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Entry version 38 (11 Dec 2019)
Sequence version 1 (04 Feb 2015)
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Protein
Submitted name:

Protein patched homolog 1

Gene

Ptch1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein patched homolog 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptch1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:105373 Ptch1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei288 – 307HelicalSequence analysisAdd BLAST20
Transmembranei319 – 344HelicalSequence analysisAdd BLAST26
Transmembranei350 – 372HelicalSequence analysisAdd BLAST23
Transmembranei393 – 416HelicalSequence analysisAdd BLAST24
Transmembranei422 – 445HelicalSequence analysisAdd BLAST24
Transmembranei600 – 617HelicalSequence analysisAdd BLAST18
Transmembranei637 – 655HelicalSequence analysisAdd BLAST19
Transmembranei876 – 897HelicalSequence analysisAdd BLAST22
Transmembranei903 – 925HelicalSequence analysisAdd BLAST23
Transmembranei932 – 958HelicalSequence analysisAdd BLAST27
Transmembranei970 – 990HelicalSequence analysisAdd BLAST21
Transmembranei1002 – 1027HelicalSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A0A6YWC4

PRoteomics IDEntifications database

More...
PRIDEi
A0A0A6YWC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000021466 Expressed in 441 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A0A6YWC4 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini287 – 447SSDInterPro annotationAdd BLAST161

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1038 – 1082DisorderedSequence analysisAdd BLAST45
Regioni1120 – 1212DisorderedSequence analysisAdd BLAST93
Regioni1231 – 1259DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1042 – 1056Pro-richSequence analysisAdd BLAST15
Compositional biasi1062 – 1082PolarSequence analysisAdd BLAST21
Compositional biasi1127 – 1148PolarSequence analysisAdd BLAST22
Compositional biasi1151 – 1175PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1195 – 1212PolarSequence analysisAdd BLAST18

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1935 Eukaryota
ENOG410XRKU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159011

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEYPTQQ

Database of Orthologous Groups

More...
OrthoDBi
1190129at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD
IPR004766 TM_rcpt_patched

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02460 Patched, 1 hit
PF12349 Sterol-sensing, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00918 2A060602, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A0A6YWC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNPQLMIQT PKEEGANVLT TEALLQHLDS ALQASRVHVY MYNRQWKLEH
60 70 80 90 100
LCYKSGELIT ETGYMDQIIE YLYPCLIITP LDCFWEGAKL QSGTAYLLGK
110 120 130 140 150
PPLRWTNFDP LEFLEELKKI NYQVDSWEEM LNKAEVGHGY MDRPCLNPAD
160 170 180 190 200
PDCPATAPNK NSTKPLDVAL VLNGGCQGLS RKYMHWQEEL IVGGTVKNAT
210 220 230 240 250
GKLVSAHALQ TMFQLMTPKQ MYEHFRGYDY VSHINWNEDR AAAILEAWQR
260 270 280 290 300
TYVEVVHQSV APNSTQKVLP FTTTTLDDIL KSFSDVSVIR VASGYLLMLA
310 320 330 340 350
YACLTMLRWD CSKSQGAVGL AGVLLVALSV AAGLGLCSLI GISFNAATTQ
360 370 380 390 400
VLPFLALGVG VDDVFLLAHA FSETGQNKRI PFEDRTGECL KRTGASVALT
410 420 430 440 450
SISNVTAFFM AALIPIPALR AFSLQAAVVV VFNFAMVLLI FPAILSMDLY
460 470 480 490 500
RREDRRLDIF CCFTSPCVSR VIQVEPQAYT EPHSNTRYSP PPPYTSHSFA
510 520 530 540 550
HETHITMQST VQLRTEYDPH THVYYTTAEP RSEISVQPVT VTQDNLSCQS
560 570 580 590 600
PESTSSTRDL LSQFSDSSLH CLEPPCTKWT LSSFAEKHYA PFLLKPKAKV
610 620 630 640 650
VVILLFLGLL GVSLYGTTRV RDGLDLTDIV PRETREYDFI AAQFKYFSFY
660 670 680 690 700
NMYIVTQKAD YPNIQHLLYD LHKSFSNVKY VMLEENKQLP QMWLHYFRDW
710 720 730 740 750
LQGLQDAFDS DWETGRIMPN NYKNGSDDGV LAYKLLVQTG SRDKPIDISQ
760 770 780 790 800
LTKQRLVDAD GIINPSAFYI YLTAWVSNDP VAYAASQANI RPHRPEWVHD
810 820 830 840 850
KADYMPETRL RIPAAEPIEY AQFPFYLNGL RDTSDFVEAI EKVRVICNNY
860 870 880 890 900
TSLGLSSYPN GYPFLFWEQY ISLRHWLLLS ISVVLACTFL VCAVFLLNPW
910 920 930 940 950
TAGIIVMVLA LMTVELFGMM GLIGIKLSAV PVVILIASVG IGVEFTVHVA
960 970 980 990 1000
LAFLTAIGDK NHRAMLALEH MFAPVLDGAV STLLGVLMLA GSEFDFIVRY
1010 1020 1030 1040 1050
FFAVLAILTV LGVLNGLVLL PVLLSFFGPC PEVSPANGLN RLPTPSPEPP
1060 1070 1080 1090 1100
PSVVRFAVPP GHTNNGSDSS DSEYSSQTTV SGISEELRQY EAQQGAGGPA
1110 1120 1130 1140 1150
HQVIVEATEN PVFARSTVVH PDSRHQPPLT PRQQPHLDSG SLSPGRQGQQ
1160 1170 1180 1190 1200
PRRDPPREGL RPPPYRPRRD AFEISTEGHS GPSNRDRSGP RGARSHNPRN
1210 1220 1230 1240 1250
PTSTAMGSSV PSYCQPITTV TASASVTVAV HPPPGPGRNP RGGPCPGYES
1260 1270 1280 1290
YPETDHGVFE DPHVPFHVRC ERRDSKVEVI ELQDVECEER PWGSSSN
Length:1,297
Mass (Da):144,358
Last modified:February 4, 2015 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E73D39C664D1C89
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q61115PTC1_MOUSE
Protein patched homolog 1
Ptch1 Ptch
1,434Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWZ4A0A0A6YWZ4_MOUSE
Protein patched homolog 1
Ptch1
581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5R1U4Q5R1U4_MOUSE
Protein patched homolog 1
Ptch1 patched c isoform, patched e isoform, PTCH
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YVX7A0A0A6YVX7_MOUSE
Protein patched homolog 1
Ptch1
456Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YVW7A0A0A6YVW7_MOUSE
Protein patched homolog 1
Ptch1
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC154638 Genomic DNA No translation available.
AC160114 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006517225.1, XM_006517162.3
XP_006517226.1, XM_006517163.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000192155; ENSMUSP00000141489; ENSMUSG00000021466

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154638 Genomic DNA No translation available.
AC160114 Genomic DNA No translation available.
RefSeqiXP_006517225.1, XM_006517162.3
XP_006517226.1, XM_006517163.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

jPOSTiA0A0A6YWC4
PRIDEiA0A0A6YWC4

Genome annotation databases

EnsembliENSMUST00000192155; ENSMUSP00000141489; ENSMUSG00000021466

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5727
MGIiMGI:105373 Ptch1

Phylogenomic databases

eggNOGiKOG1935 Eukaryota
ENOG410XRKU LUCA
GeneTreeiENSGT00940000159011
OMAiFEYPTQQ
OrthoDBi1190129at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ptch1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000021466 Expressed in 441 organ(s), highest expression level in embryo
ExpressionAtlasiA0A0A6YWC4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR003392 Ptc/Disp
IPR000731 SSD
IPR004766 TM_rcpt_patched
PfamiView protein in Pfam
PF02460 Patched, 1 hit
PF12349 Sterol-sensing, 1 hit
TIGRFAMsiTIGR00918 2A060602, 1 hit
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A0A6YWC4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A0A6YWC4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 4, 2015
Last sequence update: February 4, 2015
Last modified: December 11, 2019
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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