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UniProtKB - A0A0A6YWM5 (A0A0A6YWM5_MOUSE)

Entry version 45 (02 Dec 2020)
Sequence version 1 (04 Feb 2015)
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Protein
Submitted name:

Rab3 GTPase-activating protein non-catalytic subunit

Gene

Rab3gap2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rab3 GTPase-activating protein non-catalytic subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rab3gap2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1916043, Rab3gap2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A0A0A6YWM5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A0A0A6YWM5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039318, Expressed in secondary oocyte and 278 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A0A6YWM5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini73 – 497RAB3GAP2_NInterPro annotationAdd BLAST425
Domaini767 – 1345RAB3GAP2_CInterPro annotationAdd BLAST579

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 69DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili671 – 698Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 65PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Rab3-GAP regulatory subunit family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005794

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006591_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		CKTVASN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026059, Rab3-gap_reg
IPR029257, RAB3GAP2_C
IPR032839, RAB3GAP_N

The PANTHER Classification System

More...PANTHERi		PTHR12472, PTHR12472, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14656, RAB3GAP2_C, 1 hit
PF14655, RAB3GAP2_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A0A6YWM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACSIVQFCS FQDLQSARDF LFPHLREETP GALKRDPSKT SSWEDDSWGA 
        60         70         80         90        100
WEETEPREPE EEGNTSKTQK NSWLQECVLS LSPTSDLMVI AREQKAAFLV 
       110        120        130        140        150
PKWKHGDKGK EEMQFAVGWS GSVSAEEGEY VTSALCIPLA SQKRSSTGRP 
       160        170        180        190        200
DWTCIVVGFT SGYVRFYTES GVLLLAQLLN EDKVLQLKCR TYEIPRHPGV 
       210        220        230        240        250
TEQNEELSIL YPAAIVTIDG FSLFQSLRAC RNQVAKAAAS GNENIQPPPL 
       260        270        280        290        300
AYKKWGLQDI DTIIDHASIG IMTLSPFDQM KTASNIGGFN AAIKNSPPAM 
       310        320        330        340        350
SQYITVGSSP FTGFFYALEG STQPLLSHVA LAVASKLTSA LFSAASGWLG 
       360        370        380        390        400
WKSKHEEDTV QKQKPKMEPA TPLAVRFGLP DSRRHGESIC LSPCNTLAAV 
       410        420        430        440        450
TDDFGRVILL DVARGIAIRM WKGYRDAQVG WIQIVEDLHE RVPEKGGFSP 
       460        470        480        490        500
FGNTQGPSRV AQFLVIYAPR RGILEVWNTQ QGPRVGAFNV GKHCRLLYPG 
       510        520        530        540        550
YKIMGLNNVT SQSWQPQTYQ ICLVDPVSAS VKAVNVPFHL ALSDKKSERA 
       560        570        580        590        600
KDLHLVKKLS ALLRAKSPRP DSFETEIKEL ILDIKYPATK KQALESILAS 
       610        620        630        640        650
DRLSFSCLRN VTQTLMDTLK NQELESVDEG LLQFCASKLK LLHLYESVSQ 
       660        670        680        690        700
LNTLDFHSDT PFSDNDLAVL LRLDDKELLK LRALLEKYKQ ENTKATVRFS 
       710        720        730        740        750
EDADRVLPVK TFLEYLEYEK DALSIRKVGE EECVALGSFF FWKCLHGESS 
       760        770        780        790        800
TEEMCHSLES AGLSPQQLLS LLLSVWLSKE KDILDKPQSV CCLHTMLSLL 
       810        820        830        840        850
SKMKVAIDET WDSQSVSPWW QQMRMACIQS ENSGAALLSA HVGHSVAAQM 
       860        870        880        890        900
SSGATDKKFS QMVLDADAEA LTDSWEALSL DTEYWKLLLR QLEDCLILQT 
       910        920        930        940        950
LLHSKLSPPA AKAPSLQSEP LPRLSVKKLL EGGKGGIADS VAKWIFKQDL 
       960        970        980        990       1000
SPELLKCANK ERDVENPDEP REDLLHLAYE QFPCSLELDV LHAHCCWEYV 
      1010       1020       1030       1040       1050
VQWNKDPEEA RFLVRSIEHL KHILNPHVQN GIALMMWNTF LVKRFSAATY 
      1060       1070       1080       1090       1100
LMDKVGKSPK DRLCRRDVGM SDTALTSFLG SCLELLQTSL EADISRDEVQ 
      1110       1120       1130       1140       1150
VPVLDTEDAW LSVEGPISIV ELALEQKPIH YPLVEHHSVL CSILYASMRF 
      1160       1170       1180       1190       1200
SLKSVKPLAL FDSKGKNAFF KDLTSIQLLP SGEMDPNFIS VRQQFLLKVV 
      1210       1220       1230       1240       1250
SAAVQAQHSK DKDPSAEAAN THWKDLNWPG LAVDLAHHLQ VSDDVIRRHY 
      1260       1270       1280       1290       1300
VGELYSHGAD LLGEEAIFQV QDKEVLASQL LVLTGQRLAH ALFHTQTKEG 
      1310       1320       1330       1340       1350
MELLARLPPT LCTWLKAMNP QDLQNTGVPI AATAKLVHKV MELLPEKHGQ 
      1360 
YSLALHLIDA VEAMATL
Length:1,367
Mass (Da):152,543
Last modified:February 4, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1120E11BBFB3D917
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BMG7RBGPR_MOUSE
Rab3 GTPase-activating protein non-...
Rab3gap2 Kiaa0839
1,366Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QKE4E9QKE4_MOUSE
Rab3 GTPase-activating protein non-...
Rab3gap2
1,387Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC129195 Genomic DNA No translation available.
AC131084 Genomic DNA No translation available.
AC158963 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_006497279.1, XM_006497216.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000194740; ENSMUSP00000141608; ENSMUSG00000039318

Database of genes from NCBI RefSeq genomes

More...GeneIDi		98732

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129195 Genomic DNA No translation available.
AC131084 Genomic DNA No translation available.
AC158963 Genomic DNA No translation available.
RefSeqiXP_006497279.1, XM_006497216.3

3D structure databases

SMRiA0A0A6YWM5
ModBaseiSearch...

Proteomic databases

EPDiA0A0A6YWM5
jPOSTiA0A0A6YWM5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20736, 117 antibodies

Genome annotation databases

EnsembliENSMUST00000194740; ENSMUSP00000141608; ENSMUSG00000039318
GeneIDi98732

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25782
MGIiMGI:1916043, Rab3gap2

Phylogenomic databases

GeneTreeiENSGT00390000005794
HOGENOMiCLU_006591_0_0_1
OMAiCKTVASN

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		98732, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Rab3gap2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039318, Expressed in secondary oocyte and 278 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR026059, Rab3-gap_reg
IPR029257, RAB3GAP2_C
IPR032839, RAB3GAP_N
PANTHERiPTHR12472, PTHR12472, 1 hit
PfamiView protein in Pfam
PF14656, RAB3GAP2_C, 1 hit
PF14655, RAB3GAP2_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A6YWM5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A6YWM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 4, 2015
Last sequence update: February 4, 2015
Last modified: December 2, 2020
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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