1
PRIDEiA0A0A6YWX1

Genome annotation databases

EnsembliENSMUST00000193678; ENSMUSP00000141738; ENSMUSG00000006676
GeneIDi71472

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10869
MGIiMGI:1918722 Usp19

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
GeneTreeiENSGT00940000159085
OrthoDBi1283205at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Usp19 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000006676 Expressed in 290 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiA0A0A6YWX1 baseline and differential

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF04969 CS, 2 hits
PF00443 UCH, 1 hit
PF01753 zf-MYND, 1 hit
SUPFAMiSSF49764 SSF49764, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 2 hits
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A6YWX1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A6YWX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 4, 2015
Last sequence update: February 4, 2015
Last modified: July 31, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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