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Protein

General transcription factor IIH subunit 4

Gene

EIN_229820

Organism
Entamoeba invadens IP1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
ORF Names:EIN_229820Imported
OrganismiEntamoeba invadens IP1Imported
Taxonomic identifieri370355 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
Proteomesi
  • UP000014680 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EIN_229820

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A0A1U347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENILEKDVL KYFQDFPEGA YRVIYQTKWS SSGIFRLLPS LCQSLLLRLV
60 70 80 90 100
FLSSTIDLPT VEKQFTITKQ EIIHVLSLLE SVKIIKKVMI NGKTQFQMNA
110 120 130 140 150
DFQTHLKESI LGPMVPNYVV SDCNFSVKDA LIKKASLNNA VKMFEDFLMK
160 170 180 190 200
LLTFNESHNL PKSAFELFKD LELVNDAGSQ ITRKGYQFLF QETKTQIWIL
210 220 230 240 250
MLSIFGPAQR KRRMGKLINE FFELTYLAPE TCYNADPFTK IYSAAPLILF
260 270 280 290 300
DMMGIIAYSK EKNALVVTPL MSLLRSNALV PSDLVTKPRT ITETNYTVYI
310 320 330 340 350
YTESFFQVKL YSLFIRQNLQ LTNLCVGRIT YDTVTEAFLK GITNEMLVNF
360 370 380 390 400
LQPNLPKNIQ AQIDLWKREL NRLKEVRAVK FRFYEPELEV QKELYHLTKS
410 420 430 440 450
EAEKMKGVVF YKEEELTLFV RYDVAEKIKE FLRRKTREES FIARLRKSES
460 470 480 490 500
DEKKESRSFS SFPQRGISRQ EPSKSISRSE SKSFKDQRSI SRPDTKRPPI
510 520 530
SNPGVNKRLP EPTQIKSVPT KKSYVLSDSD D
Length:531
Mass (Da):61,693
Last modified:February 4, 2015 - v1
Checksum:i4562606AE0BB8F7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB206756 Genomic DNA Translation: ELP88449.1
RefSeqiXP_004255220.1, XM_004255172.1

Genome annotation databases

EnsemblProtistsiELP88449; ELP88449; EIN_229820
GeneIDi14887088
KEGGieiv:EIN_229820

Entry informationi

Entry nameiA0A0A1U347_ENTIV
AccessioniPrimary (citable) accession number: A0A0A1U347
Entry historyiIntegrated into UniProtKB/TrEMBL: February 4, 2015
Last sequence update: February 4, 2015
Last modified: February 28, 2018
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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